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Protein

Serine/threonine-protein kinase PKH3

Gene

PKH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase which may phosphorylate the same targets substrates as PKH1 and PKH2, 2 upstream activators of PKC1.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1
Active sitei138Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • MAPK cascade involved in cell wall organization or biogenesis Source: SGD
  • peptidyl-serine phosphorylation Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29994-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PKH3 (EC:2.7.11.1)
Alternative name(s):
Pkb-activating kinase homolog 3
Gene namesi
Name:PKH3
Ordered Locus Names:YDR466W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR466W
SGDiS000002874 PKH3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865541 – 898Serine/threonine-protein kinase PKH3Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei696PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03306
PaxDbiQ03306
PRIDEiQ03306

PTM databases

iPTMnetiQ03306

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32520, 127 interactors
DIPiDIP-8781N
IntActiQ03306, 17 interactors
MINTiQ03306
STRINGi4932.YDR466W

Structurei

3D structure databases

ProteinModelPortaliQ03306
SMRiQ03306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 293Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000146378
HOGENOMiHOG000001069
InParanoidiQ03306
KOiK06276
OMAiTFHDEEN
OrthoDBiEOG092C0HH3

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q03306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRKRSPHD FIFKEELGHG SYSTVFKALD KKSPNKIYAI KVCSKKHIIK
60 70 80 90 100
EAKVKYVTIE KNTMNLLAQK HHAGIIKLYY TFHDEENLYF VLDFAPGGEL
110 120 130 140 150
LSLLHKMGTF NDIWTRHFTA QLIDALEFIH SHGIIHRDLK PENVLLDRDG
160 170 180 190 200
RLMITDFGAA ATIDPSLSGD SAKFNSDSNG SKDNQNCASF VGTAEYVSPE
210 220 230 240 250
LLLYNQCGYG SDIWALGCMI YQFVQGQPPF RGENELKTFE KIVALDYPWG
260 270 280 290 300
PNNRINNSTS PINPLVINLV QKILVIEVNE RISLEQIKRH PYFSKVDWND
310 320 330 340 350
KIKIWRGIWQ SQGQSLQQTT LGLPNIPQNI LPTRQLHVID TPARSIQITK
360 370 380 390 400
QKRKKPTKIS NTTSSIVVWR KRLGISTGKD DLGTVPSTTP AVTAPNDTNV
410 420 430 440 450
LTNTAAHSTA NIALPPNSQS NQVKRAQLVA PNRIPPKVPV INDNVRNKSI
460 470 480 490 500
PRTKPNVPPL QTSSIPQKLS TSSASSALSA PSTEIRNQDL THTLDGRNSI
510 520 530 540 550
DIHVLKQDYV FIYGIPYEHE GPAMSLNSYN KIDNDLITSL VAQHKEELKN
560 570 580 590 600
SESFLQVLTL KKSGMLSYKN TVMEGNDDQE NKEHQMANIE DTDLSMYDFE
610 620 630 640 650
FNELTRKGFL ILEKYKNRIW FISLPSYSTL SKIPFNAVKS STINNNENWV
660 670 680 690 700
DCFFRARQLL EEKQILDKIS NVSFDSKASS EPSSPPPISR KERPLSIGNN
710 720 730 740 750
VTTLSYTAKN GSQNNAPQND NVGEEKPFRI PSSTKDRPGA NSTPSSRHPR
760 770 780 790 800
VLSSNNAGET PKKMNGRLPN SAPSTNTYTN GSVPAFNHRP STNVGNNKHN
810 820 830 840 850
ILTSKKQGSS VFSPSSSTTK PQIKTTGYRQ PTPSPPLPQM EFPTTREKYS
860 870 880 890
APSNMVISSS RYEVLHTLNN SQTNFDREIA SRGASAAFRS LQKSKKKK
Length:898
Mass (Da):100,476
Last modified:November 1, 1996 - v1
Checksum:i44715C40DD26B89E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33050 Genomic DNA Translation: AAB64902.1
BK006938 Genomic DNA Translation: DAA12301.1
PIRiS69634
RefSeqiNP_010754.1, NM_001180774.1

Genome annotation databases

EnsemblFungiiYDR466W; YDR466W; YDR466W
GeneIDi852077
KEGGisce:YDR466W

Similar proteinsi

Entry informationi

Entry nameiPKH3_YEAST
AccessioniPrimary (citable) accession number: Q03306
Secondary accession number(s): D6VT91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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