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Q03263 (YM8M_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uncharacterized transporter YMR279C
Gene names
Ordered Locus Names:YMR279C
ORF Names:YM8021.05C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from sequence model PubMed 12192589. Source: SGD

   Molecular_functionborate efflux transmembrane transporter activity

Inferred from sequence alignment PubMed 21621519. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Uncharacterized transporter YMR279C
PRO_0000173429

Regions

Topological domain1 – 6161Cytoplasmic Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 10826Extracellular Potential
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 1312Cytoplasmic Potential
Transmembrane132 – 15221Helical; Potential
Topological domain153 – 16917Extracellular Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 20313Cytoplasmic Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 2328Extracellular Potential
Transmembrane233 – 25321Helical; Potential
Topological domain254 – 27219Cytoplasmic Potential
Transmembrane273 – 29321Helical; Potential
Topological domain294 – 2952Extracellular Potential
Transmembrane296 – 31621Helical; Potential
Topological domain317 – 33418Cytoplasmic Potential
Transmembrane335 – 35521Helical; Potential
Topological domain356 – 37217Extracellular Potential
Transmembrane373 – 39321Helical; Potential
Topological domain394 – 3985Cytoplasmic Potential
Transmembrane399 – 41921Helical; Potential
Topological domain420 – 42910Extracellular Potential
Transmembrane430 – 45021Helical; Potential
Topological domain451 – 46111Cytoplasmic Potential
Transmembrane462 – 48221Helical; Potential
Topological domain483 – 50220Extracellular Potential
Transmembrane503 – 52321Helical; Potential
Topological domain524 – 54017Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q03263 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 687D06CB0D70AF91

FASTA54059,562
        10         20         30         40         50         60 
MFSIFKKKTS VQGTDSEIDE KITVKAKDKV VVSTEDEEVT TIVSSTKSTQ VTNDSPWQDP 

        70         80         90        100        110        120 
TYFSSFGKEL MFIATCMLAQ LLNQAGQTHA LCIMNVLSKS FNSEANNQAW LMASFPLAAG 

       130        140        150        160        170        180 
SFILISGRLG DIYGLKKMLI VGYVIVIVWS IISGLSKYSN SDAFFITSRA FQGVGIAFIL 

       190        200        210        220        230        240 
PNIMGLVGHV YKVGSFRKNI VISFIGACAP TGGMFGGLFG GLIVTEDPNQ WPWVFYAFGI 

       250        260        270        280        290        300 
ATFLSLLMAW YSIPNNVPTN IHGLSMDWTG SALAIIGLIL FNFVWNQAPI VGWDKPYIIV 

       310        320        330        340        350        360 
LLIISVIFLV AFFVYESKYA EVPLLPRAMT KNRHMIMILL AVFLGWGSFG IWTFYYVSFQ 

       370        380        390        400        410        420 
LNLRHYSPVW TGGTYFVFVI FGSMAAFFVA FSIKRLGPAL LLCFSLMAFD AGSIMFSVLP 

       430        440        450        460        470        480 
VEQSYWKLNF AMQAILCFGM DLSFPASSII LSDGLPMQYQ GMAGSLVNTV INYSASLCLG 

       490        500        510        520        530        540 
MGGTVEHQIN KSGNDLLKGY RAAVYLGVGL ASLGVVISVT YMLENLWNRH RKSEDRSLEA

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z49704 Genomic DNA. Translation: CAA89777.1.
BK006946 Genomic DNA. Translation: DAA10180.1.
PIRS54586.
RefSeqNP_014006.1. NM_001182786.1.

3D structure databases

ProteinModelPortalQ03263.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4642N.
IntActQ03263. 2 interactions.
MINTMINT-520725.
STRING4932.YMR279C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR279C; YMR279C; YMR279C.
GeneID855322.
KEGGsce:YMR279C.

Organism-specific databases

CYGDYMR279c.
SGDS000004892. YMR279C.

Phylogenomic databases

eggNOGNOG284661.
GeneTreeENSGT00390000001190.
HOGENOMHOG000174951.
KOK08165.
OMALNAGMAI.
OrthoDBEOG4W3WWP.

Gene expression databases

GenevestigatorQ03263.
GermOnlineYMR279C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979029.

Entry information

Entry nameYM8M_YEAST
AccessionPrimary (citable) accession number: Q03263
Secondary accession number(s): D6W0A6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

SIMILARITY comments

Index of protein domains and families

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