Q03351 (NTRK3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NT-3 growth factor receptor
EC=2.7.10.1

Alternative name(s):
GP145-TrkC
Short name=Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase

Gene names

Name:	Ntrk3
Synonyms:	Trkc

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	864 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for neurotrophin-3 (NTF3). This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLCG1. TrkC isoforms containing insertions within the kinase domain can autophosphorylate in response to NT-3, but cannot mediate downstream phenotypic responses.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220. Ref.4 Ref.5 Ref.6
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Widely expressed, mainly in the nervous tissue.
Post-translational modification	Ligand-mediated auto-phosphorylation.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to retinoic acid Inferred from expression pattern PubMed 10027563. Source: RGD cochlea development Inferred from expression pattern PubMed 10494076. Source: RGD mechanoreceptor differentiation Inferred from electronic annotation. Source: Compara modulation by virus of host transcription Inferred from expression pattern PubMed 11175319. Source: RGD negative regulation of astrocyte differentiation Inferred from mutant phenotype PubMed 12075995. Source: RGD negative regulation of cell death Inferred from mutant phenotype PubMed 12075995. Source: RGD neuron fate specification Inferred from mutant phenotype PubMed 15247919. Source: RGD neuron migration Inferred from mutant phenotype PubMed 12075995. Source: RGD positive regulation of axon extension involved in regeneration Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from mutant phenotype Ref.2. Source: RGD response to axon injury Inferred from expression pattern PubMed 17532148. Source: RGD response to corticosterone stimulus Inferred from expression pattern PubMed 14557907. Source: RGD response to ethanol Inferred from expression pattern PubMed 11743997. Source: RGD transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome integral to plasma membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from direct assay PubMed 17532148. Source: RGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW neurotrophin receptor activity Inferred from mutant phenotype Ref.2. Source: RGD transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform KI39 (identifier: Q03351-1)

Also known as: TRKC(KI39); TRKC-39;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform TRKC (identifier: Q03351-2)

The sequence of this isoform differs from the canonical sequence as follows:
     712-736: Missing.
     737-750: Missing.

Isoform KI14 (identifier: Q03351-3)

Also known as: TRKC(KI14); TRKC-14;

The sequence of this isoform differs from the canonical sequence as follows:
     712-736: Missing.

Isoform KI25 (identifier: Q03351-4)

Also known as: TRKC-25;

The sequence of this isoform differs from the canonical sequence as follows:
     737-750: Missing.

Isoform IC158 (identifier: Q03351-5)

Also known as: TRKC(IC158); TRKCTK-;

The sequence of this isoform differs from the canonical sequence as follows:
     529-612: YVQHIKRRDI...FYGVCGDGDP → WVFSNIDNHG...VYFSKGRHGF
     613-864: Missing.

Isoform IC143 (identifier: Q03351-6)

Also known as: TRKC(IC143);

The sequence of this isoform differs from the canonical sequence as follows:
     529-597: YVQHIKRRDI...EAELLTNLQH → WVFSNIDNHG...LPLPVLILKT
     598-864: Missing.

Isoform IC113 (identifier: Q03351-7)

Also known as: TRKC(IC113);

The sequence of this isoform differs from the canonical sequence as follows:
     529-567: YVQHIKRRDI...YNLSPTKDKM → CFREIMLNPI...VYFSKGRHGF
     568-864: Missing.

Isoform IC108 (identifier: Q03351-8)

Also known as: TRKC(IC108);

