Q03246 (RT17_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
37S ribosomal protein S17, mitochondrial

Gene names

Name:	MRPS17
Ordered Locus Names:	YMR188C
ORF Names:	YM8010.18C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a meiosis-specific role as it accumulates during the middle stage of sporulation. Ref.8
Subunit structure	Component of the mitochondrial small ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.4
Subcellular location	Mitochondrion Ref.5 Ref.7 Ref.8.
Miscellaneous	Present with 2810 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ribosomal protein S17P family.

Ontologies

Keywords
Biological process	Sporulation
Cellular component	Mitochondrion
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial translation Inferred by curator Ref.4. Source: SGD sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial small ribosomal subunit Inferred from physical interaction Ref.4. Source: SGD
Molecular_function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from physical interaction Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	37S ribosomal protein S17, mitochondrial		PRO_0000128525

Sequences

	Sequence		Length	Mass (Da)
	Q03246 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: F9D606434D1310D6	FASTA	237	27,635
	10 20 30 40 50 60 MARQNFLGLV VSQGKMQKTV KVRVETKVFN KKINKELFHR RDYLVHDEGE ISREGDLVRI 70 80 90 100 110 120 EATRPLSKRK FFAIAEIIRN KGQQFALYES EAQLSVAKEE AQKAKEFLDK RSVRENKLNE 130 140 150 160 170 180 KTTLLRDIRT IQDALSSGST PKELLEIKQR YGIQDFSQET VRQLLQLDIS GLEVNLEKQR 190 200 210 220 230 SLIDRIQTRL SELLSNDLKC DQFLKDHGVE DPLTLKKNIK KNLLRKHVMM DMQQPSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Genetics of the synthesis of serine from glycine and the utilization of glycine as sole nitrogen source by Saccharomyces cerevisiae." Sinclair D.A., Dawes I.W. Genetics 140:1213-1222(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47.
[4]	"Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components." Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K. Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL SMALL COMPLEX, MASS SPECTROMETRY.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
[8]	"Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae." Hanlon S.E., Xu Z., Norris D.N., Vershon A.K. Yeast 21:1241-1252(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49808 Genomic DNA. Translation: CAA89921.1. U20641 Genomic DNA. Translation: AAB18932.1. BK006946 Genomic DNA. Translation: DAA10086.1.
PIR	S55135.
RefSeq	NP_013913.1. NM_001182694.1.
3D structure databases
ProteinModelPortal	Q03246.
SMR	Q03246. Positions 3-84.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6688N.
IntAct	Q03246. 6 interactions.
MINT	MINT-615939.
Proteomic databases
PaxDb	Q03246.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR188C; YMR188C; YMR188C.
GeneID	855226.
KEGG	sce:YMR188C.
Organism-specific databases
CYGD	YMR188c.
SGD	S000004800. MRPS17.
Phylogenomic databases
eggNOG	COG0186.
HOGENOM	HOG000248070.
KO	K02961.
OMA	KMQKTVK.
OrthoDB	EOG466ZWW.
Gene expression databases
Genevestigator	Q03246.
GermOnline	YMR188C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR012340. NA-bd_OB-fold. IPR000266. Ribosomal_S17. [Graphical view]
PANTHER	PTHR10744. PTHR10744. 1 hit.
Pfam	PF00366. Ribosomal_S17. 1 hit. [Graphical view]
ProDom	PD001295. Ribosomal_S17. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
PROSITE	PS00056. RIBOSOMAL_S17. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	978756.

Entry information

Entry name

RT17_YEAST

Accession

Primary (citable) accession number: Q03246
Secondary accession number(s): D6W012, Q02523

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program