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Reviewed, UniProtKB/Swiss-Prot Q03266 (PABC_YEAST)

Last modified November 24, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aminodeoxychorismate lyase
    EC=4.1.3.38
Alternative name(s):
    4-amino-4-deoxychorismate lyase
      Short name=ADC lyase
      Short name=ADCL
Gene names
Name: ABZ2
Ordered Locus Names: YMR289W
ORF Names: YM8021.15
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate By similarity.

Catalytic activity

4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Miscellaneous

Present with 768 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
   Biological processFolate biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfolic acid biosynthetic process

Inferred from mutant phenotype. Source: SGD

   Cellular componentcytoplasm Ref.2

Inferred from direct assay. Source: SGD

   Molecular function4-amino-4-deoxychorismate lyase activity

Inferred from direct assay. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Aminodeoxychorismate lyase
PRO_0000203350

Sequences

Sequence LengthMass (Da)Tools
Q03266-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 560B9757F6BBBB73

FASTA37442,640
        10         20         30         40         50         60 
MSLMDNWKTD MESYDEGGLV ANPNFEVLAT FRYDPGFARQ SASKKEIFET PDPRLGLRDE 

        70         80         90        100        110        120 
DIRQQIINED YSSYLRVREV NSGGDLLENI QHPDAWKHDC KTIVCQRVED MLQVIYERFF 

       130        140        150        160        170        180 
LLDEQYQRIR IALSYFKIDF STSLNDLLKL LVENLINCKE GNSEYHEKIQ KMINERQCYK 

       190        200        210        220        230        240 
MRVLVSKTGD IRIEAIPMPM EPILKLTTDY DSVSTYFIKT MLNGFLIDST INWDVVVSSE 

       250        260        270        280        290        300 
PLNASAFTSF KTTSRDHYAR ARVRMQTAIN NLRGSEPTSS VSQCEILFSN KSGLLMEGSI 

       310        320        330        340        350        360 
TNVAVIQKDP NGSKKYVTPR LATGCLCGTM RHYLLRLGLI EEGDIDIGSL TVGNEVLLFN 

       370 
GVMGCIKGTV KTKY 

« Hide

References

[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed: 9169872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

Z49704 Genomic DNA. Translation: CAA89787.1.
X80836 Genomic DNA. Translation: CAA56798.1.
PIRS54596.
RefSeqNP_014016.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ03266. 4 interactions.
STRINGQ03266.

Genome annotation databases

EnsemblYMR289W; YMR289W; YMR289W; Saccharomyces cerevisiae. [Genome view]
GeneID855333.
KEGGsce:YMR289W.
NMPDRfig|4932.3.peg.5074.

Organism-specific databases

CYGDYMR289w.
SGDS000004902. ABZ2.

Phylogenomic databases

HOGENOMQ03266.
OMATIRYDPH
OrthoDBEOG9M937Z

Enzyme and pathway databases

BRENDA4.1.3.38. 250.

Gene expression databases

ArrayExpressQ03266.
GenevestigatorQ03266.
GermOnlineYMR289W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001544. Aminotrans_IV.
[Graphical view]
PANTHERPTHR11825. Aminotrans_IV. 1 hit.
PROSITEPS00770. AA_TRANSFER_CLASS_4. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio979061.

Entry information

Entry namePABC_YEAST
AccessionPrimary (citable) accession number: Q03266
Secondary accession number(s): Q03531
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents