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Q03388

- VPS72_YEAST

UniProt

Q03388 - VPS72_YEAST

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Protein

Vacuolar protein sorting-associated protein 72

Gene

VPS72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in the catalytic exchange of histone H2A for the H2A variant HTZ1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting.4 Publications

GO - Molecular functioni

  1. histone binding Source: SGD

GO - Biological processi

  1. chromatin remodeling Source: SGD
  2. histone exchange Source: SGD
  3. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

BioCyciYEAST:G3O-30010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 72
Alternative name(s):
SWR complex protein 2
Gene namesi
Name:VPS72
Synonyms:SWC2
Ordered Locus Names:YDR485C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR485c.
SGDiS000002893. VPS72.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Swr1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 795795Vacuolar protein sorting-associated protein 72PRO_0000065909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei425 – 4251Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03388.
PaxDbiQ03388.

Expressioni

Gene expression databases

GenevestigatoriQ03388.

Interactioni

Subunit structurei

Belongs to the SWR1 complex at least composed of ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWR1 and HTZ1. Interacts with HTZ1.4 Publications

Protein-protein interaction databases

BioGridi32537. 350 interactions.
DIPiDIP-1008N.
IntActiQ03388. 14 interactions.
MINTiMINT-2782183.
STRINGi4932.YDR485C.

Structurei

3D structure databases

ProteinModelPortaliQ03388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 281281Interaction with HTZ1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili28 – 6336Sequence AnalysisAdd
BLAST
Coiled coili121 – 15030Sequence AnalysisAdd
BLAST
Coiled coili204 – 28178Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 8529Asp-richAdd
BLAST
Compositional biasi315 – 34329Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the VPS72/YL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG253988.
HOGENOMiHOG000141998.
InParanoidiQ03388.
KOiK11664.
OMAiLLFQEDE.
OrthoDBiEOG78PVK3.

Family and domain databases

InterProiIPR008895. YL1.
IPR013272. YL1_C.
[Graphical view]
PfamiPF05764. YL1. 1 hit.
PF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03388-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDEGADKSL DTNTEFIIQT RSRRSNAGNK LQKLLEQELR DIESTKRQIS
60 70 80 90 100
SYKNGNDDEE DEIGLLFQED EDDEDFEMMA KDDDDEGEEK EDETQSIRKE
110 120 130 140 150
PSQASSEQAA DDLMFSSSES EDSSNENDED AEEKEIRRQE LLSRKKRNKR
160 170 180 190 200
LQKGPVVIKK QKPKPKSGEA IPRSHHTHEQ LNAETLLLNT RRTSKRSSVM
210 220 230 240 250
ENTMKVYEKL SKAEKKRKII QERIRKHKEQ ESQHMLTQEE RLRIAKETEK
260 270 280 290 300
LNILSLDKFK EQEVWKKENR LALQKRQKQK FQPNETILQF LSTAWLMTPA
310 320 330 340 350
MELEDRKYWQ EQLNKRDKKK KKYPRKPKKN LNLGKQDASD DKKRESEESI
360 370 380 390 400
KNDGDVNSLG ENSSSVHNQK RIEETSTNDT VEGESSPDAA VSRVNSDELK
410 420 430 440 450
PTALPDVTLD AIANKQSTVD EAPNSQPQKN IITNEQKITN VGEPIQNLHN
460 470 480 490 500
EEIKDEMVSA LESRENTFEN SSPAAQVVSQ RDNSATPTPS NSTGTEDTIL
510 520 530 540 550
ISPDTDIKGE PEPCLKTEGI ENLSHNVPQE TKSNTDVSFL KQVTFTDHPQ
560 570 580 590 600
VAIIDTEESP SKKDTANVDE SSAENSLSTQ TYEGPEQLTS RNFVTLYDFP
610 620 630 640 650
NAPPNLKDFN TNLFGDRWSY TNGLSATQRP QDMKTVFHSI LPSPPQSSVP
660 670 680 690 700
SPTVDISLDL SALANFPSFG EYDKKIVHQI NTEINKDLEI KIKTQPPTGV
710 720 730 740 750
FLANGIRKKC LITNKECQYF DPRTGVPYSD VEAYKIIQRI QDPISKEEGR
760 770 780 790
SDIKRDETTN EDSDDQVRFK WFGFKNGGIY LDLSQRPAKG VPEGF
Length:795
Mass (Da):90,580
Last modified:April 26, 2005 - v2
Checksum:i6D3053EBB610DB95
GO

