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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi65 – 133HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Calmodulin-binding, DNA-binding, Repressor
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:SRY
Synonyms:TDF
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487071 – 240Sex-determining region Y proteinAdd BLAST240

Interactioni

Subunit structurei

Interacts with CALM, EP300, HDAC3, KPNB1, KRAB-O/ZFP748, PARP1, SLC9A3R2 and WT1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ03257.
SMRiQ03257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRY family.Curated

Phylogenomic databases

HOVERGENiHBG008712.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR017253. SRY.
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 2 hits.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRTVQSYAS AMFRVLKDDV YSPAVVQQQN TFAFGKTSSL CTDNHSANDQ
60 70 80 90 100
RERGENVRES SQNHVKRPMN AFIVWSRERR RKVALENPKL QNSEISKQLG
110 120 130 140 150
YEWKRLTDAE KRPFFEEAQR LLAIHRDKYP GYKYRPRRKA KRPQKSLAAD
160 170 180 190 200
SSILCNQMDA ETLHPFTYRD DCAKTTHSQM ESQLSRSQSV IITNSLLQKE
210 220 230 240
HHSSWTNLGH DRVTLASRIS ADFPFYQSLE PGLSCAYVQY
Length:240
Mass (Da):27,882
Last modified:October 1, 1996 - v2
Checksum:i26E5BBB02CB56F2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30265 Genomic DNA. Translation: CAA82946.1.
Z18807 Genomic DNA. Translation: CAA79271.1.
Z26912 Genomic DNA. Translation: CAA81538.1.
PIRiS51744.

Similar proteinsi

Entry informationi

Entry nameiSRY_SHEEP
AccessioniPrimary (citable) accession number: Q03257
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families