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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

Ptpra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei404 – 4041SubstrateBy similarity
Active sitei436 – 4361Phosphocysteine intermediateBy similarity
Binding sitei480 – 4801SubstrateBy similarity
Active sitei726 – 7261Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein complex binding Source: RGD
  2. protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  1. oligodendrocyte differentiation Source: RGD
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. positive regulation of oligodendrocyte differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Gene namesi
Name:Ptpra
Synonyms:Lrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3450. Ptpra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 145126ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16924HelicalSequence AnalysisAdd
BLAST
Topological domaini170 – 796627CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: RGD
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 796777Receptor-type tyrosine-protein phosphatase alphaPRO_0000025435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei207 – 2071PhosphoserineBy similarity
Modified residuei792 – 7921PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ03348.
PRIDEiQ03348.

PTM databases

PhosphoSiteiQ03348.

Expressioni

Gene expression databases

GenevestigatoriQ03348.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cd63P286485EBI-7784341,EBI-7784314

Protein-protein interaction databases

DIPiDIP-5790N.
IntActiQ03348. 4 interactions.
MINTiMINT-8308366.

Structurei

3D structure databases

ProteinModelPortaliQ03348.
SMRiQ03348. Positions 211-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 495261Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini527 – 785259Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni436 – 4427Substrate bindingBy similarity

Sequence similaritiesi

Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiQ03348.
PhylomeDBiQ03348.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSWFILILF GSGLIHISAN NTTTVSPSLG TTRLIKTSTT ESAKEENKTS
60 70 80 90 100
NSTSSVISLS VTPTFSPNLT LEPTYVTTVN SSHSDNGTKR AASTESGGTT
110 120 130 140 150
ISPNGTYGTW LTDNQFTDAR TEPWEGNSSS AATTPETFPP ADETPIIAVM
160 170 180 190 200
VALSSLLVIL FIIIVLYMLR FKKYKQAGSH SNSFRLSNGR TEDVEPQSVP
210 220 230 240 250
LLARSPSTNR KYPPLPVDKL EEEINRRMAD DNKLFREEFN ALPACPIQAT
260 270 280 290 300
CEAASKEENK EKNRYVNLLP YDHSRVHLTP VEGVPDSDYI NASFINGYQE
310 320 330 340 350
KNKFIAAQGP KEETVNDFWR MIWEQNTATI VMVTNLKERK ECKCAQYWPD
360 370 380 390 400
QGCWPYGNVR VSVEDVTVLV DYTVRKFCIQ QVGDVTNRKP QRLITQFHFT
410 420 430 440 450
SWPDFGVPFT PIGMLKFLKK VKACNPQYAG AIVVHCSAGV GRTGTFVVID
460 470 480 490 500
AMLDMMHSER KVDVYGFVSR IRAQRCQMVQ TDMQYVFIYQ ALLEHYLYGD
510 520 530 540 550
TELEVTSLDT HLQKIYNKIP GTSNNGLEEE FKKLTSIKIQ NDKMRTGYLP
560 570 580 590 600
ANMKKNRVLQ IIPYEFNRVI IPVKRGEENT DYVNASFIDP YRQKDSYIAS
610 620 630 640 650
QGPLLHTTED FWRMIWEWKS CSIVMLTELE ERGQEKCAQY WPSDGLVSYG
660 670 680 690 700
DITVELKKEE ECESYTVRDL LVTNTRENKS RQIRQFHFHG WPEVGIPSDG
710 720 730 740 750
KGMINIIAAV QKQQQQSGNH PITVHCSAGA GRTGTFCALS TVLECVKAEG
760 770 780 790
ILDVFQTVKT LRLQRPHMVQ ILEQYEFCYK VVQEYIDAFS DYANFK
Length:796
Mass (Da):90,260
Last modified:February 1, 1994 - v1
Checksum:i4793796191056920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01702 mRNA. Translation: AAA41983.1.
PIRiJC1285.
UniGeneiRn.18043.

Genome annotation databases

UCSCiRGD:3450. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01702 mRNA. Translation: AAA41983.1.
PIRiJC1285.
UniGeneiRn.18043.

3D structure databases

ProteinModelPortaliQ03348.
SMRiQ03348. Positions 211-787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5790N.
IntActiQ03348. 4 interactions.
MINTiMINT-8308366.

PTM databases

PhosphoSiteiQ03348.

Proteomic databases

PaxDbiQ03348.
PRIDEiQ03348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3450. rat.

Organism-specific databases

RGDi3450. Ptpra.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiQ03348.
PhylomeDBiQ03348.

Miscellaneous databases

PROiQ03348.

Gene expression databases

GenevestigatoriQ03348.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells."
    Moriyama T., Fujiwara Y., Imai E., Takenaka M., Kawanishi S., Inoue T., Noguchi T., Tanaka T., Kamada T., Ueda N.
    Biochem. Biophys. Res. Commun. 188:34-39(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPTPRA_RAT
AccessioniPrimary (citable) accession number: Q03348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 4, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.