Reviewed, UniProtKB/Swiss-Prot Q03324 (LUXC1_PHOLE)

Names and origin

Protein names

Recommended name:
    Acyl-CoA reductase
    EC=1.2.1.50

Gene names

Name:

luxC

Organism

Photobacterium leiognathi

Taxonomic identifier

658 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Catalytic activity	A long-chain aldehyde + CoA + NADP(+) = a long-chain acyl-CoA + NADPH.
Pathway	Lipid metabolism; bioluminescent fatty acid reduction.
Sequence similarities	Belongs to the luxC family.

Ontologies

Keywords
Biological process	Luminescence
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl-CoA reductase activity Inferred from electronic annotation. Source: InterPro long-chain-fatty-acyl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Acyl-CoA reductase		PRO_0000220196

Sequences

	Sequence		Length	Mass (Da)
	Q03324-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: D730A3BE2462086B	FASTA	478	53,858
	10 20 30 40 50 60 MIKKIPLIIG GEVQDTSEHD VRELTLNNNT VNVPIITDKD AESITSLKIE NKLNINQIVN 70 80 90 100 110 120 FLYTVGQKWK SENYSRRLTY IRDLVKFMGY SPEMAKLEAN WISMILCSKS ALYDIVENDL 130 140 150 160 170 180 SSRHIVDEWL PQGDCYVKAL PKGKSIHLLA GNVPLSGVTS ILRAILTKNE CIIKTSSADP 190 200 210 220 230 240 FTATALASSF IDTDANHPIT RSMSVMYWSH NEDITIPQKI MNCADVVVAW GGNDAIKWAT 250 260 270 280 290 300 KHSPAHVDIL KFGPKKSISI VDNPTDIKAA AIGVAHDICF YDQQACFSTQ DIYYMGDKLD 310 320 330 340 350 360 VFFDELTKQL NIYKVILPKG DQSFDEKGAF SLTERECLFA KYKVQKGEEQ AWLLTQSPAG 370 380 390 400 410 420 TFGNQPLSRS AYIHHVNDIS EITPYIQNDI TQTVSITPWE ASFKYRDTLA SHGAERIIES 430 440 450 460 470 GMNNIFRVGG AHDGMRPLQR LVKYISHERP STYTTKDVAV KIEQTRYLEE DKFLVFVP

References

[1]	"Nucleotide sequence of the luxC gene encoding fatty acid reductase of the lux operon from Photobacterium leiognathi." Lin J.-W., Chao Y.-F., Weng S.-F. Biochem. Biophys. Res. Commun. 191:314-318(1993) [PubMed: 8447834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 741.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X65156 Genomic DNA. Translation: CAA46274.1.
PIR	JC1475.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR016162. Ald_DHase_N. IPR008670. LuxC. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF05893. LuxC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LUXC1_PHOLE

Accession

Primary (citable) accession number: Q03324

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)