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Q03348

- PTPRA_RAT

UniProt

Q03348 - PTPRA_RAT

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Protein
Receptor-type tyrosine-protein phosphatase alpha
Gene
Ptpra, Lrp
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei404 – 4041Substrate By similarity
Active sitei436 – 4361Phosphocysteine intermediate By similarity
Binding sitei480 – 4801Substrate By similarity
Active sitei726 – 7261Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein complex binding Source: RGD
  3. protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  1. oligodendrocyte differentiation Source: RGD
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. positive regulation of oligodendrocyte differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Gene namesi
Name:Ptpra
Synonyms:Lrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3450. Ptpra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 145126Extracellular Reviewed prediction
Add
BLAST
Transmembranei146 – 16924Helical; Reviewed prediction
Add
BLAST
Topological domaini170 – 796627Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: RGD
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 796777Receptor-type tyrosine-protein phosphatase alpha
PRO_0000025435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Modified residuei205 – 2051Phosphoserine By similarity
Modified residuei207 – 2071Phosphoserine By similarity
Modified residuei792 – 7921Phosphotyrosine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ03348.
PRIDEiQ03348.

PTM databases

PhosphoSiteiQ03348.

Expressioni

Gene expression databases

GenevestigatoriQ03348.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cd63P286485EBI-7784341,EBI-7784314

Protein-protein interaction databases

DIPiDIP-5790N.
IntActiQ03348. 4 interactions.
MINTiMINT-8308366.

Structurei

3D structure databases

ProteinModelPortaliQ03348.
SMRiQ03348. Positions 211-787.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 495261Tyrosine-protein phosphatase 1
Add
BLAST
Domaini527 – 785259Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni436 – 4427Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
PhylomeDBiQ03348.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03348-1 [UniParc]FASTAAdd to Basket

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MDSWFILILF GSGLIHISAN NTTTVSPSLG TTRLIKTSTT ESAKEENKTS    50
NSTSSVISLS VTPTFSPNLT LEPTYVTTVN SSHSDNGTKR AASTESGGTT 100
ISPNGTYGTW LTDNQFTDAR TEPWEGNSSS AATTPETFPP ADETPIIAVM 150
VALSSLLVIL FIIIVLYMLR FKKYKQAGSH SNSFRLSNGR TEDVEPQSVP 200
LLARSPSTNR KYPPLPVDKL EEEINRRMAD DNKLFREEFN ALPACPIQAT 250
CEAASKEENK EKNRYVNLLP YDHSRVHLTP VEGVPDSDYI NASFINGYQE 300
KNKFIAAQGP KEETVNDFWR MIWEQNTATI VMVTNLKERK ECKCAQYWPD 350
QGCWPYGNVR VSVEDVTVLV DYTVRKFCIQ QVGDVTNRKP QRLITQFHFT 400
SWPDFGVPFT PIGMLKFLKK VKACNPQYAG AIVVHCSAGV GRTGTFVVID 450
AMLDMMHSER KVDVYGFVSR IRAQRCQMVQ TDMQYVFIYQ ALLEHYLYGD 500
TELEVTSLDT HLQKIYNKIP GTSNNGLEEE FKKLTSIKIQ NDKMRTGYLP 550
ANMKKNRVLQ IIPYEFNRVI IPVKRGEENT DYVNASFIDP YRQKDSYIAS 600
QGPLLHTTED FWRMIWEWKS CSIVMLTELE ERGQEKCAQY WPSDGLVSYG 650
DITVELKKEE ECESYTVRDL LVTNTRENKS RQIRQFHFHG WPEVGIPSDG 700
KGMINIIAAV QKQQQQSGNH PITVHCSAGA GRTGTFCALS TVLECVKAEG 750
ILDVFQTVKT LRLQRPHMVQ ILEQYEFCYK VVQEYIDAFS DYANFK 796
Length:796
Mass (Da):90,260
Last modified:February 1, 1994 - v1
Checksum:i4793796191056920
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01702 mRNA. Translation: AAA41983.1.
PIRiJC1285.
UniGeneiRn.18043.

Genome annotation databases

UCSCiRGD:3450. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01702 mRNA. Translation: AAA41983.1 .
PIRi JC1285.
UniGenei Rn.18043.

3D structure databases

ProteinModelPortali Q03348.
SMRi Q03348. Positions 211-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5790N.
IntActi Q03348. 4 interactions.
MINTi MINT-8308366.

PTM databases

PhosphoSitei Q03348.

Proteomic databases

PaxDbi Q03348.
PRIDEi Q03348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3450. rat.

Organism-specific databases

RGDi 3450. Ptpra.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000231464.
HOVERGENi HBG053758.
PhylomeDBi Q03348.

Miscellaneous databases

PROi Q03348.

Gene expression databases

Genevestigatori Q03348.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PIRSFi PIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells."
    Moriyama T., Fujiwara Y., Imai E., Takenaka M., Kawanishi S., Inoue T., Noguchi T., Tanaka T., Kamada T., Ueda N.
    Biochem. Biophys. Res. Commun. 188:34-39(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPTPRA_RAT
AccessioniPrimary (citable) accession number: Q03348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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