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Q03252

- LMNB2_HUMAN

UniProt

Q03252 - LMNB2_HUMAN

Protein

Lamin-B2

Gene

LMNB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lamin-B2
    Gene namesi
    Name:LMNB2
    Synonyms:LMN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6638. LMNB2.

    Subcellular locationi

    GO - Cellular componenti

    1. lamin filament Source: InterPro
    2. nuclear inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Intermediate filament, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Partial acquired lipodystrophy (APLD) [MIM:608709]: A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti215 – 2151R → Q in APLD. 1 Publication
    Corresponds to variant rs61726481 [ dbSNP | Ensembl ].
    VAR_031063
    Natural varianti407 – 4071A → T in APLD. 1 Publication
    Corresponds to variant rs57521499 [ dbSNP | Ensembl ].
    VAR_031064

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi608709. phenotype.
    Orphaneti79087. Partial acquired lipodystrophy.
    PharmGKBiPA30404.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 597597Lamin-B2PRO_0000063820Add
    BLAST
    Propeptidei598 – 6003Removed in mature formBy similarityPRO_0000403470

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphothreonine4 Publications
    Modified residuei17 – 171Phosphoserine1 Publication
    Modified residuei61 – 611N6-acetyllysine1 Publication
    Modified residuei400 – 4001Phosphoserine1 Publication
    Modified residuei402 – 4021Phosphoserine2 Publications
    Modified residuei404 – 4041Phosphoserine2 Publications
    Modified residuei406 – 4061Phosphoserine2 Publications
    Modified residuei597 – 5971Cysteine methyl esterBy similarity
    Lipidationi597 – 5971S-farnesyl cysteineBy similarity

    Post-translational modificationi

    B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.5 Publications

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ03252.
    PaxDbiQ03252.
    PRIDEiQ03252.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00009771.

    PTM databases

    PhosphoSiteiQ03252.

    Expressioni

    Gene expression databases

    ArrayExpressiQ03252.
    BgeeiQ03252.
    CleanExiHS_LMNB2.
    GenevestigatoriQ03252.

    Organism-specific databases

    HPAiCAB022593.

    Interactioni

    Subunit structurei

    Interacts with TMEM43.By similarity

    Protein-protein interaction databases

    BioGridi124281. 14 interactions.
    DIPiDIP-57724N.
    IntActiQ03252. 6 interactions.
    MINTiMINT-3024955.
    STRINGi9606.ENSP00000327054.

    Structurei

    Secondary structure

    1
    600
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi453 – 4597
    Beta strandi464 – 4707
    Beta strandi472 – 4743
    Beta strandi482 – 4876
    Beta strandi492 – 4965
    Beta strandi508 – 5136
    Helixi514 – 5163
    Turni522 – 5243
    Beta strandi525 – 5284
    Beta strandi532 – 5354
    Beta strandi538 – 5458
    Beta strandi551 – 56010

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LLLNMR-A449-569[»]
    ProteinModelPortaliQ03252.
    SMRiQ03252. Positions 323-377, 449-569.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini445 – 558114LTDAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828HeadAdd
    BLAST
    Regioni29 – 380352RodAdd
    BLAST
    Regioni29 – 6335Coil 1AAdd
    BLAST
    Regioni64 – 7512Linker 1Add
    BLAST
    Regioni76 – 209134Coil 1BAdd
    BLAST
    Regioni210 – 23627Linker 2Add
    BLAST
    Regioni237 – 380144Coil 2Add
    BLAST
    Regioni381 – 600220TailAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi415 – 4206Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi570 – 58213Asp/Glu-rich (highly acidic; could be involved in chromatin binding)Add
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated
    Contains 1 LTD domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG325506.
    HOGENOMiHOG000007711.
    HOVERGENiHBG013015.
    InParanoidiQ03252.
    KOiK07611.
    PhylomeDBiQ03252.
    TreeFamiTF101181.

    Family and domain databases

    Gene3Di2.60.40.1260. 1 hit.
    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR027696. Lamin.
    IPR001322. Lamin_tail_dom.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PTHR23239:SF152. PTHR23239:SF152. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    PF00932. LTD. 1 hit.
    [Graphical view]
    SUPFAMiSSF74853. SSF74853. 1 hit.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03252-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPLPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY IDRVRALELE    50
    NDRLLLKISE KEEVTTREVS GIKALYESEL ADARRVLDET ARERARLQIE 100
    IGKLRAELDE VNKSAKKREG ELTVAQGRVK DLESLFHRSE VELAAALSDK 150
    RGLESDVAEL RAQLAKAEDG HAVAKKQLEK ETLMRVDLEN RCQSLQEELD 200
    FRKSVFEEEV RETRRRHERR LVEVDSSRQQ EYDFKMAQAL EELRSQHDEQ 250
    VRLYKLELEQ TYQAKLDSAK LSSDQNDKAA SAAREELKEA RMRLESLSYQ 300
    LSGLQKQASA AEDRIRELEE AMAGERDKFR KMLDAKEQEM TEMRDVMQQQ 350
    LAEYQELLDV KLALDMEINA YRKLLEGEEE RLKLSPSPSS RVTVSRATSS 400
    SSGSLSATGR LGRSKRKRLE VEEPLGSGPS VLGTGTGGSG GFHLAQQASA 450
    SGSVSIEEID LEGKFVQLKN NSDKDQSLGN WRIKRQVLEG EEIAYKFTPK 500
    YILRAGQMVT VWAAGAGVAH SPPSTLVWKG QSSWGTGESF RTVLVNADGE 550
    EVAMRTVKKS SVMRENENGE EEEEEAEFGE EDLFHQQGDP RTTSRGCYVM 600
    Length:600
    Mass (Da):67,689
    Last modified:September 19, 2002 - v3
    Checksum:i3A1B9098F7EA943B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti381 – 3811R → S in AAA80979. (PubMed:1630457)Curated
    Sequence conflicti419 – 45537LEVEE…SGSVS → WRWRSPWQRPKRPGHGHGWQ RWLPPGPAGLGLGQRH in AAA80979. (PubMed:1630457)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti215 – 2151R → Q in APLD. 1 Publication
    Corresponds to variant rs61726481 [ dbSNP | Ensembl ].
    VAR_031063
    Natural varianti216 – 2161R → W in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036370
    Natural varianti407 – 4071A → T in APLD. 1 Publication
    Corresponds to variant rs57521499 [ dbSNP | Ensembl ].
    VAR_031064

