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Q03266

- PABC_YEAST

UniProt

Q03266 - PABC_YEAST

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Protein

Aminodeoxychorismate lyase

Gene

ABZ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.By similarity

Catalytic activityi

4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. 4-amino-4-deoxychorismate lyase activity Source: SGD

GO - Biological processi

  1. folic acid biosynthetic process Source: SGD
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:G3O-32959-MONOMER.
YEAST:MONOMER3O-131.
UniPathwayiUPA00077; UER00150.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate lyase (EC:4.1.3.38)
Alternative name(s):
4-amino-4-deoxychorismate lyase
Short name:
ADC lyase
Short name:
ADCL
Gene namesi
Name:ABZ2
Ordered Locus Names:YMR289W
ORF Names:YM8021.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR289w.
SGDiS000004902. ABZ2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Aminodeoxychorismate lyasePRO_0000203350Add
BLAST

Proteomic databases

MaxQBiQ03266.
PaxDbiQ03266.

Expressioni

Gene expression databases

GenevestigatoriQ03266.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi35469. 27 interactions.
DIPiDIP-7986N.
IntActiQ03266. 1 interaction.
MINTiMINT-536066.
STRINGi4932.YMR289W.

Structurei

Secondary structure

1
374
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 337
Helixi35 – 373
Beta strandi38 – 403
Beta strandi47 – 504
Helixi53 – 553
Helixi60 – 678
Helixi72 – 754
Helixi86 – 905
Helixi93 – 953
Beta strandi100 – 1034
Helixi108 – 11811
Helixi122 – 13514
Helixi144 – 15613
Helixi165 – 17410
Beta strandi178 – 1858
Beta strandi191 – 1988
Helixi202 – 2076
Helixi208 – 2103
Helixi213 – 2219
Helixi223 – 2253
Beta strandi232 – 2376
Helixi246 – 2494
Helixi256 – 27318
Beta strandi283 – 2897
Beta strandi293 – 30917
Turni310 – 3123
Beta strandi313 – 3197
Helixi321 – 3233
Helixi329 – 3368
Beta strandi339 – 3435
Helixi347 – 3493
Beta strandi355 – 3606
Turni361 – 3633
Beta strandi364 – 37310

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4K6NX-ray1.90A1-374[»]
ProteinModelPortaliQ03266.
SMRiQ03266. Positions 23-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0115.
HOGENOMiHOG000000769.
InParanoidiQ03266.
OMAiEINHIND.
OrthoDBiEOG7GXPR1.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
[Graphical view]
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMiSSF56752. SSF56752. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03266-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLMDNWKTD MESYDEGGLV ANPNFEVLAT FRYDPGFARQ SASKKEIFET
60 70 80 90 100
PDPRLGLRDE DIRQQIINED YSSYLRVREV NSGGDLLENI QHPDAWKHDC
110 120 130 140 150
KTIVCQRVED MLQVIYERFF LLDEQYQRIR IALSYFKIDF STSLNDLLKL
160 170 180 190 200
LVENLINCKE GNSEYHEKIQ KMINERQCYK MRVLVSKTGD IRIEAIPMPM
210 220 230 240 250
EPILKLTTDY DSVSTYFIKT MLNGFLIDST INWDVVVSSE PLNASAFTSF
260 270 280 290 300
KTTSRDHYAR ARVRMQTAIN NLRGSEPTSS VSQCEILFSN KSGLLMEGSI
310 320 330 340 350
TNVAVIQKDP NGSKKYVTPR LATGCLCGTM RHYLLRLGLI EEGDIDIGSL
360 370
TVGNEVLLFN GVMGCIKGTV KTKY
Length:374
Mass (Da):42,640
Last modified:November 1, 1997 - v1
Checksum:i560B9757F6BBBB73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49704 Genomic DNA. Translation: CAA89787.1.
X80836 Genomic DNA. Translation: CAA56798.1.
BK006946 Genomic DNA. Translation: DAA10190.1.
PIRiS54596.
RefSeqiNP_014016.1. NM_001182796.1.

Genome annotation databases

EnsemblFungiiYMR289W; YMR289W; YMR289W.
GeneIDi855333.
KEGGisce:YMR289W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49704 Genomic DNA. Translation: CAA89787.1 .
X80836 Genomic DNA. Translation: CAA56798.1 .
BK006946 Genomic DNA. Translation: DAA10190.1 .
PIRi S54596.
RefSeqi NP_014016.1. NM_001182796.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4K6N X-ray 1.90 A 1-374 [» ]
ProteinModelPortali Q03266.
SMRi Q03266. Positions 23-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35469. 27 interactions.
DIPi DIP-7986N.
IntActi Q03266. 1 interaction.
MINTi MINT-536066.
STRINGi 4932.YMR289W.

Proteomic databases

MaxQBi Q03266.
PaxDbi Q03266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR289W ; YMR289W ; YMR289W .
GeneIDi 855333.
KEGGi sce:YMR289W.

Organism-specific databases

CYGDi YMR289w.
SGDi S000004902. ABZ2.

Phylogenomic databases

eggNOGi COG0115.
HOGENOMi HOG000000769.
InParanoidi Q03266.
OMAi EINHIND.
OrthoDBi EOG7GXPR1.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00150 .
BioCyci YEAST:G3O-32959-MONOMER.
YEAST:MONOMER3O-131.

Miscellaneous databases

NextBioi 979061.

Gene expression databases

Genevestigatori Q03266.

Family and domain databases

InterProi IPR001544. Aminotrans_IV.
[Graphical view ]
Pfami PF01063. Aminotran_4. 1 hit.
[Graphical view ]
SUPFAMi SSF56752. SSF56752. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPABC_YEAST
AccessioniPrimary (citable) accession number: Q03266
Secondary accession number(s): D6W0B6, Q03531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3