Reviewed, UniProtKB/Swiss-Prot Q03271 (PO13_NASVI)

Names and origin

Protein names	Recommended name:     Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 3 Alternative name(s):     Retrovirus-related Pol polyprotein from type I retrotransposable element R1 3 Including the following 2 domains:     1- Recommended name:             Reverse transcriptase               EC=2.7.7.49     2- Recommended name:             Endonuclease
Organism	Nasonia vitripennis (Parasitic wasp)
Taxonomic identifier	7425 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Chalcidoidea › Pteromalidae › Pteromalinae › Nasonia

Protein attributes

Sequence length	383 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro transposition Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 383	›383	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 3		PRO_0000058495
Regions
	Domain	‹1 – 88	›88	Reverse transcriptase
	Region	229 – 383	155	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03271-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: DE296B380925251B	FASTA	383	43,411
	10 20 30 40 50 60 VDAFADDLLL LVQGNRRNEL EQSASEALSV VYRYGTNIGV EVSDSKTVCM MLKGSLNMLN 70 80 90 100 110 120 RVVHVSTNGM DDKRIRCVDR VRYLGVNVGI GMDFSVHIDG MKRRLTTAIM RLRGVLRKSW 130 140 150 160 170 180 GLKRGVVSMV VKGLFLPAVM YGASVWYEQL HKRKLRGSRR LSEELVSCQR VVLYACTRVC 190 200 210 220 230 240 RTVSTEAMQI LFGSLPWDIE CFRRANCTKS KGPAMNESDL VTDEDLYELS LHECRELVDQ 250 260 270 280 290 300 RALAAWQDRW EATSNGRVTY EWIRDVGFSG RSMKYFGAEP EGLLRLTGHG SMNSFLFSRN 310 320 330 340 350 360 LSNSPACACG TEREDWIHVL CECDMYAAFR DLDSIGVRRT EVGWDVSGVL LDRASMSVCV 370 380 PLSSCAFRMR ELIVQRMREN EES

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects." Jakubczak J.L., Burke W.D., Eickbush T.H. Proc. Natl. Acad. Sci. U.S.A. 88:3295-3299(1991) [PubMed: 1849649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 307-323.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L00942 Genomic DNA. Translation: AAA30339.1.
PIR	D44490.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.49. 294130.
Family and domain databases
InterPro	IPR000477. DNA_pol_RVTase. IPR015706. Reverse_transcriptase-related. [Graphical view]
PANTHER	PTHR19446. Rev_txptase. 1 hit.
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO13_NASVI

Accession

Primary (citable) accession number: Q03271

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)