Q03270 (PO12_NASVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 2 Alternative name(s): Retrovirus-related Pol polyprotein from type I retrotransposable element R1 2 Including the following 2 domains: Reverse transcriptase EC=2.7.7.49 Endonuclease
Organism	Nasonia vitripennis (Parasitic wasp)
Taxonomic identifier	7425 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Chalcidoidea › Pteromalidae › Pteromalinae › Nasonia

Protein attributes

Sequence length	410 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 410	›410	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 2		PRO_0000058494
Regions
	Domain	‹1 – 118	›118	Reverse transcriptase
	Region	254 – 410	157	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03270 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 70E210F8B66A5845	FASTA	410	46,649
	10 20 30 40 50 60 GCPQGSIGGP ILWNLSMNGM LIELAGSGVS VCAFADDVAI LAEGNTRKEV ERVINEKMEI 70 80 90 100 110 120 VYKWGEKMGV SVSEEKTVCM LLKGKYVTSN RAVRVSKTIN VYKRIKYVSC FRYLGVNVTE 130 140 150 160 170 180 GMGFGEHVRG MKVKVAKGVQ KLKRVLRRDW GLRRAASHLV LRGTFLPQVS YCASAWYEVL 190 200 210 220 230 240 KYEYGRNALS AAVRYVMYAC LNVCRTVSTE AMQVLTGWLP WDLECLKRAN VYKVRKGLSM 250 260 270 280 290 300 NEMDVVKNEE VESSSVIKLE RLVDERVYEI WQERWVVSMK GRVTARFIKD VKYAGRSRSF 310 320 330 340 350 360 EPDRWVVNIL TGHGTLNAFL HKRGLSESAS CMCGDVSEDW EHVLCRCSMY ESFRNLDEMG 370 380 390 400 410 VTVCVNGEYE FTGVLSSNVT YGKMCEFINR AYEMRESVRR RLNLELDVNG

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00941 Genomic DNA. Translation: AAA30338.1.
PIR	C44490.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000477. RVT. [Graphical view]
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO12_NASVI

Accession

Primary (citable) accession number: Q03270

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 31, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)