Q03190 (CXA4_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gap junction alpha-4 protein Alternative name(s): Connexin-37 Short name=Cx37 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 333 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Subunit structure | A connexon is composed of a hexamer of connexins. |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction › gap junction. |
| Tissue specificity | Highly expressed in lung. |
| Sequence similarities | Belongs to the connexin family. Alpha-type (group II) subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell junction Cell membrane Gap junction Membrane |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | calcium ion transport Inferred from mutant phenotype. Source: RGD cell-cell signalingInferred from mutant phenotype. Source: RGD response to painInferred from expression pattern. Source: RGD |
| Cellular component | connexon complex Inferred from direct assay. Source: RGD integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 333 | 332 | Gap junction alpha-4 protein | PRO_0000057817 | |||||
Regions | |||||||||
| Topological domain | 2 – 20 | 19 | Cytoplasmic Potential | ||||||
| Transmembrane | 21 – 40 | 20 | Helical; Potential | ||||||
| Topological domain | 41 – 76 | 36 | Extracellular Potential | ||||||
| Transmembrane | 77 – 99 | 23 | Helical; Potential | ||||||
| Topological domain | 100 – 148 | 49 | Cytoplasmic Potential | ||||||
| Transmembrane | 149 – 171 | 23 | Helical; Potential | ||||||
| Topological domain | 172 – 208 | 37 | Extracellular Potential | ||||||
| Transmembrane | 209 – 231 | 23 | Helical; Potential | ||||||
| Topological domain | 232 – 333 | 102 | Cytoplasmic Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping." Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L. J. Biol. Chem. 267:2057-2064(1992) [PubMed: 1370487] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley. Tissue: Lung. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Ovary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M76532 Genomic DNA. Translation: AAA40999.1. BC078837 mRNA. Translation: AAH78837.1. BC086576 mRNA. Translation: AAH86576.1. |
| IPI | IPI00231861. |
| PIR | B42053. |
| RefSeq | NP_067686.1. NM_021654.2. |
| UniGene | Rn.23406. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q03190. |
Proteomic databases | |
| PRIDE | Q03190. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357. |
| GeneID | 25655. |
| KEGG | rno:25655. |
| UCSC | NM_021654. rat. |
Organism-specific databases | |
| CTD | 2701. |
| RGD | 2691. Gja4. |
Phylogenomic databases | |
| eggNOG | roNOG15180. |
| GeneTree | ENSGT00560000076859. |
| HOVERGEN | HBG009576. |
| InParanoid | Q03190. |
| OMA | GFLYGQW. |
| OrthoDB | EOG4PC9SJ. |
| PhylomeDB | Q03190. |
Gene expression databases | |
| ArrayExpress | Q03190. |
| Genevestigator | Q03190. |
| GermOnline | ENSRNOG00000014357. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000500. Connexin. IPR002263. Connexin37. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. [Graphical view] |
| KO | K07613. |
| PANTHER | PTHR11984. Connexin. 1 hit. PTHR11984:SF17. Connexin37. 1 hit. |
| Pfam | PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view] |
| PRINTS | PR00206. CONNEXIN. PR01134. CONNEXINA4. |
| SMART | SM00037. CNX. 1 hit. SM01089. Connexin_CCC. 1 hit. [Graphical view] |
| PROSITE | PS00407. CONNEXINS_1. 1 hit. PS00408. CONNEXINS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 607545. |
Entry information
| Entry name | CXA4_RAT | ||||||||
| Accession | Primary (citable) accession number: Q03190 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with