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Q03167

- TGBR3_HUMAN

UniProt

Q03167 - TGBR3_HUMAN

Protein

Transforming growth factor beta receptor type 3

Gene

TGFBR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

    GO - Molecular functioni

    1. coreceptor activity Source: BHF-UCL
    2. glycosaminoglycan binding Source: BHF-UCL
    3. heparin binding Source: BHF-UCL
    4. PDZ domain binding Source: BHF-UCL
    5. protein binding Source: IntAct
    6. SMAD binding Source: BHF-UCL
    7. transforming growth factor beta-activated receptor activity Source: BHF-UCL
    8. transforming growth factor beta binding Source: BHF-UCL
    9. transforming growth factor beta receptor activity, type III Source: BHF-UCL
    10. transforming growth factor beta receptor binding Source: BHF-UCL
    11. type II transforming growth factor beta receptor binding Source: BHF-UCL

    GO - Biological processi

    1. blastocyst development Source: Ensembl
    2. blood vessel development Source: Ensembl
    3. BMP signaling pathway Source: BHF-UCL
    4. cardiac epithelial to mesenchymal transition Source: BHF-UCL
    5. cardiac muscle cell proliferation Source: BHF-UCL
    6. cell growth Source: BHF-UCL
    7. cell migration Source: BHF-UCL
    8. definitive erythrocyte differentiation Source: BHF-UCL
    9. definitive hemopoiesis Source: BHF-UCL
    10. epithelial to mesenchymal transition Source: BHF-UCL
    11. heart morphogenesis Source: BHF-UCL
    12. heart trabecula formation Source: BHF-UCL
    13. immune response Source: BHF-UCL
    14. intracellular signal transduction Source: BHF-UCL
    15. liver development Source: BHF-UCL
    16. negative regulation of cellular component movement Source: BHF-UCL
    17. negative regulation of epithelial cell migration Source: Ensembl
    18. negative regulation of epithelial cell proliferation Source: BHF-UCL
    19. negative regulation of epithelial to mesenchymal transition Source: Ensembl
    20. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    21. organ regeneration Source: Ensembl
    22. palate development Source: BHF-UCL
    23. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    24. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    25. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    26. regulation of protein binding Source: Ensembl
    27. response to follicle-stimulating hormone Source: BHF-UCL
    28. response to hypoxia Source: Ensembl
    29. response to luteinizing hormone Source: BHF-UCL
    30. response to prostaglandin E Source: BHF-UCL
    31. transforming growth factor beta receptor complex assembly Source: Ensembl
    32. transforming growth factor beta receptor signaling pathway Source: BHF-UCL
    33. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming growth factor beta receptor type 3
    Short name:
    TGF-beta receptor type 3
    Short name:
    TGFR-3
    Alternative name(s):
    Betaglycan
    Transforming growth factor beta receptor III
    Short name:
    TGF-beta receptor type III
    Gene namesi
    Name:TGFBR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11774. TGFBR3.

    Subcellular locationi

    Secreted. Secretedextracellular space. Cell membrane Curated; Single-pass type I membrane protein Curated
    Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endoplasmic reticulum Source: Ensembl
    3. external side of plasma membrane Source: BHF-UCL
    4. extracellular space Source: UniProt
    5. extracellular vesicular exosome Source: UniProt
    6. inhibin-betaglycan-ActRII complex Source: BHF-UCL
    7. integral component of plasma membrane Source: BHF-UCL
    8. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti231160. Familial cerebral saccular aneurysm.
    PharmGKBiPA36487.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 851831Transforming growth factor beta receptor type 3PRO_0000041663Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341O-linked (Xyl...) (glycosaminoglycan)By similarity
    Glycosylationi545 – 5451O-linked (Xyl...) (glycosaminoglycan)By similarity
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi639 ↔ 705By similarity
    Disulfide bondi660 ↔ 730By similarity
    Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi710 ↔ 723By similarity

    Post-translational modificationi

    Extensively modified by glycosaminoglycan groups (GAG).

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    MaxQBiQ03167.
    PaxDbiQ03167.
    PRIDEiQ03167.

    PTM databases

    PhosphoSiteiQ03167.

    Expressioni

    Gene expression databases

    ArrayExpressiQ03167.
    BgeeiQ03167.
    CleanExiHS_TGFBR3.
    GenevestigatoriQ03167.

    Organism-specific databases

    HPAiCAB018971.
    HPA008257.

