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Q03252

- LMNB2_HUMAN

UniProt

Q03252 - LMNB2_HUMAN

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Protein

Lamin-B2

Gene

LMNB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lamin-B2
Gene namesi
Name:LMNB2
Synonyms:LMN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6638. LMNB2.

Subcellular locationi

GO - Cellular componenti

  1. lamin filament Source: Ensembl
  2. nuclear inner membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Partial acquired lipodystrophy (APLD) [MIM:608709]: A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151R → Q in APLD. 1 Publication
Corresponds to variant rs61726481 [ dbSNP | Ensembl ].
VAR_031063
Natural varianti407 – 4071A → T in APLD. 1 Publication
Corresponds to variant rs57521499 [ dbSNP | Ensembl ].
VAR_031064

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi608709. phenotype.
Orphaneti79087. Partial acquired lipodystrophy.
PharmGKBiPA30404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Lamin-B2PRO_0000063820Add
BLAST
Propeptidei598 – 6003Removed in mature formBy similarityPRO_0000403470

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine4 Publications
Modified residuei17 – 171Phosphoserine1 Publication
Modified residuei61 – 611N6-acetyllysine1 Publication
Modified residuei400 – 4001Phosphoserine1 Publication
Modified residuei402 – 4021Phosphoserine2 Publications
Modified residuei404 – 4041Phosphoserine2 Publications
Modified residuei406 – 4061Phosphoserine2 Publications
Modified residuei597 – 5971Cysteine methyl esterBy similarity
Lipidationi597 – 5971S-farnesyl cysteineBy similarity

Post-translational modificationi

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.5 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ03252.
PaxDbiQ03252.
PRIDEiQ03252.

2D gel databases

REPRODUCTION-2DPAGEIPI00009771.

PTM databases

PhosphoSiteiQ03252.

Expressioni

Gene expression databases

BgeeiQ03252.
CleanExiHS_LMNB2.
ExpressionAtlasiQ03252. baseline and differential.
GenevestigatoriQ03252.

Organism-specific databases

HPAiCAB022593.

Interactioni

Subunit structurei

Interacts with TMEM43.By similarity

Protein-protein interaction databases

BioGridi124281. 16 interactions.
DIPiDIP-57724N.
IntActiQ03252. 6 interactions.
MINTiMINT-3024955.
STRINGi9606.ENSP00000327054.

Structurei

Secondary structure

1
600
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi453 – 4597Combined sources
Beta strandi464 – 4707Combined sources
Beta strandi472 – 4743Combined sources
Beta strandi482 – 4876Combined sources
Beta strandi492 – 4965Combined sources
Beta strandi508 – 5136Combined sources
Helixi514 – 5163Combined sources
Turni522 – 5243Combined sources
Beta strandi525 – 5284Combined sources
Beta strandi532 – 5354Combined sources
Beta strandi538 – 5458Combined sources
Beta strandi551 – 56010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LLLNMR-A449-569[»]
ProteinModelPortaliQ03252.
SMRiQ03252. Positions 323-377, 449-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 558114LTDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828HeadAdd
BLAST
Regioni29 – 380352RodAdd
BLAST
Regioni29 – 6335Coil 1AAdd
BLAST
Regioni64 – 7512Linker 1Add
BLAST
Regioni76 – 209134Coil 1BAdd
BLAST
Regioni210 – 23627Linker 2Add
BLAST
Regioni237 – 380144Coil 2Add
BLAST
Regioni381 – 600220TailAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi415 – 4206Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi570 – 58213Asp/Glu-rich (highly acidic; could be involved in chromatin binding)Add
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated
Contains 1 LTD domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG325506.
HOGENOMiHOG000007711.
HOVERGENiHBG013015.
InParanoidiQ03252.
KOiK07611.
PhylomeDBiQ03252.
TreeFamiTF101181.

Family and domain databases

Gene3Di2.60.40.1260. 1 hit.
InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR027696. Lamin.
IPR001322. Lamin_tail_dom.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF152. PTHR23239:SF152. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF00932. LTD. 1 hit.
[Graphical view]
SUPFAMiSSF74853. SSF74853. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03252-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPLPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY IDRVRALELE
60 70 80 90 100
NDRLLLKISE KEEVTTREVS GIKALYESEL ADARRVLDET ARERARLQIE
110 120 130 140 150
IGKLRAELDE VNKSAKKREG ELTVAQGRVK DLESLFHRSE VELAAALSDK
160 170 180 190 200
RGLESDVAEL RAQLAKAEDG HAVAKKQLEK ETLMRVDLEN RCQSLQEELD
210 220 230 240 250
FRKSVFEEEV RETRRRHERR LVEVDSSRQQ EYDFKMAQAL EELRSQHDEQ
260 270 280 290 300
VRLYKLELEQ TYQAKLDSAK LSSDQNDKAA SAAREELKEA RMRLESLSYQ
310 320 330 340 350
LSGLQKQASA AEDRIRELEE AMAGERDKFR KMLDAKEQEM TEMRDVMQQQ
360 370 380 390 400
LAEYQELLDV KLALDMEINA YRKLLEGEEE RLKLSPSPSS RVTVSRATSS
410 420 430 440 450
SSGSLSATGR LGRSKRKRLE VEEPLGSGPS VLGTGTGGSG GFHLAQQASA
460 470 480 490 500
SGSVSIEEID LEGKFVQLKN NSDKDQSLGN WRIKRQVLEG EEIAYKFTPK
510 520 530 540 550
YILRAGQMVT VWAAGAGVAH SPPSTLVWKG QSSWGTGESF RTVLVNADGE
560 570 580 590 600
EVAMRTVKKS SVMRENENGE EEEEEAEFGE EDLFHQQGDP RTTSRGCYVM
Length:600
Mass (Da):67,689
Last modified:September 19, 2002 - v3
Checksum:i3A1B9098F7EA943B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811R → S in AAA80979. (PubMed:1630457)Curated
Sequence conflicti419 – 45537LEVEE…SGSVS → WRWRSPWQRPKRPGHGHGWQ RWLPPGPAGLGLGQRH in AAA80979. (PubMed:1630457)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151R → Q in APLD. 1 Publication
Corresponds to variant rs61726481 [ dbSNP | Ensembl ].
VAR_031063
Natural varianti216 – 2161R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036370
Natural varianti407 – 4071A → T in APLD. 1 Publication
Corresponds to variant rs57521499 [ dbSNP | Ensembl ].
VAR_031064

