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Protein

Probable ATP-dependent RNA helicase prh1

Gene

prh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in pre-mRNA splicing.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi119 – 1268ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase prh1 (EC:3.6.4.13)
Gene namesi
Name:prh1
ORF Names:SPAC2G11.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2G11.11c.
PomBaseiSPAC2G11.11c. prh1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleolus Source: PomBase
  • spliceosomal complex Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Probable ATP-dependent RNA helicase prh1PRO_0000055155Add
BLAST

Proteomic databases

MaxQBiQ03319.

Interactioni

Protein-protein interaction databases

BioGridi278244. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ03319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 269164Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini294 – 466173Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi216 – 2194DEAH box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000175261.
InParanoidiQ03319.
KOiK14781.
OMAiEAIMYNE.
OrthoDBiEOG092C2SAZ.
PhylomeDBiQ03319.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVSGKLRN GGSITKQNLT DGLVGGQRIK APNKKKNRKA SKNTTKKSTV
60 70 80 90 100
SVVNFLEQDT DFGANEVVGS DNSSPEKRSE NSPSKRKDIL EQRKNLPIWE
110 120 130 140 150
AHDTLCQQIQ DNRVIVVVGE TGSGKSTQIP QFLNECPYAQ EGCVAITQPR
160 170 180 190 200
RVAAVNLAKR VAAEQGCRLG EQVGYSIRFD DTTSKKTRIK YLTDGMLLRE
210 220 230 240 250
LINDPILSQY HTLILDEAHE RTLMTDMLLG FVKKIIKKRP ALRVIIMSAT
260 270 280 290 300
LNAERFSEFF DGAEICYISG RQYPVQIHYT YTPEPDYLDA CLRTIFQLHT
310 320 330 340 350
KLPPGDILVF LTGQDEIEAL EALIKSYSKQ LPSNLPQIQA CPLFASLPQE
360 370 380 390 400
QQLQVFLPAL ANHRKVVLST NIAETSVTIS GIRYVIDTGL AKIKQFNSKL
410 420 430 440 450
GLESLTVQPI SQSAAMQRSG RAGREAAGQC YRIYTEADFD KLPKETIPEI
460 470 480 490 500
KRIDLSQAVL TLKARGQNDV INFHYMDPPS KEGLLRALEH LYSIGALDDN
510 520 530 540 550
GHINDLGYQM SLIPLLPSLA RAVLAAREHN CLSEVIDVVS CLSTDSMFLF
560 570 580 590 600
PQEKRDEAIE ARLKFLHSEG DLLTCLNALR QYLESSHDSR KQWCSQNFIN
610 620 630 640 650
RRALKTILDI RKQLREHCLK DGWELNSSPE VNSENLLLSF LSGYITNTAL
660 670 680 690 700
LHPDGSYRTI IGNQTISIHP SSSLFGKKVE AIMYHELVFT TKSYVRGVSS
710
IRSNWLNAVA PHYLARRST
Length:719
Mass (Da):80,605
Last modified:November 1, 1995 - v2
Checksum:iE6EB16EEED852115
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti719 – 7191T → HLTFQLLKKIKKAHILSHYI LVNLETTIF in BAA02516 (PubMed:1454545).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13249 Genomic DNA. Translation: BAA02516.1.
CU329670 Genomic DNA. Translation: CAA91176.1.
PIRiS35546.
S62466.
RefSeqiNP_593091.1. NM_001018489.2.

Genome annotation databases

EnsemblFungiiSPAC2G11.11c.1; SPAC2G11.11c.1:pep; SPAC2G11.11c.
GeneIDi2541750.
KEGGispo:SPAC2G11.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13249 Genomic DNA. Translation: BAA02516.1.
CU329670 Genomic DNA. Translation: CAA91176.1.
PIRiS35546.
S62466.
RefSeqiNP_593091.1. NM_001018489.2.

3D structure databases

ProteinModelPortaliQ03319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278244. 2 interactions.

Proteomic databases

MaxQBiQ03319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2G11.11c.1; SPAC2G11.11c.1:pep; SPAC2G11.11c.
GeneIDi2541750.
KEGGispo:SPAC2G11.11c.

Organism-specific databases

EuPathDBiFungiDB:SPAC2G11.11c.
PomBaseiSPAC2G11.11c. prh1.

Phylogenomic databases

HOGENOMiHOG000175261.
InParanoidiQ03319.
KOiK14781.
OMAiEAIMYNE.
OrthoDBiEOG092C2SAZ.
PhylomeDBiQ03319.

Miscellaneous databases

PROiQ03319.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRH1_SCHPO
AccessioniPrimary (citable) accession number: Q03319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.