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Protein

Nisin biosynthesis protein NisC

Gene

nisC

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Could be implicated in the processing or the export process of the nisin lantibiotic.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nisin biosynthesis protein NisC
Gene namesi
Name:nisC
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968641 – 418Nisin biosynthesis protein NisCAdd BLAST418

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 26Combined sources18
Helixi34 – 37Combined sources4
Turni39 – 41Combined sources3
Helixi43 – 51Combined sources9
Turni52 – 55Combined sources4
Helixi59 – 80Combined sources22
Turni87 – 89Combined sources3
Helixi91 – 98Combined sources8
Helixi99 – 101Combined sources3
Turni102 – 104Combined sources3
Helixi106 – 128Combined sources23
Helixi132 – 134Combined sources3
Helixi137 – 140Combined sources4
Beta strandi141 – 145Combined sources5
Helixi146 – 153Combined sources8
Helixi159 – 161Combined sources3
Helixi162 – 174Combined sources13
Beta strandi180 – 182Combined sources3
Helixi189 – 191Combined sources3
Beta strandi192 – 194Combined sources3
Helixi195 – 200Combined sources6
Beta strandi205 – 207Combined sources3
Turni210 – 212Combined sources3
Helixi214 – 227Combined sources14
Helixi232 – 248Combined sources17
Helixi252 – 254Combined sources3
Beta strandi260 – 262Combined sources3
Helixi264 – 269Combined sources6
Beta strandi283 – 286Combined sources4
Helixi287 – 300Combined sources14
Helixi304 – 320Combined sources17
Beta strandi329 – 332Combined sources4
Helixi333 – 347Combined sources15
Helixi353 – 361Combined sources9
Helixi363 – 368Combined sources6
Turni378 – 380Combined sources3
Helixi382 – 393Combined sources12
Helixi401 – 405Combined sources5
Turni409 – 413Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G02X-ray2.50A7-415[»]
2G0DX-ray2.21A7-415[»]
ProteinModelPortaliQ03202.
SMRiQ03202.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03202.

Family & Domainsi

Sequence similaritiesi

To B.subtilis SpaC and S.epidermidis EpiC.Curated

Family and domain databases

CDDicd04793. LanC. 1 hit.
Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR033889. LanC.
IPR007822. LANC-like.
IPR020468. Nisin_biosynthesis_NisC.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01950. LANCSUPER.
PR01952. NISCPROTEIN.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIMMNKKNI KRNVEKIIAQ WDERTRKNKE NFDFGELTLS TGLPGIILML
60 70 80 90 100
AELKNKDNSK IYQKKIDNYI EYIVSKLSTY GLLTGSLYSG AAGIALSILH
110 120 130 140 150
LREDDEKYKN LLDSLNRYIE YFVREKIEGF NLENITPPDY DVIEGLSGIL
160 170 180 190 200
SYLLLINDEQ YDDLKILIIN FLSNLTKENN GLISLYIKSE NQMSQSESEM
210 220 230 240 250
YPLGCLNMGL AHGLAGVGCI LAYAHIKGYS NEASLSALQK IIFIYEKFEL
260 270 280 290 300
ERKKQFLWKD GLVADELKKE KVIREASFIR DAWCYGGPGI SLLYLYGGLA
310 320 330 340 350
LDNDYFVDKA EKILESAMQR KLGIDSYMIC HGYSGLIEIC SLFKRLLNTK
360 370 380 390 400
KFDSYMEEFN VNSEQILEEY GDESGTGFLE GISGCILVLS KFEYSINFTY
410
WRQALLLFDD FLKGGKRK
Length:418
Mass (Da):47,931
Last modified:October 1, 1993 - v1
Checksum:iF3187AE5370A94DF
GO

Sequence cautioni

The sequence AAA25192 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68307 Genomic DNA. Translation: CAA48383.1.
L16226 Genomic DNA. Translation: AAA25192.1. Different initiation.
PIRiD48951.
RefSeqiWP_043991124.1. NZ_LKLX01000138.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68307 Genomic DNA. Translation: CAA48383.1.
L16226 Genomic DNA. Translation: AAA25192.1. Different initiation.
PIRiD48951.
RefSeqiWP_043991124.1. NZ_LKLX01000138.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G02X-ray2.50A7-415[»]
2G0DX-ray2.21A7-415[»]
ProteinModelPortaliQ03202.
SMRiQ03202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ03202.

Family and domain databases

CDDicd04793. LanC. 1 hit.
Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR033889. LanC.
IPR007822. LANC-like.
IPR020468. Nisin_biosynthesis_NisC.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01950. LANCSUPER.
PR01952. NISCPROTEIN.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNISC_LACLL
AccessioniPrimary (citable) accession number: Q03202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.