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Q03348

- PTPRA_RAT

UniProt

Q03348 - PTPRA_RAT

Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

Ptpra

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei404 – 4041SubstrateBy similarity
    Active sitei436 – 4361Phosphocysteine intermediateBy similarity
    Binding sitei480 – 4801SubstrateBy similarity
    Active sitei726 – 7261Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein complex binding Source: RGD
    3. protein tyrosine phosphatase activity Source: RGD

    GO - Biological processi

    1. oligodendrocyte differentiation Source: RGD
    2. peptidyl-tyrosine dephosphorylation Source: GOC
    3. positive regulation of oligodendrocyte differentiation Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase alpha
    Short name:
    R-PTP-alpha
    Gene namesi
    Name:Ptpra
    Synonyms:Lrp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3450. Ptpra.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular membrane-bounded organelle Source: RGD
    3. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 796777Receptor-type tyrosine-protein phosphatase alphaPRO_0000025435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Modified residuei205 – 2051PhosphoserineBy similarity
    Modified residuei207 – 2071PhosphoserineBy similarity
    Modified residuei792 – 7921PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ03348.
    PRIDEiQ03348.

    PTM databases

    PhosphoSiteiQ03348.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03348.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cd63P286485EBI-7784341,EBI-7784314

    Protein-protein interaction databases

    DIPiDIP-5790N.
    IntActiQ03348. 4 interactions.
    MINTiMINT-8308366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03348.
    SMRiQ03348. Positions 211-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 145126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini170 – 796627CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 16924HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini235 – 495261Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini527 – 785259Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni436 – 4427Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000231464.
    HOVERGENiHBG053758.
    PhylomeDBiQ03348.

    Family and domain databases

    Gene3Di3.90.190.10. 2 hits.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016336. Tyr_Pase_rcpt_a/e-type.
    IPR027262. Tyr_Pase_rcpt_alpha.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
    PIRSF002006. PTPR_alpha_epsilon. 1 hit.
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSWFILILF GSGLIHISAN NTTTVSPSLG TTRLIKTSTT ESAKEENKTS    50
    NSTSSVISLS VTPTFSPNLT LEPTYVTTVN SSHSDNGTKR AASTESGGTT 100
    ISPNGTYGTW LTDNQFTDAR TEPWEGNSSS AATTPETFPP ADETPIIAVM 150
    VALSSLLVIL FIIIVLYMLR FKKYKQAGSH SNSFRLSNGR TEDVEPQSVP 200
    LLARSPSTNR KYPPLPVDKL EEEINRRMAD DNKLFREEFN ALPACPIQAT 250
    CEAASKEENK EKNRYVNLLP YDHSRVHLTP VEGVPDSDYI NASFINGYQE 300
    KNKFIAAQGP KEETVNDFWR MIWEQNTATI VMVTNLKERK ECKCAQYWPD 350
    QGCWPYGNVR VSVEDVTVLV DYTVRKFCIQ QVGDVTNRKP QRLITQFHFT 400
    SWPDFGVPFT PIGMLKFLKK VKACNPQYAG AIVVHCSAGV GRTGTFVVID 450
    AMLDMMHSER KVDVYGFVSR IRAQRCQMVQ TDMQYVFIYQ ALLEHYLYGD 500
    TELEVTSLDT HLQKIYNKIP GTSNNGLEEE FKKLTSIKIQ NDKMRTGYLP 550
    ANMKKNRVLQ IIPYEFNRVI IPVKRGEENT DYVNASFIDP YRQKDSYIAS 600
    QGPLLHTTED FWRMIWEWKS CSIVMLTELE ERGQEKCAQY WPSDGLVSYG 650
    DITVELKKEE ECESYTVRDL LVTNTRENKS RQIRQFHFHG WPEVGIPSDG 700
    KGMINIIAAV QKQQQQSGNH PITVHCSAGA GRTGTFCALS TVLECVKAEG 750
    ILDVFQTVKT LRLQRPHMVQ ILEQYEFCYK VVQEYIDAFS DYANFK 796
    Length:796
    Mass (Da):90,260
    Last modified:February 1, 1994 - v1
    Checksum:i4793796191056920
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01702 mRNA. Translation: AAA41983.1.
    PIRiJC1285.
    UniGeneiRn.18043.

    Genome annotation databases

    UCSCiRGD:3450. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01702 mRNA. Translation: AAA41983.1 .
    PIRi JC1285.
    UniGenei Rn.18043.

    3D structure databases

    ProteinModelPortali Q03348.
    SMRi Q03348. Positions 211-787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5790N.
    IntActi Q03348. 4 interactions.
    MINTi MINT-8308366.

    PTM databases

    PhosphoSitei Q03348.

    Proteomic databases

    PaxDbi Q03348.
    PRIDEi Q03348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3450. rat.

    Organism-specific databases

    RGDi 3450. Ptpra.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000231464.
    HOVERGENi HBG053758.
    PhylomeDBi Q03348.

    Miscellaneous databases

    PROi Q03348.

    Gene expression databases

    Genevestigatori Q03348.

    Family and domain databases

    Gene3Di 3.90.190.10. 2 hits.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016336. Tyr_Pase_rcpt_a/e-type.
    IPR027262. Tyr_Pase_rcpt_alpha.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF500808. PTPR_alpha. 1 hit.
    PIRSF002006. PTPR_alpha_epsilon. 1 hit.
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells."
      Moriyama T., Fujiwara Y., Imai E., Takenaka M., Kawanishi S., Inoue T., Noguchi T., Tanaka T., Kamada T., Ueda N.
      Biochem. Biophys. Res. Commun. 188:34-39(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiPTPRA_RAT
    AccessioniPrimary (citable) accession number: Q03348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3