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Reviewed, UniProtKB/Swiss-Prot Q03169 (TNAP2_HUMAN)

Last modified January 19, 2010. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Tumor necrosis factor, alpha-induced protein 2
Alternative name(s):
    Primary response gene B94 protein
Gene names
Name: TNFAIP2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May play a role as a mediator of inflammation and angiogenesis.

Developmental stage

Differentially expressed in development and capillary tube-like formation in vitro.

Induction

By TNF-alpha and other proinflammatory factors.

Sequence similarities

Belongs to the SEC6 family.

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Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
   Coding sequence diversityPolymorphism
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processangiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular space Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 654654Tumor necrosis factor, alpha-induced protein 2
PRO_0000118932

Regions

Compositional bias22 – 254Poly-Glu
Compositional bias28 – 5427Lys-rich (basic)
Compositional bias105 – 1106Poly-Ala

Natural variations

Natural variant1101A → AA Ref.2
VAR_038742
Natural variant2821Q → E: dbSNP rs1132339. Ref.2 Ref.1
VAR_020772
Natural variant5651T → I: dbSNP rs2229727. Ref.2
VAR_020773
Natural variant5801T → M: dbSNP rs2234146. Ref.2
VAR_020774

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Sequences

Sequence LengthMass (Da)Tools
Q03169-1 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: 5BB18E96B193CC3D

FASTA65472,661
        10         20         30         40         50         60 
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA 

        70         80         90        100        110        120 
EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR 

       130        140        150        160        170        180 
RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA 

       190        200        210        220        230        240 
TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP 

       250        260        270        280        290        300 
AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ 

       310        320        330        340        350        360 
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL 

       370        380        390        400        410        420 
AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA 

       430        440        450        460        470        480 
NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF 

       490        500        510        520        530        540 
THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL 

       550        560        570        580        590        600 
KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY 

       610        620        630        640        650 
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG

« Hide

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References

[1]"Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro."
Sarma V., Wolf F.W., Marks R.M., Shows T.B., Dixit V.M.
J. Immunol. 148:3302-3312(1992) [PubMed: 1374453] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-282.
Tissue: Umbilical vein endothelial cell.
[2]SeattleSNPs variation discovery resource
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-110 INS; GLU-282; ILE-565 AND MET-580.
+Additional computationally mapped references.

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Web resources

SeattleSNPs

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M92357 mRNA. Translation: AAA35582.1.
AY273786 Genomic DNA. Translation: AAP12649.1.
IPIIPI00304866.
PIRI56134.
RefSeqNP_006282.2.
UniGeneHs.525607
Hs.660676

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ03169.

Proteomic databases

PeptideAtlasQ03169.
PRIDEQ03169.

Genome annotation databases

EnsemblENST00000333007; ENSP00000332326; ENSG00000185215; Homo sapiens. [Genome view]
GeneID7127.
KEGGhsa:7127.
UCSCuc001ymm.1. human.

Organism-specific databases

CTD7127.
GeneCardsGC14P102662.
H-InvDBHIX0037724.
HGNCHGNC:11895. TNFAIP2.
HPACAB004598.
MIM603300. gene.
PharmGKBPA36592.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG280136.
HOVERGENQ03169.
InParanoidQ03169.
OMANCLSFRM.
OrthoDBEOG9GXJ71.
PhylomeDBQ03169.

Gene expression databases

ArrayExpressQ03169.
BgeeQ03169.
CleanExHS_TNFAIP2.
GenevestigatorQ03169.
GermOnlineENSG00000185215. Homo sapiens.

Family and domain databases

InterProIPR010326. Sec6.
[Graphical view]
PANTHERPTHR21292. Sec6. 1 hit.
PfamPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio27891.
SOURCESearch...

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Entry information

Entry nameTNAP2_HUMAN
AccessionPrimary (citable) accession number: Q03169
Secondary accession number(s): Q86VI0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 18, 2006
Last modified: January 19, 2010
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents