Reviewed, UniProtKB/Swiss-Prot Q03277 (PO11_SCICO)

Names and origin

Protein names	Recommended name:     Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 Alternative name(s):     Retrovirus-related Pol polyprotein from type I retrotransposable element R1 Including the following 2 domains:     1- Recommended name:             Reverse transcriptase               EC=2.7.7.49     2- Recommended name:             Endonuclease
Organism	Sciara coprophila (Fungus gnat)
Taxonomic identifier	38358 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Sciaroidea › Sciaridae › Bradysia

Protein attributes

Sequence length	1004 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 1004	›1004	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1		PRO_0000058493
Regions
	Domain	450 – 717	268	Reverse transcriptase
	Region	853 – 1004	152	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03277-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 70A116B78245388A	FASTA	1,004	113,434
	10 20 30 40 50 60 LRGEVRGLPS SFRVVTSRIV NDGIGISAIV INDPEADVLV IEDCTDEYGV CVLIKGATCS 70 80 90 100 110 120 MYVVSVYCRF GTALGPYLQY MENVRVKCGN TYMIMGMDAN AVSPLWFSKG ENLGRGRLNE 130 140 150 160 170 180 ANGLLLEEWI LEGRMIVINE PSEWYTFSGP NGSSDIDVTL VNEAGGRFGY EWSVQPEWGV 190 200 210 220 230 240 SDHNLIRIRV SLDGLVADAS PSPQSARWQT RDTDWGEYMG DVKAKADVFG LAQYENVSVD 250 260 270 280 290 300 EKVDLLTEWI YGANDWNMRR HTAVRTFQNE WWSVELAEKR SELRRRRHAF QRIRNAGAAS 310 320 330 340 350 360 LADRLQAFRD CKIEYKRMLC EAKLRCWQEF VASESNENPW GRVFKLCRGR RKPVDVCSVK 370 380 390 400 410 420 VDGVYTDTWE GSVNAMMNVF FPASIDDASE IDRLKAIARP LPPDLEMDEV SDSVRRCKVR 430 440 450 460 470 480 KSPGPDGIVG EMVRAVWGAI PEYMFCLYKQ CLLESYFPQK WKIASLVILL KLLDRIRSDP 490 500 510 520 530 540 GSYRPICLLD NLGKVLEGIM VKRLDQKLMD VEVSPYQFAF TYGKSTEDAW RCVQRHVECS 550 560 570 580 590 600 EMKYVIGLNI DFQGAFDNLG WLSMLLKLDE AQSNEFGLWM SYFGGRKVYY VGKTGIVRKD 610 620 630 640 650 660 VTRGCPQGSK SGPAMWKLVM NELLLALVAA GFFIVAFADD GTIVIGANSR SALEELGTRC 670 680 690 700 710 720 LQLCHEWGKR VCVPVSAGKT TCILMKGHLS ANRPPCIRLN GTSISYKSEV KHLGIFVAER 730 740 750 760 770 780 MNFRPHFVYL RGKILGLVGC LRRVMRKSWG LGRRATCILY KGLFVACMSY GASVWFRTLR 790 800 810 820 830 840 FSYASILLNR CQRLVLYASL NVCRTVSTER MQVLHGELPW DLEATRRGLL SEFRKGITPV 850 860 870 880 890 900 DGDPITDEEM LGLSGSQFKE LLMERLLDVW QGRWDVSEKG RLTHEFIPSV RFVRENEWMA 910 920 930 940 950 960 FGLCLGYVLT GHGSMNGFLH KRGLSNTPVC MCGAPNEDVK HLLGECPLYE DLRDLNGCGL 970 980 990 1000 LIRNGSLDVS GALSEIGAFE KLNQFAVSLF GRRSRLMRGM RIRE

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L00945 Genomic DNA. Translation: AAA29813.1.
PIR	A44490.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000477. Reverse_transcriptase. IPR015706. Reverse_transcriptase-related. [Graphical view]
PANTHER	PTHR19446. Rev_txptase. 1 hit.
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO11_SCICO

Accession

Primary (citable) accession number: Q03277

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	September 22, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)