Reviewed, UniProtKB/Swiss-Prot Q03269 (PO11_NASVI)

Names and origin

Protein names	Recommended name:     Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 Alternative name(s):     Retrovirus-related Pol polyprotein from type I retrotransposable element R1 Including the following 2 domains:     1- Recommended name:             Reverse transcriptase               EC=2.7.7.49     2- Recommended name:             Endonuclease
Organism	Nasonia vitripennis (Parasitic wasp)
Taxonomic identifier	7425 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Chalcidoidea › Pteromalidae › Pteromalinae › Nasonia

Protein attributes

Sequence length	337 AA.
Sequence status	Fragment.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Sequence similarities	Contains 1 reverse transcriptase domain.

Ontologies

Keywords
Molecular function	Endonuclease Hydrolase Nuclease Nucleotidyltransferase RNA-directed DNA polymerase Transferase
Technical term	Transposable element
Gene Ontology (GO)
Biological process	RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 337	›337	Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1		PRO_0000058491
Regions
	Domain	‹1 – 118	›118	Reverse transcriptase
	Region	253 – 337	85	Nucleic acid-binding endonuclease
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q03269-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 7961F6A27A0A9788	FASTA	337	38,330
	10 20 30 40 50 60 GCPQGSISGP YMWNLCMNGL LDRLSAMNER IVAYADDLMI VANGNSRMEM ERMADECMRI 70 80 90 100 110 120 VYEWGREVGV SISEKKTVCI MLKGKLNVDG RRMRVAVAEG TISSIGYVKS ARYLGVCMGE 130 140 150 160 170 180 RMSFADDIRG LITKVMGAIG GLRRVMRKEW GVKKKTAYTW AKGLLLAGVM YGSSVWYEGM 190 200 210 220 230 240 KYKTMRESMN SIQRCAMYAC LRVCRTVSTE AMQVLLGWLP CDLECVKDKC VQGSAWHRND 250 260 270 280 290 300 ESDLVTDAEI AEKRARSCKL MKEREHEIWQ RRWCESTKGR VMHEWLCDVN FACERMWFEP 310 320 330 SLRVGYILTG HGTLNAWLYD RDPLDSAACP CGAPRED

References

[1]	"Sequence relationship of retrotransposable elements R1 and R2 within and between divergent insect species." Burke W.D., Eickbush D.G., Xiong Y., Jakubczak J.L., Eickbush T.H. Mol. Biol. Evol. 10:163-185(1993) [PubMed: 8383793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00940 Genomic DNA. Translation: AAA30337.1.
PIR	B44490.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.49. 294130.
Family and domain databases
InterPro	IPR000477. Reverse_transcriptase. IPR015706. Reverse_transcriptase-related. [Graphical view]
PANTHER	PTHR19446. Rev_txptase. 1 hit.
Pfam	PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PO11_NASVI

Accession

Primary (citable) accession number: Q03269

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	September 22, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)