Reviewed, UniProtKB/Swiss-Prot Q03181 (PPARD_HUMAN)

Names and origin

Protein names

Recommended name:
    Peroxisome proliferator-activated receptor delta
      Short name=PPAR-delta
Alternative name(s):
    Peroxisome proliferator-activated receptor beta
      Short name=PPAR-beta
    Nuclear receptor subfamily 1 group C member 2
    Nuclear hormone receptor 1
      Short name=NUC1
    NUCI

Gene names

Name:	PPARD
Synonyms:	NR1C2, PPARB

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Ref.1 Ref.11
Subunit structure	Heterodimer with the retinoid X receptor.
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous with maximal levels in placenta and skeletal muscle.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Receptor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from mutant phenotype. Source: UniProtKB axon ensheathment Inferred from sequence or structural similarity. Source: UniProtKB cholesterol metabolic process Traceable author statement. Source: UniProtKB decidualization Traceable author statement. Source: UniProtKB embryo implantation Traceable author statement. Source: UniProtKB fatty acid beta-oxidation Traceable author statement. Source: UniProtKB fatty acid transport Inferred from sequence or structural similarity. Source: UniProtKB generation of precursor metabolites and energy Ref.1 Traceable author statement. Source: ProtInc glucose metabolic process Non-traceable author statement. Source: UniProtKB glucose transport Non-traceable author statement. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of fat cell differentiation Non-traceable author statement. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	drug binding Ref.12 Inferred from direct assay. Source: UniProtKB linoleic acid binding Ref.12 Inferred from direct assay. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Ref.1 Traceable author statement. Source: ProtInc transcription activator activity Inferred from direct assay. Source: UniProtKB transcription factor activity Inferred from direct assay. Source: UniProtKB transcription repressor activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03181-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q03181-2)

The sequence of this isoform differs from the canonical sequence as follows:
     360-361: DR → GE
     362-441: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 441

441

Peroxisome proliferator-activated receptor delta

PRO_0000053486

Regions

DNA binding

71 – 145

75

Nuclear receptor

Zinc finger

74 – 94

21

NR C4-type

Zinc finger

111 – 133

23

NR C4-type

Region

254 – 441

188

Ligand-binding

Natural variations

Alternative sequence

360 – 361

2

DR → GE in isoform 2.

VSP_010133

Alternative sequence

362 – 441

80

Missing in isoform 2.

VSP_010134

Experimental info

Sequence conflict

79

1

D → G in BAF84350. Ref.5

Sequence conflict

134

1

L → P in BAH02282. Ref.3

Secondary structure

1

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441

Helix Strand Turn

Details...

