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Q03249

- GALT_MOUSE

UniProt

Q03249 - GALT_MOUSE

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Protein
Galactose-1-phosphate uridylyltransferase
Gene
Galt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.

Cofactori

Binds 1 iron ion per subunit Reviewed prediction.
Binds 1 zinc ion per subunit Reviewed prediction.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Zinc Reviewed prediction
Metal bindingi184 – 1841Zinc Reviewed prediction
Active sitei186 – 1861Tele-UMP-histidine intermediate By similarity
Metal bindingi202 – 2021Iron Reviewed prediction
Metal bindingi301 – 3011Iron Reviewed prediction
Metal bindingi319 – 3191Iron Reviewed prediction
Metal bindingi321 – 3211Iron Reviewed prediction

GO - Molecular functioni

  1. UDP-glucose:hexose-1-phosphate uridylyltransferase activity Source: MGI
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. UDP-glucose catabolic process Source: Ensembl
  2. galactose metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.12. 3474.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:Galt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95638. Galt.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Galactose-1-phosphate uridylyltransferase
PRO_0000169883Add
BLAST

Proteomic databases

MaxQBiQ03249.
PaxDbiQ03249.
PRIDEiQ03249.

PTM databases

PhosphoSiteiQ03249.

Expressioni

Gene expression databases

ArrayExpressiQ03249.
BgeeiQ03249.
CleanExiMM_GALT.
GenevestigatoriQ03249.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ03249. 1 interaction.
MINTiMINT-4095581.
STRINGi10090.ENSMUSP00000081745.

Structurei

3D structure databases

ProteinModelPortaliQ03249.
SMRiQ03249. Positions 24-366.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1085.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiQ03249.
KOiK00965.
PhylomeDBiQ03249.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03249-1 [UniParc]FASTAAdd to Basket

« Hide

MSHSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK    50
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPHYD GTFLFDNDFP 100
ALQPDAPDPG PSDHPLFRAE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV 150
IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ 200
REERSQQTYH SQHGKPLLLE YGHQELLRKE RLVLTSEHWI VLVPFWAVWP 250
FQTLLLPRRH VRRLPELNPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW 300
HGAPTGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT 350
PEQAAERLRA LPEVHYCLAQ KDKETAAIA 379
Length:379
Mass (Da):43,232
Last modified:April 30, 2003 - v3
Checksum:i8BA5C776AF6F2D64
GO

Sequence cautioni

The sequence AAA37658.1 differs from that shown. Reason: Frameshift at positions 7 and 19.
The sequence AAA83562.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH10985.2 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → T in AAA37658. 1 Publication
Sequence conflicti1 – 11M → T in AAA83562. 1 Publication
Sequence conflicti5 – 51G → D in AAA37658. 1 Publication
Sequence conflicti12 – 121Q → H in AAA37658. 1 Publication
Sequence conflicti13 – 131Q → E in AAA37658. 1 Publication
Sequence conflicti111 – 1111P → T in AAH10985. 1 Publication
Sequence conflicti274 – 2741Missing in AAA37658. 1 Publication
Sequence conflicti338 – 3381G → GPCTLAAHAHYLPPLLGSAT V in AAA37658. 1 Publication
Sequence conflicti355 – 3551A → P in AAA37658. 1 Publication
Sequence conflicti377 – 3793AIA → GSPLLDCDHIRALNLCT in AAA37658. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqiNP_057867.2. NM_016658.2.
UniGeneiMm.439669.

Genome annotation databases

GeneIDi14430.
KEGGimmu:14430.
UCSCiuc008sjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96265 mRNA. Translation: AAA37658.1 . Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1 . Different initiation.
BC010985 mRNA. Translation: AAH10985.2 . Different initiation.
RefSeqi NP_057867.2. NM_016658.2.
UniGenei Mm.439669.

3D structure databases

ProteinModelPortali Q03249.
SMRi Q03249. Positions 24-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q03249. 1 interaction.
MINTi MINT-4095581.
STRINGi 10090.ENSMUSP00000081745.

PTM databases

PhosphoSitei Q03249.

Proteomic databases

MaxQBi Q03249.
PaxDbi Q03249.
PRIDEi Q03249.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 14430.
KEGGi mmu:14430.
UCSCi uc008sjo.1. mouse.

Organism-specific databases

CTDi 2592.
MGIi MGI:95638. Galt.

Phylogenomic databases

eggNOGi COG1085.
HOGENOMi HOG000230490.
HOVERGENi HBG051700.
InParanoidi Q03249.
KOi K00965.
PhylomeDBi Q03249.

Enzyme and pathway databases

UniPathwayi UPA00214 .
BRENDAi 2.7.7.12. 3474.

Miscellaneous databases

NextBioi 286045.
PROi Q03249.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03249.
Bgeei Q03249.
CleanExi MM_GALT.
Genevestigatori Q03249.

Family and domain databases

Gene3Di 3.30.428.10. 2 hits.
InterProi IPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view ]
PANTHERi PTHR11943. PTHR11943. 1 hit.
Pfami PF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view ]
PIRSFi PIRSF000808. GalT. 1 hit.
SUPFAMi SSF54197. SSF54197. 2 hits.
TIGRFAMsi TIGR00209. galT_1. 1 hit.
PROSITEi PS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse galactose-1-phosphate uridyl transferase (GalT) gene."
    Velicescu M., Reichardt J.K.V., Dubeau L.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGALT_MOUSE
AccessioniPrimary (citable) accession number: Q03249
Secondary accession number(s): Q91VQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 30, 2003
Last modified: May 14, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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