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Protein

Ral guanine nucleotide dissociation stimulator

Gene

Ralgds

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.

GO - Molecular functioni

  • Ral guanyl-nucleotide exchange factor activity Source: RGD

GO - Biological processi

  • small GTPase mediated signal transduction Source: RGD

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator
Short name:
RalGDS
Alternative name(s):
Ral guanine nucleotide exchange factor
Short name:
RalGEF
Gene namesi
Name:Ralgds
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3533 Ralgds

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688791 – 895Ral guanine nucleotide dissociation stimulatorAdd BLAST895

Proteomic databases

PaxDbiQ03386
PRIDEiQ03386

PTM databases

iPTMnetiQ03386
PhosphoSitePlusiQ03386

Expressioni

Tissue specificityi

Expressed in all tissues examined.

Interactioni

Subunit structurei

Interacts with RIT1 and RIT2. Interacts (via Ras-associating domain) with Oog1.By similarity

GO - Molecular functioni

  • Ral guanyl-nucleotide exchange factor activity Source: RGD

Protein-protein interaction databases

IntActiQ03386, 1 interactor
STRINGi10116.ENSRNOP00000013809

Structurei

Secondary structure

1895
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi779 – 789Combined sources11
Beta strandi791 – 801Combined sources11
Helixi806 – 816Combined sources11
Helixi824 – 826Combined sources3
Beta strandi827 – 836Combined sources10
Beta strandi838 – 840Combined sources3
Helixi847 – 850Combined sources4
Beta strandi858 – 863Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LFDX-ray2.10A/C778-864[»]
1LXDX-ray2.40A/B767-864[»]
ProteinModelPortaliQ03386
SMRiQ03386
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03386

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 237N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST126
Domaini367 – 629Ras-GEFPROSITE-ProRule annotationAdd BLAST263
Domaini779 – 866Ras-associatingPROSITE-ProRule annotationAdd BLAST88

Domaini

The Ras-associating domain interacts with Ras.

Phylogenomic databases

eggNOGiKOG3629 Eukaryota
ENOG410ZQ4B LUCA
HOGENOMiHOG000231592
HOVERGENiHBG005864
InParanoidiQ03386
KOiK08732
PhylomeDBiQ03386

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR015758 RalGDS
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23113:SF35 PTHR23113:SF35, 1 hit
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF48366 SSF48366, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q03386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRMWAEAS GPIGGAEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF
60 70 80 90 100
TQLDPDLPRL ESSTQEIGEE LINGVIYSIS LRKVQLYPGA TKGQRWLGCE
110 120 130 140 150
NESALNLYET CKVRTVKAGT LEKLVEHLVP AFQGSDLSYV TVFLCTYRAF
160 170 180 190 200
TTTQQVLDLL FKRYGCILPY SSEDGGPQDQ LKNAISSILG TWLDQYSEDF
210 220 230 240 250
CQPPDFPCLK QLVAYVQLNM PGSDLERRAH LLLAQLEDLE PSEVEPEALS
260 270 280 290 300
PAPVLSLKPA SQLEPAPALL LTPSRAVAST PVREPAPVPV LASSPVVAPA
310 320 330 340 350
SELEPALEPP LDPEPTLAPA PELDPTVSQS LHLEPAPVPA PALEPSWPLP
360 370 380 390 400
ETTENGLCAK PHLLLFPPDL VAEQFTLMDA ELFKKVVPYH CLGSIWSQRA
410 420 430 440 450
KKGKEHLAPT IRATVAQFNN VANCVITTCL GDQSMKASDR ARVVEHWIEV
460 470 480 490 500
ARECRVLKNF SSLYAILSAL QSNAIHRLKK TWEEVSRGSF RVFQKLSEIF
510 520 530 540 550
SDENNYSLSR ELLIKEGTSK FATLEMNPRR TQRRQKETGV IQGTVPYLGT
560 570 580 590 600
FLTDLVMLDT AMKDYLYGRL INFEKRRKEF EVIAQIKLLQ SACNNYSIVP
610 620 630 640 650
EEHFGAWFRA MGRLSEAESY NLSCELEPPS ESASNTLRSK KSTAIVKRWE
660 670 680 690 700
RRQAPSTELS TSSSAHSKSC DQLRCSPYLS SGDITDALSV HSAGSSTSDV
710 720 730 740 750
EEINMSFVPE SPDGQEKKFW ESASQSSPET SGISSASSST SSSSASTTPV
760 770 780 790 800
STTRTHKRSV SGVCSYSSSL PLYNQQVGDC CIIRVSLDVD NGNMYKSILV
810 820 830 840 850
TSQDKAPTVI RKAMDKHNLD EDEPEDYELL QIISEDHKLK IPENANVFYA
860 870 880 890
MNSAANYDFI LKKRAFTKGA KVKHGASSTL PRMKQKGLRI ARGIF
Length:895
Mass (Da):98,869
Last modified:June 1, 1994 - v1
Checksum:i43E1674675A4E1C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07925 mRNA Translation: AAA41259.1
RefSeqiNP_062123.2, NM_019250.2
UniGeneiRn.40174

Genome annotation databases

GeneIDi29622
KEGGirno:29622
UCSCiRGD:3533 rat

Similar proteinsi

Entry informationi

Entry nameiGNDS_RAT
AccessioniPrimary (citable) accession number: Q03386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health