The sequence of this isoform differs from the canonical sequence as follows:
     529-562: YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSP → FGRIEGFAYGKRYVVMTSVHCHPCWFRFGGLEWL
     563-864: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	By similarity
	Chain	32 – 864	833	NT-3 growth factor receptor		PRO_0000016735
Regions
	Topological domain	32 – 429	398	Extracellular Potential
	Transmembrane	430 – 453	24	Helical; Potential
	Topological domain	454 – 864	411	Cytoplasmic Potential
	Repeat	104 – 125	22	LRR 1
	Repeat	128 – 149	22	LRR 2
	Domain	160 – 209	50	LRRCT
	Domain	210 – 300	91	Ig-like C2-type 1
	Domain	309 – 382	74	Ig-like C2-type 2
	Domain	538 – 853	316	Protein kinase
	Nucleotide binding	544 – 552	9	ATP By similarity
Sites
	Active site	679	1	Proton acceptor By similarity
	Binding site	572	1	ATP By similarity
	Site	516	1	Interaction with SHC1 By similarity
	Site	859	1	Interaction with PLC-gamma-1 By similarity
Amino acid modifications
	Modified residue	516	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	705	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	709	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	710	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	859	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	133	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	203	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
	Glycosylation	232	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	294	1	N-linked (GlcNAc...) Potential
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	388	1	N-linked (GlcNAc...) Potential
	Disulfide bond	320 ↔ 362		By similarity
Natural variations
	Alternative sequence	529 – 612	84	YVQHI…GDGDP → WVFSNIDNHGILNLKDNRDH LVPSTHYIYEEPEVQSGDVS YPRSHGFREIMLNPISLSGH SKPLNHGIYVEDVNVYFSKG RHGF in isoform IC158.		VSP_002934
	Alternative sequence	529 – 597	69	YVQHI…TNLQH → WVFSNIDNHGILNLKDNRDH LVPSTHYIYEEPEVQSGDVS YPRSHGELLPLTSLYEVKPL PLPVLILKT in isoform IC143.		VSP_002932
	Alternative sequence	529 – 567	39	YVQHI…TKDKM → CFREIMLNPISLSGHSKPLN HGIYVEDVNVYFSKGRHGF in isoform IC113.		VSP_002930
	Alternative sequence	529 – 562	34	YVQHI…YNLSP → FGRIEGFAYGKRYVVMTSVH CHPCWFRFGGLEWL in isoform IC108.		VSP_002928
	Alternative sequence	563 – 864	302	Missing in isoform IC108.		VSP_002929
	Alternative sequence	568 – 864	297	Missing in isoform IC113.		VSP_002931
	Alternative sequence	598 – 864	267	Missing in isoform IC143.		VSP_002933
	Alternative sequence	613 – 864	252	Missing in isoform IC158.		VSP_002935
	Alternative sequence	712 – 736	25	Missing in isoform KI14 and isoform TRKC.		VSP_002936
	Alternative sequence	737 – 750	14	Missing in isoform KI25 and isoform TRKC.		VSP_002937

Sequences

	Sequence		Length	Mass (Da)
	Isoform KI39 (TRKC(KI39)) (TRKC-39) [UniParc]. Last modified February 1, 1994. Version 2. Checksum: A202E993E208F636	FASTA	864	97,064
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY REGPYQKGPF 730 740 750 760 770 780 SVSWQQQRLA ASAASTLFNP SGNDFCIWCE VGGHTMLPIR WMPPESIMYR KFTTESDVWS 790 800 810 820 830 840 FGVILWEIFT YGKQPWFQLS NTEVIECITQ GRVLERPRVC PKEVYDVMLG CWQREPQQRL 850 860 NIKEIYKILH ALGKATPIYL DILG
	Isoform TRKC [UniParc]. Checksum: 4DE08AB546CC5BD6	FASTA	825	92,760
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 730 740 750 760 770 780 RWMPPESIMY RKFTTESDVW SFGVILWEIF TYGKQPWFQL SNTEVIECIT QGRVLERPRV 790 800 810 820 CPKEVYDVML GCWQREPQQR LNIKEIYKIL HALGKATPIY LDILG
	Isoform KI14 (TRKC(KI14)) (TRKC-14) [UniParc]. Checksum: 78F3574FD80D983A	FASTA	839	94,387
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RLFNPSGNDF 730 740 750 760 770 780 CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI 790 800 810 820 830 ECITQGRVLE RPRVCPKEVY DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG
	Isoform KI25 (TRKC-25) [UniParc]. Checksum: C4CDDD82FF313324	FASTA	850	95,437
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 550 560 570 580 590 600 KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 610 620 630 640 650 660 VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 670 680 690 700 710 720 SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY REGPYQKGPF 730 740 750 760 770 780 SVSWQQQRLA ASAASTVGGH TMLPIRWMPP ESIMYRKFTT ESDVWSFGVI LWEIFTYGKQ 790 800 810 820 830 840 PWFQLSNTEV IECITQGRVL ERPRVCPKEV YDVMLGCWQR EPQQRLNIKE IYKILHALGK 850 ATPIYLDILG
	Isoform IC158 (TRKC(IC158)) (TRKCTK-) [UniParc]. Checksum: 376F0F449792CE46	FASTA	612	68,387
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL 550 560 570 580 590 600 NLKDNRDHLV PSTHYIYEEP EVQSGDVSYP RSHGFREIML NPISLSGHSK PLNHGIYVED 610 VNVYFSKGRH GF
	Isoform IC143 (TRKC(IC143)) [UniParc]. Checksum: 202BBA3831315D3D	FASTA	597	66,618
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL 550 560 570 580 590 NLKDNRDHLV PSTHYIYEEP EVQSGDVSYP RSHGELLPLT SLYEVKPLPL PVLILKT
	Isoform IC113 (TRKC(IC113)) [UniParc]. Checksum: 87C245CD9147639B	FASTA	567	63,172
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTCF REIMLNPISL 550 560 SGHSKPLNHG IYVEDVNVYF SKGRHGF
	Isoform IC108 (TRKC(IC108)) [UniParc]. Checksum: A93D87527814D99C	FASTA	562	62,759
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRG LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 RLDSQSLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL VEPEVRLEHC IEFVVRGNPT PTLHWLYNGQ PLRESKIIHM DYYQEGEVSE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNALGTANQT INGHFLKEPF PESTDFFDFE SDASPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTFG RIEGFAYGKR 550 560 YVVMTSVHCH PCWFRFGGLE WL

