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Protein

Alpha1-proteinase inhibitor-degradation deficient protein 37

Gene

ADD37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ER-associated protein degradation (ERAD).1 Publication

Miscellaneous

Present with 1270 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • ubiquitin-dependent ERAD pathway Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32872-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha1-proteinase inhibitor-degradation deficient protein 37
Gene namesi
Name:ADD37
Ordered Locus Names:YMR184W
ORF Names:YM8010.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR184W
SGDiS000004796 ADD37

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033211 – 198Alpha1-proteinase inhibitor-degradation deficient protein 37Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03233
PaxDbiQ03233
PRIDEiQ03233

PTM databases

iPTMnetiQ03233

Expressioni

Inductioni

In response to the DNA-damaging agent MMS.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi35362, 67 interactors
DIPiDIP-3848N
IntActiQ03233, 2 interactors
MINTiQ03233
STRINGi4932.YMR184W

Structurei

3D structure databases

ProteinModelPortaliQ03233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000033805
InParanoidiQ03233
OMAiPGYNDCP
OrthoDBiEOG092C5QPK

Sequencei

Sequence statusi: Complete.

Q03233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKPTKSFQ NCLEAEVPGY NDCPTVLFSI DPNSGPRSKS KQRTKSKRCV
60 70 80 90 100
SGRLATEVLD LYGNTKTATT PPPVLRRPSV TAAQQESACE GVLVKDQGDR
110 120 130 140 150
QLQPILCSKE ELVAKINDLC VCGSKLSSKE LEFYKKKLDS NITKILQNEH
160 170 180 190
TKTVLSQIFN EKDKNMAVKT IKHWMVTDTT ISNWCPAFLK IFENAMPN
Length:198
Mass (Da):22,110
Last modified:November 1, 1997 - v1
Checksum:i2716B90391A82092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA Translation: CAA89917.1
AY557970 Genomic DNA Translation: AAS56296.1
BK006946 Genomic DNA Translation: DAA10082.1
PIRiS55131
RefSeqiNP_013909.1, NM_001182690.1

Genome annotation databases

EnsemblFungiiYMR184W; YMR184W; YMR184W
GeneIDi855222
KEGGisce:YMR184W

Similar proteinsi

Entry informationi

Entry nameiADD37_YEAST
AccessioniPrimary (citable) accession number: Q03233
Secondary accession number(s): D6W008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health