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Protein

C-C motif chemokine 7

Gene

Ccl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity).By similarity

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: GO_Central
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Intercrine/chemokine MARC
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
Protein FIC
Small-inducible cytokine A7
Gene namesi
Name:Ccl7
Synonyms:Fic, Mcp3, Scya7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99512. Ccl7.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000518424 – 97C-C motif chemokine 7Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ03366.
PeptideAtlasiQ03366.
PRIDEiQ03366.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035373.
CleanExiMM_CCL7.
ExpressionAtlasiQ03366. baseline and differential.
GenevisibleiQ03366. MM.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: BHF-UCL
  • chemokine activity Source: GO_Central

Protein-protein interaction databases

BioGridi203131. 1 interactor.
STRINGi10090.ENSMUSP00000021011.

Structurei

3D structure databases

ProteinModelPortaliQ03366.
SMRiQ03366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ03366.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG091G14KV.
PhylomeDBiQ03366.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR
60 70 80 90
RITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP
Length:97
Mass (Da):10,999
Last modified:October 1, 1993 - v1
Checksum:iB94FDA6DF1EF6140
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57 – 63Missing in CAA49662 (PubMed:7989769).Curated7
Sequence conflicti74A → R in AAA37516 (PubMed:8455595).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12297 mRNA. Translation: CAA78169.1.
L04694 mRNA. Translation: AAA37516.1.
S71251 mRNA. Translation: AAB30997.1.
X70058 Genomic DNA. Translation: CAA49662.1.
AF128193 mRNA. Translation: AAF22534.1.
AF128194 mRNA. Translation: AAF22535.1.
AK078827 mRNA. Translation: BAC37413.1.
BC061126 mRNA. Translation: AAH61126.1.
CCDSiCCDS36245.1.
PIRiA48093.
RefSeqiNP_038682.1. NM_013654.3.
UniGeneiMm.341574.

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
GeneIDi20306.
KEGGimmu:20306.
UCSCiuc007kmq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12297 mRNA. Translation: CAA78169.1.
L04694 mRNA. Translation: AAA37516.1.
S71251 mRNA. Translation: AAB30997.1.
X70058 Genomic DNA. Translation: CAA49662.1.
AF128193 mRNA. Translation: AAF22534.1.
AF128194 mRNA. Translation: AAF22535.1.
AK078827 mRNA. Translation: BAC37413.1.
BC061126 mRNA. Translation: AAH61126.1.
CCDSiCCDS36245.1.
PIRiA48093.
RefSeqiNP_038682.1. NM_013654.3.
UniGeneiMm.341574.

3D structure databases

ProteinModelPortaliQ03366.
SMRiQ03366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203131. 1 interactor.
STRINGi10090.ENSMUSP00000021011.

Proteomic databases

PaxDbiQ03366.
PeptideAtlasiQ03366.
PRIDEiQ03366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
GeneIDi20306.
KEGGimmu:20306.
UCSCiuc007kmq.2. mouse.

Organism-specific databases

CTDi6354.
MGIiMGI:99512. Ccl7.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ03366.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG091G14KV.
PhylomeDBiQ03366.
TreeFamiTF334888.

Miscellaneous databases

PROiQ03366.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035373.
CleanExiMM_CCL7.
ExpressionAtlasiQ03366. baseline and differential.
GenevisibleiQ03366. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL7_MOUSE
AccessioniPrimary (citable) accession number: Q03366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.