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007441 mRNA. Translation: AAP36109.1.
AC011522 Genomic DNA. No translation available.
AC005624 Genomic DNA. Translation: AAC34573.1.
BC006551 mRNA. Translation: AAH06551.1.
M94362 mRNA. Translation: AAA80979.1.
M94363 Genomic DNA. Translation: AAB00873.1. Sequence problems.
RefSeqiNP_116126.3. NM_032737.3.
UniGeneiHs.538286.

Genome annotation databases

EnsembliENST00000582871; ENSP00000462730; ENSG00000176619.
GeneIDi84823.
KEGGihsa:84823.

Polymorphism databases

DMDMi23503078.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT007441 mRNA. Translation: AAP36109.1 .
AC011522 Genomic DNA. No translation available.
AC005624 Genomic DNA. Translation: AAC34573.1 .
BC006551 mRNA. Translation: AAH06551.1 .
M94362 mRNA. Translation: AAA80979.1 .
M94363 Genomic DNA. Translation: AAB00873.1 . Sequence problems.
RefSeqi NP_116126.3. NM_032737.3.
UniGenei Hs.538286.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LLL NMR - A 449-569 [» ]
ProteinModelPortali Q03252.
SMRi Q03252. Positions 323-377, 449-569.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124281. 16 interactions.
DIPi DIP-57724N.
IntActi Q03252. 6 interactions.
MINTi MINT-3024955.
STRINGi 9606.ENSP00000327054.

PTM databases

PhosphoSitei Q03252.

Polymorphism databases

DMDMi 23503078.

2D gel databases

REPRODUCTION-2DPAGE IPI00009771.

Proteomic databases

MaxQBi Q03252.
PaxDbi Q03252.
PRIDEi Q03252.

Protocols and materials databases

DNASUi 84823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000582871 ; ENSP00000462730 ; ENSG00000176619 .
GeneIDi 84823.
KEGGi hsa:84823.

Organism-specific databases

CTDi 84823.
GeneCardsi GC19M002428.
HGNCi HGNC:6638. LMNB2.
HPAi CAB022593.
MIMi 150341. gene.
608709. phenotype.
neXtProti NX_Q03252.
Orphaneti 79087. Partial acquired lipodystrophy.
PharmGKBi PA30404.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325506.
HOGENOMi HOG000007711.
HOVERGENi HBG013015.
InParanoidi Q03252.
KOi K07611.
PhylomeDBi Q03252.
TreeFami TF101181.

Miscellaneous databases

ChiTaRSi LMNB2. human.
GenomeRNAii 84823.
NextBioi 75028.
PROi Q03252.
SOURCEi Search...

Gene expression databases

Bgeei Q03252.
CleanExi HS_LMNB2.
ExpressionAtlasi Q03252. baseline and differential.
Genevestigatori Q03252.

Family and domain databases

Gene3Di 2.60.40.1260. 1 hit.
InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR027696. Lamin.
IPR001322. Lamin_tail_dom.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
PTHR23239:SF152. PTHR23239:SF152. 1 hit.
Pfami PF00038. Filament. 1 hit.
PF00932. LTD. 1 hit.
[Graphical view ]
SUPFAMi SSF74853. SSF74853. 1 hit.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 74-84; 131-150; 152-161; 192-202; 236-244; 294-306; 345-372; 486-496 AND 530-555, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  5. "The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase."
    Biamonti G., Giacca M., Perini G., Contreas G., Zentilin L., Weighardt F., Guerra M., Valle G.D., Saccone S., Riva S., Falaschi A.
    Mol. Cell. Biol. 12:3499-3506(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-600, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 511-600.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17; SER-402; SER-404 AND SER-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400; SER-402; SER-404 AND SER-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy."
    Hegele R.A., Cao H., Liu D.M., Costain G.A., Charlton-Menys V., Rodger N.W., Durrington P.N.
    Am. J. Hum. Genet. 79:383-389(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS APLD GLN-215 AND THR-407.
  18. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-216.

Entry informationi

Entry nameiLMNB2_HUMAN
AccessioniPrimary (citable) accession number: Q03252
Secondary accession number(s): O75292, Q14734, Q96DF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 19, 2002
Last modified: November 26, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3