References

[1]	"Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system." Merlio J.P., Ernfors P., Jaber M., Persson H. Neuroscience 51:513-532(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKC).
[2]	"Alternative forms of rat TrkC with different functional capabilities." Valenzuela D.M., Maisonpierre P.C., Glass D.J., Rojas E., Nunez L., Kong Y., Gies D.R., Stitt T.N., Ip N.Y., Yancopoulos G.D. Neuron 10:963-974(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING. Strain: Sprague-Dawley. Tissue: Brain.
[3]	"The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells." Tsoulfas P., Soppet D., Escandon E., Tessarollo L., Mendoza-Ramirez J.-L., Rosenthal A., Nikolics K., Parada L.F. Neuron 10:975-990(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING. Tissue: Brain cortex and Hippocampus.
[4]	"Identification and characterization of novel substrates of Trk receptors in developing neurons." Qian X., Riccio A., Zhang Y., Ginty D.D. Neuron 21:1017-1029(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SH2B2.
[5]	"Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling." Geetha T., Wooten M.W. J. Biol. Chem. 278:4730-4739(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SQSTM1.
[6]	"A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein." Arevalo J.C., Yano H., Teng K.K., Chao M.V. EMBO J. 23:2358-2368(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KIDINS220.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L03813 mRNA. Translation: AAA42285.1. L14445 mRNA. Translation: AAA42282.1. L14446 mRNA. Translation: AAA42283.1. L14447 mRNA. Translation: AAA42284.1. S60953 mRNA. Translation: AAB26714.2. S62924 mRNA. Translation: AAB26716.2. S62933 mRNA. Translation: AAB26715.2.
IPI	IPI00194553. IPI00210007. IPI00231029. IPI00231030. IPI00231031. IPI00231032. IPI00231034. IPI00231035.
RefSeq	NP_001257584.1. NM_001270655.1. NP_001257585.1. NM_001270656.1. NP_062121.1. NM_019248.2.
UniGene	Rn.9963.
3D structure databases
ProteinModelPortal	Q03351.
SMR	Q03351. Positions 300-401.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5718N.
MINT	MINT-1208236.
STRING	10116.ENSRNOP00000046935.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q03351.
Proteomic databases
PaxDb	Q03351.
PRIDE	Q03351.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000025536; ENSRNOP00000025536; ENSRNOG00000018674. ENSRNOT00000041839; ENSRNOP00000046059; ENSRNOG00000018674. ENSRNOT00000045165; ENSRNOP00000049463; ENSRNOG00000018674. ENSRNOT00000046080; ENSRNOP00000044960; ENSRNOG00000018674. ENSRNOT00000046849; ENSRNOP00000044402; ENSRNOG00000018674. ENSRNOT00000047776; ENSRNOP00000050248; ENSRNOG00000018674.
GeneID	29613.
KEGG	rno:29613.
UCSC	RGD:3214. rat.
Organism-specific databases
CTD	4916.
RGD	3214. Ntrk3.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00700000104172.
HOGENOM	HOG000264255.
HOVERGEN	HBG056735.
InParanoid	Q03351.
KO	K05101.
OMA	NFVSIYE.
OrthoDB	EOG4W3SM8.
Enzyme and pathway databases
BRENDA	2.7.10.1. 5301.
Reactome	REACT_111984. Signal Transduction.
Gene expression databases
ArrayExpress	Q03351.
Genevestigator	Q03351.
GermOnline	ENSRNOG00000018674. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR011009. Kinase-like_dom. IPR001611. Leu-rich_rpt. IPR000372. LRR-contain_N. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR020446. Tyr_kin_neurotrophic_rcpt_3. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR020777. Tyr_kinase_NGF_rcpt. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
Pfam	PF07679. I-set. 2 hits. PF01462. LRRNT. 1 hit. PF07714. Pkinase_Tyr. 2 hits. [Graphical view]
PRINTS	PR01939. NTKRECEPTOR. PR01942. NTKRECEPTOR3. PR00109. TYRKINASE.
SMART	SM00409. IG. 1 hit. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS51450. LRR. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	609800.

Entry information

Entry name

NTRK3_RAT

Accession

Primary (citable) accession number: Q03351

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 137 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program