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Protein

C-C motif chemokine 7

Gene

Ccl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity).By similarity

GO - Molecular functioni

  1. CCR2 chemokine receptor binding Source: BHF-UCL
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to ethanol Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. positive regulation of natural killer cell chemotaxis Source: Ensembl
  7. regulation of cell shape Source: Ensembl
  8. response to gamma radiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Intercrine/chemokine MARC
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
Protein FIC
Small-inducible cytokine A7
Gene namesi
Name:Ccl7
Synonyms:Fic, Mcp3, Scya7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:99512. Ccl7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9774C-C motif chemokine 7PRO_0000005184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ03366.

Expressioni

Gene expression databases

BgeeiQ03366.
CleanExiMM_CCL7.
ExpressionAtlasiQ03366. baseline and differential.
GenevestigatoriQ03366.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi203131. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ03366.
SMRiQ03366. Positions 24-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ03366.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG7673DP.
PhylomeDBiQ03366.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03366-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR
60 70 80 90
RITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP
Length:97
Mass (Da):10,999
Last modified:October 1, 1993 - v1
Checksum:iB94FDA6DF1EF6140
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 637Missing in CAA49662. (PubMed:7989769)Curated
Sequence conflicti74 – 741A → R in AAA37516. (PubMed:8455595)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12297 mRNA. Translation: CAA78169.1.
L04694 mRNA. Translation: AAA37516.1.
S71251 mRNA. Translation: AAB30997.1.
X70058 Genomic DNA. Translation: CAA49662.1.
AF128193 mRNA. Translation: AAF22534.1.
AF128194 mRNA. Translation: AAF22535.1.
AK078827 mRNA. Translation: BAC37413.1.
BC061126 mRNA. Translation: AAH61126.1.
CCDSiCCDS36245.1.
PIRiA48093.
RefSeqiNP_038682.1. NM_013654.3.
UniGeneiMm.341574.

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
GeneIDi20306.
KEGGimmu:20306.
UCSCiuc007kmq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12297 mRNA. Translation: CAA78169.1.
L04694 mRNA. Translation: AAA37516.1.
S71251 mRNA. Translation: AAB30997.1.
X70058 Genomic DNA. Translation: CAA49662.1.
AF128193 mRNA. Translation: AAF22534.1.
AF128194 mRNA. Translation: AAF22535.1.
AK078827 mRNA. Translation: BAC37413.1.
BC061126 mRNA. Translation: AAH61126.1.
CCDSiCCDS36245.1.
PIRiA48093.
RefSeqiNP_038682.1. NM_013654.3.
UniGeneiMm.341574.

3D structure databases

ProteinModelPortaliQ03366.
SMRiQ03366. Positions 24-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203131. 1 interaction.

Proteomic databases

PRIDEiQ03366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
GeneIDi20306.
KEGGimmu:20306.
UCSCiuc007kmq.2. mouse.

Organism-specific databases

CTDi6354.
MGIiMGI:99512. Ccl7.

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ03366.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG7673DP.
PhylomeDBiQ03366.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi298063.
PROiQ03366.
SOURCEiSearch...

Gene expression databases

BgeeiQ03366.
CleanExiMM_CCL7.
ExpressionAtlasiQ03366. baseline and differential.
GenevestigatoriQ03366.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cells."
    Kulmburg P.A., Huber N.E., Scheer B.J., Wrann M., Baumruker T.
    J. Exp. Med. 176:1773-1778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mast cell.
  2. "Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC."
    Thirion S., Nys G., Fiten P., Masure S., van Damme J., Opdenakker G.
    Biochem. Biophys. Res. Commun. 201:493-499(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Werner F.
    Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The product of a novel growth factor-activated gene, fic, is a biologically active 'C-C'-type cytokine."
    Heinrich J.N., Ryseck R.P., Macdonald-Bravo H., Bravo R.
    Mol. Cell. Biol. 13:2020-2030(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "A transcription factor with AP3-like binding specificity mediates gene regulation after an allergic triggering with IgE and Ag in mouse mast cells."
    Jarmin D.I., Kulmburg P.A., Huber N.E., Baumann G., Prieschl-Strassmayr E.E., Baumruker T.
    J. Immunol. 153:5720-5729(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J and SJL/J.
    Tissue: Spleen.
  7. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCCL7_MOUSE
AccessioniPrimary (citable) accession number: Q03366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 7, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.