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Protein

Galactose-1-phosphate uridylyltransferase

Gene

Galt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in galactose metabolism.By similarity

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 zinc ions per subunit.By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Zinc 1PROSITE-ProRule annotation1
Binding sitei81UDP-alpha-D-glucose; via amide nitrogenBy similarity1
Binding sitei173UDP-alpha-D-glucose; shared with dimeric partnerBy similarity1
Metal bindingi184Zinc 1PROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediatePROSITE-ProRule annotation1
Binding sitei188UDP-alpha-D-glucoseBy similarity1
Metal bindingi202Zinc 2By similarity1
Metal bindingi301Zinc 2By similarity1
Metal bindingi319Zinc 2By similarity1
Metal bindingi321Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • galactose catabolic process via UDP-galactose Source: MGI
  • galactose metabolic process Source: MGI
  • glycolytic process from galactose Source: MGI
  • UDP-glucose metabolic process Source: UniProtKB

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.12. 3474.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferase (EC:2.7.7.12By similarity)
Short name:
Gal-1-P uridylyltransferase
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene namesi
Name:Galt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95638. Galt.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001698831 – 379Galactose-1-phosphate uridylyltransferaseAdd BLAST379

Proteomic databases

EPDiQ03249.
MaxQBiQ03249.
PaxDbiQ03249.
PRIDEiQ03249.

PTM databases

iPTMnetiQ03249.
PhosphoSitePlusiQ03249.

Expressioni

Gene expression databases

CleanExiMM_GALT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ03249. 1 interactor.
MINTiMINT-4095581.
STRINGi10090.ENSMUSP00000081745.

Structurei

3D structure databases

ProteinModelPortaliQ03249.
SMRiQ03249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 98UDP-alpha-D-glucose bindingBy similarity2
Regioni334 – 337UDP-alpha-D-glucose bindingBy similarity4
Regioni339 – 340UDP-alpha-D-glucose bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2958. Eukaryota.
COG1085. LUCA.
HOGENOMiHOG000230490.
HOVERGENiHBG051700.
InParanoidiQ03249.
KOiK00965.
PhylomeDBiQ03249.

Family and domain databases

CDDicd00608. GalT. 1 hit.
Gene3Di3.30.428.10. 2 hits.
InterProiView protein in InterPro
IPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. HIT-like.
PANTHERiPTHR11943. PTHR11943. 1 hit.
PfamiView protein in Pfam
PF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
PIRSFiPIRSF000808. GalT. 1 hit.
SUPFAMiSSF54197. SSF54197. 2 hits.
TIGRFAMsiTIGR00209. galT_1. 1 hit.
PROSITEiView protein in PROSITE
PS00117. GAL_P_UDP_TRANSF_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHSGADPEQ RQQASEADAM AATFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPQ LLKTVPRHDP LNPLCPGATR ANGEVNPHYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPDPG PSDHPLFRAE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
IDAWASVTEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDIAQ
210 220 230 240 250
REERSQQTYH SQHGKPLLLE YGHQELLRKE RLVLTSEHWI VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VRRLPELNPA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGLKTG ATCDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYCLAQ KDKETAAIA
Length:379
Mass (Da):43,232
Last modified:April 30, 2003 - v3
Checksum:i8BA5C776AF6F2D64
GO

Sequence cautioni

The sequence AAA37658 differs from that shown. Reason: Frameshift at positions 7 and 19.Curated
The sequence AAA83562 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10985 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti1M → T in AAA83562 (Ref. 2) Curated1
Sequence conflicti5G → D in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti12Q → H in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti13Q → E in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti111P → T in AAH10985 (PubMed:15489334).Curated1
Sequence conflicti274Missing in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti338G → GPCTLAAHAHYLPPLLGSAT V in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti355A → P in AAA37658 (PubMed:1427861).Curated1
Sequence conflicti377 – 379AIA → GSPLLDCDHIRALNLCT in AAA37658 (PubMed:1427861).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96265 mRNA. Translation: AAA37658.1. Frameshift.
U41282 Genomic DNA. Translation: AAA83562.1. Different initiation.
BC010985 mRNA. Translation: AAH10985.2. Different initiation.
RefSeqiNP_057867.2. NM_016658.3.
UniGeneiMm.439669.
Mm.488220.

Genome annotation databases

GeneIDi14430.
KEGGimmu:14430.
UCSCiuc008sjo.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGALT_MOUSE
AccessioniPrimary (citable) accession number: Q03249
Secondary accession number(s): Q91VQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 30, 2003
Last modified: September 27, 2017
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families