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Protein

Superoxide dismutase [Mn] 2

Gene

sod2

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281ManganeseBy similarity
Metal bindingi75 – 751ManganeseBy similarity
Metal bindingi157 – 1571ManganeseBy similarity
Metal bindingi161 – 1611ManganeseBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-2919-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 2 (EC:1.15.1.1)
Gene namesi
Name:sod2
Ordered Locus Names:HVO_2913
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
ProteomesiUP000008243 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Superoxide dismutase [Mn] 2PRO_0000160117Add
BLAST

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000013583.
KOiK04564.
OMAiKHHNAYT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYELDPLPY EYDALEPHIS EQVLTWHHDT HHQGYVNGWN AAEETLAENR
60 70 80 90 100
EAGEFGSSAG ALRNVTHNGS GHILHDLFWQ NMSPEGGDEP EGALAERIAE
110 120 130 140 150
DFGSYEAWKG EFEAAAGAAG GWALLVYDSF SNQLRNVVVD KHDQGALWGS
160 170 180 190
HPILALDVWE HSYYHDYGPA RGDFVSAFFE VVDWDEPAAR YEQAVELFE
Length:199
Mass (Da):22,297
Last modified:September 21, 2011 - v2
Checksum:i6315C33F3B7265CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 432AE → DD in AAA73376 (PubMed:8449865).Curated
Sequence conflicti62 – 621L → V in AAA73376 (PubMed:8449865).Curated
Sequence conflicti93 – 931A → L in AAA73376 (PubMed:8449865).Curated
Sequence conflicti120 – 1201G → A in AAA73376 (PubMed:8449865).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97487 Genomic DNA. Translation: AAA73376.1.
CP001956 Genomic DNA. Translation: ADE03299.1.
PIRiT50046.
RefSeqiYP_003536923.1. NC_013967.1.

Genome annotation databases

EnsemblBacteriaiADE03299; ADE03299; HVO_2913.
GeneIDi8924540.
KEGGihvo:HVO_2913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97487 Genomic DNA. Translation: AAA73376.1.
CP001956 Genomic DNA. Translation: ADE03299.1.
PIRiT50046.
RefSeqiYP_003536923.1. NC_013967.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE03299; ADE03299; HVO_2913.
GeneIDi8924540.
KEGGihvo:HVO_2913.

Phylogenomic databases

HOGENOMiHOG000013583.
KOiK04564.
OMAiKHHNAYT.

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-2919-MONOMER.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of paralogous and orthologous members of the superoxide dismutase gene family from genera of the halophilic archaebacteria."
    Joshi P.B., Dennis P.P.
    J. Bacteriol. 175:1561-1571(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

Entry informationi

Entry nameiSODM2_HALVD
AccessioniPrimary (citable) accession number: Q03301
Secondary accession number(s): D4GXS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 21, 2011
Last modified: March 4, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.