Q032Z5 (Q032Z5_LACLS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Ordered Locus Names:

LACR_0102

Organism

Lactococcus lactis subsp. cremoris (strain SK11) [Complete proteome] [HAMAP] EMBL ABJ71727.1

Taxonomic identifier

272622 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361 EMBL ABJ71727.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q032Z5 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 01383AD8380D5498	FASTA	345	39,281
	10 20 30 40 50 60 MTFKEISPKI NIDAIKMLGH LNSEQQEKKM LRDKELEAII KGEDDRLLLI IGPCSSDNEE 70 80 90 100 110 120 AVLEYARRLA KLQEAVKDKI FMVMRVYTAK PRTNGDGYKG LIHEPDADGH TDLINGIKMV 130 140 150 160 170 180 RDLHYKVITE TGLTTADEML YPENLPMVDD LVSYHAIGAR SVENQQHRFV ASGIDVPTGL 190 200 210 220 230 240 KNPTSGNLKV MFNGIYAAQQ SQDFLFGRVE VQTSGNPLAH AILRGGQDEN GKYHPNYYTD 250 260 270 280 290 300 NLLETIEIYE KMGLKNPFIL IDTNHDNSGK KFMEQIRIVR QTLVNRDWDD KIRQNVRGFM 310 320 330 340 IESYLEDGRQ DKPEVFGKSI TDPCLGWDKT EALVQEIYEA ESKNK

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000425 Genomic DNA. Translation: ABJ71727.1.
RefSeq	YP_808149.1. NC_008527.1.
3D structure databases
ProteinModelPortal	Q032Z5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q032Z5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4432502.
GenomeReviews	Gene locus LACR_0102 in contig CP000425_GR.
KEGG	llc:LACR_0102.
PATRIC	22286955. VBILacLac38071_0264.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0722.
HOGENOM	HBG670536.
OMA	MDNSFKL.
ProtClustDB	PRK09261.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q032Z5_LACLS

Accession

Primary (citable) accession number: Q032Z5

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)