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Protein

RNA exonuclease NGL2

Gene

NGL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E.1 Publication

Miscellaneous

Present with 3570 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • endoribonuclease activity Source: SGD
  • exonuclease activity Source: UniProtKB-KW
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • rRNA processing Source: SGD

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32955-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease NGL2 (EC:3.1.-.-)
Alternative name(s):
Carbon catabolite repressor protein 4 homolog
Gene namesi
Name:NGL2
Ordered Locus Names:YMR285C
ORF Names:YM8021.11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR285C
SGDiS000004898 NGL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185791 – 515RNA exonuclease NGL2Add BLAST515

Proteomic databases

MaxQBiQ03264
PaxDbiQ03264
PRIDEiQ03264

PTM databases

iPTMnetiQ03264

Interactioni

Protein-protein interaction databases

BioGridi35465, 161 interactors
DIPiDIP-894N
IntActiQ03264, 8 interactors
STRINGi4932.YMR285C

Structurei

3D structure databases

ProteinModelPortaliQ03264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000076051
HOGENOMiHOG000248147
InParanoidiQ03264
KOiK14812
OMAiGTTHLFW
OrthoDBiEOG092C28FD

Family and domain databases

InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SUPFAMiSSF56219 SSF56219, 3 hits

Sequencei

Sequence statusi: Complete.

Q03264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDKEVKVV APDVAPDQEV EINKSVKDAK HQTNDDSLLQ HKKKGKKGKK
60 70 80 90 100
SKPIVTPEHI AKVRAEREVM RKAKRDAMLA QGVDPDCPPE LHFIRRPFLS
110 120 130 140 150
LHEAEPVTGF RFKLMTYNCL AQALIRRKLF PDSGDALKWY RRSKVLLNEF
160 170 180 190 200
KYYNSDVICL QEIDHIQFQS FWKDEFSKLG YDGQYYRNAT KNHGVAIMWR
210 220 230 240 250
RELFHQVDKM LIDYDKESSE SISTRTTTNN VGLVLALKFS EKVLSNLGKK
260 270 280 290 300
SSKKCGILIG TTHLFWHPFG TYERTRQCYI VLKKMKEFMH RVNVLQNEND
310 320 330 340 350
GDLSHWFPFF CGDFNSQPFD TPYLSMTSKP VHYRNRAKTV IGCSTSYKFS
360 370 380 390 400
KVRDGEEGAD DEEGGNIEKY GKDQPESPVP EKFHANEEQS ELVDKMAQLH
410 420 430 440 450
NSLDMRAISL YSVGYKNVHP ENAGLDNDRG EPEISNWANT WRGLLDYLFY
460 470 480 490 500
VKKWDPQSNC QEVETLGDFE KENKVKCRGF LRMPPGNEMT KHGQPHVGEY
510
ASDHLSMVCD LELQL
Length:515
Mass (Da):59,540
Last modified:November 1, 1997 - v1
Checksum:i89B30A7D24D6EBC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49704 Genomic DNA Translation: CAA89783.1
BK006946 Genomic DNA Translation: DAA10186.1
PIRiS54592
RefSeqiNP_014012.1, NM_001182792.1

Genome annotation databases

EnsemblFungiiYMR285C; YMR285C; YMR285C
GeneIDi855329
KEGGisce:YMR285C

Similar proteinsi

Entry informationi

Entry nameiNGL2_YEAST
AccessioniPrimary (citable) accession number: Q03264
Secondary accession number(s): D6W0B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health