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Q03266

- PABC_YEAST

UniProt

Q03266 - PABC_YEAST

Protein

Aminodeoxychorismate lyase

Gene

ABZ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.By similarity

    Catalytic activityi

    4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 4-amino-4-deoxychorismate lyase activity Source: SGD

    GO - Biological processi

    1. folic acid biosynthetic process Source: SGD
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32959-MONOMER.
    YEAST:MONOMER3O-131.
    UniPathwayiUPA00077; UER00150.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminodeoxychorismate lyase (EC:4.1.3.38)
    Alternative name(s):
    4-amino-4-deoxychorismate lyase
    Short name:
    ADC lyase
    Short name:
    ADCL
    Gene namesi
    Name:ABZ2
    Ordered Locus Names:YMR289W
    ORF Names:YM8021.15
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR289w.
    SGDiS000004902. ABZ2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Aminodeoxychorismate lyasePRO_0000203350Add
    BLAST

    Proteomic databases

    MaxQBiQ03266.
    PaxDbiQ03266.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03266.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi35469. 26 interactions.
    DIPiDIP-7986N.
    IntActiQ03266. 1 interaction.
    MINTiMINT-536066.
    STRINGi4932.YMR289W.

    Structurei

    Secondary structure

    1
    374
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 337
    Helixi35 – 373
    Beta strandi38 – 403
    Beta strandi47 – 504
    Helixi53 – 553
    Helixi60 – 678
    Helixi72 – 754
    Helixi86 – 905
    Helixi93 – 953
    Beta strandi100 – 1034
    Helixi108 – 11811
    Helixi122 – 13514
    Helixi144 – 15613
    Helixi165 – 17410
    Beta strandi178 – 1858
    Beta strandi191 – 1988
    Helixi202 – 2076
    Helixi208 – 2103
    Helixi213 – 2219
    Helixi223 – 2253
    Beta strandi232 – 2376
    Helixi246 – 2494
    Helixi256 – 27318
    Beta strandi283 – 2897
    Beta strandi293 – 30917
    Turni310 – 3123
    Beta strandi313 – 3197
    Helixi321 – 3233
    Helixi329 – 3368
    Beta strandi339 – 3435
    Helixi347 – 3493
    Beta strandi355 – 3606
    Turni361 – 3633
    Beta strandi364 – 37310

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4K6NX-ray1.90A1-374[»]
    ProteinModelPortaliQ03266.
    SMRiQ03266. Positions 23-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0115.
    HOGENOMiHOG000000769.
    OMAiEINHIND.
    OrthoDBiEOG7GXPR1.

    Family and domain databases

    InterProiIPR001544. Aminotrans_IV.
    [Graphical view]
    PfamiPF01063. Aminotran_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF56752. SSF56752. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q03266-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLMDNWKTD MESYDEGGLV ANPNFEVLAT FRYDPGFARQ SASKKEIFET    50
    PDPRLGLRDE DIRQQIINED YSSYLRVREV NSGGDLLENI QHPDAWKHDC 100
    KTIVCQRVED MLQVIYERFF LLDEQYQRIR IALSYFKIDF STSLNDLLKL 150
    LVENLINCKE GNSEYHEKIQ KMINERQCYK MRVLVSKTGD IRIEAIPMPM 200
    EPILKLTTDY DSVSTYFIKT MLNGFLIDST INWDVVVSSE PLNASAFTSF 250
    KTTSRDHYAR ARVRMQTAIN NLRGSEPTSS VSQCEILFSN KSGLLMEGSI 300
    TNVAVIQKDP NGSKKYVTPR LATGCLCGTM RHYLLRLGLI EEGDIDIGSL 350
    TVGNEVLLFN GVMGCIKGTV KTKY 374
    Length:374
    Mass (Da):42,640
    Last modified:November 1, 1997 - v1
    Checksum:i560B9757F6BBBB73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49704 Genomic DNA. Translation: CAA89787.1.
    X80836 Genomic DNA. Translation: CAA56798.1.
    BK006946 Genomic DNA. Translation: DAA10190.1.
    PIRiS54596.
    RefSeqiNP_014016.1. NM_001182796.1.

    Genome annotation databases

    EnsemblFungiiYMR289W; YMR289W; YMR289W.
    GeneIDi855333.
    KEGGisce:YMR289W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49704 Genomic DNA. Translation: CAA89787.1 .
    X80836 Genomic DNA. Translation: CAA56798.1 .
    BK006946 Genomic DNA. Translation: DAA10190.1 .
    PIRi S54596.
    RefSeqi NP_014016.1. NM_001182796.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4K6N X-ray 1.90 A 1-374 [» ]
    ProteinModelPortali Q03266.
    SMRi Q03266. Positions 23-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35469. 26 interactions.
    DIPi DIP-7986N.
    IntActi Q03266. 1 interaction.
    MINTi MINT-536066.
    STRINGi 4932.YMR289W.

    Proteomic databases

    MaxQBi Q03266.
    PaxDbi Q03266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR289W ; YMR289W ; YMR289W .
    GeneIDi 855333.
    KEGGi sce:YMR289W.

    Organism-specific databases

    CYGDi YMR289w.
    SGDi S000004902. ABZ2.

    Phylogenomic databases

    eggNOGi COG0115.
    HOGENOMi HOG000000769.
    OMAi EINHIND.
    OrthoDBi EOG7GXPR1.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00150 .
    BioCyci YEAST:G3O-32959-MONOMER.
    YEAST:MONOMER3O-131.

    Miscellaneous databases

    NextBioi 979061.

    Gene expression databases

    Genevestigatori Q03266.

    Family and domain databases

    InterProi IPR001544. Aminotrans_IV.
    [Graphical view ]
    Pfami PF01063. Aminotran_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56752. SSF56752. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPABC_YEAST
    AccessioniPrimary (citable) accession number: Q03266
    Secondary accession number(s): D6W0B6, Q03531
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 768 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3