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Q03324 (LUXC1_PHOLE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-CoA reductase

EC=1.2.1.50
Gene names
Name:luxC
OrganismPhotobacterium leiognathi
Taxonomic identifier553611 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

Catalytic activity

A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

Pathway

Lipid metabolism; fatty acid reduction for biolumincescence.

Sequence similarities

Belongs to the LuxC family.

Ontologies

Keywords
   Biological processLuminescence
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processbioluminescence

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

long-chain-fatty-acyl-CoA reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Acyl-CoA reductase
PRO_0000220196

Sequences

Sequence LengthMass (Da)Tools
Q03324 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: D730A3BE2462086B

FASTA47853,858
        10         20         30         40         50         60 
MIKKIPLIIG GEVQDTSEHD VRELTLNNNT VNVPIITDKD AESITSLKIE NKLNINQIVN 

        70         80         90        100        110        120 
FLYTVGQKWK SENYSRRLTY IRDLVKFMGY SPEMAKLEAN WISMILCSKS ALYDIVENDL 

       130        140        150        160        170        180 
SSRHIVDEWL PQGDCYVKAL PKGKSIHLLA GNVPLSGVTS ILRAILTKNE CIIKTSSADP 

       190        200        210        220        230        240 
FTATALASSF IDTDANHPIT RSMSVMYWSH NEDITIPQKI MNCADVVVAW GGNDAIKWAT 

       250        260        270        280        290        300 
KHSPAHVDIL KFGPKKSISI VDNPTDIKAA AIGVAHDICF YDQQACFSTQ DIYYMGDKLD 

       310        320        330        340        350        360 
VFFDELTKQL NIYKVILPKG DQSFDEKGAF SLTERECLFA KYKVQKGEEQ AWLLTQSPAG 

       370        380        390        400        410        420 
TFGNQPLSRS AYIHHVNDIS EITPYIQNDI TQTVSITPWE ASFKYRDTLA SHGAERIIES 

       430        440        450        460        470 
GMNNIFRVGG AHDGMRPLQR LVKYISHERP STYTTKDVAV KIEQTRYLEE DKFLVFVP 

« Hide

References

[1]"Nucleotide sequence of the luxC gene encoding fatty acid reductase of the lux operon from Photobacterium leiognathi."
Lin J.-W., Chao Y.-F., Weng S.-F.
Biochem. Biophys. Res. Commun. 191:314-318(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 741.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65156 Genomic DNA. Translation: CAA46274.1.
PIRJC1475.

3D structure databases

ProteinModelPortalQ03324.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00569.

Family and domain databases

Gene3D3.40.605.10. 1 hit.
InterProIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFPIRSF009414. LuxC. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLUXC1_PHOLE
AccessionPrimary (citable) accession number: Q03324
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways