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Protein

Gap junction alpha-4 protein

Gene

Gja4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • blood vessel development Source: Ensembl
  • calcium ion transport Source: RGD
  • cell-cell signaling Source: RGD
  • cell communication Source: RGD
  • endothelium development Source: RGD
  • response to pain Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-37
Short name:
Cx37
Gene namesi
Name:Gja4
Synonyms:Cxn-37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2691. Gja4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence analysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence analysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence analysisAdd
BLAST
Topological domaini100 – 14849CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 17123HelicalSequence analysisAdd
BLAST
Topological domaini172 – 20837ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 23123HelicalSequence analysisAdd
BLAST
Topological domaini232 – 333102CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • connexon complex Source: RGD
  • gap junction Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Gap junction alpha-4 proteinPRO_0000057817Add
BLAST

Proteomic databases

PaxDbiQ03190.
PRIDEiQ03190.

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

GenevisibleiQ03190. RN.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019246.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF97. Eukaryota.
ENOG4110JTW. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ03190.
KOiK07613.
OMAiQNWANLT.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ03190.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFECNTAQPG CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPSKD PHVERALAAI EHQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVISVL CKSVLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHVVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI KARRDHDTRP
260 270 280 290 300
AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
TSTRPPPFVN AAPQGGQKSS SRPNSSASKK QYV
Length:333
Mass (Da):37,556
Last modified:January 23, 2007 - v2
Checksum:iABAF5D9462CBBC97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76532 Genomic DNA. Translation: AAA40999.1.
BC078837 mRNA. Translation: AAH78837.1.
BC086576 mRNA. Translation: AAH86576.1.
PIRiB42053.
RefSeqiNP_067686.1. NM_021654.2.
UniGeneiRn.23406.

Genome annotation databases

EnsembliENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357.
GeneIDi25655.
KEGGirno:25655.
UCSCiRGD:2691. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76532 Genomic DNA. Translation: AAA40999.1.
BC078837 mRNA. Translation: AAH78837.1.
BC086576 mRNA. Translation: AAH86576.1.
PIRiB42053.
RefSeqiNP_067686.1. NM_021654.2.
UniGeneiRn.23406.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019246.

Proteomic databases

PaxDbiQ03190.
PRIDEiQ03190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357.
GeneIDi25655.
KEGGirno:25655.
UCSCiRGD:2691. rat.

Organism-specific databases

CTDi2701.
RGDi2691. Gja4.

Phylogenomic databases

eggNOGiENOG410IF97. Eukaryota.
ENOG4110JTW. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ03190.
KOiK07613.
OMAiQNWANLT.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ03190.
TreeFamiTF329606.

Miscellaneous databases

NextBioi607545.
PROiQ03190.

Gene expression databases

GenevisibleiQ03190. RN.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002263. Connexin37.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01134. CONNEXINA4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."
    Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.
    J. Biol. Chem. 267:2057-2064(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Ovary.

Entry informationi

Entry nameiCXA4_RAT
AccessioniPrimary (citable) accession number: Q03190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.