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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

Ptpra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei404SubstrateBy similarity1
Active sitei436Phosphocysteine intermediateBy similarity1
Binding sitei480SubstrateBy similarity1
Active sitei726Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  • oligodendrocyte differentiation Source: RGD
  • positive regulation of oligodendrocyte differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Gene namesi
Name:Ptpra
Synonyms:Lrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3450. Ptpra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 145ExtracellularSequence analysisAdd BLAST126
Transmembranei146 – 169HelicalSequence analysisAdd BLAST24
Topological domaini170 – 796CytoplasmicSequence analysisAdd BLAST627

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002543520 – 796Receptor-type tyrosine-protein phosphatase alphaAdd BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Modified residuei205PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei792PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ03348.
PRIDEiQ03348.

PTM databases

iPTMnetiQ03348.
PhosphoSitePlusiQ03348.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cd63P286485EBI-7784341,EBI-7784314

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

DIPiDIP-5790N.
IntActiQ03348. 4 interactors.
MINTiMINT-8308366.
STRINGi10116.ENSRNOP00000052657.

Structurei

3D structure databases

ProteinModelPortaliQ03348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 495Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST261
Domaini527 – 785Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni436 – 442Substrate bindingBy similarity7

Sequence similaritiesi

Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiQ03348.
PhylomeDBiQ03348.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSWFILILF GSGLIHISAN NTTTVSPSLG TTRLIKTSTT ESAKEENKTS
60 70 80 90 100
NSTSSVISLS VTPTFSPNLT LEPTYVTTVN SSHSDNGTKR AASTESGGTT
110 120 130 140 150
ISPNGTYGTW LTDNQFTDAR TEPWEGNSSS AATTPETFPP ADETPIIAVM
160 170 180 190 200
VALSSLLVIL FIIIVLYMLR FKKYKQAGSH SNSFRLSNGR TEDVEPQSVP
210 220 230 240 250
LLARSPSTNR KYPPLPVDKL EEEINRRMAD DNKLFREEFN ALPACPIQAT
260 270 280 290 300
CEAASKEENK EKNRYVNLLP YDHSRVHLTP VEGVPDSDYI NASFINGYQE
310 320 330 340 350
KNKFIAAQGP KEETVNDFWR MIWEQNTATI VMVTNLKERK ECKCAQYWPD
360 370 380 390 400
QGCWPYGNVR VSVEDVTVLV DYTVRKFCIQ QVGDVTNRKP QRLITQFHFT
410 420 430 440 450
SWPDFGVPFT PIGMLKFLKK VKACNPQYAG AIVVHCSAGV GRTGTFVVID
460 470 480 490 500
AMLDMMHSER KVDVYGFVSR IRAQRCQMVQ TDMQYVFIYQ ALLEHYLYGD
510 520 530 540 550
TELEVTSLDT HLQKIYNKIP GTSNNGLEEE FKKLTSIKIQ NDKMRTGYLP
560 570 580 590 600
ANMKKNRVLQ IIPYEFNRVI IPVKRGEENT DYVNASFIDP YRQKDSYIAS
610 620 630 640 650
QGPLLHTTED FWRMIWEWKS CSIVMLTELE ERGQEKCAQY WPSDGLVSYG
660 670 680 690 700
DITVELKKEE ECESYTVRDL LVTNTRENKS RQIRQFHFHG WPEVGIPSDG
710 720 730 740 750
KGMINIIAAV QKQQQQSGNH PITVHCSAGA GRTGTFCALS TVLECVKAEG
760 770 780 790
ILDVFQTVKT LRLQRPHMVQ ILEQYEFCYK VVQEYIDAFS DYANFK
Length:796
Mass (Da):90,260
Last modified:February 1, 1994 - v1
Checksum:i4793796191056920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01702 mRNA. Translation: AAA41983.1.
PIRiJC1285.
UniGeneiRn.18043.

Genome annotation databases

UCSCiRGD:3450. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01702 mRNA. Translation: AAA41983.1.
PIRiJC1285.
UniGeneiRn.18043.

3D structure databases

ProteinModelPortaliQ03348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5790N.
IntActiQ03348. 4 interactors.
MINTiMINT-8308366.
STRINGi10116.ENSRNOP00000052657.

PTM databases

iPTMnetiQ03348.
PhosphoSitePlusiQ03348.

Proteomic databases

PaxDbiQ03348.
PRIDEiQ03348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3450. rat.

Organism-specific databases

RGDi3450. Ptpra.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiQ03348.
PhylomeDBiQ03348.

Miscellaneous databases

PROiQ03348.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRA_RAT
AccessioniPrimary (citable) accession number: Q03348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.