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Q03266 (PABC_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminodeoxychorismate lyase

EC=4.1.3.38
Alternative name(s):
4-amino-4-deoxychorismate lyase
Short name=ADC lyase
Short name=ADCL
Gene names
Name:ABZ2
Ordered Locus Names:YMR289W
ORF Names:YM8021.15
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate By similarity.

Catalytic activity

4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Ref.3.

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
   Biological processFolate biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfolic acid biosynthetic process

Inferred from mutant phenotype PubMed 17873082. Source: SGD

tetrahydrofolate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function4-amino-4-deoxychorismate lyase activity

Inferred from direct assay PubMed 17873082. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Aminodeoxychorismate lyase
PRO_0000203350

Secondary structure

............................................................... 374
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q03266 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 560B9757F6BBBB73

FASTA37442,640
        10         20         30         40         50         60 
MSLMDNWKTD MESYDEGGLV ANPNFEVLAT FRYDPGFARQ SASKKEIFET PDPRLGLRDE 

        70         80         90        100        110        120 
DIRQQIINED YSSYLRVREV NSGGDLLENI QHPDAWKHDC KTIVCQRVED MLQVIYERFF 

       130        140        150        160        170        180 
LLDEQYQRIR IALSYFKIDF STSLNDLLKL LVENLINCKE GNSEYHEKIQ KMINERQCYK 

       190        200        210        220        230        240 
MRVLVSKTGD IRIEAIPMPM EPILKLTTDY DSVSTYFIKT MLNGFLIDST INWDVVVSSE 

       250        260        270        280        290        300 
PLNASAFTSF KTTSRDHYAR ARVRMQTAIN NLRGSEPTSS VSQCEILFSN KSGLLMEGSI 

       310        320        330        340        350        360 
TNVAVIQKDP NGSKKYVTPR LATGCLCGTM RHYLLRLGLI EEGDIDIGSL TVGNEVLLFN 

       370 
GVMGCIKGTV KTKY 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49704 Genomic DNA. Translation: CAA89787.1.
X80836 Genomic DNA. Translation: CAA56798.1.
BK006946 Genomic DNA. Translation: DAA10190.1.
PIRS54596.
RefSeqNP_014016.1. NM_001182796.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4K6NX-ray1.90A1-374[»]
ProteinModelPortalQ03266.
SMRQ03266. Positions 23-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35469. 26 interactions.
DIPDIP-7986N.
IntActQ03266. 1 interaction.
MINTMINT-536066.
STRING4932.YMR289W.

Proteomic databases

MaxQBQ03266.
PaxDbQ03266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR289W; YMR289W; YMR289W.
GeneID855333.
KEGGsce:YMR289W.

Organism-specific databases

CYGDYMR289w.
SGDS000004902. ABZ2.

Phylogenomic databases

eggNOGCOG0115.
HOGENOMHOG000000769.
OMAEINHIND.
OrthoDBEOG7GXPR1.

Enzyme and pathway databases

BioCycYEAST:G3O-32959-MONOMER.
YEAST:MONOMER3O-131.
UniPathwayUPA00077; UER00150.

Gene expression databases

GenevestigatorQ03266.

Family and domain databases

InterProIPR001544. Aminotrans_IV.
[Graphical view]
PfamPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMSSF56752. SSF56752. 1 hit.
ProtoNetSearch...

Other

NextBio979061.

Entry information

Entry namePABC_YEAST
AccessionPrimary (citable) accession number: Q03266
Secondary accession number(s): D6W0B6, Q03531
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways