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Protein

Transforming growth factor beta receptor type 3

Gene

TGFBR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

GO - Molecular functioni

  • coreceptor activity Source: BHF-UCL
  • glycosaminoglycan binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • PDZ domain binding Source: BHF-UCL
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta-activated receptor activity Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type III Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069702-MONOMER.
SIGNORiQ03167.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:TGFBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11774. TGFBR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 787ExtracellularSequence analysisAdd BLAST767
Transmembranei788 – 809HelicalSequence analysisAdd BLAST22
Topological domaini810 – 851CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • inhibin-betaglycan-ActRII complex Source: BHF-UCL
  • integral component of plasma membrane Source: BHF-UCL
  • proteinaceous extracellular matrix Source: Ensembl
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7049.
MalaCardsiTGFBR3.
OpenTargetsiENSG00000069702.
Orphaneti231160. Familial cerebral saccular aneurysm.
PharmGKBiPA36487.

Polymorphism and mutation databases

BioMutaiTGFBR3.
DMDMi311033535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004166321 – 851Transforming growth factor beta receptor type 3Add BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi492N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534O-linked (Xyl...) (glycosaminoglycan)By similarity1
Glycosylationi545O-linked (Xyl...) (glycosaminoglycan)By similarity1
Glycosylationi571N-linked (GlcNAc...)Sequence analysis1
Glycosylationi590N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi639 ↔ 705By similarity
Disulfide bondi660 ↔ 730By similarity
Glycosylationi697N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi710 ↔ 723By similarity

Post-translational modificationi

Extensively modified by glycosaminoglycan groups (GAG).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ03167.
PaxDbiQ03167.
PeptideAtlasiQ03167.
PRIDEiQ03167.

PTM databases

iPTMnetiQ03167.
PhosphoSitePlusiQ03167.

Expressioni

Gene expression databases

BgeeiENSG00000069702.
CleanExiHS_TGFBR3.
ExpressionAtlasiQ03167. baseline and differential.
GenevisibleiQ03167. HS.

Organism-specific databases

HPAiCAB018971.
HPA008257.

Interactioni

Subunit structurei

Interacts with TCTEX1D4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GIPC1O149083EBI-2852679,EBI-373132
TGFB1P011372EBI-2852679,EBI-779636

GO - Molecular functioni

  • PDZ domain binding Source: BHF-UCL
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112907. 20 interactors.
DIPiDIP-5940N.
IntActiQ03167. 4 interactors.
MINTiMINT-1785606.
STRINGi9606.ENSP00000212355.

Structurei

3D structure databases

ProteinModelPortaliQ03167.
SMRiQ03167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini455 – 730ZPPROSITE-ProRule annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni737 – 751Interaction with TGF-beta ligandBy similarityAdd BLAST15

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7K. Eukaryota.
ENOG410XSMK. LUCA.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiQ03167.
KOiK05843.
OMAiFAIQTCF.
OrthoDBiEOG091G030O.
PhylomeDBiQ03167.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS
60 70 80 90 100
GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV
110 120 130 140 150
VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE
160 170 180 190 200
RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG
210 220 230 240 250
KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV
260 270 280 290 300
DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI
310 320 330 340 350
GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR
360 370 380 390 400
FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG
410 420 430 440 450
LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI
460 470 480 490 500
ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES
510 520 530 540 550
PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF
560 570 580 590 600
PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT
610 620 630 640 650
DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM
660 670 680 690 700
SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL
710 720 730 740 750
LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK
760 770 780 790 800
PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL
810 820 830 840 850
LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST

A
Length:851
Mass (Da):93,499
Last modified:November 2, 2010 - v3
Checksum:iAEC56C4477C003B2
GO
Isoform 2 (identifier: Q03167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: Missing.

Show »
Length:850
Mass (Da):93,428
Checksum:i1469BB567BD05230
GO

Sequence cautioni

The sequence AAA67061 differs from that shown. Reason: Frameshift at positions 70, 73, 349 and 350.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89P → S in BAF84034 (PubMed:14702039).Curated1
Sequence conflicti238I → V in BAF84034 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02089114S → N.1 PublicationCorresponds to variant rs17884205dbSNPEnsembl.1
Natural variantiVAR_01492015S → F.3 PublicationsCorresponds to variant rs1805110dbSNPEnsembl.1
Natural variantiVAR_020892163W → L.1 PublicationCorresponds to variant rs17885124dbSNPEnsembl.1
Natural variantiVAR_057499351F → I.Corresponds to variant rs11466592dbSNPEnsembl.1
Natural variantiVAR_020893635A → T.1 PublicationCorresponds to variant rs17882578dbSNPEnsembl.1
Natural variantiVAR_020894765G → R.1 PublicationCorresponds to variant rs17882828dbSNPEnsembl.1
Natural variantiVAR_066625777P → S.Corresponds to variant rs35352606dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040018359Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07594 mRNA. Translation: AAA67061.1. Frameshift.
AJ251961 mRNA. Translation: CAB64374.1.
AY796304 Genomic DNA. Translation: AAV50003.1.
AK291345 mRNA. Translation: BAF84034.1.
AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1.
AL162263
, AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1.
AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1.
AL390780
, AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1.
AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1.
AL445992
, AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1.
BC126116 mRNA. Translation: AAI26117.1.
BC136295 mRNA. Translation: AAI36296.1.
CCDSiCCDS30770.1. [Q03167-1]
CCDS55614.1. [Q03167-2]
PIRiJC1350.
RefSeqiNP_001182612.1. NM_001195683.1. [Q03167-2]
NP_001182613.1. NM_001195684.1. [Q03167-2]
NP_003234.2. NM_003243.4. [Q03167-1]
XP_006710930.1. XM_006710867.2. [Q03167-1]
XP_006710931.1. XM_006710868.2. [Q03167-1]
UniGeneiHs.482390.
Hs.735919.

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702. [Q03167-1]
ENST00000370399; ENSP00000359426; ENSG00000069702. [Q03167-2]
ENST00000465892; ENSP00000432638; ENSG00000069702. [Q03167-2]
ENST00000525962; ENSP00000436127; ENSG00000069702. [Q03167-1]
GeneIDi7049.
KEGGihsa:7049.
UCSCiuc001doh.4. human. [Q03167-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07594 mRNA. Translation: AAA67061.1. Frameshift.
AJ251961 mRNA. Translation: CAB64374.1.
AY796304 Genomic DNA. Translation: AAV50003.1.
AK291345 mRNA. Translation: BAF84034.1.
AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1.
AL162263
, AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1.
AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1.
AL390780
, AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1.
AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1.
AL445992
, AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1.
BC126116 mRNA. Translation: AAI26117.1.
BC136295 mRNA. Translation: AAI36296.1.
CCDSiCCDS30770.1. [Q03167-1]
CCDS55614.1. [Q03167-2]
PIRiJC1350.
RefSeqiNP_001182612.1. NM_001195683.1. [Q03167-2]
NP_001182613.1. NM_001195684.1. [Q03167-2]
NP_003234.2. NM_003243.4. [Q03167-1]
XP_006710930.1. XM_006710867.2. [Q03167-1]
XP_006710931.1. XM_006710868.2. [Q03167-1]
UniGeneiHs.482390.
Hs.735919.

3D structure databases

ProteinModelPortaliQ03167.
SMRiQ03167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112907. 20 interactors.
DIPiDIP-5940N.
IntActiQ03167. 4 interactors.
MINTiMINT-1785606.
STRINGi9606.ENSP00000212355.

PTM databases

iPTMnetiQ03167.
PhosphoSitePlusiQ03167.

Polymorphism and mutation databases

BioMutaiTGFBR3.
DMDMi311033535.

Proteomic databases

MaxQBiQ03167.
PaxDbiQ03167.
PeptideAtlasiQ03167.
PRIDEiQ03167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702. [Q03167-1]
ENST00000370399; ENSP00000359426; ENSG00000069702. [Q03167-2]
ENST00000465892; ENSP00000432638; ENSG00000069702. [Q03167-2]
ENST00000525962; ENSP00000436127; ENSG00000069702. [Q03167-1]
GeneIDi7049.
KEGGihsa:7049.
UCSCiuc001doh.4. human. [Q03167-1]

Organism-specific databases

CTDi7049.
DisGeNETi7049.
GeneCardsiTGFBR3.
H-InvDBHIX0028622.
HGNCiHGNC:11774. TGFBR3.
HPAiCAB018971.
HPA008257.
MalaCardsiTGFBR3.
MIMi600742. gene.
neXtProtiNX_Q03167.
OpenTargetsiENSG00000069702.
Orphaneti231160. Familial cerebral saccular aneurysm.
PharmGKBiPA36487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK7K. Eukaryota.
ENOG410XSMK. LUCA.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiQ03167.
KOiK05843.
OMAiFAIQTCF.
OrthoDBiEOG091G030O.
PhylomeDBiQ03167.
TreeFamiTF337375.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069702-MONOMER.
SIGNORiQ03167.

Miscellaneous databases

ChiTaRSiTGFBR3. human.
GeneWikiiTGFBR3.
GenomeRNAii7049.
PROiQ03167.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069702.
CleanExiHS_TGFBR3.
ExpressionAtlasiQ03167. baseline and differential.
GenevisibleiQ03167. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGBR3_HUMAN
AccessioniPrimary (citable) accession number: Q03167
Secondary accession number(s): A0AUW8
, A8K5N0, B9EG88, Q5T2T4, Q5U731, Q9UGI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.