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Q031V6 (NADK_LACLS) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:LACR_0409
OrganismLactococcus lactis subsp. cremoris (strain SK11) [Complete proteome] [HAMAP]
Taxonomic identifier272622 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270NAD kinase HAMAP-Rule MF_00361
PRO_1000005419

Regions

Nucleotide binding49 – 502NAD By similarity
Nucleotide binding126 – 1272NAD By similarity
Nucleotide binding165 – 1706NAD By similarity

Sites

Active site491Proton acceptor By similarity
Binding site541NAD By similarity
Binding site1521NAD By similarity
Binding site1541NAD By similarity
Binding site1891NAD; via carbonyl oxygen By similarity
Binding site2271NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q031V6 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 4A963F5ADBC09146

FASTA27030,408
        10         20         30         40         50         60 
MNFGKKVWLI GNSSEKSKKI LNKLSKILKA EHFVFDDINP EIVISVGGDG TLLRAMHMYE 

        70         80         90        100        110        120 
YQLDRVRFLG VHTGHLGFYT DFTDEDLFEV VEALYDENPA QAIHYPLIRV QVSFTDGYQI 

       130        140        150        160        170        180 
VRHVLNEATI RRASKTMVGD VRISDYLFER FRGDGLSIST PTGSTAYNKS IGGAVVHPRV 

       190        200        210        220        230        240 
KAMQIAEIAS LNNVVYRTLG SPMIVAEKDT ITVCPAPEDD YSLTFDQLTF EYKNIKSIEF 

       250        260        270 
SLDGTTISFA NCAHTPFWER VSKSFIGEVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000425 Genomic DNA. Translation: ABJ72016.1.
RefSeqYP_808438.1. NC_008527.1.

3D structure databases

ProteinModelPortalQ031V6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272622.LACR_0409.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ72016; ABJ72016; LACR_0409.
GeneID4433344.
KEGGllc:LACR_0409.
PATRIC22287587. VBILacLac38071_0571.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAQWITIVP.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycLLAC272622:GJUG-409-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_LACLS
AccessionPrimary (citable) accession number: Q031V6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families