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Protein

Nisin biosynthesis protein NisC

Gene

nisC

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Could be implicated in the processing or the export process of the nisin lantibiotic.

Names & Taxonomyi

Protein namesi
Recommended name:
Nisin biosynthesis protein NisC
Gene namesi
Name:nisC
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Nisin biosynthesis protein NisCPRO_0000096864Add
BLAST

Structurei

Secondary structure

1
418
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2618Combined sources
Helixi34 – 374Combined sources
Turni39 – 413Combined sources
Helixi43 – 519Combined sources
Turni52 – 554Combined sources
Helixi59 – 8022Combined sources
Turni87 – 893Combined sources
Helixi91 – 988Combined sources
Helixi99 – 1013Combined sources
Turni102 – 1043Combined sources
Helixi106 – 12823Combined sources
Helixi132 – 1343Combined sources
Helixi137 – 1404Combined sources
Beta strandi141 – 1455Combined sources
Helixi146 – 1538Combined sources
Helixi159 – 1613Combined sources
Helixi162 – 17413Combined sources
Beta strandi180 – 1823Combined sources
Helixi189 – 1913Combined sources
Beta strandi192 – 1943Combined sources
Helixi195 – 2006Combined sources
Beta strandi205 – 2073Combined sources
Turni210 – 2123Combined sources
Helixi214 – 22714Combined sources
Helixi232 – 24817Combined sources
Helixi252 – 2543Combined sources
Beta strandi260 – 2623Combined sources
Helixi264 – 2696Combined sources
Beta strandi283 – 2864Combined sources
Helixi287 – 30014Combined sources
Helixi304 – 32017Combined sources
Beta strandi329 – 3324Combined sources
Helixi333 – 34715Combined sources
Helixi353 – 3619Combined sources
Helixi363 – 3686Combined sources
Turni378 – 3803Combined sources
Helixi382 – 39312Combined sources
Helixi401 – 4055Combined sources
Turni409 – 4135Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G02X-ray2.50A7-415[»]
2G0DX-ray2.21A7-415[»]
ProteinModelPortaliQ03202.
SMRiQ03202. Positions 7-415.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03202.

Family & Domainsi

Sequence similaritiesi

To B.subtilis SpaC and S.epidermidis EpiC.Curated

Family and domain databases

InterProiIPR007822. LANC-like.
IPR020468. Nisin_biosynthesis_NisC.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01950. LANCSUPER.
PR01952. NISCPROTEIN.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIMMNKKNI KRNVEKIIAQ WDERTRKNKE NFDFGELTLS TGLPGIILML
60 70 80 90 100
AELKNKDNSK IYQKKIDNYI EYIVSKLSTY GLLTGSLYSG AAGIALSILH
110 120 130 140 150
LREDDEKYKN LLDSLNRYIE YFVREKIEGF NLENITPPDY DVIEGLSGIL
160 170 180 190 200
SYLLLINDEQ YDDLKILIIN FLSNLTKENN GLISLYIKSE NQMSQSESEM
210 220 230 240 250
YPLGCLNMGL AHGLAGVGCI LAYAHIKGYS NEASLSALQK IIFIYEKFEL
260 270 280 290 300
ERKKQFLWKD GLVADELKKE KVIREASFIR DAWCYGGPGI SLLYLYGGLA
310 320 330 340 350
LDNDYFVDKA EKILESAMQR KLGIDSYMIC HGYSGLIEIC SLFKRLLNTK
360 370 380 390 400
KFDSYMEEFN VNSEQILEEY GDESGTGFLE GISGCILVLS KFEYSINFTY
410
WRQALLLFDD FLKGGKRK
Length:418
Mass (Da):47,931
Last modified:October 1, 1993 - v1
Checksum:iF3187AE5370A94DF
GO

Sequence cautioni

The sequence AAA25192.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68307 Genomic DNA. Translation: CAA48383.1.
L16226 Genomic DNA. Translation: AAA25192.1. Different initiation.
PIRiD48951.
RefSeqiWP_043991124.1. NZ_LKLX01000138.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68307 Genomic DNA. Translation: CAA48383.1.
L16226 Genomic DNA. Translation: AAA25192.1. Different initiation.
PIRiD48951.
RefSeqiWP_043991124.1. NZ_LKLX01000138.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G02X-ray2.50A7-415[»]
2G0DX-ray2.21A7-415[»]
ProteinModelPortaliQ03202.
SMRiQ03202. Positions 7-415.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ03202.

Family and domain databases

InterProiIPR007822. LANC-like.
IPR020468. Nisin_biosynthesis_NisC.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01950. LANCSUPER.
PR01952. NISCPROTEIN.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein."
    Engelke G., Gutowski-Eckel Z., Hammelmann M., Entian K.-D.
    Appl. Environ. Microbiol. 58:3730-3743(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 6F3.
  2. "Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity."
    Kuipers O.P., Beerthuyzen M.M., Siezen R.J., de Vos W.M.
    Eur. J. Biochem. 216:281-291(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NIZO R5.
  3. "Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3."
    Engelke G., Gutowski-Eckel Z., Kiesau P., Siegers K., Hammelmann M., Entian K.-D.
    Appl. Environ. Microbiol. 60:814-825(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 397-418.
    Strain: 6F3.

Entry informationi

Entry nameiNISC_LACLL
AccessioniPrimary (citable) accession number: Q03202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.