    Interactioni

    Subunit structurei

    Interacts with TCTEX1D4.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GIPC1O149083EBI-2852679,EBI-373132
    TGFB1P011372EBI-2852679,EBI-779636

    Protein-protein interaction databases

    BioGridi112907. 4 interactions.
    DIPiDIP-5940N.
    IntActiQ03167. 4 interactions.
    MINTiMINT-1785606.
    STRINGi9606.ENSP00000212355.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03167.
    SMRiQ03167. Positions 587-755.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 787767ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini810 – 85142CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei788 – 80922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini455 – 730276ZPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni737 – 75115Interaction with TGF-beta ligandBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ZP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40778.
    HOGENOMiHOG000090193.
    HOVERGENiHBG057515.
    KOiK05843.
    OMAiIENICPK.
    OrthoDBiEOG72ZCDK.
    PhylomeDBiQ03167.
    TreeFamiTF337375.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]
    PRINTSiPR00023. ZPELLUCIDA.
    SMARTiSM00241. ZP. 1 hit.
    [Graphical view]
    PROSITEiPS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q03167-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS    50
    GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV 100
    VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE 150
    RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG 200
    KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV 250
    DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 300
    GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR 350
    FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG 400
    LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI 450
    ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES 500
    PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF 550
    PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT 600
    DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM 650
    SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL 700
    LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK 750
    PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL 800
    LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST 850
    A 851
    Length:851
    Mass (Da):93,499
    Last modified:November 2, 2010 - v3
    Checksum:iAEC56C4477C003B2
    GO
    Isoform 2 (identifier: Q03167-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         359-359: Missing.

    Show »
    Length:850
    Mass (Da):93,428
    Checksum:i1469BB567BD05230
    GO

    Sequence cautioni

    The sequence AAA67061.1 differs from that shown. Reason: Frameshift at positions 70, 73, 349 and 350.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891P → S in BAF84034. (PubMed:14702039)Curated
    Sequence conflicti238 – 2381I → V in BAF84034. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141S → N.1 Publication
    Corresponds to variant rs17884205 [ dbSNP | Ensembl ].
    VAR_020891
    Natural varianti15 – 151S → F.3 Publications
    Corresponds to variant rs1805110 [ dbSNP | Ensembl ].
    VAR_014920
    Natural varianti163 – 1631W → L.1 Publication
    Corresponds to variant rs17885124 [ dbSNP | Ensembl ].
    VAR_020892
    Natural varianti351 – 3511F → I.
    Corresponds to variant rs11466592 [ dbSNP | Ensembl ].
    VAR_057499
    Natural varianti635 – 6351A → T.1 Publication
    Corresponds to variant rs17882578 [ dbSNP | Ensembl ].
    VAR_020893
    Natural varianti765 – 7651G → R.1 Publication
    Corresponds to variant rs17882828 [ dbSNP | Ensembl ].
    VAR_020894
    Natural varianti777 – 7771P → S.
    Corresponds to variant rs35352606 [ dbSNP | Ensembl ].
    VAR_066625

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei359 – 3591Missing in isoform 2. 1 PublicationVSP_040018

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07594 mRNA. Translation: AAA67061.1. Frameshift.
    AJ251961 mRNA. Translation: CAB64374.1.
    AY796304 Genomic DNA. Translation: AAV50003.1.
    AK291345 mRNA. Translation: BAF84034.1.
    AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1.
    AL162263
    , AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1.
    AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1.
    AL390780
    , AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1.
    AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1.
    AL445992
    , AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1.
    BC126116 mRNA. Translation: AAI26117.1.
    BC136295 mRNA. Translation: AAI36296.1.
    CCDSiCCDS30770.1. [Q03167-1]
    CCDS55614.1. [Q03167-2]
    PIRiJC1350.
    RefSeqiNP_001182612.1. NM_001195683.1. [Q03167-2]
    NP_001182613.1. NM_001195684.1. [Q03167-2]
    NP_003234.2. NM_003243.4. [Q03167-1]
    XP_006710930.1. XM_006710867.1. [Q03167-1]
    XP_006710931.1. XM_006710868.1. [Q03167-1]
    UniGeneiHs.482390.
    Hs.735919.

