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Protein

37S ribosomal protein S17, mitochondrial

Gene

MRPS17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). uS17m may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521).2 Publications1 Publication

Miscellaneous

Present with 2810 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
Biological processSporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32876-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S17, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS17m1 Publication
Gene namesi
Name:MRPS17
Ordered Locus Names:YMR188C
ORF Names:YM8010.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR188C.
SGDiS000004800. MRPS17.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: GO_Central
  • mitochondrial small ribosomal subunit Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001285251 – 23737S ribosomal protein S17, mitochondrialAdd BLAST237

Proteomic databases

MaxQBiQ03246.
PRIDEiQ03246.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Protein-protein interaction databases

BioGridi35366. 46 interactors.
DIPiDIP-6688N.
IntActiQ03246. 6 interactors.
MINTiMINT-615939.
STRINGi4932.YMR188C.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25QQ1-237[»]
5MREelectron microscopy3.75QQ1-237[»]
5MRFelectron microscopy4.97QQ1-237[»]
ProteinModelPortaliQ03246.
SMRiQ03246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248070.
InParanoidiQ03246.
KOiK02961.
OMAiKDYLVHD.
OrthoDBiEOG092C5UXJ.

Family and domain databases

InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR000266. Ribosomal_S17/S11.
PANTHERiPTHR10744. PTHR10744. 1 hit.
PfamiView protein in Pfam
PF00366. Ribosomal_S17. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001295. Ribosomal_S17. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARQNFLGLV VSQGKMQKTV KVRVETKVFN KKINKELFHR RDYLVHDEGE
60 70 80 90 100
ISREGDLVRI EATRPLSKRK FFAIAEIIRN KGQQFALYES EAQLSVAKEE
110 120 130 140 150
AQKAKEFLDK RSVRENKLNE KTTLLRDIRT IQDALSSGST PKELLEIKQR
160 170 180 190 200
YGIQDFSQET VRQLLQLDIS GLEVNLEKQR SLIDRIQTRL SELLSNDLKC
210 220 230
DQFLKDHGVE DPLTLKKNIK KNLLRKHVMM DMQQPSQ
Length:237
Mass (Da):27,635
Last modified:November 1, 1997 - v1
Checksum:iF9D606434D1310D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA. Translation: CAA89921.1.
U20641 Genomic DNA. Translation: AAB18932.1.
BK006946 Genomic DNA. Translation: DAA10086.1.
PIRiS55135.
RefSeqiNP_013913.1. NM_001182694.1.

Genome annotation databases

EnsemblFungiiYMR188C; YMR188C; YMR188C.
GeneIDi855226.
KEGGisce:YMR188C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT17_YEAST
AccessioniPrimary (citable) accession number: Q03246
Secondary accession number(s): D6W012, Q02523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names