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Q032L5

- UNG_LACLS

UniProt

Q032L5 - UNG_LACLS

Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

    Catalytic activityi

    Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciLLAC272622:GJUG-239-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
    Short name:
    UDGUniRule annotation
    Gene namesi
    Name:ungUniRule annotation
    Ordered Locus Names:LACR_0239
    OrganismiLactococcus lactis subsp. cremoris (strain SK11)
    Taxonomic identifieri272622 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000000240: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Uracil-DNA glycosylasePRO_1000009907Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272622.LACR_0239.

    Structurei

    3D structure databases

    ProteinModelPortaliQ032L5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uracil-DNA glycosylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0692.
    HOGENOMiHOG000229528.
    KOiK03648.
    OMAiWARQGVM.
    OrthoDBiEOG6MSS63.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_00148. UDG.
    InterProiIPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR11264. PTHR11264. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00628. ung. 1 hit.
    PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q032L5-1 [UniParc]FASTAAdd to Basket

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    MKKTDWSQPL RNRLAEDYFP KMIEFINQTY QEGKIYPPEN QIFRAIELTP    50
    LAQTKVIIVG QDPYPQPGKA QGLAFSYPAT FKVNRPDSIV NIQKELREEG 100
    FSKEDSDLTA WAEQGVLLLN AVLTVPEFAS NAHAGKIWEP LTDEIIKIAS 150
    DDERPKVFIL WGGFARKKAK LIDGSKHLIL EAAHPSPLSA SRGFFGSHPF 200
    SKTNDFLVQT GQSPIDWSK 219
    Length:219
    Mass (Da):24,656
    Last modified:November 14, 2006 - v1
    Checksum:i6CE0D98646EFFB05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ71857.1.
    RefSeqiWP_011675270.1. NC_008527.1.
    YP_808279.1. NC_008527.1.

    Genome annotation databases

    EnsemblBacteriaiABJ71857; ABJ71857; LACR_0239.
    GeneIDi4433789.
    KEGGillc:LACR_0239.
    PATRICi22287229. VBILacLac38071_0398.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ71857.1 .
    RefSeqi WP_011675270.1. NC_008527.1.
    YP_808279.1. NC_008527.1.

    3D structure databases

    ProteinModelPortali Q032L5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272622.LACR_0239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ71857 ; ABJ71857 ; LACR_0239 .
    GeneIDi 4433789.
    KEGGi llc:LACR_0239.
    PATRICi 22287229. VBILacLac38071_0398.

    Phylogenomic databases

    eggNOGi COG0692.
    HOGENOMi HOG000229528.
    KOi K03648.
    OMAi WARQGVM.
    OrthoDBi EOG6MSS63.

    Enzyme and pathway databases

    BioCyci LLAC272622:GJUG-239-MONOMER.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_00148. UDG.
    InterProi IPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR11264. PTHR11264. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00628. ung. 1 hit.
    PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK11.

    Entry informationi

    Entry nameiUNG_LACLS
    AccessioniPrimary (citable) accession number: Q032L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3