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Q03348 (PTPRA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase alpha
Short name=Protein-tyrosine phosphatase alpha
Short name=R-PTP-alpha
EC=3.1.3.48
Gene names
Name:Ptpra
Synonyms:Lrp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length796 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.

Contains 2 tyrosine-protein phosphatase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 796777Receptor-type tyrosine-protein phosphatase alpha
PRO_0000025435

Regions

Topological domain20 – 145126Extracellular Potential
Transmembrane146 – 16924Helical; Potential
Topological domain170 – 796627Cytoplasmic Potential
Domain235 – 495261Tyrosine-protein phosphatase 1
Domain527 – 785259Tyrosine-protein phosphatase 2
Region436 – 4427Substrate binding By similarity

Sites

Active site4361Phosphocysteine intermediate By similarity
Active site7261Phosphocysteine intermediate By similarity
Binding site4041Substrate By similarity
Binding site4801Substrate By similarity

Amino acid modifications

Modified residue2071Phosphoserine By similarity
Modified residue7921Phosphotyrosine By similarity
Glycosylation201N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q03348 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 4793796191056920

FASTA79690,260
        10         20         30         40         50         60 
MDSWFILILF GSGLIHISAN NTTTVSPSLG TTRLIKTSTT ESAKEENKTS NSTSSVISLS 

        70         80         90        100        110        120 
VTPTFSPNLT LEPTYVTTVN SSHSDNGTKR AASTESGGTT ISPNGTYGTW LTDNQFTDAR 

       130        140        150        160        170        180 
TEPWEGNSSS AATTPETFPP ADETPIIAVM VALSSLLVIL FIIIVLYMLR FKKYKQAGSH 

       190        200        210        220        230        240 
SNSFRLSNGR TEDVEPQSVP LLARSPSTNR KYPPLPVDKL EEEINRRMAD DNKLFREEFN 

       250        260        270        280        290        300 
ALPACPIQAT CEAASKEENK EKNRYVNLLP YDHSRVHLTP VEGVPDSDYI NASFINGYQE 

       310        320        330        340        350        360 
KNKFIAAQGP KEETVNDFWR MIWEQNTATI VMVTNLKERK ECKCAQYWPD QGCWPYGNVR 

       370        380        390        400        410        420 
VSVEDVTVLV DYTVRKFCIQ QVGDVTNRKP QRLITQFHFT SWPDFGVPFT PIGMLKFLKK 

       430        440        450        460        470        480 
VKACNPQYAG AIVVHCSAGV GRTGTFVVID AMLDMMHSER KVDVYGFVSR IRAQRCQMVQ 

       490        500        510        520        530        540 
TDMQYVFIYQ ALLEHYLYGD TELEVTSLDT HLQKIYNKIP GTSNNGLEEE FKKLTSIKIQ 

       550        560        570        580        590        600 
NDKMRTGYLP ANMKKNRVLQ IIPYEFNRVI IPVKRGEENT DYVNASFIDP YRQKDSYIAS 

       610        620        630        640        650        660 
QGPLLHTTED FWRMIWEWKS CSIVMLTELE ERGQEKCAQY WPSDGLVSYG DITVELKKEE 

       670        680        690        700        710        720 
ECESYTVRDL LVTNTRENKS RQIRQFHFHG WPEVGIPSDG KGMINIIAAV QKQQQQSGNH 

       730        740        750        760        770        780 
PITVHCSAGA GRTGTFCALS TVLECVKAEG ILDVFQTVKT LRLQRPHMVQ ILEQYEFCYK 

       790 
VVQEYIDAFS DYANFK

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References

[1]"cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells."
Moriyama T., Fujiwara Y., Imai E., Takenaka M., Kawanishi S., Inoue T., Noguchi T., Tanaka T., Kamada T., Ueda N.
Biochem. Biophys. Res. Commun. 188:34-39(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L01702 mRNA. Translation: AAA41983.1.
IPIIPI00882495.
PIRJC1285.
UniGeneRn.18043.

3D structure databases

ProteinModelPortalQ03348.
SMRQ03348. Positions 211-787.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5790N.

PTM databases

PhosphoSiteQ03348.

Proteomic databases

PaxDbQ03348.
PRIDEQ03348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3450. rat.

Organism-specific databases

RGD3450. Ptpra.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000231464.
HOVERGENHBG053758.
OrthoDBEOG4K3KVP.

Gene expression databases

ArrayExpressQ03348.
GenevestigatorQ03348.
GermOnlineENSRNOG00000021223. Rattus norvegicus.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view]
PfamPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 2 hits.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTPRA_RAT
AccessionPrimary (citable) accession number: Q03348
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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