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Protein

Mitochondrial-processing peptidase subunit beta

Gene

Pmpcb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101ZincPROSITE-ProRule annotation1
Active sitei104Proton acceptorPROSITE-ProRule annotation1
Metal bindingi105ZincPROSITE-ProRule annotation1
Metal bindingi181ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • endopeptidase activity Source: RGD
  • metalloendopeptidase activity Source: GO_Central
  • zinc ion binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-8949664 Processing of SMDT1

Protein family/group databases

MEROPSiM16.003

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
P-52
Gene namesi
Name:Pmpcb
Synonyms:Mppb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621297 Pmpcb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000002677946 – 489Mitochondrial-processing peptidase subunit betaAdd BLAST444

Proteomic databases

PaxDbiQ03346
PRIDEiQ03346

PTM databases

iPTMnetiQ03346
PhosphoSitePlusiQ03346

Expressioni

Gene expression databases

BgeeiENSRNOG00000012693
GenevisibleiQ03346 RN

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017017

Structurei

3D structure databases

ProteinModelPortaliQ03346
SMRiQ03346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074701
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiQ03346
KOiK17732
OMAiNGSYRDM
OrthoDBiEOG091G05W9
PhylomeDBiQ03346
TreeFamiTF105032

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR037718 MPP_beat
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PANTHERiPTHR11851:SF103 PTHR11851:SF103, 1 hit
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVSRTL LPVAGRRLWG FTRRLPLRAA AAQPLYFGGD RLRSTQAAPQ
60 70 80 90 100
VVLNVPETQV TCLENGLRVA SENSGISTCT VGLWIDAGSR YENEKNNGTA
110 120 130 140 150
HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSKDL
160 170 180 190 200
PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT
210 220 230 240 250
AYQNTALGRT ILGPTENIKS ISRKDLVDYI TTHYKGPRIV LAAAGGVCHN
260 270 280 290 300
ELLELAKFHF GDSLCAHKGD VPALPPCKFT GSEIRVRDDK MPLAHLAVAI
310 320 330 340 350
EAVGWTHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF
360 370 380 390 400
QSFNTSYTDT GLWGLYMVCE QATVADMLHA VQKEWMRLCT AVSESEVARA
410 420 430 440 450
KNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVDAEMV
460 470 480
REVCTKYIYG KSPAIAALGP IERLPDFNQI CSNMRWTRD
Length:489
Mass (Da):54,265
Last modified:January 9, 2007 - v3
Checksum:i79B9C1ED7385533F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167G → R in BAA03007 (PubMed:8422255).Curated1
Sequence conflicti312C → R in AAA41633 (PubMed:8506385).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12965 mRNA Translation: AAA41633.1
BC078826 mRNA Translation: AAH78826.1
D13907 mRNA Translation: BAA03007.1
PIRiS36390
RefSeqiNP_071790.1, NM_022395.2
UniGeneiRn.841

Genome annotation databases

EnsembliENSRNOT00000017018; ENSRNOP00000017017; ENSRNOG00000012693
GeneIDi64198
KEGGirno:64198

Similar proteinsi

Entry informationi

Entry nameiMPPB_RAT
AccessioniPrimary (citable) accession number: Q03346
Secondary accession number(s): Q68G08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health