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Q03264 (NGL2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA exonuclease NGL2

EC=3.1.-.-
Alternative name(s):
Carbon catabolite repressor protein 4 homolog
Gene names
Name:NGL2
Ordered Locus Names:YMR285C
ORF Names:YM8021.11C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E. Ref.3

Subcellular location

Cytoplasm Potential. Nucleus Potential.

Miscellaneous

Present with 3570 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the CCR4/nocturin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515RNA exonuclease NGL2
PRO_0000218579

Sequences

Sequence LengthMass (Da)Tools
Q03264 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 89B30A7D24D6EBC8

FASTA51559,540
        10         20         30         40         50         60 
MTQDKEVKVV APDVAPDQEV EINKSVKDAK HQTNDDSLLQ HKKKGKKGKK SKPIVTPEHI 

        70         80         90        100        110        120 
AKVRAEREVM RKAKRDAMLA QGVDPDCPPE LHFIRRPFLS LHEAEPVTGF RFKLMTYNCL 

       130        140        150        160        170        180 
AQALIRRKLF PDSGDALKWY RRSKVLLNEF KYYNSDVICL QEIDHIQFQS FWKDEFSKLG 

       190        200        210        220        230        240 
YDGQYYRNAT KNHGVAIMWR RELFHQVDKM LIDYDKESSE SISTRTTTNN VGLVLALKFS 

       250        260        270        280        290        300 
EKVLSNLGKK SSKKCGILIG TTHLFWHPFG TYERTRQCYI VLKKMKEFMH RVNVLQNEND 

       310        320        330        340        350        360 
GDLSHWFPFF CGDFNSQPFD TPYLSMTSKP VHYRNRAKTV IGCSTSYKFS KVRDGEEGAD 

       370        380        390        400        410        420 
DEEGGNIEKY GKDQPESPVP EKFHANEEQS ELVDKMAQLH NSLDMRAISL YSVGYKNVHP 

       430        440        450        460        470        480 
ENAGLDNDRG EPEISNWANT WRGLLDYLFY VKKWDPQSNC QEVETLGDFE KENKVKCRGF 

       490        500        510 
LRMPPGNEMT KHGQPHVGEY ASDHLSMVCD LELQL 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae."
Faber A.W., van Dijk M., Raue H.A., Vos J.C.
RNA 8:1095-1101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49704 Genomic DNA. Translation: CAA89783.1.
BK006946 Genomic DNA. Translation: DAA10186.1.
PIRS54592.
RefSeqNP_014012.1. NM_001182792.1.

3D structure databases

ProteinModelPortalQ03264.
SMRQ03264. Positions 96-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35465. 53 interactions.
DIPDIP-894N.
MINTMINT-4498988.
STRING4932.YMR285C.

Proteomic databases

MaxQBQ03264.
PaxDbQ03264.
PeptideAtlasQ03264.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR285C; YMR285C; YMR285C.
GeneID855329.
KEGGsce:YMR285C.

Organism-specific databases

CYGDYMR285c.
SGDS000004898. NGL2.

Phylogenomic databases

eggNOGCOG5239.
GeneTreeENSGT00550000076051.
HOGENOMHOG000248147.
KOK14812.
OMAYPSDHLC.
OrthoDBEOG73NGD0.

Enzyme and pathway databases

BioCycYEAST:G3O-32955-MONOMER.

Gene expression databases

GenevestigatorQ03264.

Family and domain databases

Gene3D3.60.10.10. 2 hits.
InterProIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMSSF56219. SSF56219. 3 hits.
ProtoNetSearch...

Other

NextBio979049.

Entry information

Entry nameNGL2_YEAST
AccessionPrimary (citable) accession number: Q03264
Secondary accession number(s): D6W0B2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families