Q033M9 (MTLD_LACC3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	LSEI_2885

Organism

Lactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]

Taxonomic identifier

321967 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011802
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q033M9 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 1D8EE9999EBE6EF9	FASTA	384	42,584
	10 20 30 40 50 60 MMEAVHFGAG NIGRGFIGET LAANGFKINF VDVNETIINA LNQRGEYTIT LAAPGEKKIH 70 80 90 100 110 120 VDNVDGLNNA KDPEAVVKAI AQADLVTTAI GPKILPIIAP LIAQGLQARD AANNHQALDV 130 140 150 160 170 180 IACENMIGGS QSLKKSVYEH LDDAGKTFAD TYVGFPNAAV DRIVPQQKHD DPLAVSVEDF 190 200 210 220 230 240 KEWVVDESQM KNKDLKLKTV DYVPDLEPYI ERKLFSVNTG HATTAYTGKY LGYTTIGDAI 250 260 270 280 290 300 KDPKVFNQAK GALAETRSLL LSEFKNFDEK DLENYQNRVL QRFQNPYISD DISRVARTPI 310 320 330 340 350 360 RKLGYDERFI RPIRELKERG LNYSVLMDTV GMMFHYVEPN DAEAVKLQAM LKDQPLVDVI 370 380 KEVTGLKDAG LIDEVEASVK SKDR

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 334.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000423 Genomic DNA. Translation: ABJ71593.1.
RefSeq	YP_808035.1. NC_008526.1.
3D structure databases
ProteinModelPortal	Q033M9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q033M9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4421455.
GenomeReviews	Gene locus LSEI_2885 in contig CP000423_GR.
KEGG	lca:LSEI_2885.
PATRIC	22209478. VBILacCas62221_2827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG568825.
OMA	FANTAVD.
PhylomeDB	Q033M9.
ProtClustDB	PRK02318.
Enzyme and pathway databases
BioCyc	LCAS321967:LSEI_2885-MONOMER.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LACC3

Accession

Primary (citable) accession number: Q033M9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program