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Q03301

- SODM2_HALVD

UniProt

Q03301 - SODM2_HALVD

Protein

Superoxide dismutase [Mn] 2

Gene

sod2

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281ManganeseBy similarity
    Metal bindingi75 – 751ManganeseBy similarity
    Metal bindingi157 – 1571ManganeseBy similarity
    Metal bindingi161 – 1611ManganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciHVOL309800:GCOK-2919-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn] 2 (EC:1.15.1.1)
    Gene namesi
    Name:sod2
    Ordered Locus Names:HVO_2913
    OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
    Taxonomic identifieri309800 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
    ProteomesiUP000008243: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Superoxide dismutase [Mn] 2PRO_0000160117Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiRAYVPIG.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03301-1 [UniParc]FASTAAdd to Basket

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    MSYELDPLPY EYDALEPHIS EQVLTWHHDT HHQGYVNGWN AAEETLAENR    50
    EAGEFGSSAG ALRNVTHNGS GHILHDLFWQ NMSPEGGDEP EGALAERIAE 100
    DFGSYEAWKG EFEAAAGAAG GWALLVYDSF SNQLRNVVVD KHDQGALWGS 150
    HPILALDVWE HSYYHDYGPA RGDFVSAFFE VVDWDEPAAR YEQAVELFE 199
    Length:199
    Mass (Da):22,297
    Last modified:September 21, 2011 - v2
    Checksum:i6315C33F3B7265CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 432AE → DD in AAA73376. (PubMed:8449865)Curated
    Sequence conflicti62 – 621L → V in AAA73376. (PubMed:8449865)Curated
    Sequence conflicti93 – 931A → L in AAA73376. (PubMed:8449865)Curated
    Sequence conflicti120 – 1201G → A in AAA73376. (PubMed:8449865)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97487 Genomic DNA. Translation: AAA73376.1.
    CP001956 Genomic DNA. Translation: ADE03299.1.
    PIRiT50046.
    RefSeqiWP_013035375.1. NC_013967.1.
    YP_003536923.1. NC_013967.1.

    Genome annotation databases

    EnsemblBacteriaiADE03299; ADE03299; HVO_2913.
    GeneIDi8924540.
    KEGGihvo:HVO_2913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97487 Genomic DNA. Translation: AAA73376.1 .
    CP001956 Genomic DNA. Translation: ADE03299.1 .
    PIRi T50046.
    RefSeqi WP_013035375.1. NC_013967.1.
    YP_003536923.1. NC_013967.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE03299 ; ADE03299 ; HVO_2913 .
    GeneIDi 8924540.
    KEGGi hvo:HVO_2913.

    Phylogenomic databases

    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi RAYVPIG.

    Enzyme and pathway databases

    BioCyci HVOL309800:GCOK-2919-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of paralogous and orthologous members of the superoxide dismutase gene family from genera of the halophilic archaebacteria."
      Joshi P.B., Dennis P.P.
      J. Bacteriol. 175:1561-1571(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

    Entry informationi

    Entry nameiSODM2_HALVD
    AccessioniPrimary (citable) accession number: Q03301
    Secondary accession number(s): D4GXS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3