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Protein

Transforming growth factor beta receptor type 3

Gene

TGFBR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

GO - Molecular functioni

  • coreceptor activity Source: BHF-UCL
  • glycosaminoglycan binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • PDZ domain binding Source: BHF-UCL
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta-activated receptor activity Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type III Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

  • BMP signaling pathway Source: BHF-UCL
  • cardiac epithelial to mesenchymal transition Source: BHF-UCL
  • cardiac muscle cell proliferation Source: BHF-UCL
  • cell growth Source: BHF-UCL
  • cell migration Source: BHF-UCL
  • definitive erythrocyte differentiation Source: BHF-UCL
  • definitive hemopoiesis Source: BHF-UCL
  • epithelial to mesenchymal transition Source: BHF-UCL
  • heart morphogenesis Source: BHF-UCL
  • heart trabecula formation Source: BHF-UCL
  • immune response Source: BHF-UCL
  • intracellular signal transduction Source: BHF-UCL
  • liver development Source: BHF-UCL
  • negative regulation of cellular component movement Source: BHF-UCL
  • negative regulation of epithelial cell proliferation Source: BHF-UCL
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  • organ regeneration Source: Ensembl
  • palate development Source: BHF-UCL
  • pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  • regulation of protein binding Source: Ensembl
  • response to follicle-stimulating hormone Source: BHF-UCL
  • response to hypoxia Source: Ensembl
  • response to luteinizing hormone Source: BHF-UCL
  • response to prostaglandin E Source: BHF-UCL
  • transforming growth factor beta receptor complex assembly Source: Ensembl
  • transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:TGFBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11774. TGFBR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 787767ExtracellularSequence AnalysisAdd
BLAST
Transmembranei788 – 80922HelicalSequence AnalysisAdd
BLAST
Topological domaini810 – 85142CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • inhibin-betaglycan-ActRII complex Source: BHF-UCL
  • integral component of plasma membrane Source: BHF-UCL
  • proteinaceous extracellular matrix Source: Ensembl
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti231160. Familial cerebral saccular aneurysm.
PharmGKBiPA36487.

Polymorphism and mutation databases

BioMutaiTGFBR3.
DMDMi311033535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 851831Transforming growth factor beta receptor type 3PRO_0000041663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi534 – 5341O-linked (Xyl...) (glycosaminoglycan)By similarity
Glycosylationi545 – 5451O-linked (Xyl...) (glycosaminoglycan)By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi639 ↔ 705By similarity
Disulfide bondi660 ↔ 730By similarity
Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi710 ↔ 723By similarity

Post-translational modificationi

Extensively modified by glycosaminoglycan groups (GAG).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ03167.
PaxDbiQ03167.
PRIDEiQ03167.

PTM databases

PhosphoSiteiQ03167.

Expressioni

Gene expression databases

BgeeiQ03167.
CleanExiHS_TGFBR3.
ExpressionAtlasiQ03167. baseline and differential.
GenevisibleiQ03167. HS.

Organism-specific databases

HPAiCAB018971.
HPA008257.

Interactioni

Subunit structurei

Interacts with TCTEX1D4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GIPC1O149083EBI-2852679,EBI-373132
TGFB1P011372EBI-2852679,EBI-779636

Protein-protein interaction databases

BioGridi112907. 16 interactions.
DIPiDIP-5940N.
IntActiQ03167. 4 interactions.
MINTiMINT-1785606.
STRINGi9606.ENSP00000212355.

Structurei

3D structure databases

ProteinModelPortaliQ03167.
SMRiQ03167. Positions 587-755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini455 – 730276ZPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni737 – 75115Interaction with TGF-beta ligandBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40778.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiQ03167.
KOiK05843.
OMAiFAIQTCF.
OrthoDBiEOG72ZCDK.
PhylomeDBiQ03167.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS
60 70 80 90 100
GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV
110 120 130 140 150
VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE
160 170 180 190 200
RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG
210 220 230 240 250
KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV
260 270 280 290 300
DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI
310 320 330 340 350
GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR
360 370 380 390 400
FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG
410 420 430 440 450
LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI
460 470 480 490 500
ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES
510 520 530 540 550
PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF
560 570 580 590 600
PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT
610 620 630 640 650
DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM
660 670 680 690 700
SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL
710 720 730 740 750
LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK
760 770 780 790 800
PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL
810 820 830 840 850
LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST

A
Length:851
Mass (Da):93,499
Last modified:November 2, 2010 - v3
Checksum:iAEC56C4477C003B2
GO
Isoform 2 (identifier: Q03167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: Missing.

