Q03190 (CXA4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gap junction alpha-4 protein

Alternative name(s):
Connexin-37
Short name=Cx37

Gene names

Name:	Gja4
Synonyms:	Cxn-37

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit structure	A connexon is composed of a hexamer of connexins.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
Tissue specificity	Highly expressed in lung.
Sequence similarities	Belongs to the connexin family. Alpha-type (group II) subfamily.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from mutant phenotype. Source: RGD cell-cell signaling Inferred from mutant phenotype. Source: RGD response to pain Inferred from expression pattern. Source: RGD
Cellular component	connexon complex Inferred from direct assay. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 333	332	Gap junction alpha-4 protein		PRO_0000057817
Regions
	Topological domain	2 – 20	19	Cytoplasmic Potential
	Transmembrane	21 – 40	20	Helical; Potential
	Topological domain	41 – 76	36	Extracellular Potential
	Transmembrane	77 – 99	23	Helical; Potential
	Topological domain	100 – 148	49	Cytoplasmic Potential
	Transmembrane	149 – 171	23	Helical; Potential
	Topological domain	172 – 208	37	Extracellular Potential
	Transmembrane	209 – 231	23	Helical; Potential
	Topological domain	232 – 333	102	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q03190 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: ABAF5D9462CBBC97	FASTA	333	37,556
	10 20 30 40 50 60 MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 70 80 90 100 110 120 CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS RREERLRQKE GELRALPSKD 130 140 150 160 170 180 PHVERALAAI EHQMAKISVA EDGRLRIRGA LMGTYVISVL CKSVLEAGFL YGQWRLYGWT 190 200 210 220 230 240 MEPVFVCQRA PCPHVVDCYV SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI 250 260 270 280 290 300 KARRDHDTRP AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL 310 320 330 TSTRPPPFVN AAPQGGQKSS SRPNSSASKK QYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping." Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L. J. Biol. Chem. 267:2057-2064(1992) [PubMed: 1370487] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley. Tissue: Lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76532 Genomic DNA. Translation: AAA40999.1. BC078837 mRNA. Translation: AAH78837.1. BC086576 mRNA. Translation: AAH86576.1.
IPI	IPI00231861.
PIR	B42053.
RefSeq	NP_067686.1. NM_021654.2.
UniGene	Rn.23406.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q03190.
Proteomic databases
PRIDE	Q03190.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000019246; ENSRNOP00000019246; ENSRNOG00000014357.
GeneID	25655.
KEGG	rno:25655.
UCSC	NM_021654. rat.
Organism-specific databases
CTD	2701.
RGD	2691. Gja4.
Phylogenomic databases
eggNOG	roNOG15180.
GeneTree	ENSGT00560000076859.
HOVERGEN	HBG009576.
InParanoid	Q03190.
OMA	GFLYGQW.
OrthoDB	EOG4PC9SJ.
PhylomeDB	Q03190.
Gene expression databases
ArrayExpress	Q03190.
Genevestigator	Q03190.
GermOnline	ENSRNOG00000014357. Rattus norvegicus.
Family and domain databases
InterPro	IPR000500. Connexin. IPR002263. Connexin37. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. [Graphical view]
KO	K07613.
PANTHER	PTHR11984. Connexin. 1 hit. PTHR11984:SF17. Connexin37. 1 hit.
Pfam	PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view]
PRINTS	PR00206. CONNEXIN. PR01134. CONNEXINA4.
SMART	SM00037. CNX. 1 hit. SM01089. Connexin_CCC. 1 hit. [Graphical view]
PROSITE	PS00407. CONNEXINS_1. 1 hit. PS00408. CONNEXINS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607545.

Entry information

Entry name

CXA4_RAT

Accession

Primary (citable) accession number: Q03190

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program