Sequence cautioni

The sequence AAB64928.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAT93172.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33050 Genomic DNA. Translation: AAB64928.1. Different initiation.
AY693153 Genomic DNA. Translation: AAT93172.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12318.1.
PIRiS69652.
RefSeqiNP_010773.4. NM_001180793.3.

Genome annotation databases

EnsemblFungiiYDR485C; YDR485C; YDR485C.
GeneIDi852096.
KEGGisce:YDR485C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33050 Genomic DNA. Translation: AAB64928.1 . Different initiation.
AY693153 Genomic DNA. Translation: AAT93172.1 . Different initiation.
BK006938 Genomic DNA. Translation: DAA12318.1 .
PIRi S69652.
RefSeqi NP_010773.4. NM_001180793.3.

3D structure databases

ProteinModelPortali Q03388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32537. 350 interactions.
DIPi DIP-1008N.
IntActi Q03388. 14 interactions.
MINTi MINT-2782183.
STRINGi 4932.YDR485C.

Proteomic databases

MaxQBi Q03388.
PaxDbi Q03388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR485C ; YDR485C ; YDR485C .
GeneIDi 852096.
KEGGi sce:YDR485C.

Organism-specific databases

CYGDi YDR485c.
SGDi S000002893. VPS72.

Phylogenomic databases

eggNOGi NOG253988.
HOGENOMi HOG000141998.
InParanoidi Q03388.
KOi K11664.
OMAi LLFQEDE.
OrthoDBi EOG78PVK3.

Enzyme and pathway databases

BioCyci YEAST:G3O-30010-MONOMER.

Miscellaneous databases

NextBioi 970433.
PROi Q03388.

Gene expression databases

Genevestigatori Q03388.

Family and domain databases

InterProi IPR008895. YL1.
IPR013272. YL1_C.
[Graphical view ]
Pfami PF05764. YL1. 1 hit.
PF08265. YL1_C. 1 hit.
[Graphical view ]
SMARTi SM00993. YL1_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  5. "Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae."
    Bonangelino C.J., Chavez E.M., Bonifacino J.S.
    Mol. Biol. Cell 13:2486-2501(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: FUNCTION, INTERACTION WITH ACT1; ARP4; RVB1; RVB2; ARP6; YAF9; VPS71; SWC3; SWC4; SWC5; SWR1 AND HTZ1.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex."
    Mizuguchi G., Shen X., Landry J., Wu W.-H., Sen S., Wu C.
    Science 303:343-348(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ACT1; ARP4; RVB1; RVB2; ARP6; YAF9; VPS71; SWC3; SWC4; SWC5; SWR1 AND HTZ1.
  10. "A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin."
    Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W., Jennings J.L., Link A.J., Madhani H.D., Rine J.
    PLoS Biol. 2:587-599(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ACT1; ARP4; RVB1; RVB2; ARP6; YAF9; VPS71; SWC3; SWC4; SWC5; SWR1 AND HTZ1.
  11. "Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange."
    Wu W.-H., Alami S., Luk E., Wu C.-H., Sen S., Mizuguchi G., Wei D., Wu C.
    Nat. Struct. Mol. Biol. 12:1064-1071(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTZ1.
  12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVPS72_YEAST
AccessioniPrimary (citable) accession number: Q03388
Secondary accession number(s): D6VTA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3