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Q031V6

- NADK_LACLS

UniProt

Q031V6 - NADK_LACLS

Protein

NAD kinase

Gene

nadK

Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptorUniRule annotation
    Binding sitei54 – 541NADUniRule annotation
    Binding sitei152 – 1521NADUniRule annotation
    Binding sitei154 – 1541NADUniRule annotation
    Binding sitei189 – 1891NAD; via carbonyl oxygenUniRule annotation
    Binding sitei227 – 2271NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 502NADUniRule annotation
    Nucleotide bindingi126 – 1272NADUniRule annotation
    Nucleotide bindingi165 – 1706NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLLAC272622:GJUG-409-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:LACR_0409
    OrganismiLactococcus lactis subsp. cremoris (strain SK11)
    Taxonomic identifieri272622 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000000240: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270NAD kinasePRO_1000005419Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272622.LACR_0409.

    Structurei

    3D structure databases

    ProteinModelPortaliQ031V6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiQWITIVP.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q031V6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFGKKVWLI GNSSEKSKKI LNKLSKILKA EHFVFDDINP EIVISVGGDG    50
    TLLRAMHMYE YQLDRVRFLG VHTGHLGFYT DFTDEDLFEV VEALYDENPA 100
    QAIHYPLIRV QVSFTDGYQI VRHVLNEATI RRASKTMVGD VRISDYLFER 150
    FRGDGLSIST PTGSTAYNKS IGGAVVHPRV KAMQIAEIAS LNNVVYRTLG 200
    SPMIVAEKDT ITVCPAPEDD YSLTFDQLTF EYKNIKSIEF SLDGTTISFA 250
    NCAHTPFWER VSKSFIGEVE 270
    Length:270
    Mass (Da):30,408
    Last modified:November 14, 2006 - v1
    Checksum:i4A963F5ADBC09146
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ72016.1.
    RefSeqiYP_808438.1. NC_008527.1.

    Genome annotation databases

    EnsemblBacteriaiABJ72016; ABJ72016; LACR_0409.
    GeneIDi4433344.
    KEGGillc:LACR_0409.
    PATRICi22287587. VBILacLac38071_0571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000425 Genomic DNA. Translation: ABJ72016.1 .
    RefSeqi YP_808438.1. NC_008527.1.

    3D structure databases

    ProteinModelPortali Q031V6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272622.LACR_0409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ72016 ; ABJ72016 ; LACR_0409 .
    GeneIDi 4433344.
    KEGGi llc:LACR_0409.
    PATRICi 22287587. VBILacLac38071_0571.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi QWITIVP.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci LLAC272622:GJUG-409-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK11.

    Entry informationi

    Entry nameiNADK_LACLS
    AccessioniPrimary (citable) accession number: Q031V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3