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Q03366

- CCL7_MOUSE

UniProt

Q03366 - CCL7_MOUSE

Protein

C-C motif chemokine 7

Gene

Ccl7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity By similarity.By similarity

    GO - Molecular functioni

    1. CCR2 chemokine receptor binding Source: BHF-UCL
    2. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to ethanol Source: Ensembl
    2. cytoskeleton organization Source: Ensembl
    3. eosinophil chemotaxis Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. positive regulation of natural killer cell chemotaxis Source: Ensembl
    7. regulation of cell shape Source: Ensembl
    8. response to gamma radiation Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 7
    Alternative name(s):
    Intercrine/chemokine MARC
    Monocyte chemoattractant protein 3
    Monocyte chemotactic protein 3
    Short name:
    MCP-3
    Protein FIC
    Small-inducible cytokine A7
    Gene namesi
    Name:Ccl7
    Synonyms:Fic, Mcp3, Scya7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:99512. Ccl7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9774C-C motif chemokine 7PRO_0000005184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiQ03366.

    Expressioni

    Gene expression databases

    ArrayExpressiQ03366.
    BgeeiQ03366.
    CleanExiMM_CCL7.
    GenevestigatoriQ03366.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi203131. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03366.
    SMRiQ03366. Positions 24-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG140372.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ03366.
    KOiK05509.
    OMAiNSINIIM.
    OrthoDBiEOG7673DP.
    PhylomeDBiQ03366.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03366-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR   50
    RITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP 97
    Length:97
    Mass (Da):10,999
    Last modified:October 1, 1993 - v1
    Checksum:iB94FDA6DF1EF6140
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 637Missing in CAA49662. (PubMed:7989769)Curated
    Sequence conflicti74 – 741A → R in AAA37516. (PubMed:8455595)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12297 mRNA. Translation: CAA78169.1.
    L04694 mRNA. Translation: AAA37516.1.
    S71251 mRNA. Translation: AAB30997.1.
    X70058 Genomic DNA. Translation: CAA49662.1.
    AF128193 mRNA. Translation: AAF22534.1.
    AF128194 mRNA. Translation: AAF22535.1.
    AK078827 mRNA. Translation: BAC37413.1.
    BC061126 mRNA. Translation: AAH61126.1.
    CCDSiCCDS36245.1.
    PIRiA48093.
    RefSeqiNP_038682.1. NM_013654.3.
    UniGeneiMm.341574.

    Genome annotation databases

    EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
    GeneIDi20306.
    KEGGimmu:20306.
    UCSCiuc007kmq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12297 mRNA. Translation: CAA78169.1 .
    L04694 mRNA. Translation: AAA37516.1 .
    S71251 mRNA. Translation: AAB30997.1 .
    X70058 Genomic DNA. Translation: CAA49662.1 .
    AF128193 mRNA. Translation: AAF22534.1 .
    AF128194 mRNA. Translation: AAF22535.1 .
    AK078827 mRNA. Translation: BAC37413.1 .
    BC061126 mRNA. Translation: AAH61126.1 .
    CCDSi CCDS36245.1.
    PIRi A48093.
    RefSeqi NP_038682.1. NM_013654.3.
    UniGenei Mm.341574.

    3D structure databases

    ProteinModelPortali Q03366.
    SMRi Q03366. Positions 24-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203131. 1 interaction.

    Proteomic databases

    PRIDEi Q03366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021011 ; ENSMUSP00000021011 ; ENSMUSG00000035373 .
    GeneIDi 20306.
    KEGGi mmu:20306.
    UCSCi uc007kmq.2. mouse.

    Organism-specific databases

    CTDi 6354.
    MGIi MGI:99512. Ccl7.

    Phylogenomic databases

    eggNOGi NOG140372.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q03366.
    KOi K05509.
    OMAi NSINIIM.
    OrthoDBi EOG7673DP.
    PhylomeDBi Q03366.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298063.
    PROi Q03366.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03366.
    Bgeei Q03366.
    CleanExi MM_CCL7.
    Genevestigatori Q03366.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cells."
      Kulmburg P.A., Huber N.E., Scheer B.J., Wrann M., Baumruker T.
      J. Exp. Med. 176:1773-1778(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mast cell.
    2. "Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC."
      Thirion S., Nys G., Fiten P., Masure S., van Damme J., Opdenakker G.
      Biochem. Biophys. Res. Commun. 201:493-499(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Werner F.
      Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "The product of a novel growth factor-activated gene, fic, is a biologically active 'C-C'-type cytokine."
      Heinrich J.N., Ryseck R.P., Macdonald-Bravo H., Bravo R.
      Mol. Cell. Biol. 13:2020-2030(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "A transcription factor with AP3-like binding specificity mediates gene regulation after an allergic triggering with IgE and Ag in mouse mast cells."
      Jarmin D.I., Kulmburg P.A., Huber N.E., Baumann G., Prieschl-Strassmayr E.E., Baumruker T.
      J. Immunol. 153:5720-5729(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10.S/J and SJL/J.
      Tissue: Spleen.
    7. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCCL7_MOUSE
    AccessioniPrimary (citable) accession number: Q03366
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3