Q03279 (PO21_SCICO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 Alternative name(s): Retrovirus-related Pol polyprotein from type I retrotransposable element R2 Including the following 2 domains: Reverse transcriptase EC=2.7.7.49 Endonuclease
Organism	Sciara coprophila (Fungus gnat)
Taxonomic identifier	38358 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Sciaroidea › Sciaridae › Bradysia

Protein attributes

Sequence length	869 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 869	›869	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2		PRO_0000058499
Regions
	Domain	199 – 475	277	Reverse transcriptase
	Region	601 – 869	269	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03279 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 9584756BFA7AF818	FASTA	869	97,399
	10 20 30 40 50 60 VSVPPTSYRD RIMNALEESM IDVDAIRGSS ARELVEIGKV ALLNQPMDEG RIMSWLSDRF 70 80 90 100 110 120 PDTQKPKGPI YSKTTIYHGT NKQKRKQRYA LVQSLYKKDI SAAARVVLDE NDKIATKIPP 130 140 150 160 170 180 VRHMFDYWKD VFATGGGSAA TNINRAPPAP HMETLWDPVS LIEIKSARAS NEKGAGPDGV 190 200 210 220 230 240 TPRSWNALDD RYKRLLYNIF VFYGRVPSPI KGSRTVFTPK IEGGPDPGVF RPLSICSVIL 250 260 270 280 290 300 REFNKILARR FVSCYTYDER QTAYLPIDGV CINVSMLTAI IAEAKRLRKE LHIAILDLVK 310 320 330 340 350 360 AFNSVYHSAL IDAITEAGCP PGVVDYIADM YNNVITEMQF EGKCELASIL AGVYQGDPLS 370 380 390 400 410 420 GPLFTLAYEK ALRALNNEGR FDIADVRVNA SAYSDDGLLL AMTVIGLQHN LDKFGETLAK 430 440 450 460 470 480 IGLRINSRKS KTVSLVPSGR EKKMKIVSNR RLLLKASELK PLTISDLWKY LGVVYTTSGP 490 500 510 520 530 540 EVAKVSMDDD LSKLTKGPLK PQQRIHLLKT FVIPKHLNRL VLSRTTATGL CKMDLLIRKY 550 560 570 580 590 600 VRRWLRLPGD VPVAFLYAPV KAGGKGIPCL KQWIPLMRFL RLNKAKRTGG DRIAAVLNCQ 610 620 630 640 650 660 LYASISHSCK TGPVSVGLWR STNTGGLSAY WRRILIGMVD GKDLKSAQNH SSATSFNSIR 670 680 690 700 710 720 MNDISGEDYI HYNQLRTNSI PTRKRTARGR PNKPTACRAG CDKLKRLQHD IQGCIRSQGG 730 740 750 760 770 780 LVQRHDRVVD LLFDECETKG YAAEKVVHLR TSEELWKPDL VLKKNGRVVV VDAQVVQCGR 790 800 810 820 830 840 LESDHRVKVS KYRDDPELAD VIREKYAVQE VTFEACTLSY KGIWSKNSVE GLQKLGISNY 850 860 CLFKIVTSVL RGSWLNWVRF NNVTTVVHW

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00951 Genomic DNA. Translation: AAA29814.1.
PIR	G44490.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000477. RVT. [Graphical view]
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO21_SCICO

Accession

Primary (citable) accession number: Q03279

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	March 8, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)