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Protein

Proliferating cell nuclear antigen

Gene

pcn1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: PomBase
  • DNA polymerase processivity factor activity Source: PomBase

GO - Biological processi

  • DNA strand elongation involved in DNA replication Source: PomBase
  • error-free translesion synthesis Source: PomBase
  • error-prone translesion synthesis Source: PomBase
  • leading strand elongation Source: GO_Central
  • mismatch repair Source: GO_Central
  • mitotic DNA replication lagging strand elongation Source: PomBase
  • mitotic DNA replication leading strand elongation Source: PomBase
  • positive regulation of cellular protein catabolic process Source: PomBase
  • positive regulation of DNA-directed DNA polymerase activity Source: PomBase
  • postreplication repair Source: PomBase
  • UV-damage excision repair Source: PomBase

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-SPO-110312 Translesion synthesis by REV1
R-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-110320 Translesion Synthesis by POLH
R-SPO-174411 Polymerase switching on the C-strand of the telomere
R-SPO-174414 Processive synthesis on the C-strand of the telomere
R-SPO-174417 Telomere C-strand (Lagging Strand) Synthesis
R-SPO-174437 Removal of the Flap Intermediate from the C-strand
R-SPO-4615885 SUMOylation of DNA replication proteins
R-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5655862 Translesion synthesis by POLK
R-SPO-5656121 Translesion synthesis by POLI
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-69091 Polymerase switching
R-SPO-69166 Removal of the Flap Intermediate
R-SPO-69183 Processive synthesis on the lagging strand
R-SPO-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Gene namesi
Name:pcn1
Synonyms:pcn
ORF Names:SPBC16D10.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16D10.09
PomBaseiSPBC16D10.09 pcn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491751 – 260Proliferating cell nuclear antigenAdd BLAST260

Proteomic databases

MaxQBiQ03392
PaxDbiQ03392
PRIDEiQ03392

PTM databases

iPTMnetiQ03392

Interactioni

Subunit structurei

Interacts with cdc24, rfc1, and rtf2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi276564, 39 interactors
DIPiDIP-33811N
IntActiQ03392, 11 interactors
STRINGi4896.SPBC16D10.09.1

Structurei

3D structure databases

ProteinModelPortaliQ03392
SMRiQ03392
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

HOGENOMiHOG000211098
InParanoidiQ03392
KOiK04802
OMAiSDGFDKY
OrthoDBiEOG092C4AWZ
PhylomeDBiQ03392

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q03392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEARFQQAA LLKKLLDAIK ELVTDANFDC NDNGISLQAM DSSHVALVSM
60 70 80 90 100
LIKSDGFEPY RCDRNIALGI NLNALSKVLR CAQNEDLVTL KAEDTPEVLN
110 120 130 140 150
LVFESEKNDR ISDYDVKLMD IDQEHLGIPD IEYDATITMP AAEFQRITRD
160 170 180 190 200
LLTLSDSVTI NASKEGVRFS CKGDIGNGST TLKQHTDLSD QDQSIEISLT
210 220 230 240 250
QAVTLTFSLK YLAQFTKATP LATRVTLSMS NDVPLLVEYK MESGFLRFYL
260
APKIGEEDEE
Length:260
Mass (Da):28,969
Last modified:October 1, 1993 - v1
Checksum:i1EE5B2A27A899C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54857 Genomic DNA Translation: CAA38636.1
CU329671 Genomic DNA Translation: CAB38513.1
PIRiS28053 WMZPET
RefSeqiNP_596504.1, NM_001022425.2

Genome annotation databases

EnsemblFungiiSPBC16D10.09.1; SPBC16D10.09.1:pep; SPBC16D10.09
GeneIDi2540020
KEGGispo:SPBC16D10.09

Similar proteinsi

Entry informationi

Entry nameiPCNA_SCHPO
AccessioniPrimary (citable) accession number: Q03392
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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