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Q03366

- CCL7_MOUSE

UniProt

Q03366 - CCL7_MOUSE

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Protein
C-C motif chemokine 7
Gene
Ccl7, Fic, Mcp3, Scya7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity By similarity.

GO - Molecular functioni

  1. CCR2 chemokine receptor binding Source: BHF-UCL
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to ethanol Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. positive regulation of natural killer cell chemotaxis Source: Ensembl
  7. regulation of cell shape Source: Ensembl
  8. response to gamma radiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Intercrine/chemokine MARC
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
Protein FIC
Small-inducible cytokine A7
Gene namesi
Name:Ccl7
Synonyms:Fic, Mcp3, Scya7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:99512. Ccl7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9774C-C motif chemokine 7
PRO_0000005184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ03366.

Expressioni

Gene expression databases

ArrayExpressiQ03366.
BgeeiQ03366.
CleanExiMM_CCL7.
GenevestigatoriQ03366.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

BioGridi203131. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ03366.
SMRiQ03366. Positions 24-96.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ03366.
KOiK05509.
OMAiNSINIIM.
OrthoDBiEOG7673DP.
PhylomeDBiQ03366.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03366-1 [UniParc]FASTAAdd to Basket

« Hide

MRISATLLCL LLIAAAFSIQ VWAQPDGPNA STCCYVKKQK IPKRNLKSYR   50
RITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTPTPKP 97
Length:97
Mass (Da):10,999
Last modified:October 1, 1993 - v1
Checksum:iB94FDA6DF1EF6140
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 637Missing in CAA49662. 1 Publication
Sequence conflicti74 – 741A → R in AAA37516. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12297 mRNA. Translation: CAA78169.1.
L04694 mRNA. Translation: AAA37516.1.
S71251 mRNA. Translation: AAB30997.1.
X70058 Genomic DNA. Translation: CAA49662.1.
AF128193 mRNA. Translation: AAF22534.1.
AF128194 mRNA. Translation: AAF22535.1.
AK078827 mRNA. Translation: BAC37413.1.
BC061126 mRNA. Translation: AAH61126.1.
CCDSiCCDS36245.1.
PIRiA48093.
RefSeqiNP_038682.1. NM_013654.3.
UniGeneiMm.341574.

Genome annotation databases

EnsembliENSMUST00000021011; ENSMUSP00000021011; ENSMUSG00000035373.
GeneIDi20306.
KEGGimmu:20306.
UCSCiuc007kmq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12297 mRNA. Translation: CAA78169.1 .
L04694 mRNA. Translation: AAA37516.1 .
S71251 mRNA. Translation: AAB30997.1 .
X70058 Genomic DNA. Translation: CAA49662.1 .
AF128193 mRNA. Translation: AAF22534.1 .
AF128194 mRNA. Translation: AAF22535.1 .
AK078827 mRNA. Translation: BAC37413.1 .
BC061126 mRNA. Translation: AAH61126.1 .
CCDSi CCDS36245.1.
PIRi A48093.
RefSeqi NP_038682.1. NM_013654.3.
UniGenei Mm.341574.

3D structure databases

ProteinModelPortali Q03366.
SMRi Q03366. Positions 24-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203131. 1 interaction.

Proteomic databases

PRIDEi Q03366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021011 ; ENSMUSP00000021011 ; ENSMUSG00000035373 .
GeneIDi 20306.
KEGGi mmu:20306.
UCSCi uc007kmq.2. mouse.

Organism-specific databases

CTDi 6354.
MGIi MGI:99512. Ccl7.

Phylogenomic databases

eggNOGi NOG140372.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q03366.
KOi K05509.
OMAi NSINIIM.
OrthoDBi EOG7673DP.
PhylomeDBi Q03366.
TreeFami TF334888.

Miscellaneous databases

NextBioi 298063.
PROi Q03366.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03366.
Bgeei Q03366.
CleanExi MM_CCL7.
Genevestigatori Q03366.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cells."
    Kulmburg P.A., Huber N.E., Scheer B.J., Wrann M., Baumruker T.
    J. Exp. Med. 176:1773-1778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mast cell.
  2. "Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC."
    Thirion S., Nys G., Fiten P., Masure S., van Damme J., Opdenakker G.
    Biochem. Biophys. Res. Commun. 201:493-499(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Werner F.
    Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The product of a novel growth factor-activated gene, fic, is a biologically active 'C-C'-type cytokine."
    Heinrich J.N., Ryseck R.P., Macdonald-Bravo H., Bravo R.
    Mol. Cell. Biol. 13:2020-2030(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "A transcription factor with AP3-like binding specificity mediates gene regulation after an allergic triggering with IgE and Ag in mouse mast cells."
    Jarmin D.I., Kulmburg P.A., Huber N.E., Baumann G., Prieschl-Strassmayr E.E., Baumruker T.
    J. Immunol. 153:5720-5729(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.S/J and SJL/J.
    Tissue: Spleen.
  7. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCCL7_MOUSE
AccessioniPrimary (citable) accession number: Q03366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi