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Protein

Acyl-CoA reductase

Gene

luxC

Organism
Photobacterium leiognathi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

Catalytic activityi

A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

Pathway:ifatty acid reduction for biolumincescence

This protein is involved in the pathway fatty acid reduction for biolumincescence, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid reduction for biolumincescence and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Luminescence

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00569.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA reductase (EC:1.2.1.50)
Gene namesi
Name:luxC
OrganismiPhotobacterium leiognathi
Taxonomic identifieri553611 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Acyl-CoA reductasePRO_0000220196Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1001530.PMSV_1845.

Structurei

3D structure databases

ProteinModelPortaliQ03324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxC family.Curated

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKIPLIIG GEVQDTSEHD VRELTLNNNT VNVPIITDKD AESITSLKIE
60 70 80 90 100
NKLNINQIVN FLYTVGQKWK SENYSRRLTY IRDLVKFMGY SPEMAKLEAN
110 120 130 140 150
WISMILCSKS ALYDIVENDL SSRHIVDEWL PQGDCYVKAL PKGKSIHLLA
160 170 180 190 200
GNVPLSGVTS ILRAILTKNE CIIKTSSADP FTATALASSF IDTDANHPIT
210 220 230 240 250
RSMSVMYWSH NEDITIPQKI MNCADVVVAW GGNDAIKWAT KHSPAHVDIL
260 270 280 290 300
KFGPKKSISI VDNPTDIKAA AIGVAHDICF YDQQACFSTQ DIYYMGDKLD
310 320 330 340 350
VFFDELTKQL NIYKVILPKG DQSFDEKGAF SLTERECLFA KYKVQKGEEQ
360 370 380 390 400
AWLLTQSPAG TFGNQPLSRS AYIHHVNDIS EITPYIQNDI TQTVSITPWE
410 420 430 440 450
ASFKYRDTLA SHGAERIIES GMNNIFRVGG AHDGMRPLQR LVKYISHERP
460 470
STYTTKDVAV KIEQTRYLEE DKFLVFVP
Length:478
Mass (Da):53,858
Last modified:June 1, 1994 - v1
Checksum:iD730A3BE2462086B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65156 Genomic DNA. Translation: CAA46274.1.
PIRiJC1475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65156 Genomic DNA. Translation: CAA46274.1.
PIRiJC1475.

3D structure databases

ProteinModelPortaliQ03324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1001530.PMSV_1845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00569.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the luxC gene encoding fatty acid reductase of the lux operon from Photobacterium leiognathi."
    Lin J.-W., Chao Y.-F., Weng S.-F.
    Biochem. Biophys. Res. Commun. 191:314-318(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 741.

Entry informationi

Entry nameiLUXC1_PHOLE
AccessioniPrimary (citable) accession number: Q03324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.