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Protein

37S ribosomal protein S17, mitochondrial

Gene

MRPS17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). uS17m may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521).2 Publications1 Publication

Miscellaneous

Present with 2810 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
Biological processSporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32876-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S17, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS17m1 Publication
Gene namesi
Name:MRPS17
Ordered Locus Names:YMR188C
ORF Names:YM8010.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR188C
SGDiS000004800 MRPS17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001285251 – 23737S ribosomal protein S17, mitochondrialAdd BLAST237

Proteomic databases

MaxQBiQ03246
PaxDbiQ03246
PRIDEiQ03246

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Protein-protein interaction databases

BioGridi35366, 49 interactors
DIPiDIP-6688N
IntActiQ03246, 6 interactors
MINTiQ03246
STRINGi4932.YMR188C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25QQ1-237[»]
5MREelectron microscopy3.75QQ1-237[»]
5MRFelectron microscopy4.97QQ1-237[»]
ProteinModelPortaliQ03246
SMRiQ03246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248070
InParanoidiQ03246
KOiK02961
OMAiKDYLVHD
OrthoDBiEOG092C5UXJ

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000266 Ribosomal_S17/S11
PANTHERiPTHR10744 PTHR10744, 1 hit
PfamiView protein in Pfam
PF00366 Ribosomal_S17, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001295 Ribosomal_S17, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequencei

Sequence statusi: Complete.

Q03246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARQNFLGLV VSQGKMQKTV KVRVETKVFN KKINKELFHR RDYLVHDEGE
60 70 80 90 100
ISREGDLVRI EATRPLSKRK FFAIAEIIRN KGQQFALYES EAQLSVAKEE
110 120 130 140 150
AQKAKEFLDK RSVRENKLNE KTTLLRDIRT IQDALSSGST PKELLEIKQR
160 170 180 190 200
YGIQDFSQET VRQLLQLDIS GLEVNLEKQR SLIDRIQTRL SELLSNDLKC
210 220 230
DQFLKDHGVE DPLTLKKNIK KNLLRKHVMM DMQQPSQ
Length:237
Mass (Da):27,635
Last modified:November 1, 1997 - v1
Checksum:iF9D606434D1310D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA Translation: CAA89921.1
U20641 Genomic DNA Translation: AAB18932.1
BK006946 Genomic DNA Translation: DAA10086.1
PIRiS55135
RefSeqiNP_013913.1, NM_001182694.1

Genome annotation databases

EnsemblFungiiYMR188C; YMR188C; YMR188C
GeneIDi855226
KEGGisce:YMR188C

Similar proteinsi

Entry informationi

Entry nameiRT17_YEAST
AccessioniPrimary (citable) accession number: Q03246
Secondary accession number(s): D6W012, Q02523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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