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Protein

Gap junction alpha-4 protein

Gene

Gja4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • blood vessel development Source: Ensembl
  • calcium ion transport Source: RGD
  • cell-cell signaling Source: RGD
  • cell communication Source: RGD
  • endothelium development Source: RGD
  • response to pain Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-37
Short name:
Cx37
Gene namesi
Name:Gja4
Synonyms:Cxn-37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2691 Gja4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 148CytoplasmicSequence analysisAdd BLAST49
Transmembranei149 – 171HelicalSequence analysisAdd BLAST23
Topological domaini172 – 208ExtracellularSequence analysisAdd BLAST37
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Topological domaini232 – 333CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578171 – 333Gap junction alpha-4 proteinAdd BLAST333

Proteomic databases

PaxDbiQ03190
PRIDEiQ03190

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiENSRNOG00000014357
GenevisibleiQ03190 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019246

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF97 Eukaryota
ENOG4110JTW LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ03190
KOiK07613
OMAiSDFECNT
OrthoDBiEOG091G0FKH
PhylomeDBiQ03190
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002263 Connexin37
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01134 CONNEXINA4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q03190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPSKD PHVERALAAI EHQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVISVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHVVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDTRP
260 270 280 290 300
AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
TSTRPPPFVN AAPQGGQKSS SRPNSSASKK QYV
Length:333
Mass (Da):37,556
Last modified:January 23, 2007 - v2
Checksum:iABAF5D9462CBBC97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76532 Genomic DNA Translation: AAA40999.1
BC078837 mRNA Translation: AAH78837.1
BC086576 mRNA Translation: AAH86576.1
PIRiB42053
RefSeqiNP_067686.1, NM_021654.2
UniGeneiRn.23406

Genome annotation databases

EnsembliENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357
GeneIDi25655
KEGGirno:25655
UCSCiRGD:2691 rat

Entry informationi

Entry nameiCXA4_RAT
AccessioniPrimary (citable) accession number: Q03190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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