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Q03337

- TRS31_YEAST

UniProt

Q03337 - TRS31_YEAST

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Protein

Trafficking protein particle complex subunit 31

Gene

TRS31

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.4 Publications

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. ER to Golgi vesicle-mediated transport Source: SGD
  3. positive regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Biological processi

Autophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29999-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 31
Short name:
TRAPP subunit 31
Alternative name(s):
Transport protein particle 31 kDa subunit
Gene namesi
Name:TRS31
Ordered Locus Names:YDR472W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR472w.
SGDiS000002880. TRS31.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. TRAPPIII protein complex Source: SGD
  3. TRAPPII protein complex Source: SGD
  4. TRAPPI protein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Trafficking protein particle complex subunit 31PRO_0000211585Add
BLAST

Proteomic databases

MaxQBiQ03337.
PaxDbiQ03337.

Expressioni

Gene expression databases

GenevestigatoriQ03337.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BET3P3614913EBI-38770,EBI-3567
TRS20P383345EBI-38770,EBI-19468

Protein-protein interaction databases

BioGridi32525. 58 interactions.
DIPiDIP-1709N.
IntActiQ03337. 10 interactions.
MINTiMINT-401389.
STRINGi4932.YDR472W.

Structurei

Secondary structure

1
283
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi56 – 583
Helixi59 – 7618
Helixi83 – 897
Helixi97 – 1015
Beta strandi170 – 1723
Helixi176 – 1838
Helixi187 – 1904
Beta strandi197 – 2015
Beta strandi209 – 2157
Beta strandi217 – 2193
Helixi228 – 2314
Turni241 – 2433
Beta strandi251 – 2533
Beta strandi264 – 2674
Helixi272 – 2776

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CUEX-ray3.70B/H/N/T1-283[»]
ProteinModelPortaliQ03337.
SMRiQ03337. Positions 54-282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03337.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5128.
GeneTreeiENSGT00390000000976.
HOGENOMiHOG000176758.
InParanoidiQ03337.
OMAiSANERLQ.
OrthoDBiEOG7XSTS0.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR016696. TRAPP-I_su5.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR20902. PTHR20902. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF017479. TRAPP_I_complex_Trs31. 1 hit.
SUPFAMiSSF111126. SSF111126. 2 hits.

Sequencei

Sequence statusi: Complete.

Q03337-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQRIIQPSA SDQQFPGKSD GYEYTVGPKQ AITSEASTTY IPSRIYSESL
60 70 80 90 100
LFKRQEASLS AMAFLFQEMI SQLHRTCKTA GDFETKLSDY GHNIGIRLLE
110 120 130 140 150
LLNFRASVSP SSLPRASAFL SQNESSSKLS NASNSPGMLA NSSTATSASA
160 170 180 190 200
NERLQEKQTE SLSNYITKMR RRDLKILDIL QFIHGTLWSY LFNHVSDDLV
210 220 230 240 250
KSSERDNEYM IVDNFPTLTQ FIPGENVSCE YFVCGIIKGF LFNAGFPCGV
260 270 280
TAHRMPQGGH SQRTVYLIQF DRQVLDREGL RFG
Length:283
Mass (Da):31,722
Last modified:November 1, 1996 - v1
Checksum:i857BBA3E03423D42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA. Translation: AAB64914.1.
BK006938 Genomic DNA. Translation: DAA12306.1.
PIRiS69639.
RefSeqiNP_010760.3. NM_001180780.3.

Genome annotation databases

EnsemblFungiiYDR472W; YDR472W; YDR472W.
GeneIDi852083.
KEGGisce:YDR472W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA. Translation: AAB64914.1 .
BK006938 Genomic DNA. Translation: DAA12306.1 .
PIRi S69639.
RefSeqi NP_010760.3. NM_001180780.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CUE X-ray 3.70 B/H/N/T 1-283 [» ]
ProteinModelPortali Q03337.
SMRi Q03337. Positions 54-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32525. 58 interactions.
DIPi DIP-1709N.
IntActi Q03337. 10 interactions.
MINTi MINT-401389.
STRINGi 4932.YDR472W.

Proteomic databases

MaxQBi Q03337.
PaxDbi Q03337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR472W ; YDR472W ; YDR472W .
GeneIDi 852083.
KEGGi sce:YDR472W.

Organism-specific databases

CYGDi YDR472w.
SGDi S000002880. TRS31.

Phylogenomic databases

eggNOGi COG5128.
GeneTreei ENSGT00390000000976.
HOGENOMi HOG000176758.
InParanoidi Q03337.
OMAi SANERLQ.
OrthoDBi EOG7XSTS0.

Enzyme and pathway databases

BioCyci YEAST:G3O-29999-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q03337.
NextBioi 970397.
PROi Q03337.

Gene expression databases

Genevestigatori Q03337.

Family and domain databases

InterProi IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR016696. TRAPP-I_su5.
IPR007194. TRAPP_component.
[Graphical view ]
PANTHERi PTHR20902. PTHR20902. 1 hit.
Pfami PF04051. TRAPP. 1 hit.
[Graphical view ]
PIRSFi PIRSF017479. TRAPP_I_complex_Trs31. 1 hit.
SUPFAMi SSF111126. SSF111126. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."
    Sacher M., Jiang Y., Barrowman J., Scarpa A., Burston J., Zhang L., Schieltz D., Yates J.R. III, Abeliovich H., Ferro-Novick S.
    EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE TRAPP II COMPLEX.
  4. "TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport."
    Sacher M., Barrowman J., Wang W., Horecka J., Zhang Y., Pypaert M., Ferro-Novick S.
    Mol. Cell 7:433-442(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE TRAPP II COMPLEX, IDENTIFICATION IN THE TRAPP II COMPLEX, FUNCTION OF THE TRAPP I COMPLEX, IDENTIFICATION IN THE TRAPP I COMPLEX, SUBCELLULAR LOCATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Molecular architecture of the TRAPPII complex and implications for vesicle tethering."
    Yip C.K., Berscheminski J., Walz T.
    Nat. Struct. Mol. Biol. 17:1298-1304(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TRAP II COMPLEX, FUNCTION OF THE TRAP II COMPLEX.
  8. Cited for: IDENTIFICATION IN THE TRAPP III COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE TRAPP III COMPLEX.

Entry informationi

Entry nameiTRS31_YEAST
AccessioniPrimary (citable) accession number: Q03337
Secondary accession number(s): D6VT96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3