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Protein

Mitochondrial-processing peptidase subunit beta

Gene

Pmpcb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011ZincPROSITE-ProRule annotation
Active sitei104 – 1041Proton acceptorPROSITE-ProRule annotation
Metal bindingi105 – 1051ZincPROSITE-ProRule annotation
Metal bindingi181 – 1811ZincPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM16.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
P-52
Gene namesi
Name:Pmpcb
Synonyms:Mppb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621297. Pmpcb.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrial respiratory chain complex III Source: GO_Central
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionBy similarityAdd
BLAST
Chaini46 – 489444Mitochondrial-processing peptidase subunit betaPRO_0000026779Add
BLAST

Proteomic databases

PaxDbiQ03346.
PRIDEiQ03346.

PTM databases

iPTMnetiQ03346.
PhosphoSiteiQ03346.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012693.
GenevisibleiQ03346. RN.

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017017.

Structurei

3D structure databases

ProteinModelPortaliQ03346.
SMRiQ03346. Positions 50-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiQ03346.
KOiK17732.
OMAiVSWTHED.
OrthoDBiEOG091G05W9.
PhylomeDBiQ03346.
TreeFamiTF105032.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVSRTL LPVAGRRLWG FTRRLPLRAA AAQPLYFGGD RLRSTQAAPQ
60 70 80 90 100
VVLNVPETQV TCLENGLRVA SENSGISTCT VGLWIDAGSR YENEKNNGTA
110 120 130 140 150
HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSKDL
160 170 180 190 200
PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT
210 220 230 240 250
AYQNTALGRT ILGPTENIKS ISRKDLVDYI TTHYKGPRIV LAAAGGVCHN
260 270 280 290 300
ELLELAKFHF GDSLCAHKGD VPALPPCKFT GSEIRVRDDK MPLAHLAVAI
310 320 330 340 350
EAVGWTHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF
360 370 380 390 400
QSFNTSYTDT GLWGLYMVCE QATVADMLHA VQKEWMRLCT AVSESEVARA
410 420 430 440 450
KNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVDAEMV
460 470 480
REVCTKYIYG KSPAIAALGP IERLPDFNQI CSNMRWTRD
Length:489
Mass (Da):54,265
Last modified:January 9, 2007 - v3
Checksum:i79B9C1ED7385533F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671G → R in BAA03007 (PubMed:8422255).Curated
Sequence conflicti312 – 3121C → R in AAA41633 (PubMed:8506385).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12965 mRNA. Translation: AAA41633.1.
BC078826 mRNA. Translation: AAH78826.1.
D13907 mRNA. Translation: BAA03007.1.
PIRiS36390.
RefSeqiNP_071790.1. NM_022395.2.
UniGeneiRn.841.

Genome annotation databases

EnsembliENSRNOT00000017018; ENSRNOP00000017017; ENSRNOG00000012693.
GeneIDi64198.
KEGGirno:64198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12965 mRNA. Translation: AAA41633.1.
BC078826 mRNA. Translation: AAH78826.1.
D13907 mRNA. Translation: BAA03007.1.
PIRiS36390.
RefSeqiNP_071790.1. NM_022395.2.
UniGeneiRn.841.

3D structure databases

ProteinModelPortaliQ03346.
SMRiQ03346. Positions 50-488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017017.

Protein family/group databases

MEROPSiM16.981.

PTM databases

iPTMnetiQ03346.
PhosphoSiteiQ03346.

Proteomic databases

PaxDbiQ03346.
PRIDEiQ03346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017018; ENSRNOP00000017017; ENSRNOG00000012693.
GeneIDi64198.
KEGGirno:64198.

Organism-specific databases

CTDi9512.
RGDi621297. Pmpcb.

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiQ03346.
KOiK17732.
OMAiVSWTHED.
OrthoDBiEOG091G05W9.
PhylomeDBiQ03346.
TreeFamiTF105032.

Miscellaneous databases

PROiQ03346.

Gene expression databases

BgeeiENSRNOG00000012693.
GenevisibleiQ03346. RN.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPPB_RAT
AccessioniPrimary (citable) accession number: Q03346
Secondary accession number(s): Q68G08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.