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Protein

Vacuolar protein sorting-associated protein 72

Gene

VPS72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the catalytic exchange of histone H2A for the H2A variant HTZ1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting.4 Publications

GO - Molecular functioni

  • histone binding Source: SGD

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromatin remodeling Source: SGD
  • histone exchange Source: SGD
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

BioCyciYEAST:G3O-30010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 72
Alternative name(s):
SWR complex protein 2
Gene namesi
Name:VPS72
Synonyms:SWC2
Ordered Locus Names:YDR485C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR485C.
SGDiS000002893. VPS72.

Subcellular locationi

GO - Cellular componenti

  • Swr1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659091 – 795Vacuolar protein sorting-associated protein 72Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei425PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03388.
PRIDEiQ03388.

PTM databases

iPTMnetiQ03388.

Interactioni

Subunit structurei

Belongs to the SWR1 complex at least composed of ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWR1 and HTZ1. Interacts with HTZ1.4 Publications

GO - Molecular functioni

  • histone binding Source: SGD

Protein-protein interaction databases

BioGridi32537. 353 interactors.
DIPiDIP-1008N.
IntActiQ03388. 14 interactors.
MINTiMINT-2782183.

Structurei

3D structure databases

ProteinModelPortaliQ03388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 281Interaction with HTZ1Add BLAST281

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 63Sequence analysisAdd BLAST36
Coiled coili121 – 150Sequence analysisAdd BLAST30
Coiled coili204 – 281Sequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 85Asp-richAdd BLAST29
Compositional biasi315 – 343Lys-richAdd BLAST29

Sequence similaritiesi

Belongs to the VPS72/YL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000141998.
InParanoidiQ03388.
KOiK11664.
OMAiNGVPYSD.
OrthoDBiEOG092C1YKY.

Family and domain databases

InterProiIPR008895. Vps72/YL1.
IPR013272. Vps72/YL1_C.
[Graphical view]
PANTHERiPTHR13275. PTHR13275. 3 hits.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEGADKSL DTNTEFIIQT RSRRSNAGNK LQKLLEQELR DIESTKRQIS
60 70 80 90 100
SYKNGNDDEE DEIGLLFQED EDDEDFEMMA KDDDDEGEEK EDETQSIRKE
110 120 130 140 150
PSQASSEQAA DDLMFSSSES EDSSNENDED AEEKEIRRQE LLSRKKRNKR
160 170 180 190 200
LQKGPVVIKK QKPKPKSGEA IPRSHHTHEQ LNAETLLLNT RRTSKRSSVM
210 220 230 240 250
ENTMKVYEKL SKAEKKRKII QERIRKHKEQ ESQHMLTQEE RLRIAKETEK
260 270 280 290 300
LNILSLDKFK EQEVWKKENR LALQKRQKQK FQPNETILQF LSTAWLMTPA
310 320 330 340 350
MELEDRKYWQ EQLNKRDKKK KKYPRKPKKN LNLGKQDASD DKKRESEESI
360 370 380 390 400
KNDGDVNSLG ENSSSVHNQK RIEETSTNDT VEGESSPDAA VSRVNSDELK
410 420 430 440 450
PTALPDVTLD AIANKQSTVD EAPNSQPQKN IITNEQKITN VGEPIQNLHN
460 470 480 490 500
EEIKDEMVSA LESRENTFEN SSPAAQVVSQ RDNSATPTPS NSTGTEDTIL
510 520 530 540 550
ISPDTDIKGE PEPCLKTEGI ENLSHNVPQE TKSNTDVSFL KQVTFTDHPQ
560 570 580 590 600
VAIIDTEESP SKKDTANVDE SSAENSLSTQ TYEGPEQLTS RNFVTLYDFP
610 620 630 640 650
NAPPNLKDFN TNLFGDRWSY TNGLSATQRP QDMKTVFHSI LPSPPQSSVP
660 670 680 690 700
SPTVDISLDL SALANFPSFG EYDKKIVHQI NTEINKDLEI KIKTQPPTGV
710 720 730 740 750
FLANGIRKKC LITNKECQYF DPRTGVPYSD VEAYKIIQRI QDPISKEEGR
760 770 780 790
SDIKRDETTN EDSDDQVRFK WFGFKNGGIY LDLSQRPAKG VPEGF
Length:795
Mass (Da):90,580
Last modified:April 26, 2005 - v2
Checksum:i6D3053EBB610DB95
GO

Sequence cautioni

The sequence AAB64928 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT93172 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA. Translation: AAB64928.1. Different initiation.
AY693153 Genomic DNA. Translation: AAT93172.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12318.1.
PIRiS69652.
RefSeqiNP_010773.4. NM_001180793.3.

Genome annotation databases

EnsemblFungiiYDR485C; YDR485C; YDR485C.
GeneIDi852096.
KEGGisce:YDR485C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA. Translation: AAB64928.1. Different initiation.
AY693153 Genomic DNA. Translation: AAT93172.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA12318.1.
PIRiS69652.
RefSeqiNP_010773.4. NM_001180793.3.

3D structure databases

ProteinModelPortaliQ03388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32537. 353 interactors.
DIPiDIP-1008N.
IntActiQ03388. 14 interactors.
MINTiMINT-2782183.

PTM databases

iPTMnetiQ03388.

Proteomic databases

MaxQBiQ03388.
PRIDEiQ03388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR485C; YDR485C; YDR485C.
GeneIDi852096.
KEGGisce:YDR485C.

Organism-specific databases

EuPathDBiFungiDB:YDR485C.
SGDiS000002893. VPS72.

Phylogenomic databases

HOGENOMiHOG000141998.
InParanoidiQ03388.
KOiK11664.
OMAiNGVPYSD.
OrthoDBiEOG092C1YKY.

Enzyme and pathway databases

BioCyciYEAST:G3O-30010-MONOMER.

Miscellaneous databases

PROiQ03388.

Family and domain databases

InterProiIPR008895. Vps72/YL1.
IPR013272. Vps72/YL1_C.
[Graphical view]
PANTHERiPTHR13275. PTHR13275. 3 hits.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPS72_YEAST
AccessioniPrimary (citable) accession number: Q03388
Secondary accession number(s): D6VTA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.