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Protein

Myb-related protein B

Gene

MYBL2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi54 – 7724H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi106 – 12924H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi157 – 18024H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-related protein B
Short name:
B-Myb
Alternative name(s):
Myb-like protein 2
Gene namesi
Name:MYBL2
Synonyms:BMYB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Myb-related protein BPRO_0000197060Add
BLAST

Proteomic databases

PaxDbiQ03237.

Expressioni

Tissue specificityi

Expressed in hematopoietic and non hematopoietic cells.

Interactioni

Subunit structurei

Component of the DREAM complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033926.

Structurei

Secondary structure

1
686
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi88 – 10114Combined sources
Helixi106 – 1127Combined sources
Helixi122 – 1254Combined sources
Beta strandi133 – 1375Combined sources
Helixi140 – 1478Combined sources
Turni148 – 1525Combined sources
Helixi157 – 1637Combined sources
Helixi169 – 17810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A5JNMR-A79-186[»]
ProteinModelPortaliQ03237.
SMRiQ03237. Positions 31-186.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03237.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7752HTH myb-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 13356HTH myb-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 18451HTH myb-type 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiQ03237.
KOiK09421.
PhylomeDBiQ03237.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR028311. MYBL2.
IPR001005. SANT/Myb.
[Graphical view]
PANTHERiPTHR10641:SF461. PTHR10641:SF461. 1 hit.
PfamiPF09316. Cmyb_C. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRSRGEDQ DELHCQDTDS DVPEQRDGRC KVKWTQEEDE QLKMLVRHYG
60 70 80 90 100
QNDWKFLASH FPNRSDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK
110 120 130 140 150
YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSSWTE EEDRIIFEAH
160 170 180 190 200
KVLGNRWAEI AKLLPGRTDN AVKNHWNSTI KRKVDTGGFL NETKESQPLY
210 220 230 240 250
LLVEVDDNES QSGTRAESQT IVPNWPVDIS EIKEEDVSDE EVTGLQELPS
260 270 280 290 300
ELPAADLAEH NEEGTPDDVV PEDASASVAS PYKWVVEAAN YLCPTSVPAL
310 320 330 340 350
NEALDMIESD PDGWCDLTQF DLPEEPSAGS SSSSNSPVRQ TPSKPTPSLP
360 370 380 390 400
NVTEYRLDGH TISDLSKSRK GELIPISPHA EVSFGTPPSV LKRQKKRKIS
410 420 430 440 450
LSPVTENAPS TSLSFLDSCN SMTPKSTPVK TLPFSPSQFL NFWTKQDTLE
460 470 480 490 500
LENPSLTSTP VCSQKVIVTT PLHRDKTPLL QKNSAFVTPD QKYVVDNTPH
510 520 530 540 550
TPTPFKNALE KYGPIRPLPQ TPHLEEDLKE VLRSEAGIEL IIEDDVKPHK
560 570 580 590 600
QKRKQGLRRS PIKKVRKSLA LDIVDEDMTQ NMPALPKTIC FKRTQPVNFL
610 620 630 640 650
SRSLNLSSSN RKNDSGLLNR AFVQVQSEKM SYRKMPSHFR PPAPMTRAWK
660 670 680
AVACGGTQDQ LFMQEKARQF LGTLKQSHTS RTLILS
Length:686
Mass (Da):77,737
Last modified:October 1, 1993 - v1
Checksum:i2D1209EAD6489D7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67505 mRNA. Translation: CAA47839.1.
PIRiS28050.
RefSeqiNP_990649.1. NM_205318.1.
UniGeneiGga.4532.

Genome annotation databases

GeneIDi396258.
KEGGigga:396258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67505 mRNA. Translation: CAA47839.1.
PIRiS28050.
RefSeqiNP_990649.1. NM_205318.1.
UniGeneiGga.4532.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A5JNMR-A79-186[»]
ProteinModelPortaliQ03237.
SMRiQ03237. Positions 31-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033926.

Proteomic databases

PaxDbiQ03237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396258.
KEGGigga:396258.

Organism-specific databases

CTDi4605.

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiQ03237.
KOiK09421.
PhylomeDBiQ03237.

Miscellaneous databases

EvolutionaryTraceiQ03237.
NextBioi20816310.
PROiQ03237.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR028311. MYBL2.
IPR001005. SANT/Myb.
[Graphical view]
PANTHERiPTHR10641:SF461. PTHR10641:SF461. 1 hit.
PfamiPF09316. Cmyb_C. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Functional antagonism between members of the myb family: B-myb inhibits v-myb-induced gene activation."
    Foos G., Grimm S., Klempnauer K.-H.
    EMBO J. 11:4619-4629(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression."
    McIntosh P.B., Frenkiel T.A., Wollborn U., McCormick J.E., Klempnauer K.H., Feeney J., Carr M.D.
    Biochemistry 37:9619-9629(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 79-186.

Entry informationi

Entry nameiMYBB_CHICK
AccessioniPrimary (citable) accession number: Q03237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 20, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.