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Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationCuratedNote: Binds 1 Fe cation per subunit.Curated
  • Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Pathway: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751ZincPROSITE-ProRule annotation
Metal bindingi184 – 1841ZincPROSITE-ProRule annotation
Active sitei186 – 1861Tele-UMP-histidine intermediatePROSITE-ProRule annotation
Metal bindingi202 – 2021IronSequence Analysis
Metal bindingi301 – 3011IronSequence Analysis
Metal bindingi319 – 3191IronSequence Analysis
Metal bindingi321 – 3211IronSequence Analysis

GO - Molecular functioni

GO - Biological processi

  • galactose metabolic process Source: MGI
  • UDP-glucose catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.12. 3474.
ReactomeiREACT_296113. Galactose catabolism.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:Galt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95638. Galt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Galactose-1-phosphate uridylyltransferasePRO_0000169883Add
BLAST

Proteomic databases

MaxQBiQ03249.
PaxDbiQ03249.
PRIDEiQ03249.

PTM databases

PhosphoSiteiQ03249.

Expressioni

Gene expression databases

BgeeiQ03249.
CleanExiMM_GALT.
ExpressionAtlasiQ03249. baseline and differential.
GenevisibleiQ03249. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ03249. 1 interaction.
MINTiMINT-4095581.
STRINGi10090.ENSMUSP00000081745.

Structurei

3D structure databases

ProteinModelPortaliQ03249.
SMRiQ03249. Positions 24-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1085.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiQ03249.
KOiK00965.
PhylomeDBiQ03249.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPHYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPDPG PSDHPLFRAE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQQTYH SQHGKPLLLE YGHQELLRKE RLVLTSEHWI VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VRRLPELNPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYCLAQ KDKETAAIA
Length:379
Mass (Da):43,232
Last modified:April 30, 2003 - v3
Checksum:i8BA5C776AF6F2D64
GO

Sequence cautioni

The sequence AAA37658.1 differs from that shown. Reason: Frameshift at positions 7 and 19. Curated
The sequence AAA83562.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH10985.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → T in AAA37658 (PubMed:1427861).Curated
Sequence conflicti1 – 11M → T in AAA83562 (Ref. 2) Curated
Sequence conflicti5 – 51G → D in AAA37658 (PubMed:1427861).Curated
Sequence conflicti12 – 121Q → H in AAA37658 (PubMed:1427861).Curated
Sequence conflicti13 – 131Q → E in AAA37658 (PubMed:1427861).Curated
Sequence conflicti111 – 1111P → T in AAH10985 (PubMed:15489334).Curated
Sequence conflicti274 – 2741Missing in AAA37658 (PubMed:1427861).Curated
Sequence conflicti338 – 3381G → GPCTLAAHAHYLPPLLGSAT V in AAA37658 (PubMed:1427861).Curated
Sequence conflicti355 – 3551A → P in AAA37658 (PubMed:1427861).Curated
Sequence conflicti377 – 3793AIA → GSPLLDCDHIRALNLCT in AAA37658 (PubMed:1427861).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqiNP_057867.2. NM_016658.3.
UniGeneiMm.439669.
Mm.488220.

Genome annotation databases

GeneIDi14430.
KEGGimmu:14430.
UCSCiuc008sjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqiNP_057867.2. NM_016658.3.
UniGeneiMm.439669.
Mm.488220.

3D structure databases

ProteinModelPortaliQ03249.
SMRiQ03249. Positions 24-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03249. 1 interaction.
MINTiMINT-4095581.
STRINGi10090.ENSMUSP00000081745.

PTM databases

PhosphoSiteiQ03249.

Proteomic databases

MaxQBiQ03249.
PaxDbiQ03249.
PRIDEiQ03249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14430.
KEGGimmu:14430.
UCSCiuc008sjo.1. mouse.

Organism-specific databases

CTDi2592.
MGIiMGI:95638. Galt.

Phylogenomic databases

eggNOGiCOG1085.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiQ03249.
KOiK00965.
PhylomeDBiQ03249.

Enzyme and pathway databases

UniPathwayiUPA00214.
BRENDAi2.7.7.12. 3474.
ReactomeiREACT_296113. Galactose catabolism.

Miscellaneous databases

NextBioi286045.
PROiQ03249.
SOURCEiSearch...

Gene expression databases

BgeeiQ03249.
CleanExiMM_GALT.
ExpressionAtlasiQ03249. baseline and differential.
GenevisibleiQ03249. MM.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse galactose-1-phosphate uridyl transferase (GalT) gene."
    Velicescu M., Reichardt J.K.V., Dubeau L.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGALT_MOUSE
AccessioniPrimary (citable) accession number: Q03249
Secondary accession number(s): Q91VQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 30, 2003
Last modified: June 24, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.