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Q03301 (SODM2_HALVD) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Mn] 2

EC=1.15.1.1
Gene names
Name:sod2
Ordered Locus Names:HVO_2913
OrganismHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) [Reference proteome] [HAMAP]
Taxonomic identifier309800 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 manganese ion per subunit By similarity.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
   LigandManganese
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsuperoxide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Superoxide dismutase [Mn] 2
PRO_0000160117

Sites

Metal binding281Manganese By similarity
Metal binding751Manganese By similarity
Metal binding1571Manganese By similarity
Metal binding1611Manganese By similarity

Experimental info

Sequence conflict42 – 432AE → DD in AAA73376. Ref.1
Sequence conflict621L → V in AAA73376. Ref.1
Sequence conflict931A → L in AAA73376. Ref.1
Sequence conflict1201G → A in AAA73376. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q03301 [UniParc].

Last modified September 21, 2011. Version 2.
Checksum: 6315C33F3B7265CB

FASTA19922,297
        10         20         30         40         50         60 
MSYELDPLPY EYDALEPHIS EQVLTWHHDT HHQGYVNGWN AAEETLAENR EAGEFGSSAG 

        70         80         90        100        110        120 
ALRNVTHNGS GHILHDLFWQ NMSPEGGDEP EGALAERIAE DFGSYEAWKG EFEAAAGAAG 

       130        140        150        160        170        180 
GWALLVYDSF SNQLRNVVVD KHDQGALWGS HPILALDVWE HSYYHDYGPA RGDFVSAFFE 

       190 
VVDWDEPAAR YEQAVELFE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of paralogous and orthologous members of the superoxide dismutase gene family from genera of the halophilic archaebacteria."
Joshi P.B., Dennis P.P.
J. Bacteriol. 175:1561-1571(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
[2]"The complete genome sequence of Haloferax volcanii DS2, a model archaeon."
Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R., Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J., Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.
PLoS ONE 5:E9605-E9605(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97487 Genomic DNA. Translation: AAA73376.1.
CP001956 Genomic DNA. Translation: ADE03299.1.
PIRT50046.
RefSeqYP_003536923.1. NC_013967.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADE03299; ADE03299; HVO_2913.
GeneID8924540.
KEGGhvo:HVO_2913.

Phylogenomic databases

HOGENOMHOG000013583.
KOK04564.
OMAWNVFNWD.

Enzyme and pathway databases

BioCycHVOL309800:GCOK-2919-MONOMER.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODM2_HALVD
AccessionPrimary (citable) accession number: Q03301
Secondary accession number(s): D4GXS2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 21, 2011
Last modified: November 13, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families