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Q03366 (CCL7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 7
Alternative name(s):
Intercrine/chemokine MARC
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name=MCP-3
Protein FIC
Small-inducible cytokine A7
Gene names
Name:Ccl7
Synonyms:Fic, Mcp3, Scya7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9774C-C motif chemokine 7
PRO_0000005184

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Glycosylation291N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Experimental info

Sequence conflict57 – 637Missing in CAA49662. Ref.5
Sequence conflict741A → R in AAA37516. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q03366 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: B94FDA6DF1EF6140

FASTA9710,999
        10         20         30         40         50         60 
MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR RITSSRCPWE 

        70         80         90 
AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP 

« Hide

References

« Hide 'large scale' references
[1]"Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cells."
Kulmburg P.A., Huber N.E., Scheer B.J., Wrann M., Baumruker T.
J. Exp. Med. 176:1773-1778(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mast cell.
[2]"Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC."
Thirion S., Nys G., Fiten P., Masure S., van Damme J., Opdenakker G.
Biochem. Biophys. Res. Commun. 201:493-499(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Werner F.
Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]"The product of a novel growth factor-activated gene, fic, is a biologically active 'C-C'-type cytokine."
Heinrich J.N., Ryseck R.P., Macdonald-Bravo H., Bravo R.
Mol. Cell. Biol. 13:2020-2030(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"A transcription factor with AP3-like binding specificity mediates gene regulation after an allergic triggering with IgE and Ag in mouse mast cells."
Jarmin D.I., Kulmburg P.A., Huber N.E., Baumann G., Prieschl-Strassmayr E.E., Baumruker T.
J. Immunol. 153:5720-5729(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B10.S/J and SJL/J.
Tissue: Spleen.
[7]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pancreas.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z12297 mRNA. Translation: CAA78169.1.
L04694 mRNA. Translation: AAA37516.1.
S71251 mRNA. Translation: AAB30997.1.
X70058 Genomic DNA. Translation: CAA49662.1.
AF128193 mRNA. Translation: AAF22534.1.
AF128194 mRNA. Translation: AAF22535.1.
AK078827 mRNA. Translation: BAC37413.1.
BC061126 mRNA. Translation: AAH61126.1.
CCDSCCDS36245.1.
PIRA48093.
RefSeqNP_038682.1. NM_013654.3.
UniGeneMm.341574.

3D structure databases

ProteinModelPortalQ03366.
SMRQ03366. Positions 24-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203131. 1 interaction.

Proteomic databases

PRIDEQ03366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
GeneID20306.
KEGGmmu:20306.
UCSCuc007kmq.2. mouse.

Organism-specific databases

CTD6354.
MGIMGI:99512. Ccl7.

Phylogenomic databases

eggNOGNOG140372.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidQ03366.
KOK05509.
OMANSINIIM.
OrthoDBEOG7673DP.
PhylomeDBQ03366.
TreeFamTF334888.

Gene expression databases

ArrayExpressQ03366.
BgeeQ03366.
CleanExMM_CCL7.
GenevestigatorQ03366.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298063.
PROQ03366.
SOURCESearch...

Entry information

Entry nameCCL7_MOUSE
AccessionPrimary (citable) accession number: Q03366
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot