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Protein

Trefoil factor 3

Gene

Tff3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity).By similarity

GO - Biological processi

  • digestion Source: GO_Central
  • regulation of glucose metabolic process Source: RGD
  • response to peptide hormone Source: RGD
  • wound healing Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 3
Alternative name(s):
Intestinal trefoil factor
Short name:
rITF
Polypeptide P1.B
Short name:
rP1.B
Gene namesi
Name:Tff3
Synonyms:Itf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3847. Tff3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002346723 – 81Trefoil factor 3Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 59PROSITE-ProRule annotation
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi53 ↔ 70PROSITE-ProRule annotation
Disulfide bondi79InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ03191.

Expressioni

Tissue specificityi

Expressed in goblet cells of the intestines, and colon, in paraventricular hypothalamus and supraoptic nuclei. Weakly expressed in gastric epithelial cells (at protein level). Expressed by goblet cells of small and large intestinal epithelia, kidney and stomach. Expressed in the paraventricular hypothalamus, arcuate nucleus and amygdala of the brain. Weakly expressed in gastric epithelial cells.5 Publications

Inductioni

Up-regulated by hypoxia in gastric epithelial cells. Up-regulated by hypoxia-inducible factor 1 alpha (HIF1A).1 Publication

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060620.

Structurei

3D structure databases

ProteinModelPortaliQ03191.
SMRiQ03191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 74P-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0FX. Eukaryota.
ENOG41114KR. LUCA.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ03191.
PhylomeDBiQ03191.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
InterProiView protein in InterPro
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
PfamiView protein in Pfam
PF00088. Trefoil. 1 hit.
PRINTSiPR00680. PTREFOIL.
SMARTiView protein in SMART
SM00018. PD. 1 hit.
PROSITEiView protein in PROSITE
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRAFWTTL LLVLVAGSSC KAQEFVGLSP SQCMVPANVR VDCGYPTVTS
60 70 80
EQCNNRGCCF DSSIPNVPWC FKPLQETECT F
Length:81
Mass (Da):8,944
Last modified:October 1, 1994 - v1
Checksum:i915052312C7B517E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8T → I in AAC52439 (PubMed:8750886).Curated1
Sequence conflicti8T → I in AAH78873 (PubMed:15489334).Curated1
Sequence conflicti8T → I in AAB01063 (PubMed:7721858).Curated1
Sequence conflicti35V → A in AAA42270 (PubMed:1763017).Curated1
Sequence conflicti37A → T in AAA42270 (PubMed:1763017).Curated1
Sequence conflicti44G → N in AAA42270 (PubMed:1763017).Curated1
Sequence conflicti81F → LDPA in AAB24079 (PubMed:1439565).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80826 mRNA. Translation: AAA42270.1.
S49317 mRNA. Translation: AAB24079.2.
U48825 mRNA. Translation: AAC52439.1.
BC078873 mRNA. Translation: AAH78873.1.
X66956 mRNA. Translation: CAA47378.1.
U20984 Genomic DNA. Translation: AAB01063.1.
AF012534 mRNA. Translation: AAB71352.1.
PIRiA41441.
A56366.
JC5623.
S23963.
RefSeqiNP_037174.2. NM_013042.2.
UniGeneiRn.87477.

Genome annotation databases

GeneIDi25563.
KEGGirno:25563.
UCSCiRGD:3847. rat.

Similar proteinsi

Entry informationi

Entry nameiTFF3_RAT
AccessioniPrimary (citable) accession number: Q03191
Secondary accession number(s): Q68FZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 22, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome