Q03233 (ADD37_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha1-proteinase inhibitor-degradation deficient protein 37

Gene names

Name:	ADD37
Ordered Locus Names:	YMR184W
ORF Names:	YM8010.14

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in ER-associated protein degradation (ERAD). Ref.4
Subcellular location	Cytoplasm Ref.5.
Induction	In response to the DNA-damaging agent MMS. Ref.9
Miscellaneous	Present with 1270 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER-associated protein catabolic process Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Alpha1-proteinase inhibitor-degradation deficient protein 37		PRO_0000203321
Amino acid modifications
	Modified residue	70	1	Phosphothreonine Ref.10
	Modified residue	79	1	Phosphoserine Ref.7 Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q03233 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 2716B90391A82092	FASTA	198	22,110
	10 20 30 40 50 60 MAIKPTKSFQ NCLEAEVPGY NDCPTVLFSI DPNSGPRSKS KQRTKSKRCV SGRLATEVLD 70 80 90 100 110 120 LYGNTKTATT PPPVLRRPSV TAAQQESACE GVLVKDQGDR QLQPILCSKE ELVAKINDLC 130 140 150 160 170 180 VCGSKLSSKE LEFYKKKLDS NITKILQNEH TKTVLSQIFN EKDKNMAVKT IKHWMVTDTT 190 ISNWCPAFLK IFENAMPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation." Palmer E.A., Kruse K.B., Fewell S.W., Buchanan S.M., Brodsky J.L., McCracken A.A. J. Cell Sci. 116:2361-2373(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, MASS SPECTROMETRY. Strain: ADR376.
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, MASS SPECTROMETRY.
[9]	"Global protein expression profiling of budding yeast in response to DNA damage." Lee M.-W., Kim B.-J., Choi H.-K., Ryu M.-J., Kim S.-B., Kang K.-M., Cho E.-J., Youn H.-D., Huh W.-K., Kim S.-T. Yeast 24:145-154(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[10]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-70, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49808 Genomic DNA. Translation: CAA89917.1. AY557970 Genomic DNA. Translation: AAS56296.1. BK006946 Genomic DNA. Translation: DAA10082.1.
PIR	S55131.
RefSeq	NP_013909.1. NM_001182690.1.
3D structure databases
ProteinModelPortal	Q03233.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3848N.
IntAct	Q03233. 1 interaction.
MINT	MINT-536444.
STRING	4932.YMR184W.
Proteomic databases
PaxDb	Q03233.
PeptideAtlas	Q03233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR184W; YMR184W; YMR184W.
GeneID	855222.
KEGG	sce:YMR184W.
Organism-specific databases
CYGD	YMR184w.
SGD	S000004796. ADD37.
Phylogenomic databases
eggNOG	NOG69217.
HOGENOM	HOG000033805.
OMA	PGYNDCP.
OrthoDB	EOG4MKRS5.
Gene expression databases
Genevestigator	Q03233.
GermOnline	YMR184W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	978744.

Entry information

Entry name

ADD37_YEAST

Accession

Primary (citable) accession number: Q03233
Secondary accession number(s): D6W008

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program