Reviewed, UniProtKB/Swiss-Prot Q03276 (PO11_POPJA)

Names and origin

Protein names	Recommended name:     Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 Alternative name(s):     Retrovirus-related Pol polyprotein from type I retrotransposable element R1 Including the following 2 domains:     1- Recommended name:             Reverse transcriptase               EC=2.7.7.49     2- Recommended name:             Endonuclease
Organism	Popillia japonica (Japanese beetle)
Taxonomic identifier	7064 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Scarabaeiformia › Scarabaeidae › Rutelinae › Popillia

Protein attributes

Sequence length	245 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Molecular function	RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 245	›245	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1		PRO_0000058492
Regions
	Domain	‹1 – 105	›105	Reverse transcriptase
	Region	106 – 245	140	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03276-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 44D5C5C55E0D6166	FASTA	245	28,406
	10 20 30 40 50 60 LKDGTGIVAA ELVAIEKGCE ELLSRRKSGW IVTDSEGAIG ALRKWKSEDR VTQDIKRAIW 70 80 90 100 110 120 QGEREAIDIT IRIRGPKTET QEADRAAKKA RDRPQVDLET YCNKAEVRQK FREKELTKWQ 130 140 150 160 170 180 SEWGKRNHRR EHIGFPAVTD EWPGLNERAV QLVTGHGYFK AYYRRFKLRE GSGLCECGEA 190 200 210 220 230 240 EETADHVWWE CTVEERERAR REFTEAVGTR ADVRQKLSEV HRDRLISELN KLADAIVRDD SNLEQ

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects." Jakubczak J.L., Burke W.D., Eickbush T.H. Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991) [PubMed: 1849649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-191.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L00944 Genomic DNA. Translation: AAA29783.1.
PIR	F44490.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.49. 295234.
Family and domain databases
PROSITE	PS50878. RT_POL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO11_POPJA

Accession

Primary (citable) accession number: Q03276

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	September 22, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)