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Q03233

- ADD37_YEAST

UniProt

Q03233 - ADD37_YEAST

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Protein

Alpha1-proteinase inhibitor-degradation deficient protein 37

Gene

ADD37

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in ER-associated protein degradation (ERAD).1 Publication

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32872-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha1-proteinase inhibitor-degradation deficient protein 37
Gene namesi
Name:ADD37
Ordered Locus Names:YMR184W
ORF Names:YM8010.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR184w.
SGDiS000004796. ADD37.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Alpha1-proteinase inhibitor-degradation deficient protein 37PRO_0000203321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03233.
PaxDbiQ03233.
PeptideAtlasiQ03233.

Expressioni

Inductioni

In response to the DNA-damaging agent MMS.1 Publication

Gene expression databases

GenevestigatoriQ03233.

Interactioni

Protein-protein interaction databases

BioGridi35362. 23 interactions.
DIPiDIP-3848N.
IntActiQ03233. 1 interaction.
MINTiMINT-536444.
STRINGi4932.YMR184W.

Structurei

3D structure databases

ProteinModelPortaliQ03233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG69217.
HOGENOMiHOG000033805.
InParanoidiQ03233.
OMAiANETEPI.
OrthoDBiEOG7VHT9J.

Sequencei

Sequence statusi: Complete.

Q03233-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIKPTKSFQ NCLEAEVPGY NDCPTVLFSI DPNSGPRSKS KQRTKSKRCV
60 70 80 90 100
SGRLATEVLD LYGNTKTATT PPPVLRRPSV TAAQQESACE GVLVKDQGDR
110 120 130 140 150
QLQPILCSKE ELVAKINDLC VCGSKLSSKE LEFYKKKLDS NITKILQNEH
160 170 180 190
TKTVLSQIFN EKDKNMAVKT IKHWMVTDTT ISNWCPAFLK IFENAMPN
Length:198
Mass (Da):22,110
Last modified:November 1, 1997 - v1
Checksum:i2716B90391A82092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA. Translation: CAA89917.1.
AY557970 Genomic DNA. Translation: AAS56296.1.
BK006946 Genomic DNA. Translation: DAA10082.1.
PIRiS55131.
RefSeqiNP_013909.1. NM_001182690.1.

Genome annotation databases

EnsemblFungiiYMR184W; YMR184W; YMR184W.
GeneIDi855222.
KEGGisce:YMR184W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA. Translation: CAA89917.1 .
AY557970 Genomic DNA. Translation: AAS56296.1 .
BK006946 Genomic DNA. Translation: DAA10082.1 .
PIRi S55131.
RefSeqi NP_013909.1. NM_001182690.1.

3D structure databases

ProteinModelPortali Q03233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35362. 23 interactions.
DIPi DIP-3848N.
IntActi Q03233. 1 interaction.
MINTi MINT-536444.
STRINGi 4932.YMR184W.

Proteomic databases

MaxQBi Q03233.
PaxDbi Q03233.
PeptideAtlasi Q03233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR184W ; YMR184W ; YMR184W .
GeneIDi 855222.
KEGGi sce:YMR184W.

Organism-specific databases

CYGDi YMR184w.
SGDi S000004796. ADD37.

Phylogenomic databases

eggNOGi NOG69217.
HOGENOMi HOG000033805.
InParanoidi Q03233.
OMAi ANETEPI.
OrthoDBi EOG7VHT9J.

Enzyme and pathway databases

BioCyci YEAST:G3O-32872-MONOMER.

Miscellaneous databases

NextBioi 978744.

Gene expression databases

Genevestigatori Q03233.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation."
    Palmer E.A., Kruse K.B., Fewell S.W., Buchanan S.M., Brodsky J.L., McCracken A.A.
    J. Cell Sci. 116:2361-2373(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global protein expression profiling of budding yeast in response to DNA damage."
    Lee M.-W., Kim B.-J., Choi H.-K., Ryu M.-J., Kim S.-B., Kang K.-M., Cho E.-J., Youn H.-D., Huh W.-K., Kim S.-T.
    Yeast 24:145-154(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADD37_YEAST
AccessioniPrimary (citable) accession number: Q03233
Secondary accession number(s): D6W008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1270 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3