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT007441 mRNA. Translation: AAP36109.1.
    AC011522 Genomic DNA. No translation available.
    AC005624 Genomic DNA. Translation: AAC34573.1.
    BC006551 mRNA. Translation: AAH06551.1.
    M94362 mRNA. Translation: AAA80979.1.
    M94363 Genomic DNA. Translation: AAB00873.1. Sequence problems.
    RefSeqiNP_116126.3. NM_032737.3.
    UniGeneiHs.538286.

    Genome annotation databases

    EnsembliENST00000582871; ENSP00000462730; ENSG00000176619.
    GeneIDi84823.
    KEGGihsa:84823.

    Polymorphism databases

    DMDMi23503078.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT007441 mRNA. Translation: AAP36109.1 .
    AC011522 Genomic DNA. No translation available.
    AC005624 Genomic DNA. Translation: AAC34573.1 .
    BC006551 mRNA. Translation: AAH06551.1 .
    M94362 mRNA. Translation: AAA80979.1 .
    M94363 Genomic DNA. Translation: AAB00873.1 . Sequence problems.
    RefSeqi NP_116126.3. NM_032737.3.
    UniGenei Hs.538286.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LLL NMR - A 449-569 [» ]
    ProteinModelPortali Q03252.
    SMRi Q03252. Positions 323-377, 449-569.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124281. 14 interactions.
    DIPi DIP-57724N.
    IntActi Q03252. 6 interactions.
    MINTi MINT-3024955.
    STRINGi 9606.ENSP00000327054.

    PTM databases

    PhosphoSitei Q03252.

    Polymorphism databases

    DMDMi 23503078.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00009771.

    Proteomic databases

    MaxQBi Q03252.
    PaxDbi Q03252.
    PRIDEi Q03252.

    Protocols and materials databases

    DNASUi 84823.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000582871 ; ENSP00000462730 ; ENSG00000176619 .
    GeneIDi 84823.
    KEGGi hsa:84823.

    Organism-specific databases

    CTDi 84823.
    GeneCardsi GC19M002428.
    HGNCi HGNC:6638. LMNB2.
    HPAi CAB022593.
    MIMi 150341. gene.
    608709. phenotype.
    neXtProti NX_Q03252.
    Orphaneti 79087. Partial acquired lipodystrophy.
    PharmGKBi PA30404.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325506.
    HOGENOMi HOG000007711.
    HOVERGENi HBG013015.
    InParanoidi Q03252.
    KOi K07611.
    PhylomeDBi Q03252.
    TreeFami TF101181.

    Miscellaneous databases

    ChiTaRSi LMNB2. human.
    GenomeRNAii 84823.
    NextBioi 75028.
    PROi Q03252.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03252.
    Bgeei Q03252.
    CleanExi HS_LMNB2.
    Genevestigatori Q03252.

    Family and domain databases

    Gene3Di 2.60.40.1260. 1 hit.
    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR027696. Lamin.
    IPR001322. Lamin_tail_dom.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    PTHR23239:SF152. PTHR23239:SF152. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    PF00932. LTD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74853. SSF74853. 1 hit.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 74-84; 131-150; 152-161; 192-202; 236-244; 294-306; 345-372; 486-496 AND 530-555, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    5. "The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase."
      Biamonti G., Giacca M., Perini G., Contreas G., Zentilin L., Weighardt F., Guerra M., Valle G.D., Saccone S., Riva S., Falaschi A.
      Mol. Cell. Biol. 12:3499-3506(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-600, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 511-600.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17; SER-402; SER-404 AND SER-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400; SER-402; SER-404 AND SER-406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy."
      Hegele R.A., Cao H., Liu D.M., Costain G.A., Charlton-Menys V., Rodger N.W., Durrington P.N.
      Am. J. Hum. Genet. 79:383-389(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS APLD GLN-215 AND THR-407.
    18. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-216.

    Entry informationi

    Entry nameiLMNB2_HUMAN
    AccessioniPrimary (citable) accession number: Q03252
    Secondary accession number(s): O75292, Q14734, Q96DF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3