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Q03249

- GALT_MOUSE

UniProt

Q03249 - GALT_MOUSE

Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (30 Apr 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.

    Cofactori

    Binds 1 iron ion per subunit.Curated
    Binds 1 zinc ion per subunit.Curated

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751ZincPROSITE-ProRule annotation
    Metal bindingi184 – 1841ZincPROSITE-ProRule annotation
    Active sitei186 – 1861Tele-UMP-histidine intermediatePROSITE-ProRule annotation
    Metal bindingi202 – 2021IronSequence Analysis
    Metal bindingi301 – 3011IronSequence Analysis
    Metal bindingi319 – 3191IronSequence Analysis
    Metal bindingi321 – 3211IronSequence Analysis

    GO - Molecular functioni

    1. UDP-glucose:hexose-1-phosphate uridylyltransferase activity Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. galactose metabolic process Source: MGI
    2. UDP-glucose catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Galactose metabolism

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi2.7.7.12. 3474.
    UniPathwayiUPA00214.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
    Short name:
    Gal-1-P uridylyltransferase
    Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase
    Gene namesi
    Name:Galt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:95638. Galt.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Galactose-1-phosphate uridylyltransferasePRO_0000169883Add
    BLAST

    Proteomic databases

    MaxQBiQ03249.
    PaxDbiQ03249.
    PRIDEiQ03249.

    PTM databases

    PhosphoSiteiQ03249.

    Expressioni

    Gene expression databases

    ArrayExpressiQ03249.
    BgeeiQ03249.
    CleanExiMM_GALT.
    GenevestigatoriQ03249.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ03249. 1 interaction.
    MINTiMINT-4095581.
    STRINGi10090.ENSMUSP00000081745.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03249.
    SMRiQ03249. Positions 24-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1085.
    HOGENOMiHOG000230490.
    HOVERGENiHBG051700.
    InParanoidiQ03249.
    KOiK00965.
    PhylomeDBiQ03249.

    Family and domain databases

    Gene3Di3.30.428.10. 2 hits.
    InterProiIPR001937. GalP_UDPtransf1.
    IPR019779. GalP_UDPtransf1_His-AS.
    IPR005850. GalP_Utransf_C.
    IPR005849. GalP_Utransf_N.
    IPR011146. HIT-like.
    [Graphical view]
    PANTHERiPTHR11943. PTHR11943. 1 hit.
    PfamiPF02744. GalP_UDP_tr_C. 1 hit.
    PF01087. GalP_UDP_transf. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000808. GalT. 1 hit.
    SUPFAMiSSF54197. SSF54197. 2 hits.
    TIGRFAMsiTIGR00209. galT_1. 1 hit.
    PROSITEiPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03249-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK    50
    RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPHYD GTFLFDNDFP 100
    ALQPDAPDPG PSDHPLFRAE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV 150
    IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ 200
    REERSQQTYH SQHGKPLLLE YGHQELLRKE RLVLTSEHWI VLVPFWAVWP 250
    FQTLLLPRRH VRRLPELNPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW 300
    HGAPTGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT 350
    PEQAAERLRA LPEVHYCLAQ KDKETAAIA 379
    Length:379
    Mass (Da):43,232
    Last modified:April 30, 2003 - v3
    Checksum:i8BA5C776AF6F2D64
    GO

    Sequence cautioni

    The sequence AAA37658.1 differs from that shown. Reason: Frameshift at positions 7 and 19.
    The sequence AAA83562.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH10985.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → T in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti1 – 11M → T in AAA83562. 1 PublicationCurated
    Sequence conflicti5 – 51G → D in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti12 – 121Q → H in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti13 – 131Q → E in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti111 – 1111P → T in AAH10985. (PubMed:15489334)Curated
    Sequence conflicti274 – 2741Missing in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti338 – 3381G → GPCTLAAHAHYLPPLLGSAT V in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti355 – 3551A → P in AAA37658. (PubMed:1427861)Curated
    Sequence conflicti377 – 3793AIA → GSPLLDCDHIRALNLCT in AAA37658. (PubMed:1427861)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96265 mRNA. Translation: AAA37658.1. Frameshift.
    U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
    BC010985 mRNA. Translation: AAH10985.2. Different initiation.
    RefSeqiNP_057867.2. NM_016658.2.
    UniGeneiMm.439669.

    Genome annotation databases

    GeneIDi14430.
    KEGGimmu:14430.
    UCSCiuc008sjo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96265 mRNA. Translation: AAA37658.1 . Frameshift.
    U41282 Genomic DNA. Translation: AAA83562.1 . Different initiation.
    BC010985 mRNA. Translation: AAH10985.2 . Different initiation.
    RefSeqi NP_057867.2. NM_016658.2.
    UniGenei Mm.439669.

    3D structure databases

    ProteinModelPortali Q03249.
    SMRi Q03249. Positions 24-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q03249. 1 interaction.
    MINTi MINT-4095581.
    STRINGi 10090.ENSMUSP00000081745.

    PTM databases

    PhosphoSitei Q03249.

    Proteomic databases

    MaxQBi Q03249.
    PaxDbi Q03249.
    PRIDEi Q03249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 14430.
    KEGGi mmu:14430.
    UCSCi uc008sjo.1. mouse.

    Organism-specific databases

    CTDi 2592.
    MGIi MGI:95638. Galt.

    Phylogenomic databases

    eggNOGi COG1085.
    HOGENOMi HOG000230490.
    HOVERGENi HBG051700.
    InParanoidi Q03249.
    KOi K00965.
    PhylomeDBi Q03249.

    Enzyme and pathway databases

    UniPathwayi UPA00214 .
    BRENDAi 2.7.7.12. 3474.

    Miscellaneous databases

    NextBioi 286045.
    PROi Q03249.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03249.
    Bgeei Q03249.
    CleanExi MM_GALT.
    Genevestigatori Q03249.

    Family and domain databases

    Gene3Di 3.30.428.10. 2 hits.
    InterProi IPR001937. GalP_UDPtransf1.
    IPR019779. GalP_UDPtransf1_His-AS.
    IPR005850. GalP_Utransf_C.
    IPR005849. GalP_Utransf_N.
    IPR011146. HIT-like.
    [Graphical view ]
    PANTHERi PTHR11943. PTHR11943. 1 hit.
    Pfami PF02744. GalP_UDP_tr_C. 1 hit.
    PF01087. GalP_UDP_transf. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000808. GalT. 1 hit.
    SUPFAMi SSF54197. SSF54197. 2 hits.
    TIGRFAMsi TIGR00209. galT_1. 1 hit.
    PROSITEi PS00117. GAL_P_UDP_TRANSF_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse galactose-1-phosphate uridyl transferase (GalT) gene."
      Velicescu M., Reichardt J.K.V., Dubeau L.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C129.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiGALT_MOUSE
    AccessioniPrimary (citable) accession number: Q03249
    Secondary accession number(s): Q91VQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: April 30, 2003
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3