Helix

170 – 173

4

Helix

175 – 189

15

Helix

194 – 200

7

Beta strand

211 – 213

3

Helix

216 – 223

8

Turn

224 – 226

3

Helix

241 – 264

24

Turn

268 – 272

5

Helix

275 – 294

20

Helix

295 – 297

3

Beta strand

302 – 305

4

Helix

306 – 308

3

Beta strand

310 – 313

4

Helix

314 – 318

5

Helix

322 – 339

18

Helix

345 – 356

12

Helix

367 – 388

22

Helix

395 – 423

29

Helix

431 – 437

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 94FBB2A4B46521E8	FASTA	441	49,903
	10 20 30 40 50 60 MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM 70 80 90 100 110 120 GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK 130 140 150 160 170 180 NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK 190 200 210 220 230 240 HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE 250 260 270 280 290 300 ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK 310 320 330 340 350 360 DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGD 370 380 390 400 410 420 RPGLMNVPRV EAIQDTILRA LEFHLQANHP DAQYLFPKLL QKMADLRQLV TEHAQMMQRI 430 440 KKTETETSLH PLLQEIYKDM Y
	Isoform 2. Checksum: F97757AC266EF8BA	FASTA	361	40,406
	10 20 30 40 50 60 MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM 70 80 90 100 110 120 GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK 130 140 150 160 170 180 NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK 190 200 210 220 230 240 HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE 250 260 270 280 290 300 ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK 310 320 330 340 350 360 DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGG E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids." Schmidt A., Endo N., Rutledge S.J., Vogel R., Shinar D., Rodan G.A. Mol. Endocrinol. 6:1634-1641(1992) [PubMed: 1333051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, FATTY ACID BINDING.
[2]	"Characterization of the human peroxisome proliferator activated receptor delta gene and its expression." Skogsberg J., Kannisto K., Roshani L., Gagne E., Hamsten A., Larsson C., Ehrenborg E. Int. J. Mol. Med. 6:73-81(2000) [PubMed: 10851270] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Placenta.
[3]	"DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system." Kobayashi T., Kodani Y., Nozawa A., Endo Y., Sawasaki T. FEBS Lett. 582:2737-2744(2008) [PubMed: 18619963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Human PPARdelta cDNA." Cho M.-C., Yoon D.-Y. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Spleen.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[6]	NIEHS SNPs program Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[10]	"PPAR-delta 5'-complete cDNA fragment." Aoto T., Ishizuka M., Kazusaka A., Fujita S. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-161.
[11]	"Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1." van der Veen J.N., Kruit J.K., Havinga R., Baller J.F.W., Chimini G., Lestavel S., Staels B., Groot P.H.E., Groen A.K., Kuipers F. J. Lipid Res. 46:526-534(2005) [PubMed: 15604518] [Abstract] Cited for: FUNCTION IN NPC1L1 EXPRESSION.
[12]	"Molecular recognition of fatty acids by peroxisome proliferator-activated receptors." Xu H.E., Lambert M.H., Montana V.G., Parks D.J., Blanchard S.G., Brown P.J., Sternbach D.D., Lehmann J.M., Wisely G.B., Willson T.M., Kliewer S.A., Milburn M.V. Mol. Cell 3:397-403(1999) [PubMed: 10198642] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 171-441 IN COMPLEXES WITH EICOSAPENTAENOIC ACID AND THE SYNTHETIC AGONIST GW2433, UNSATURATED FATTY ACID BINDING.
[13]	"Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype." Takada I., Yu R.T., Xu H.E., Lambert M.H., Montana V.G., Kliewer S.A., Evans R.M., Umesono K. Mol. Endocrinol. 14:733-740(2000) [PubMed: 10809235] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 170-441 IN COMPLEX WITH THE SYNTHETIC AGONIST GW2331.
[14]	"3,4,5-trisubstituted isoxazoles as novel PPARdelta agonists. Part 2." Epple R., Azimioara M., Russo R., Xie Y., Wang X., Cow C., Wityak J., Karanewsky D., Bursulaya B., Kreusch A., Tuntland T., Gerken A., Iskandar M., Saez E., Martin Seidel H., Tian S.-S. Bioorg. Med. Chem. Lett. 16:5488-5492(2006) [PubMed: 16931011] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 165-441 IN COMPLEX WITH SYNTHETIC AGONIST.
[15]	"Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids." Fyffe S.A., Alphey M.S., Buetow L., Smith T.K., Ferguson M.A., Soerensen M.D., Bjoerkling F., Hunter W.N. J. Mol. Biol. 356:1005-1013(2006) [PubMed: 16405912] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 169-440 IN COMPLEX WITH FATTY ACIDS.
[16]	"Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form." Fyffe S.A., Alphey M.S., Buetow L., Smith T.K., Ferguson M.A., Soerensen M.D., Bjoerkling F., Hunter W.N. Mol. Cell 21:1-2(2006) [PubMed: 16387648] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 175-441.
[17]	"Design of a partial PPARdelta agonist." Pettersson I., Ebdrup S., Havranek M., Pihera P., Korinek M., Mogensen J.P., Jeppesen C.B., Johansson E., Sauerberg P. Bioorg. Med. Chem. Lett. 17:4625-4629(2007) [PubMed: 17560785] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 165-441 IN COMPLEX WITH SYNTHETIC AGONIST.
[18]	"Discovery of a novel class of PPARdelta partial agonists." Shearer B.G., Patel H.S., Billin A.N., Way J.M., Winegar D.A., Lambert M.H., Xu R.X., Leesnitzer L.M., Merrihew R.V., Huet S., Willson T.M. Bioorg. Med. Chem. Lett. 18:5018-5022(2008) [PubMed: 18722772] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 171-441.
[19]	"Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures." Oyama T., Toyota K., Waku T., Hirakawa Y., Nagasawa N., Kasuga J.I., Hashimoto Y., Miyachi H., Morikawa K. Acta Crystallogr. D 65:786-795(2009) [PubMed: 19622862] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 170-441 IN COMPLEXES WITH THE SYNTHETIC AGONISTS TIPP-401 AND TIPP-204.
[20]	"Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma." Connors R.V., Wang Z., Harrison M., Zhang A., Wanska M., Hiscock S., Fox B., Dore M., Labelle M., Sudom A., Johnstone S., Liu J., Walker N.P., Chai A., Siegler K., Li Y., Coward P. Bioorg. Med. Chem. Lett. 19:3550-3554(2009) [PubMed: 19464171] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 171-439 IN COMPLEX WITH SYNTHETIC AGONIST.
[21]	"Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent." Artis D.R., Lin J.J., Zhang C., Wang W., Mehra U., Perreault M., Erbe D., Krupka H.I., England B.P., Arnold J., Plotnikov A.N., Marimuthu A., Nguyen H., Will S., Signaevsky M., Kral J., Cantwell J., Settachatgull C. , Yan D.S., Fong D., Oh A., Shi S., Womack P., Powell B., Habets G., West B.L., Zhang K.Y.J., Milburn M.V., Vlasuk G.P., Hirth K.P., Nolop K., Bollag G., Ibrahim P.N., Tobin J.F. Proc. Natl. Acad. Sci. U.S.A. 106:262-267(2009) [PubMed: 19116277] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 165-441 IN COMPLEX WITH INDEGLITAZAR.
[22]	"Solution sturcture of the C4-type zinc finger domain from human peroxisome proliferator-activated receptor delta." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 66-151.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Wikipedia

