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Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationCuratedNote: Binds 1 Fe cation per subunit.Curated
  • Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75ZincPROSITE-ProRule annotation1
Metal bindingi184ZincPROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediatePROSITE-ProRule annotation1
Metal bindingi202IronSequence analysis1
Metal bindingi301IronSequence analysis1
Metal bindingi319IronSequence analysis1
Metal bindingi321IronSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • galactose catabolic process via UDP-galactose Source: MGI
  • galactose metabolic process Source: MGI
  • glycolytic process from galactose Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.12. 3474.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:Galt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95638. Galt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698831 – 379Galactose-1-phosphate uridylyltransferaseAdd BLAST379

Proteomic databases

EPDiQ03249.
MaxQBiQ03249.
PaxDbiQ03249.
PRIDEiQ03249.

PTM databases

iPTMnetiQ03249.
PhosphoSitePlusiQ03249.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036073.
CleanExiMM_GALT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ03249. 1 interactor.
MINTiMINT-4095581.
STRINGi10090.ENSMUSP00000081745.

Structurei

3D structure databases

ProteinModelPortaliQ03249.
SMRiQ03249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2958. Eukaryota.
COG1085. LUCA.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiQ03249.
KOiK00965.
PhylomeDBiQ03249.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPHYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPDPG PSDHPLFRAE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQQTYH SQHGKPLLLE YGHQELLRKE RLVLTSEHWI VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VRRLPELNPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYCLAQ KDKETAAIA
Length:379
Mass (Da):43,232
Last modified:April 30, 2003 - v3
Checksum:i8BA5C776AF6F2D64
GO

Sequence cautioni

The sequence AAA37658 differs from that shown. Reason: Frameshift at positions 7 and 19.Curated
The sequence AAA83562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10985 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti1M → T in AAA83562 (Ref. 2) Curated1
Sequence conflicti5G → D in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti12Q → H in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti13Q → E in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti111P → T in AAH10985 (PubMed:15489334).Curated1
Sequence conflicti274Missing in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti338G → GPCTLAAHAHYLPPLLGSAT V in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti355A → P in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti377 – 379AIA → GSPLLDCDHIRALNLCT in AAA37658 (PubMed:1427861).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqiNP_057867.2. NM_016658.3.
UniGeneiMm.439669.
Mm.488220.

Genome annotation databases

GeneIDi14430.
KEGGimmu:14430.
UCSCiuc008sjo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqiNP_057867.2. NM_016658.3.
UniGeneiMm.439669.
Mm.488220.

3D structure databases

ProteinModelPortaliQ03249.
SMRiQ03249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03249. 1 interactor.
MINTiMINT-4095581.
STRINGi10090.ENSMUSP00000081745.

PTM databases

iPTMnetiQ03249.
PhosphoSitePlusiQ03249.

Proteomic databases

EPDiQ03249.
MaxQBiQ03249.
PaxDbiQ03249.
PRIDEiQ03249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14430.
KEGGimmu:14430.
UCSCiuc008sjo.2. mouse.

Organism-specific databases

CTDi2592.
MGIiMGI:95638. Galt.

Phylogenomic databases

eggNOGiKOG2958. Eukaryota.
COG1085. LUCA.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiQ03249.
KOiK00965.
PhylomeDBiQ03249.

Enzyme and pathway databases

UniPathwayiUPA00214.
BRENDAi2.7.7.12. 3474.

Miscellaneous databases

PROiQ03249.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036073.
CleanExiMM_GALT.

Family and domain databases

Gene3Di3.30.428.10. 2 hits.
InterProiIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALT_MOUSE
AccessioniPrimary (citable) accession number: Q03249
Secondary accession number(s): Q91VQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 30, 2003
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.