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Protein

Polynucleotide 5'-triphosphatase

Gene

CTL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in an RNA processing event other than mRNA capping. Releases gamma-phosphate from the 5'-end of RNA to produce a diphosphate terminus.

Catalytic activityi

A 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate.

Cofactori

Mg2+, Mn2+Note: Magnesium and/or manganese. Specific for polynucleotide RNA in the presence of magnesium, but becomes specific for nucleotide triphosphates in the presence of manganese.

GO - Molecular functioni

  • polynucleotide 5'-phosphatase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32868-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polynucleotide 5'-triphosphatase (EC:3.1.3.33)
Alternative name(s):
mRNA 5'-triphosphatase
Short name:
TPase
Gene namesi
Name:CTL1
Ordered Locus Names:YMR180C
ORF Names:YM8010.10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR180C
SGDiS000004792 CTL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101201 – 320Polynucleotide 5'-triphosphataseAdd BLAST320

Proteomic databases

MaxQBiQ03220
PaxDbiQ03220
PRIDEiQ03220

Interactioni

Protein-protein interaction databases

BioGridi35358, 75 interactors
DIPiDIP-1776N
IntActiQ03220, 1 interactor
MINTiQ03220
STRINGi4932.YMR180C

Structurei

3D structure databases

ProteinModelPortaliQ03220
SMRiQ03220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fungal TPase family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000067072
KOiK01098
OrthoDBiEOG092C2R8I

Family and domain databases

CDDicd07470 CYTH-like_mRNA_RTPase, 1 hit
Gene3Di3.20.100.10, 1 hit
InterProiView protein in InterPro
IPR033469 CYTH-like_dom_sf
IPR004206 mRNA_triPase_Cet1
IPR037009 mRNA_triPase_Cet1_sf
PfamiView protein in Pfam
PF02940 mRNA_triPase, 1 hit
SUPFAMiSSF55154 SSF55154, 1 hit

Sequencei

Sequence statusi: Complete.

Q03220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQPETPSN SRNSHENVGA KKADANVASK FRSLHISETT KPLTSTRALY
60 70 80 90 100
KTTRNNSRGA TEFHKHVCKL AWKYLACIDK SSISHIEIEM KFGVITDKRT
110 120 130 140 150
HRRMTPHNKP FIVQNRNGRL VSNVPEQMFS SFQELLRSKS ENPSKCAPRV
160 170 180 190 200
VKQVQKYTKD SIYNCNNASK VGKLTSWRCS EDLRNKELKL TYIKKVRVKD
210 220 230 240 250
FLIRYPQSSL DAKISISLEV PEYETSAAFR NGFILQRTKS RSTYTFNDKM
260 270 280 290 300
PLHLDLTKVT TTRRNSHQYT SHEVEVEMDP IFKETISAND REKFNEYMCS
310 320
FLNASDLIRK AAERDNMLTT
Length:320
Mass (Da):36,974
Last modified:November 1, 1997 - v1
Checksum:i82EFBDF3E100B57B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49808 Genomic DNA Translation: CAA89913.1
AY693065 Genomic DNA Translation: AAT93084.1
BK006946 Genomic DNA Translation: DAA10077.1
PIRiS55127
RefSeqiNP_013905.1, NM_001182686.1

Genome annotation databases

EnsemblFungiiYMR180C; YMR180C; YMR180C
GeneIDi855218
KEGGisce:YMR180C

Similar proteinsi

Entry informationi

Entry nameiCTL1_YEAST
AccessioniPrimary (citable) accession number: Q03220
Secondary accession number(s): D6W003
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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