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Protein

40S ribosomal protein S13

Gene

RpS13

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S13
Gene namesi
Name:RpS13
Synonyms:M(2)32A, Rp17
ORF Names:CG13389
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0010265. RpS13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • cytosolic ribosome Source: FlyBase
  • cytosolic small ribosomal subunit Source: FlyBase
  • nuclear chromosome Source: FlyBase
  • nucleolus Source: FlyBase
  • ribosome Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001156762 – 15140S ribosomal protein S13Add BLAST150

Proteomic databases

PaxDbiQ03334.
PRIDEiQ03334.

Expressioni

Gene expression databases

BgeeiFBgn0010265.
ExpressionAtlasiQ03334. differential.
GenevisibleiQ03334. DM.

Interactioni

Protein-protein interaction databases

BioGridi60275. 21 interactors.
DIPiDIP-17858N.
IntActiQ03334. 1 interactor.
MINTiMINT-1001577.
STRINGi7227.FBpp0079328.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AN1-151[»]
ProteinModelPortaliQ03334.
SMRiQ03334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0400. Eukaryota.
COG0184. LUCA.
InParanoidiQ03334.
KOiK02953.
OMAiWHLVKKA.
OrthoDBiEOG091G0X8F.
PhylomeDBiQ03334.

Family and domain databases

CDDicd00353. Ribosomal_S15p_S13e. 1 hit.
HAMAPiMF_01343_A. Ribosomal_S15_A. 1 hit.
InterProiView protein in InterPro
IPR012606. Ribosomal_S13/S15_N.
IPR000589. Ribosomal_S15.
IPR023029. Ribosomal_S15P.
IPR009068. S15_NS1_RNA-bd.
PANTHERiPTHR11885. PTHR11885. 1 hit.
PfamiView protein in Pfam
PF08069. Ribosomal_S13_N. 1 hit.
PF00312. Ribosomal_S15. 1 hit.
SMARTiView protein in SMART
SM01386. Ribosomal_S13_N. 1 hit.
SM01387. Ribosomal_S15. 1 hit.
SUPFAMiSSF47060. SSF47060. 1 hit.
PROSITEiView protein in PROSITE
PS00362. RIBOSOMAL_S15. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRMHAPGKG ISQSALPYRR TVPSWLKLNA DDVKEQIKKL GKKGLTPSKI
60 70 80 90 100
GIILRDSHGV AQVRFVNGNK ILRIMKSVGL KPDIPEDLYH MIKKAVAIRK
110 120 130 140 150
HLERNRKDKD GKFRLILVES RIHRLARYYK TKSVLPPNWK YESSTASALV

A
Length:151
Mass (Da):17,178
Last modified:January 23, 2007 - v3
Checksum:i498306F4F14B76F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40 – 49LGKKGLTPSK → AGQEGSDSLQ in CAA79496 (PubMed:8506150).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19052 mRNA. Translation: CAA79496.1.
X91853 Genomic DNA. Translation: CAA62964.1.
X91854 mRNA. Translation: CAA62965.1.
AE014134 Genomic DNA. Translation: AAF52649.1.
AE014134 Genomic DNA. Translation: ABC65883.1.
AY058536 mRNA. Translation: AAL13765.1.
PIRiS70391. S33684.
RefSeqiNP_001033885.1. NM_001038796.3.
NP_001285747.1. NM_001298818.1.
NP_476938.1. NM_057590.5.
UniGeneiDm.3535.

Genome annotation databases

EnsemblMetazoaiFBtr0079724; FBpp0079328; FBgn0010265.
FBtr0100541; FBpp0099990; FBgn0010265.
FBtr0346454; FBpp0312104; FBgn0010265.
GeneIDi34149.
KEGGidme:Dmel_CG13389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19052 mRNA. Translation: CAA79496.1.
X91853 Genomic DNA. Translation: CAA62964.1.
X91854 mRNA. Translation: CAA62965.1.
AE014134 Genomic DNA. Translation: AAF52649.1.
AE014134 Genomic DNA. Translation: ABC65883.1.
AY058536 mRNA. Translation: AAL13765.1.
PIRiS70391. S33684.
RefSeqiNP_001033885.1. NM_001038796.3.
NP_001285747.1. NM_001298818.1.
NP_476938.1. NM_057590.5.
UniGeneiDm.3535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AN1-151[»]
ProteinModelPortaliQ03334.
SMRiQ03334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60275. 21 interactors.
DIPiDIP-17858N.
IntActiQ03334. 1 interactor.
MINTiMINT-1001577.
STRINGi7227.FBpp0079328.

Proteomic databases

PaxDbiQ03334.
PRIDEiQ03334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079724; FBpp0079328; FBgn0010265.
FBtr0100541; FBpp0099990; FBgn0010265.
FBtr0346454; FBpp0312104; FBgn0010265.
GeneIDi34149.
KEGGidme:Dmel_CG13389.

Organism-specific databases

CTDi6207.
FlyBaseiFBgn0010265. RpS13.

Phylogenomic databases

eggNOGiKOG0400. Eukaryota.
COG0184. LUCA.
InParanoidiQ03334.
KOiK02953.
OMAiWHLVKKA.
OrthoDBiEOG091G0X8F.
PhylomeDBiQ03334.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpS13. fly.
GenomeRNAii34149.
PROiPR:Q03334.

Gene expression databases

BgeeiFBgn0010265.
ExpressionAtlasiQ03334. differential.
GenevisibleiQ03334. DM.

Family and domain databases

CDDicd00353. Ribosomal_S15p_S13e. 1 hit.
HAMAPiMF_01343_A. Ribosomal_S15_A. 1 hit.
InterProiView protein in InterPro
IPR012606. Ribosomal_S13/S15_N.
IPR000589. Ribosomal_S15.
IPR023029. Ribosomal_S15P.
IPR009068. S15_NS1_RNA-bd.
PANTHERiPTHR11885. PTHR11885. 1 hit.
PfamiView protein in Pfam
PF08069. Ribosomal_S13_N. 1 hit.
PF00312. Ribosomal_S15. 1 hit.
SMARTiView protein in SMART
SM01386. Ribosomal_S13_N. 1 hit.
SM01387. Ribosomal_S15. 1 hit.
SUPFAMiSSF47060. SSF47060. 1 hit.
PROSITEiView protein in PROSITE
PS00362. RIBOSOMAL_S15. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRS13_DROME
AccessioniPrimary (citable) accession number: Q03334
Secondary accession number(s): A4V0F6, Q9VLN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.