Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q03233

- ADD37_YEAST

UniProt

Q03233 - ADD37_YEAST

Protein

Alpha1-proteinase inhibitor-degradation deficient protein 37

Gene

ADD37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in ER-associated protein degradation (ERAD).1 Publication

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32872-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha1-proteinase inhibitor-degradation deficient protein 37
    Gene namesi
    Name:ADD37
    Ordered Locus Names:YMR184W
    ORF Names:YM8010.14
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR184w.
    SGDiS000004796. ADD37.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Alpha1-proteinase inhibitor-degradation deficient protein 37PRO_0000203321Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ03233.
    PaxDbiQ03233.
    PeptideAtlasiQ03233.

    Expressioni

    Inductioni

    In response to the DNA-damaging agent MMS.1 Publication

    Gene expression databases

    GenevestigatoriQ03233.

    Interactioni

    Protein-protein interaction databases

    BioGridi35362. 22 interactions.
    DIPiDIP-3848N.
    IntActiQ03233. 1 interaction.
    MINTiMINT-536444.
    STRINGi4932.YMR184W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG69217.
    HOGENOMiHOG000033805.
    OMAiANETEPI.
    OrthoDBiEOG7VHT9J.

    Sequencei

    Sequence statusi: Complete.

    Q03233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIKPTKSFQ NCLEAEVPGY NDCPTVLFSI DPNSGPRSKS KQRTKSKRCV    50
    SGRLATEVLD LYGNTKTATT PPPVLRRPSV TAAQQESACE GVLVKDQGDR 100
    QLQPILCSKE ELVAKINDLC VCGSKLSSKE LEFYKKKLDS NITKILQNEH 150
    TKTVLSQIFN EKDKNMAVKT IKHWMVTDTT ISNWCPAFLK IFENAMPN 198
    Length:198
    Mass (Da):22,110
    Last modified:November 1, 1997 - v1
    Checksum:i2716B90391A82092
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49808 Genomic DNA. Translation: CAA89917.1.
    AY557970 Genomic DNA. Translation: AAS56296.1.
    BK006946 Genomic DNA. Translation: DAA10082.1.
    PIRiS55131.
    RefSeqiNP_013909.1. NM_001182690.1.

    Genome annotation databases

    EnsemblFungiiYMR184W; YMR184W; YMR184W.
    GeneIDi855222.
    KEGGisce:YMR184W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49808 Genomic DNA. Translation: CAA89917.1 .
    AY557970 Genomic DNA. Translation: AAS56296.1 .
    BK006946 Genomic DNA. Translation: DAA10082.1 .
    PIRi S55131.
    RefSeqi NP_013909.1. NM_001182690.1.

    3D structure databases

    ProteinModelPortali Q03233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35362. 22 interactions.
    DIPi DIP-3848N.
    IntActi Q03233. 1 interaction.
    MINTi MINT-536444.
    STRINGi 4932.YMR184W.

    Proteomic databases

    MaxQBi Q03233.
    PaxDbi Q03233.
    PeptideAtlasi Q03233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR184W ; YMR184W ; YMR184W .
    GeneIDi 855222.
    KEGGi sce:YMR184W.

    Organism-specific databases

    CYGDi YMR184w.
    SGDi S000004796. ADD37.

    Phylogenomic databases

    eggNOGi NOG69217.
    HOGENOMi HOG000033805.
    OMAi ANETEPI.
    OrthoDBi EOG7VHT9J.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32872-MONOMER.

    Miscellaneous databases

    NextBioi 978744.

    Gene expression databases

    Genevestigatori Q03233.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation."
      Palmer E.A., Kruse K.B., Fewell S.W., Buchanan S.M., Brodsky J.L., McCracken A.A.
      J. Cell Sci. 116:2361-2373(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "Global protein expression profiling of budding yeast in response to DNA damage."
      Lee M.-W., Kim B.-J., Choi H.-K., Ryu M.-J., Kim S.-B., Kang K.-M., Cho E.-J., Youn H.-D., Huh W.-K., Kim S.-T.
      Yeast 24:145-154(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADD37_YEAST
    AccessioniPrimary (citable) accession number: Q03233
    Secondary accession number(s): D6W008
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1270 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3