    Genome annotation databases

    EnsembliENST00000212355; ENSP00000212355; ENSG00000069702. [Q03167-1]
    ENST00000370399; ENSP00000359426; ENSG00000069702. [Q03167-2]
    ENST00000465892; ENSP00000432638; ENSG00000069702. [Q03167-2]
    ENST00000525962; ENSP00000436127; ENSG00000069702. [Q03167-1]
    GeneIDi7049.
    KEGGihsa:7049.
    UCSCiuc001doh.3. human. [Q03167-1]
    uc001doi.3. human. [Q03167-2]

    Polymorphism databases

    DMDMi311033535.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07594 mRNA. Translation: AAA67061.1 . Frameshift.
    AJ251961 mRNA. Translation: CAB64374.1 .
    AY796304 Genomic DNA. Translation: AAV50003.1 .
    AK291345 mRNA. Translation: BAF84034.1 .
    AL162263 , AL390780 , AL445992 Genomic DNA. Translation: CAI22636.1 .
    AL162263
    , AC099334 , AL390780 , AL445992 Genomic DNA. Translation: CAI22637.1 .
    AL390780 , AL162263 , AL445992 Genomic DNA. Translation: CAI14570.1 .
    AL390780
    , AC099334 , AL162263 , AL445992 Genomic DNA. Translation: CAI14571.1 .
    AL445992 , AL162263 , AL390780 Genomic DNA. Translation: CAI13392.1 .
    AL445992
    , AC099334 , AL162263 , AL390780 Genomic DNA. Translation: CAI13393.1 .
    BC126116 mRNA. Translation: AAI26117.1 .
    BC136295 mRNA. Translation: AAI36296.1 .
    CCDSi CCDS30770.1. [Q03167-1 ]
    CCDS55614.1. [Q03167-2 ]
    PIRi JC1350.
    RefSeqi NP_001182612.1. NM_001195683.1. [Q03167-2 ]
    NP_001182613.1. NM_001195684.1. [Q03167-2 ]
    NP_003234.2. NM_003243.4. [Q03167-1 ]
    XP_006710930.1. XM_006710867.1. [Q03167-1 ]
    XP_006710931.1. XM_006710868.1. [Q03167-1 ]
    UniGenei Hs.482390.
    Hs.735919.

    3D structure databases

    ProteinModelPortali Q03167.
    SMRi Q03167. Positions 587-755.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112907. 4 interactions.
    DIPi DIP-5940N.
    IntActi Q03167. 4 interactions.
    MINTi MINT-1785606.
    STRINGi 9606.ENSP00000212355.

    PTM databases

    PhosphoSitei Q03167.

    Polymorphism databases

    DMDMi 311033535.

    Proteomic databases

    MaxQBi Q03167.
    PaxDbi Q03167.
    PRIDEi Q03167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000212355 ; ENSP00000212355 ; ENSG00000069702 . [Q03167-1 ]
    ENST00000370399 ; ENSP00000359426 ; ENSG00000069702 . [Q03167-2 ]
    ENST00000465892 ; ENSP00000432638 ; ENSG00000069702 . [Q03167-2 ]
    ENST00000525962 ; ENSP00000436127 ; ENSG00000069702 . [Q03167-1 ]
    GeneIDi 7049.
    KEGGi hsa:7049.
    UCSCi uc001doh.3. human. [Q03167-1 ]
    uc001doi.3. human. [Q03167-2 ]

    Organism-specific databases

    CTDi 7049.
    GeneCardsi GC01M092145.
    H-InvDB HIX0028622.
    HGNCi HGNC:11774. TGFBR3.
    HPAi CAB018971.
    HPA008257.
    MIMi 600742. gene.
    neXtProti NX_Q03167.
    Orphaneti 231160. Familial cerebral saccular aneurysm.
    PharmGKBi PA36487.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40778.
    HOGENOMi HOG000090193.
    HOVERGENi HBG057515.
    KOi K05843.
    OMAi IENICPK.
    OrthoDBi EOG72ZCDK.
    PhylomeDBi Q03167.
    TreeFami TF337375.

    Miscellaneous databases

    ChiTaRSi TGFBR3. human.
    GeneWikii TGFBR3.
    GenomeRNAii 7049.
    NextBioi 27547.
    PROi Q03167.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q03167.
    Bgeei Q03167.
    CleanExi HS_TGFBR3.
    Genevestigatori Q03167.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    PRINTSi PR00023. ZPELLUCIDA.
    SMARTi SM00241. ZP. 1 hit.
    [Graphical view ]
    PROSITEi PS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
      Moren A., Ichijo H., Miyazono K.
      Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PHE-15.
      Tissue: Placenta.
    2. "Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene."
      Zippert R., Baessler A., Holmer S.R., Hengstenberg C., Schunkert H.
      J. Hum. Genet. 45:250-253(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-15.
      Tissue: Blood.
    3. NIEHS SNPs program
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-14; PHE-15; LEU-163; THR-635 AND ARG-765.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
      Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
      J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TCTEX1D4.

    Entry informationi

    Entry nameiTGBR3_HUMAN
    AccessioniPrimary (citable) accession number: Q03167
    Secondary accession number(s): A0AUW8
    , A8K5N0, B9EG88, Q5T2T4, Q5U731, Q9UGI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3