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Q03233

- ADD37_YEAST

UniProt

Q03233 - ADD37_YEAST

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Protein
Alpha1-proteinase inhibitor-degradation deficient protein 37
Gene
ADD37, YMR184W, YM8010.14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in ER-associated protein degradation (ERAD).1 Publication

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32872-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha1-proteinase inhibitor-degradation deficient protein 37
Gene namesi
Name:ADD37
Ordered Locus Names:YMR184W
ORF Names:YM8010.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR184w.
SGDiS000004796. ADD37.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Alpha1-proteinase inhibitor-degradation deficient protein 37
PRO_0000203321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03233.
PaxDbiQ03233.
PeptideAtlasiQ03233.

Expressioni

Inductioni

In response to the DNA-damaging agent MMS.1 Publication

Gene expression databases

GenevestigatoriQ03233.

Interactioni

Protein-protein interaction databases

BioGridi35362. 22 interactions.
DIPiDIP-3848N.
IntActiQ03233. 1 interaction.
MINTiMINT-536444.
STRINGi4932.YMR184W.

Structurei

3D structure databases

ProteinModelPortaliQ03233.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG69217.
HOGENOMiHOG000033805.
OMAiANETEPI.
OrthoDBiEOG7VHT9J.

Sequencei

Sequence statusi: Complete.

Q03233-1 [UniParc]FASTAAdd to Basket

« Hide

MAIKPTKSFQ NCLEAEVPGY NDCPTVLFSI DPNSGPRSKS KQRTKSKRCV    50
SGRLATEVLD LYGNTKTATT PPPVLRRPSV TAAQQESACE GVLVKDQGDR 100
QLQPILCSKE ELVAKINDLC VCGSKLSSKE LEFYKKKLDS NITKILQNEH 150
TKTVLSQIFN EKDKNMAVKT IKHWMVTDTT ISNWCPAFLK IFENAMPN 198
Length:198
Mass (Da):22,110
Last modified:November 1, 1997 - v1
Checksum:i2716B90391A82092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49808 Genomic DNA. Translation: CAA89917.1.
AY557970 Genomic DNA. Translation: AAS56296.1.
BK006946 Genomic DNA. Translation: DAA10082.1.
PIRiS55131.
RefSeqiNP_013909.1. NM_001182690.1.

Genome annotation databases

EnsemblFungiiYMR184W; YMR184W; YMR184W.
GeneIDi855222.
KEGGisce:YMR184W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49808 Genomic DNA. Translation: CAA89917.1 .
AY557970 Genomic DNA. Translation: AAS56296.1 .
BK006946 Genomic DNA. Translation: DAA10082.1 .
PIRi S55131.
RefSeqi NP_013909.1. NM_001182690.1.

3D structure databases

ProteinModelPortali Q03233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35362. 22 interactions.
DIPi DIP-3848N.
IntActi Q03233. 1 interaction.
MINTi MINT-536444.
STRINGi 4932.YMR184W.

Proteomic databases

MaxQBi Q03233.
PaxDbi Q03233.
PeptideAtlasi Q03233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR184W ; YMR184W ; YMR184W .
GeneIDi 855222.
KEGGi sce:YMR184W.

Organism-specific databases

CYGDi YMR184w.
SGDi S000004796. ADD37.

Phylogenomic databases

eggNOGi NOG69217.
HOGENOMi HOG000033805.
OMAi ANETEPI.
OrthoDBi EOG7VHT9J.

Enzyme and pathway databases

BioCyci YEAST:G3O-32872-MONOMER.

Miscellaneous databases

NextBioi 978744.

Gene expression databases

Genevestigatori Q03233.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation."
    Palmer E.A., Kruse K.B., Fewell S.W., Buchanan S.M., Brodsky J.L., McCracken A.A.
    J. Cell Sci. 116:2361-2373(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global protein expression profiling of budding yeast in response to DNA damage."
    Lee M.-W., Kim B.-J., Choi H.-K., Ryu M.-J., Kim S.-B., Kang K.-M., Cho E.-J., Youn H.-D., Huh W.-K., Kim S.-T.
    Yeast 24:145-154(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADD37_YEAST
AccessioniPrimary (citable) accession number: Q03233
Secondary accession number(s): D6W008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1270 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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