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Q032L5

- UNG_LACLS

UniProt

Q032L5 - UNG_LACLS

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Protein
Uracil-DNA glycosylase
Gene
ung, LACR_0239
Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Proton acceptor By similarity

GO - Molecular functioni

  1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciLLAC272622:GJUG-239-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Ordered Locus Names:LACR_0239
OrganismiLactococcus lactis subsp. cremoris (strain SK11)
Taxonomic identifieri272622 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000240: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Uracil-DNA glycosylaseUniRule annotation
PRO_1000009907Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272622.LACR_0239.

Structurei

3D structure databases

ProteinModelPortaliQ032L5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0692.
HOGENOMiHOG000229528.
KOiK03648.
OMAiWARQGVM.
OrthoDBiEOG6MSS63.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q032L5-1 [UniParc]FASTAAdd to Basket

« Hide

MKKTDWSQPL RNRLAEDYFP KMIEFINQTY QEGKIYPPEN QIFRAIELTP    50
LAQTKVIIVG QDPYPQPGKA QGLAFSYPAT FKVNRPDSIV NIQKELREEG 100
FSKEDSDLTA WAEQGVLLLN AVLTVPEFAS NAHAGKIWEP LTDEIIKIAS 150
DDERPKVFIL WGGFARKKAK LIDGSKHLIL EAAHPSPLSA SRGFFGSHPF 200
SKTNDFLVQT GQSPIDWSK 219
Length:219
Mass (Da):24,656
Last modified:November 14, 2006 - v1
Checksum:i6CE0D98646EFFB05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000425 Genomic DNA. Translation: ABJ71857.1.
RefSeqiWP_011675270.1. NC_008527.1.
YP_808279.1. NC_008527.1.

Genome annotation databases

EnsemblBacteriaiABJ71857; ABJ71857; LACR_0239.
GeneIDi4433789.
KEGGillc:LACR_0239.
PATRICi22287229. VBILacLac38071_0398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000425 Genomic DNA. Translation: ABJ71857.1 .
RefSeqi WP_011675270.1. NC_008527.1.
YP_808279.1. NC_008527.1.

3D structure databases

ProteinModelPortali Q032L5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272622.LACR_0239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ71857 ; ABJ71857 ; LACR_0239 .
GeneIDi 4433789.
KEGGi llc:LACR_0239.
PATRICi 22287229. VBILacLac38071_0398.

Phylogenomic databases

eggNOGi COG0692.
HOGENOMi HOG000229528.
KOi K03648.
OMAi WARQGVM.
OrthoDBi EOG6MSS63.

Enzyme and pathway databases

BioCyci LLAC272622:GJUG-239-MONOMER.

Family and domain databases

Gene3Di 3.40.470.10. 1 hit.
HAMAPi MF_00148. UDG.
InterProi IPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view ]
PANTHERi PTHR11264. PTHR11264. 1 hit.
Pfami PF03167. UDG. 1 hit.
[Graphical view ]
SMARTi SM00986. UDG. 1 hit.
[Graphical view ]
SUPFAMi SSF52141. SSF52141. 1 hit.
TIGRFAMsi TIGR00628. ung. 1 hit.
PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK11.

Entry informationi

Entry nameiUNG_LACLS
AccessioniPrimary (citable) accession number: Q032L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi