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Q03264

- NGL2_YEAST

UniProt

Q03264 - NGL2_YEAST

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Protein

RNA exonuclease NGL2

Gene

NGL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-rRNA processing. Required for the final stage of 3'-end maturation of 5.8S rRNA at site E.1 Publication

GO - Molecular functioni

  1. endoribonuclease activity Source: SGD
  2. exonuclease activity Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  2. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease NGL2 (EC:3.1.-.-)
Alternative name(s):
Carbon catabolite repressor protein 4 homolog
Gene namesi
Name:NGL2
Ordered Locus Names:YMR285C
ORF Names:YM8021.11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR285c.
SGDiS000004898. NGL2.

Subcellular locationi

Cytoplasm Curated. Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. intracellular Source: SGD
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515RNA exonuclease NGL2PRO_0000218579Add
BLAST

Proteomic databases

MaxQBiQ03264.
PaxDbiQ03264.
PeptideAtlasiQ03264.

Expressioni

Gene expression databases

GenevestigatoriQ03264.

Interactioni

Protein-protein interaction databases

BioGridi35465. 56 interactions.
DIPiDIP-894N.
MINTiMINT-4498988.
STRINGi4932.YMR285C.

Structurei

3D structure databases

ProteinModelPortaliQ03264.
SMRiQ03264. Positions 96-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGiCOG5239.
GeneTreeiENSGT00550000076051.
HOGENOMiHOG000248147.
InParanoidiQ03264.
KOiK14812.
OMAiYPSDHLC.
OrthoDBiEOG73NGD0.

Family and domain databases

Gene3Di3.60.10.10. 2 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 3 hits.

Sequencei

Sequence statusi: Complete.

Q03264 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQDKEVKVV APDVAPDQEV EINKSVKDAK HQTNDDSLLQ HKKKGKKGKK
60 70 80 90 100
SKPIVTPEHI AKVRAEREVM RKAKRDAMLA QGVDPDCPPE LHFIRRPFLS
110 120 130 140 150
LHEAEPVTGF RFKLMTYNCL AQALIRRKLF PDSGDALKWY RRSKVLLNEF
160 170 180 190 200
KYYNSDVICL QEIDHIQFQS FWKDEFSKLG YDGQYYRNAT KNHGVAIMWR
210 220 230 240 250
RELFHQVDKM LIDYDKESSE SISTRTTTNN VGLVLALKFS EKVLSNLGKK
260 270 280 290 300
SSKKCGILIG TTHLFWHPFG TYERTRQCYI VLKKMKEFMH RVNVLQNEND
310 320 330 340 350
GDLSHWFPFF CGDFNSQPFD TPYLSMTSKP VHYRNRAKTV IGCSTSYKFS
360 370 380 390 400
KVRDGEEGAD DEEGGNIEKY GKDQPESPVP EKFHANEEQS ELVDKMAQLH
410 420 430 440 450
NSLDMRAISL YSVGYKNVHP ENAGLDNDRG EPEISNWANT WRGLLDYLFY
460 470 480 490 500
VKKWDPQSNC QEVETLGDFE KENKVKCRGF LRMPPGNEMT KHGQPHVGEY
510
ASDHLSMVCD LELQL
Length:515
Mass (Da):59,540
Last modified:November 1, 1997 - v1
Checksum:i89B30A7D24D6EBC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49704 Genomic DNA. Translation: CAA89783.1.
BK006946 Genomic DNA. Translation: DAA10186.1.
PIRiS54592.
RefSeqiNP_014012.1. NM_001182792.1.

Genome annotation databases

EnsemblFungiiYMR285C; YMR285C; YMR285C.
GeneIDi855329.
KEGGisce:YMR285C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49704 Genomic DNA. Translation: CAA89783.1 .
BK006946 Genomic DNA. Translation: DAA10186.1 .
PIRi S54592.
RefSeqi NP_014012.1. NM_001182792.1.

3D structure databases

ProteinModelPortali Q03264.
SMRi Q03264. Positions 96-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35465. 56 interactions.
DIPi DIP-894N.
MINTi MINT-4498988.
STRINGi 4932.YMR285C.

Proteomic databases

MaxQBi Q03264.
PaxDbi Q03264.
PeptideAtlasi Q03264.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR285C ; YMR285C ; YMR285C .
GeneIDi 855329.
KEGGi sce:YMR285C.

Organism-specific databases

CYGDi YMR285c.
SGDi S000004898. NGL2.

Phylogenomic databases

eggNOGi COG5239.
GeneTreei ENSGT00550000076051.
HOGENOMi HOG000248147.
InParanoidi Q03264.
KOi K14812.
OMAi YPSDHLC.
OrthoDBi EOG73NGD0.

Enzyme and pathway databases

BioCyci YEAST:G3O-32955-MONOMER.

Miscellaneous databases

NextBioi 979049.

Gene expression databases

Genevestigatori Q03264.

Family and domain databases

Gene3Di 3.60.10.10. 2 hits.
InterProi IPR005135. Endo/exonuclease/phosphatase.
[Graphical view ]
Pfami PF03372. Exo_endo_phos. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae."
    Faber A.W., van Dijk M., Raue H.A., Vos J.C.
    RNA 8:1095-1101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNGL2_YEAST
AccessioniPrimary (citable) accession number: Q03264
Secondary accession number(s): D6W0B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3570 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3