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Protein

Aminodeoxychorismate lyase

Gene

ABZ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.By similarity

Catalytic activityi

4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.

Cofactori

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 4-aminobenzoate from chorismate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Aminodeoxychorismate synthase (ABZ1)
  2. Aminodeoxychorismate lyase (ABZ2)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-131.
BRENDAi4.1.3.38. 984.
UniPathwayiUPA00077; UER00150.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate lyase (EC:4.1.3.38)
Alternative name(s):
4-amino-4-deoxychorismate lyase
Short name:
ADC lyase
Short name:
ADCL
Gene namesi
Name:ABZ2
Ordered Locus Names:YMR289W
ORF Names:YM8021.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR289W.
SGDiS000004902. ABZ2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033501 – 374Aminodeoxychorismate lyaseAdd BLAST374

Proteomic databases

MaxQBiQ03266.
PRIDEiQ03266.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi35469. 27 interactors.
DIPiDIP-7986N.
IntActiQ03266. 1 interactor.
MINTiMINT-536066.

Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 33Combined sources7
Helixi35 – 37Combined sources3
Beta strandi38 – 40Combined sources3
Beta strandi47 – 50Combined sources4
Helixi53 – 55Combined sources3
Helixi60 – 67Combined sources8
Helixi72 – 75Combined sources4
Helixi86 – 90Combined sources5
Helixi93 – 95Combined sources3
Beta strandi100 – 103Combined sources4
Helixi108 – 118Combined sources11
Helixi122 – 135Combined sources14
Helixi144 – 156Combined sources13
Helixi165 – 174Combined sources10
Beta strandi178 – 185Combined sources8
Beta strandi191 – 198Combined sources8
Helixi202 – 207Combined sources6
Helixi208 – 210Combined sources3
Helixi213 – 221Combined sources9
Helixi223 – 225Combined sources3
Beta strandi232 – 237Combined sources6
Helixi246 – 249Combined sources4
Helixi256 – 273Combined sources18
Beta strandi283 – 289Combined sources7
Beta strandi293 – 309Combined sources17
Turni310 – 312Combined sources3
Beta strandi313 – 319Combined sources7
Helixi321 – 323Combined sources3
Helixi329 – 336Combined sources8
Beta strandi339 – 343Combined sources5
Helixi347 – 349Combined sources3
Beta strandi355 – 360Combined sources6
Turni361 – 363Combined sources3
Beta strandi364 – 373Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K6NX-ray1.90A1-374[»]
ProteinModelPortaliQ03266.
SMRiQ03266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000000769.
InParanoidiQ03266.
OMAiCVKGVIR.
OrthoDBiEOG092C59MV.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMDNWKTD MESYDEGGLV ANPNFEVLAT FRYDPGFARQ SASKKEIFET
60 70 80 90 100
PDPRLGLRDE DIRQQIINED YSSYLRVREV NSGGDLLENI QHPDAWKHDC
110 120 130 140 150
KTIVCQRVED MLQVIYERFF LLDEQYQRIR IALSYFKIDF STSLNDLLKL
160 170 180 190 200
LVENLINCKE GNSEYHEKIQ KMINERQCYK MRVLVSKTGD IRIEAIPMPM
210 220 230 240 250
EPILKLTTDY DSVSTYFIKT MLNGFLIDST INWDVVVSSE PLNASAFTSF
260 270 280 290 300
KTTSRDHYAR ARVRMQTAIN NLRGSEPTSS VSQCEILFSN KSGLLMEGSI
310 320 330 340 350
TNVAVIQKDP NGSKKYVTPR LATGCLCGTM RHYLLRLGLI EEGDIDIGSL
360 370
TVGNEVLLFN GVMGCIKGTV KTKY
Length:374
Mass (Da):42,640
Last modified:November 1, 1997 - v1
Checksum:i560B9757F6BBBB73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49704 Genomic DNA. Translation: CAA89787.1.
X80836 Genomic DNA. Translation: CAA56798.1.
BK006946 Genomic DNA. Translation: DAA10190.1.
PIRiS54596.
RefSeqiNP_014016.1. NM_001182796.1.

Genome annotation databases

EnsemblFungiiYMR289W; YMR289W; YMR289W.
GeneIDi855333.
KEGGisce:YMR289W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49704 Genomic DNA. Translation: CAA89787.1.
X80836 Genomic DNA. Translation: CAA56798.1.
BK006946 Genomic DNA. Translation: DAA10190.1.
PIRiS54596.
RefSeqiNP_014016.1. NM_001182796.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K6NX-ray1.90A1-374[»]
ProteinModelPortaliQ03266.
SMRiQ03266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35469. 27 interactors.
DIPiDIP-7986N.
IntActiQ03266. 1 interactor.
MINTiMINT-536066.

Proteomic databases

MaxQBiQ03266.
PRIDEiQ03266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR289W; YMR289W; YMR289W.
GeneIDi855333.
KEGGisce:YMR289W.

Organism-specific databases

EuPathDBiFungiDB:YMR289W.
SGDiS000004902. ABZ2.

Phylogenomic databases

HOGENOMiHOG000000769.
InParanoidiQ03266.
OMAiCVKGVIR.
OrthoDBiEOG092C59MV.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00150.
BioCyciYEAST:MONOMER3O-131.
BRENDAi4.1.3.38. 984.

Miscellaneous databases

PROiQ03266.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPABC_YEAST
AccessioniPrimary (citable) accession number: Q03266
Secondary accession number(s): D6W0B6, Q03531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.