Peroxisome proliferator-activated receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L07592 mRNA. Translation: AAA36469.1.
AF246303 , AF246299, AF246300, AF246301, AF246302 Genomic DNA. Translation: AAF62553.1.
AB307691 mRNA. Translation: BAH02282.1.
AY919140 mRNA. Translation: AAX14041.1.
AK291661 mRNA. Translation: BAF84350.1.
AK122614 mRNA. Translation: BAG53624.1.
AY442342 Genomic DNA. Translation: AAR05439.1.
AL022721 Genomic DNA. Translation: CAB38629.1.
AL022721 Genomic DNA. Translation: CAD92505.1.
CH471081 Genomic DNA. Translation: EAX03825.1.
BC002715 mRNA. Translation: AAH02715.1.
BC007578 mRNA. Translation: AAH07578.1.
AB099507 mRNA. Translation: BAC78903.1.

IPI

IPI00009330.
IPI00219761.

PIR

A45360.

RefSeq

NP_006229.1.
NP_803184.1.

UniGene

Hs.696032

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GWX	X-ray	2.50	A/B	171-441	[»]
1Y0S	X-ray	2.65	A/B	170-441	[»]
2AWH	X-ray	2.00	A/B	174-441	[»]
2B50	X-ray	2.00	A/B	169-440	[»]
2BAW	X-ray	2.30	A/B	175-441	[»]
2ENV	NMR	-	A	72-146	[»]
2GWX	X-ray	2.30	A/B	175-441	[»]
2J14	X-ray	2.80	A/B	165-441	[»]
2Q5G	X-ray	2.70	A/B	165-441	[»]
2ZNP	X-ray	3.00	A/B	170-441	[»]
2ZNQ	X-ray	2.65	A/B	170-441	[»]
3D5F	X-ray	2.20	A/B	175-441	[»]
3DY6	X-ray	2.90	A/B	171-441	[»]
3ET2	X-ray	2.24	A/B	165-441	[»]
3GWX	X-ray	2.40	A/B	171-441	[»]
3GZ9	X-ray	2.00	A	171-439	[»]

SMR

Q03181. Positions 65-151.

ModBase

Search...

Protein-protein interaction databases

STRING

Q03181.

PTM databases

PhosphoSite

Q03181.

Proteomic databases

PRIDE

Q03181.

Genome annotation databases

Ensembl

ENST00000311565; ENSP00000310928; ENSG00000112033; Homo sapiens. [Genome view]
ENST00000360694; ENSP00000353916; ENSG00000112033; Homo sapiens. [Genome view]

GeneID

5467.

KEGG

hsa:5467.

UCSC

uc003okl.2. human.
uc003okm.1. human.

Organism-specific databases

CTD

5467.

GeneCards

GC06P035418.

H-InvDB

HIX0005804.

HGNC

HGNC:9235. PPARD.

HPA

CAB017635.

MIM

600409. gene.

PharmGKB

PA33557.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG09323.

HOGENOM

HBG446936.

HOVERGEN

Q03181.

InParanoid

Q03181.

OMA

SSLFLND.

OrthoDB

EOG9V45TJ.

PhylomeDB

Q03181.

Enzyme and pathway databases

Pathway_Interaction_DB

ps1pathway. Presenilin action in Notch and Wnt signaling.
rxr_vdr_pathway. RXR and RAR hetrodimerization with other nuclear receptor.

Reactome

REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

Q03181.

Bgee

Q03181.

CleanEx

HS_PPARD.

Genevestigator

Q03181.

GermOnline

ENSG00000112033. Homo sapiens.

Family and domain databases

InterPro

IPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]

Gene3D

G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit.
G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.

Pfam

PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]

PRINTS

PR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.

SMART

SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]

PROSITE

PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

BindingDB

Q03181.

DrugBank

DB00159. Icosapent.
DB00605. Sulindac.
DB00374. Treprostinil.

NextBio

21160.

SOURCE

Search...

Entry information

Entry name

PPARD_HUMAN

Accession

Primary (citable) accession number: Q03181
Secondary accession number(s): A8K6J6 , B6ZGS1, Q5D1P0, Q7Z5K0, Q9BUD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	February 9, 2010
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.