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Q033U7

- ASSY_LACC3

UniProt

Q033U7 - ASSY_LACC3

Protein

Argininosuccinate synthase

Gene

argG

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861CitrullineUniRule annotation
    Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181AspartateUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei122 – 1221CitrullineUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei174 – 1741CitrullineUniRule annotation
    Binding sitei259 – 2591CitrullineUniRule annotation
    Binding sitei271 – 2711CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCAS321967:GH4S-2808-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:LSEI_2811
    OrganismiLactobacillus casei (strain ATCC 334)
    Taxonomic identifieri321967 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001651: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Argininosuccinate synthasePRO_0000329471Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi321967.LSEI_2811.

    Structurei

    3D structure databases

    ProteinModelPortaliQ033U7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiPECEYIR.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q033U7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKIVLAYS GGLDTSVAIP WLKDKGYEVI AVVLNVGQPN ADFDAIQQKA    50
    LNVGALDSIV VDAQDEFADH YVAPVIKANA LYEGDYPLVS ALSRPLIIEH 100
    LVKIAHAQNA TAIAHGSTGK GNDQVRFEAA IHALDPEMKI EAPIRDFHWS 150
    REEEIDYAKE HNVPVPIGKK SPYSIDANLW GRANEAGILE NPWNQAPDDA 200
    WGMTVSPEAA PDDPTFIDLT FKQGVPVALN DEPMALATMI KELNKLAGDN 250
    GIGRIDKIEN RLVGIKSREV YEAPAAAVIM AAHHDLENLT LERDVQHFKP 300
    TIEDKITNMI YEAQWISPLF DALMAFIDKT QAVVNGTVKM KLYKGNATAV 350
    ARKSAHNSLY DEDLATYTSA DSFDQEAAAG FIKLWTLPTT VFEQVNHVHS 400
    EEKQHD 406
    Length:406
    Mass (Da):44,699
    Last modified:November 14, 2006 - v1
    Checksum:i49A3AC4BD4AA1648
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ71525.1.
    RefSeqiYP_807967.1. NC_008526.1.

    Genome annotation databases

    EnsemblBacteriaiABJ71525; ABJ71525; LSEI_2811.
    GeneIDi4421381.
    KEGGilca:LSEI_2811.
    PATRICi22209332. VBILacCas62221_2755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ71525.1 .
    RefSeqi YP_807967.1. NC_008526.1.

    3D structure databases

    ProteinModelPortali Q033U7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321967.LSEI_2811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ71525 ; ABJ71525 ; LSEI_2811 .
    GeneIDi 4421381.
    KEGGi lca:LSEI_2811.
    PATRICi 22209332. VBILacCas62221_2755.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi PECEYIR.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci LCAS321967:GH4S-2808-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 334.

    Entry informationi

    Entry nameiASSY_LACC3
    AccessioniPrimary (citable) accession number: Q033U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3