ID   CXA4_RAT                Reviewed;         333 AA.
AC   Q03190;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-NOV-2009, entry version 66.
DE   RecName: Full=Gap junction alpha-4 protein;
DE   AltName: Full=Connexin-37;
DE            Short=Cx37;
GN   Name=Gja4; Synonyms=Cxn-37;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Lung;
RX   MEDLINE=92112940; PubMed=1370487;
RA   Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J.,
RA   Copeland N.G., Paul D.L.;
RT   "Four novel members of the connexin family of gap junction proteins.
RT   Molecular cloning, expression, and chromosome mapping.";
RL   J. Biol. Chem. 267:2057-2064(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which
CC       materials of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Cell junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Highly expressed in lung.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily.
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DR   EMBL; M76532; AAA40999.1; -; Genomic_DNA.
DR   EMBL; BC078837; AAH78837.1; -; mRNA.
DR   EMBL; BC086576; AAH86576.1; -; mRNA.
DR   IPI; IPI00231861; -.
DR   PIR; B42053; B42053.
DR   RefSeq; NP_067686.1; -.
DR   UniGene; Rn.23406; -.
DR   STRING; Q03190; -.
DR   Ensembl; ENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357; Rattus norvegicus.
DR   GeneID; 25655; -.
DR   KEGG; rno:25655; -.
DR   UCSC; NM_021654; rat.
DR   CTD; 25655; -.
DR   RGD; 2691; Gja4.
DR   HOVERGEN; Q03190; -.
DR   OMA; WANLTTE; -.
DR   NextBio; 607545; -.
DR   ArrayExpress; Q03190; -.
DR   Genevestigator; Q03190; -.
DR   GermOnline; ENSRNOG00000014357; Rattus norvegicus.
DR   GO; GO:0005922; C:connexon complex; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006816; P:calcium ion transport; IMP:RGD.
DR   GO; GO:0007267; P:cell-cell signaling; IMP:RGD.
DR   GO; GO:0048265; P:response to pain; IEP:RGD.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002263; Connexin37.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR017991; connexins_rgn.
DR   PANTHER; PTHR11984; Connexin; 1.
DR   PANTHER; PTHR11984:SF17; Connexin37; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF10582; Connexin_CCC; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01134; CONNEXINA4.
DR   SMART; SM00037; CNX; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Transmembrane.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    333       Gap junction alpha-4 protein.
FT                                /FTId=PRO_0000057817.
FT   TOPO_DOM      2     20       Cytoplasmic (Potential).
FT   TRANSMEM     21     40       Potential.
FT   TOPO_DOM     41     76       Extracellular (Potential).
FT   TRANSMEM     77     99       Potential.
FT   TOPO_DOM    100    148       Cytoplasmic (Potential).
FT   TRANSMEM    149    171       Potential.
FT   TOPO_DOM    172    208       Extracellular (Potential).
FT   TRANSMEM    209    231       Potential.
FT   TOPO_DOM    232    333       Cytoplasmic (Potential).
SQ   SEQUENCE   333 AA;  37556 MW;  ABAF5D9462CBBC97 CRC64;
     MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG
     CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS RREERLRQKE GELRALPSKD
     PHVERALAAI EHQMAKISVA EDGRLRIRGA LMGTYVISVL CKSVLEAGFL YGQWRLYGWT
     MEPVFVCQRA PCPHVVDCYV SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI
     KARRDHDTRP AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
     TSTRPPPFVN AAPQGGQKSS SRPNSSASKK QYV
//