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Protein

Tumor necrosis factor alpha-induced protein 2

Gene

TNFAIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as a mediator of inflammation and angiogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Protein family/group databases

TCDBi1.L.1.1.1. the tunneling nanotube (tnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 2
Short name:
TNF alpha-induced protein 2
Alternative name(s):
Primary response gene B94 protein
Gene namesi
Name:TNFAIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11895. TNFAIP2.

Subcellular locationi

GO - Cellular componenti

  • exocyst Source: GO_Central
  • extracellular space Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36592.

Polymorphism and mutation databases

BioMutaiTNFAIP2.
DMDMi93141326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Tumor necrosis factor alpha-induced protein 2PRO_0000118932Add
BLAST

Proteomic databases

EPDiQ03169.
MaxQBiQ03169.
PaxDbiQ03169.
PeptideAtlasiQ03169.
PRIDEiQ03169.

PTM databases

iPTMnetiQ03169.
PhosphoSiteiQ03169.
SwissPalmiQ03169.

Expressioni

Developmental stagei

Differentially expressed in development and capillary tube-like formation in vitro.

Inductioni

By TNF and other proinflammatory factors.

Gene expression databases

BgeeiENSG00000185215.
CleanExiHS_TNFAIP2.
ExpressionAtlasiQ03169. baseline and differential.
GenevisibleiQ03169. HS.

Organism-specific databases

HPAiCAB004598.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112982. 5 interactions.
IntActiQ03169. 2 interactions.
MINTiMINT-7944790.
STRINGi9606.ENSP00000332326.

Structurei

3D structure databases

ProteinModelPortaliQ03169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 254Poly-Glu
Compositional biasi28 – 5427Lys-rich (basic)Add
BLAST
Compositional biasi105 – 1106Poly-Ala

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000060133.
HOVERGENiHBG079271.
InParanoidiQ03169.
KOiK19989.
OMAiESYHQHF.
OrthoDBiEOG091G02QY.
PhylomeDBiQ03169.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG
60 70 80 90 100
KKKKGQPSSA EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL
110 120 130 140 150
ERELAAAAAA GGVSEEELVR RQSKVEALYE LLRDQVLGVL RRPLEAPPER
160 170 180 190 200
LRQALAVVAE QEREDRQAAA AGPGTSGLAA TRPRRWLQLW RRGVAEAAEE
210 220 230 240 250
RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP AEFGVVAAYA
260 270 280 290 300
ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ
310 320 330 340 350
GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ
360 370 380 390 400
RLDGHCHSEL AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS
410 420 430 440 450
YQRAFNEFLE RGKQLTNYRA NVIANINNCL SFRMSMEQNW QVPQDTLSLL
460 470 480 490 500
LGPLGELKSH GFDTLLQNLH EDLKPLFKRF THTRWAAPVE TLENIIATVD
510 520 530 540 550
TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL KTAEQQQQLA
560 570 580 590 600
GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY
610 620 630 640 650
ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL

IKVG
Length:654
Mass (Da):72,661
Last modified:April 18, 2006 - v2
Checksum:i5BB18E96B193CC3D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101A → AA.1 Publication
VAR_038742
Natural varianti282 – 2821Q → E.2 Publications
Corresponds to variant rs1132339 [ dbSNP | Ensembl ].
VAR_020772
Natural varianti565 – 5651T → I.1 Publication
Corresponds to variant rs2229727 [ dbSNP | Ensembl ].
VAR_020773
Natural varianti580 – 5801T → M.1 Publication
Corresponds to variant rs2234146 [ dbSNP | Ensembl ].
VAR_020774

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92357 mRNA. Translation: AAA35582.1.
AL161669 Genomic DNA. No translation available.
AY273786 Genomic DNA. Translation: AAP12649.1.
CCDSiCCDS9979.1.
PIRiI56134.
RefSeqiNP_006282.2. NM_006291.2.
XP_011535416.1. XM_011537114.2.
UniGeneiHs.525607.
Hs.736562.

Genome annotation databases

EnsembliENST00000333007; ENSP00000332326; ENSG00000185215.
ENST00000560869; ENSP00000452634; ENSG00000185215.
GeneIDi7127.
KEGGihsa:7127.
UCSCiuc001ymm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92357 mRNA. Translation: AAA35582.1.
AL161669 Genomic DNA. No translation available.
AY273786 Genomic DNA. Translation: AAP12649.1.
CCDSiCCDS9979.1.
PIRiI56134.
RefSeqiNP_006282.2. NM_006291.2.
XP_011535416.1. XM_011537114.2.
UniGeneiHs.525607.
Hs.736562.

3D structure databases

ProteinModelPortaliQ03169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112982. 5 interactions.
IntActiQ03169. 2 interactions.
MINTiMINT-7944790.
STRINGi9606.ENSP00000332326.

Protein family/group databases

TCDBi1.L.1.1.1. the tunneling nanotube (tnt) family.

PTM databases

iPTMnetiQ03169.
PhosphoSiteiQ03169.
SwissPalmiQ03169.

Polymorphism and mutation databases

BioMutaiTNFAIP2.
DMDMi93141326.

Proteomic databases

EPDiQ03169.
MaxQBiQ03169.
PaxDbiQ03169.
PeptideAtlasiQ03169.
PRIDEiQ03169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333007; ENSP00000332326; ENSG00000185215.
ENST00000560869; ENSP00000452634; ENSG00000185215.
GeneIDi7127.
KEGGihsa:7127.
UCSCiuc001ymm.1. human.

Organism-specific databases

CTDi7127.
GeneCardsiTNFAIP2.
H-InvDBHIX0037724.
HGNCiHGNC:11895. TNFAIP2.
HPAiCAB004598.
MIMi603300. gene.
neXtProtiNX_Q03169.
PharmGKBiPA36592.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000060133.
HOVERGENiHBG079271.
InParanoidiQ03169.
KOiK19989.
OMAiESYHQHF.
OrthoDBiEOG091G02QY.
PhylomeDBiQ03169.
TreeFamiTF314979.

Miscellaneous databases

ChiTaRSiTNFAIP2. human.
GenomeRNAii7127.
PROiQ03169.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185215.
CleanExiHS_TNFAIP2.
ExpressionAtlasiQ03169. baseline and differential.
GenevisibleiQ03169. HS.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNAP2_HUMAN
AccessioniPrimary (citable) accession number: Q03169
Secondary accession number(s): Q86VI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 18, 2006
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.