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Protein

Tumor necrosis factor alpha-induced protein 2

Gene

TNFAIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role as a mediator of inflammation and angiogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Protein family/group databases

TCDBi1.L.1.1.1 the tunneling nanotube (tnt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 2
Short name:
TNF alpha-induced protein 2
Alternative name(s):
Primary response gene B94 protein
Gene namesi
Name:TNFAIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000185215.8
HGNCiHGNC:11895 TNFAIP2
MIMi603300 gene
neXtProtiNX_Q03169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7127
OpenTargetsiENSG00000185215
PharmGKBiPA36592

Polymorphism and mutation databases

BioMutaiTNFAIP2
DMDMi93141326

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189321 – 654Tumor necrosis factor alpha-induced protein 2Add BLAST654

Proteomic databases

EPDiQ03169
MaxQBiQ03169
PaxDbiQ03169
PeptideAtlasiQ03169
PRIDEiQ03169

PTM databases

iPTMnetiQ03169
PhosphoSitePlusiQ03169
SwissPalmiQ03169

Expressioni

Developmental stagei

Differentially expressed in development and capillary tube-like formation in vitro.

Inductioni

By TNF and other proinflammatory factors.

Gene expression databases

BgeeiENSG00000185215
CleanExiHS_TNFAIP2
ExpressionAtlasiQ03169 baseline and differential
GenevisibleiQ03169 HS

Organism-specific databases

HPAiCAB004598
HPA030624

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1129825 interactors.
IntActiQ03169 3 interactors.
MINTiQ03169
STRINGi9606.ENSP00000332326

Structurei

3D structure databases

ProteinModelPortaliQ03169
SMRiQ03169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Glu4
Compositional biasi28 – 54Lys-rich (basic)Add BLAST27
Compositional biasi105 – 110Poly-Ala6

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOGENOMiHOG000060133
HOVERGENiHBG079271
InParanoidiQ03169
KOiK19989
OMAiFTQTRWA
OrthoDBiEOG091G02QY
PhylomeDBiQ03169
TreeFamiTF314979

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit

Sequencei

Sequence statusi: Complete.

Q03169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG
60 70 80 90 100
KKKKGQPSSA EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL
110 120 130 140 150
ERELAAAAAA GGVSEEELVR RQSKVEALYE LLRDQVLGVL RRPLEAPPER
160 170 180 190 200
LRQALAVVAE QEREDRQAAA AGPGTSGLAA TRPRRWLQLW RRGVAEAAEE
210 220 230 240 250
RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP AEFGVVAAYA
260 270 280 290 300
ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ
310 320 330 340 350
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ
360 370 380 390 400
RLDGHCHSEL AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS
410 420 430 440 450
YQRAFNEFLE RGKQLTNYRA NVIANINNCL SFRMSMEQNW QVPQDTLSLL
460 470 480 490 500
LGPLGELKSH GFDTLLQNLH EDLKPLFKRF THTRWAAPVE TLENIIATVD
510 520 530 540 550
TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL KTAEQQQQLA
560 570 580 590 600
GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY
610 620 630 640 650
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL

IKVG
Length:654
Mass (Da):72,661
Last modified:April 18, 2006 - v2
Checksum:i5BB18E96B193CC3D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038742110A → AA1 Publication1
Natural variantiVAR_020772282Q → E2 PublicationsCorresponds to variant dbSNP:rs1132339Ensembl.1
Natural variantiVAR_020773565T → I1 PublicationCorresponds to variant dbSNP:rs2229727Ensembl.1
Natural variantiVAR_020774580T → M1 PublicationCorresponds to variant dbSNP:rs2234146Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92357 mRNA Translation: AAA35582.1
AL161669 Genomic DNA No translation available.
AY273786 Genomic DNA Translation: AAP12649.1
CCDSiCCDS9979.1
PIRiI56134
RefSeqiNP_006282.2, NM_006291.2
XP_011535416.1, XM_011537114.2
UniGeneiHs.525607
Hs.736562

Genome annotation databases

EnsembliENST00000333007; ENSP00000332326; ENSG00000185215
ENST00000560869; ENSP00000452634; ENSG00000185215
GeneIDi7127
KEGGihsa:7127
UCSCiuc001ymm.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTNAP2_HUMAN
AccessioniPrimary (citable) accession number: Q03169
Secondary accession number(s): Q86VI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 18, 2006
Last modified: February 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome