Reviewed, UniProtKB/Swiss-Prot Q03273 (PO21_POPJA)

Names and origin

Protein names	Recommended name:     Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 Alternative name(s):     Retrovirus-related Pol polyprotein from type I retrotransposable element R2 Including the following 2 domains:     1- Recommended name:             Reverse transcriptase               EC=2.7.7.49     2- Recommended name:             Endonuclease
Organism	Popillia japonica (Japanese beetle)
Taxonomic identifier	7064 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Scarabaeiformia › Scarabaeidae › Rutelinae › Popillia

Protein attributes

Sequence length	445 AA.
Sequence status	Fragment.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Molecular function	RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 445	›445	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2		PRO_0000058498
Regions
	Domain	‹1 – 114	›114	Reverse transcriptase
	Region	115 – 445	331	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03273-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 2FD15CB26E82A17D	FASTA	445	50,127
	10 20 30 40 50 60 QPSVFNLVKW LANLHKAPLK PDQKLAMLKR HIIPKLHYGL QTPNITGQIL SEADRLIRKA 70 80 90 100 110 120 VRRVLHLSVH TGSQFLYAAI RDGGLGIPQL RYHIPDVLRR RLENLSRDDS LAKAMLASAG 130 140 150 160 170 180 PAAEFRQRVS VLAARGPPQA YWREQVATRP FSRGLEDCAH DAASREWLLR TPAGWTGRDF 190 200 210 220 230 240 VRAAQLRTGN LPTMGLPYIP RERRRCRAGC ERVESVSHIL QACPVTHFER IKRHDEIVRK 250 260 270 280 290 300 IAAHCRKRGW TTEVEPRIYH QDGQLFIPDL AVHLAAESIL VCDVQVCWEG HRTLAKSWQN 310 320 330 340 350 360 KKLVYDHPRF RKAAARRWAG SRIAISPLVL GPVGVWPRSN AETAALLQLP KTIKGSCIQS 370 380 390 400 410 420 CLKWGSSIHK IFMASVWKHG PRPAHHHQPR PPEGQATANT GTLQSGRPAL SHSRKKRKRQ 430 440 LTPTQRAPSL ASPPAGATPR QLIEY

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects." Jakubczak J.L., Burke W.D., Eickbush T.H. Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991) [PubMed: 1849649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-223.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00946 Genomic DNA. Translation: AAA29784.1.
PIR	C47757.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.49. 295234.
Family and domain databases
PROSITE	PS50878. RT_POL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO21_POPJA

Accession

Primary (citable) accession number: Q03273

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	September 22, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)