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Q03264

- NGL2_YEAST

UniProt

Q03264 - NGL2_YEAST

Protein

RNA exonuclease NGL2

Gene

NGL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E.1 Publication

    GO - Molecular functioni

    1. endoribonuclease activity Source: SGD
    2. exonuclease activity Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    2. rRNA processing Source: SGD

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32955-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA exonuclease NGL2 (EC:3.1.-.-)
    Alternative name(s):
    Carbon catabolite repressor protein 4 homolog
    Gene namesi
    Name:NGL2
    Ordered Locus Names:YMR285C
    ORF Names:YM8021.11C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR285c.
    SGDiS000004898. NGL2.

    Subcellular locationi

    Cytoplasm Curated. Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular Source: SGD
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515RNA exonuclease NGL2PRO_0000218579Add
    BLAST

    Proteomic databases

    MaxQBiQ03264.
    PaxDbiQ03264.
    PeptideAtlasiQ03264.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03264.

    Interactioni

    Protein-protein interaction databases

    BioGridi35465. 55 interactions.
    DIPiDIP-894N.
    MINTiMINT-4498988.
    STRINGi4932.YMR285C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03264.
    SMRiQ03264. Positions 96-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CCR4/nocturin family.Curated

    Phylogenomic databases

    eggNOGiCOG5239.
    GeneTreeiENSGT00550000076051.
    HOGENOMiHOG000248147.
    KOiK14812.
    OMAiYPSDHLC.
    OrthoDBiEOG73NGD0.

    Family and domain databases

    Gene3Di3.60.10.10. 2 hits.
    InterProiIPR005135. Endo/exonuclease/phosphatase.
    [Graphical view]
    PfamiPF03372. Exo_endo_phos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q03264-1 [UniParc]FASTAAdd to Basket

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    MTQDKEVKVV APDVAPDQEV EINKSVKDAK HQTNDDSLLQ HKKKGKKGKK    50
    SKPIVTPEHI AKVRAEREVM RKAKRDAMLA QGVDPDCPPE LHFIRRPFLS 100
    LHEAEPVTGF RFKLMTYNCL AQALIRRKLF PDSGDALKWY RRSKVLLNEF 150
    KYYNSDVICL QEIDHIQFQS FWKDEFSKLG YDGQYYRNAT KNHGVAIMWR 200
    RELFHQVDKM LIDYDKESSE SISTRTTTNN VGLVLALKFS EKVLSNLGKK 250
    SSKKCGILIG TTHLFWHPFG TYERTRQCYI VLKKMKEFMH RVNVLQNEND 300
    GDLSHWFPFF CGDFNSQPFD TPYLSMTSKP VHYRNRAKTV IGCSTSYKFS 350
    KVRDGEEGAD DEEGGNIEKY GKDQPESPVP EKFHANEEQS ELVDKMAQLH 400
    NSLDMRAISL YSVGYKNVHP ENAGLDNDRG EPEISNWANT WRGLLDYLFY 450
    VKKWDPQSNC QEVETLGDFE KENKVKCRGF LRMPPGNEMT KHGQPHVGEY 500
    ASDHLSMVCD LELQL 515
    Length:515
    Mass (Da):59,540
    Last modified:November 1, 1997 - v1
    Checksum:i89B30A7D24D6EBC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49704 Genomic DNA. Translation: CAA89783.1.
    BK006946 Genomic DNA. Translation: DAA10186.1.
    PIRiS54592.
    RefSeqiNP_014012.1. NM_001182792.1.

    Genome annotation databases

    EnsemblFungiiYMR285C; YMR285C; YMR285C.
    GeneIDi855329.
    KEGGisce:YMR285C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49704 Genomic DNA. Translation: CAA89783.1 .
    BK006946 Genomic DNA. Translation: DAA10186.1 .
    PIRi S54592.
    RefSeqi NP_014012.1. NM_001182792.1.

    3D structure databases

    ProteinModelPortali Q03264.
    SMRi Q03264. Positions 96-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35465. 55 interactions.
    DIPi DIP-894N.
    MINTi MINT-4498988.
    STRINGi 4932.YMR285C.

    Proteomic databases

    MaxQBi Q03264.
    PaxDbi Q03264.
    PeptideAtlasi Q03264.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR285C ; YMR285C ; YMR285C .
    GeneIDi 855329.
    KEGGi sce:YMR285C.

    Organism-specific databases

    CYGDi YMR285c.
    SGDi S000004898. NGL2.

    Phylogenomic databases

    eggNOGi COG5239.
    GeneTreei ENSGT00550000076051.
    HOGENOMi HOG000248147.
    KOi K14812.
    OMAi YPSDHLC.
    OrthoDBi EOG73NGD0.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32955-MONOMER.

    Miscellaneous databases

    NextBioi 979049.

    Gene expression databases

    Genevestigatori Q03264.

    Family and domain databases

    Gene3Di 3.60.10.10. 2 hits.
    InterProi IPR005135. Endo/exonuclease/phosphatase.
    [Graphical view ]
    Pfami PF03372. Exo_endo_phos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae."
      Faber A.W., van Dijk M., Raue H.A., Vos J.C.
      RNA 8:1095-1101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNGL2_YEAST
    AccessioniPrimary (citable) accession number: Q03264
    Secondary accession number(s): D6W0B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3570 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3