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Q03249 (GALT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galactose-1-phosphate uridylyltransferase

Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene names
Name:Galt
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.

Cofactor

Binds 1 iron ion per subunit Potential.

Binds 1 zinc ion per subunit Potential.

Pathway

Carbohydrate metabolism; galactose metabolism.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Sequence caution

The sequence AAA37658.1 differs from that shown. Reason: Frameshift at positions 7 and 19.

The sequence AAA83562.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH10985.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Galactose-1-phosphate uridylyltransferase
PRO_0000169883

Sites

Active site1861Tele-UMP-histidine intermediate By similarity
Metal binding751Zinc Potential
Metal binding1841Zinc Potential
Metal binding2021Iron Potential
Metal binding3011Iron Potential
Metal binding3191Iron Potential
Metal binding3211Iron Potential

Experimental info

Sequence conflict11M → T in AAA37658. Ref.1
Sequence conflict11M → T in AAA83562. Ref.2
Sequence conflict51G → D in AAA37658. Ref.1
Sequence conflict121Q → H in AAA37658. Ref.1
Sequence conflict131Q → E in AAA37658. Ref.1
Sequence conflict1111P → T in AAH10985. Ref.3
Sequence conflict2741Missing in AAA37658. Ref.1
Sequence conflict3381G → GPCTLAAHAHYLPPLLGSAT V in AAA37658. Ref.1
Sequence conflict3551A → P in AAA37658. Ref.1
Sequence conflict377 – 3793AIA → GSPLLDCDHIRALNLCT in AAA37658. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q03249 [UniParc].

Last modified April 30, 2003. Version 3.
Checksum: 8BA5C776AF6F2D64

FASTA37943,232
        10         20         30         40         50         60 
MSHSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK RPWQGQVEPQ 

        70         80         90        100        110        120 
LLKTVPRHDP LNPLCPGATR ANGEVNPHYD GTFLFDNDFP ALQPDAPDPG PSDHPLFRAE 

       130        140        150        160        170        180 
AARGVCKVMC FHPWSDVTLP LMSVPEIRAV IDAWASVTEE LGAQYPWVQI FENKGAMMGC 

       190        200        210        220        230        240 
SNPHPHCQVW ASSFLPDIAQ REERSQQTYH SQHGKPLLLE YGHQELLRKE RLVLTSEHWI 

       250        260        270        280        290        300 
VLVPFWAVWP FQTLLLPRRH VRRLPELNPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW 

       310        320        330        340        350        360 
HGAPTGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT PEQAAERLRA 

       370 
LPEVHYCLAQ KDKETAAIA 

« Hide

References

« Hide 'large scale' references
[1]"The human galactose-1-phosphate uridyltransferase gene."
Leslie N.D., Immerman E.B., Flach J.E., Florez M., Fridovich-Keil J.L., Elsas L.J.
Genomics 14:474-480(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Mouse galactose-1-phosphate uridyl transferase (GalT) gene."
Velicescu M., Reichardt J.K.V., Dubeau L.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C129.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqNP_057867.2. NM_016658.2.
UniGeneMm.439669.

3D structure databases

ProteinModelPortalQ03249.
SMRQ03249. Positions 24-366.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ03249. 1 interaction.
MINTMINT-4095581.
STRING10090.ENSMUSP00000081745.

PTM databases

PhosphoSiteQ03249.

Proteomic databases

MaxQBQ03249.
PaxDbQ03249.
PRIDEQ03249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID14430.
KEGGmmu:14430.
UCSCuc008sjo.1. mouse.

Organism-specific databases

CTD2592.
MGIMGI:95638. Galt.

Phylogenomic databases

eggNOGCOG1085.
HOGENOMHOG000230490.
HOVERGENHBG051700.
InParanoidQ03249.
KOK00965.
PhylomeDBQ03249.

Enzyme and pathway databases

BRENDA2.7.7.12. 3474.
UniPathwayUPA00214.

Gene expression databases

ArrayExpressQ03249.
BgeeQ03249.
CleanExMM_GALT.
GenevestigatorQ03249.

Family and domain databases

Gene3D3.30.428.10. 2 hits.
InterProIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
[Graphical view]
PANTHERPTHR11943. PTHR11943. 1 hit.
PfamPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000808. GalT. 1 hit.
SUPFAMSSF54197. SSF54197. 2 hits.
TIGRFAMsTIGR00209. galT_1. 1 hit.
PROSITEPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286045.
PROQ03249.
SOURCESearch...

Entry information

Entry nameGALT_MOUSE
AccessionPrimary (citable) accession number: Q03249
Secondary accession number(s): Q91VQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 30, 2003
Last modified: May 14, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot