Reviewed, UniProtKB/Swiss-Prot Q03401 (CRIS1_MOUSE)

Names and origin

Protein names

Recommended name:
    Cysteine-rich secretory protein 1
      Short name=CRISP-1
Alternative name(s):
    Acidic epididymal glycoprotein 1
    Sperm-coating glycoprotein 1
      Short name=SCP 1

Gene names

Name:	Crisp1
Synonyms:	Aeg-1, Aeg1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.
Subcellular location	Note: Stored in secretory granules of granular convoluted tubules cells.
Tissue specificity	Mainly found in the cauda epididymis where it is synthesized by the principal cells and secreted into the lumen. Binds to the heads of spermatozoa. Also expressed in the submandibular gland.
Developmental stage	Exponential increase between days 25 and 30 after birth.
Induction	By androgens.
Sequence similarities	Belongs to the CRISP family.

Ontologies

Keywords
Domain	Signal
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 244	225	Cysteine-rich secretory protein 1		PRO_0000006262
Amino acid modifications
	Glycosylation	145	1	N-linked (GlcNAc...) Potential
	Disulfide bond	190 ↔ 197		By similarity
	Disulfide bond	193 ↔ 202		By similarity
	Disulfide bond	206 ↔ 239		By similarity
	Disulfide bond	215 ↔ 233		By similarity
	Disulfide bond	224 ↔ 237		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q03401-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: D00DD0348F85781F	FASTA	244	27,680
	10 20 30 40 50 60 MALMLVLFFL AAVLPPSLLQ DSSQENRLEK LSTTKMSVQE EIVSKHNQLR RMVSPSGSDL 70 80 90 100 110 120 LKMEWNYDAQ VNAQQWADKC TFSHSPIELR TTNLRCGENL FMSSYLASWS SAIQGWYNEY 130 140 150 160 170 180 KDLTYDVGPK QPDSVVGHYT QVVWNSTFQV ACGVAECPKN PLRYYYVCHY CPVGNYQGRL 190 200 210 220 230 240 YTPYTAGEPC ASCPDHCEDG LCTNSCGHED KYTNCKYLKK MLSCEHELLK KGCKATCLCE GKIH

References

[1]	"Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule." Mizuki N., Kasahara M. Mol. Cell. Endocrinol. 89:25-32(1992) [PubMed: 1301383] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Submandibular gland.
[2]	"Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG) and the novel related CRISP-3 are expressed under androgen control in the mouse salivary gland." Haendler B., Kraetzschmar J., Theuring F., Schleuning W.-D. Endocrinology 133:192-198(1993) [PubMed: 8319566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Submandibular gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M92849 mRNA. Translation: AAA37185.1. L05559 mRNA. Translation: AAA37460.1.
IPI	IPI00132195.
PIR	A49202.
RefSeq	NP_033768.3.
UniGene	Mm.16781
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000025431. Mus musculus. [Contig view]
GeneID	11571.
KEGG	mmu:11571.
Organism-specific databases
MGI	MGI:102553. Crisp1.
Phylogenomic databases
HOGENOM	Q03401.
HOVERGEN	Q03401.
OMA	Q03401. LASWSSA.
Gene expression databases
ArrayExpress	Q03401.
Bgee	Q03401.
CleanEx	MM_CRISP1.
GermOnline	ENSMUSG00000025431. Mus musculus.
Family and domain databases
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR013871. Cysteine_rich_secretory. IPR014044. SCP-like_extracellular. [Graphical view]
PANTHER	PTHR10334. Allrgn_V5/Tpx1. 1 hit.
Pfam	PF08562. Crisp. 1 hit. PF00188. SCP. 1 hit. [Graphical view]
PRINTS	PR00837. V5TPXLIKE.
ProDom	PD000542. Allrgn_V5/Tpx1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00198. SCP. 1 hit. [Graphical view]
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279090.
SOURCE	Search...

Entry information

Entry name

CRIS1_MOUSE

Accession

Primary (citable) accession number: Q03401

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)