Q03275 (PO24_POPJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 Alternative name(s): Retrovirus-related Pol polyprotein from type I retrotransposable element R2 Including the following 2 domains: Reverse transcriptase EC=2.7.7.49 Endonuclease
Organism	Popillia japonica (Japanese beetle)
Taxonomic identifier	7064 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Scarabaeiformia › Scarabaeidae › Rutelinae › Popillia

Protein attributes

Sequence length	482 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 482	›482	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2		PRO_0000058502
Regions
	Domain	‹1 – 84	›84	Reverse transcriptase
	Region	208 – 482	275	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03275 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 8631D8F114054C94	FASTA	482	53,735
	10 20 30 40 50 60 AYADDLILFA NDHRAANRLL KVATEFFRER GLALNATKSA ALSVGVVPGK KQLYTHTKNL 70 80 90 100 110 120 FYVGGKAIPQ LTPDDYFKYL GSRYNFSGQV RPSVELLKTQ LARVQSAPLK PAQKLTMIRD 130 140 150 160 170 180 HVVARFLSCL QSVRVTLKAL KDADRLVRLS VRKVLHLNKS SPDAYIHAPI REGGLGIISL 190 200 210 220 230 240 RAHIPAIMRS RLFKIATTAD PLTATVLQIP AVEKFYQTLL RWTEGNGGST TNIRKEWGRK 250 260 270 280 290 300 LQESYSGNGL RQGNTSGVSG DWLRNPPNFW SGADYIDAVR LRGNLLPTRG IPSNPPHERK 310 320 330 340 350 360 CRAGCNKTES LSHVLQGCPL THWHPIRRHD RVAGRLRQIA EKKGWMVEEE MRLRLADGSL 370 380 390 400 410 420 RKPDLVMAQG DTIVVCDVTI VWEGPNPLTM AYHQKVAYYS QQPVLDAIHD RFPGRSVVVL 430 440 450 460 470 480 ALVLGARGTW CDQNNAITDT LSLSRAQNSL INNCINGSII VHREFMRTSF TRATGGRGRG DI

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00949 Genomic DNA. Translation: AAB66358.1.
PIR	B47757.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000477. RVT. [Graphical view]
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO24_POPJA

Accession

Primary (citable) accession number: Q03275

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	July 15, 1998
Last modified:	May 31, 2011
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)