Show »
Length:850
Mass (Da):93,428
Checksum:i1469BB567BD05230
GO

Sequence cautioni

The sequence AAA67061.1 differs from that shown. Reason: Frameshift at positions 70, 73, 349 and 350. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891P → S in BAF84034 (PubMed:14702039).Curated
Sequence conflicti238 – 2381I → V in BAF84034 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141S → N.1 Publication
Corresponds to variant rs17884205 [ dbSNP | Ensembl ].
VAR_020891
Natural varianti15 – 151S → F.3 Publications
Corresponds to variant rs1805110 [ dbSNP | Ensembl ].
VAR_014920
Natural varianti163 – 1631W → L.1 Publication
Corresponds to variant rs17885124 [ dbSNP | Ensembl ].
VAR_020892
Natural varianti351 – 3511F → I.
Corresponds to variant rs11466592 [ dbSNP | Ensembl ].
VAR_057499
Natural varianti635 – 6351A → T.1 Publication
Corresponds to variant rs17882578 [ dbSNP | Ensembl ].
VAR_020893
Natural varianti765 – 7651G → R.1 Publication
Corresponds to variant rs17882828 [ dbSNP | Ensembl ].
VAR_020894
Natural varianti777 – 7771P → S.
Corresponds to variant rs35352606 [ dbSNP | Ensembl ].
VAR_066625

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei359 – 3591Missing in isoform 2. 1 PublicationVSP_040018

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07594 mRNA. Translation: AAA67061.1. Frameshift.
AJ251961 mRNA. Translation: CAB64374.1.
AY796304 Genomic DNA. Translation: AAV50003.1.
AK291345 mRNA. Translation: BAF84034.1.
AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1.
AL162263
, AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1.
AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1.
AL390780
, AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1.
AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1.
AL445992
, AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1.
BC126116 mRNA. Translation: AAI26117.1.
BC136295 mRNA. Translation: AAI36296.1.
CCDSiCCDS30770.1. [Q03167-1]
CCDS55614.1. [Q03167-2]
PIRiJC1350.
RefSeqiNP_001182612.1. NM_001195683.1. [Q03167-2]
NP_001182613.1. NM_001195684.1. [Q03167-2]
NP_003234.2. NM_003243.4. [Q03167-1]
XP_006710930.1. XM_006710867.1. [Q03167-1]
XP_006710931.1. XM_006710868.1. [Q03167-1]
UniGeneiHs.482390.
Hs.735919.

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702.
ENST00000525962; ENSP00000436127; ENSG00000069702.
GeneIDi7049.
KEGGihsa:7049.
UCSCiuc001doh.3. human. [Q03167-1]
uc001doi.3. human. [Q03167-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07594 mRNA. Translation: AAA67061.1. Frameshift.
AJ251961 mRNA. Translation: CAB64374.1.
AY796304 Genomic DNA. Translation: AAV50003.1.
AK291345 mRNA. Translation: BAF84034.1.
AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1.
AL162263
, AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1.
AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1.
AL390780
, AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1.
AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1.
AL445992
, AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1.
BC126116 mRNA. Translation: AAI26117.1.
BC136295 mRNA. Translation: AAI36296.1.
CCDSiCCDS30770.1. [Q03167-1]
CCDS55614.1. [Q03167-2]
PIRiJC1350.
RefSeqiNP_001182612.1. NM_001195683.1. [Q03167-2]
NP_001182613.1. NM_001195684.1. [Q03167-2]
NP_003234.2. NM_003243.4. [Q03167-1]
XP_006710930.1. XM_006710867.1. [Q03167-1]
XP_006710931.1. XM_006710868.1. [Q03167-1]
UniGeneiHs.482390.
Hs.735919.

3D structure databases

ProteinModelPortaliQ03167.
SMRiQ03167. Positions 587-755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112907. 16 interactions.
DIPiDIP-5940N.
IntActiQ03167. 4 interactions.
MINTiMINT-1785606.
STRINGi9606.ENSP00000212355.

PTM databases

PhosphoSiteiQ03167.

Polymorphism and mutation databases

BioMutaiTGFBR3.
DMDMi311033535.

Proteomic databases

MaxQBiQ03167.
PaxDbiQ03167.
PRIDEiQ03167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702.
ENST00000525962; ENSP00000436127; ENSG00000069702.
GeneIDi7049.
KEGGihsa:7049.
UCSCiuc001doh.3. human. [Q03167-1]
uc001doi.3. human. [Q03167-2]

Organism-specific databases

CTDi7049.
GeneCardsiGC01M092145.
H-InvDBHIX0028622.
HGNCiHGNC:11774. TGFBR3.
HPAiCAB018971.
HPA008257.
MIMi600742. gene.
neXtProtiNX_Q03167.
Orphaneti231160. Familial cerebral saccular aneurysm.
PharmGKBiPA36487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40778.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
InParanoidiQ03167.
KOiK05843.
OMAiFAIQTCF.
OrthoDBiEOG72ZCDK.
PhylomeDBiQ03167.
TreeFamiTF337375.

Miscellaneous databases

ChiTaRSiTGFBR3. human.
GeneWikiiTGFBR3.
GenomeRNAii7049.
NextBioi27547.
PROiQ03167.
SOURCEiSearch...

Gene expression databases

BgeeiQ03167.
CleanExiHS_TGFBR3.
ExpressionAtlasiQ03167. baseline and differential.
GenevisibleiQ03167. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
    Moren A., Ichijo H., Miyazono K.
    Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PHE-15.
    Tissue: Placenta.
  2. "Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene."
    Zippert R., Baessler A., Holmer S.R., Hengstenberg C., Schunkert H.
    J. Hum. Genet. 45:250-253(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-15.
    Tissue: Blood.
  3. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-14; PHE-15; LEU-163; THR-635 AND ARG-765.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
    Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
    J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TCTEX1D4.

Entry informationi

Entry nameiTGBR3_HUMAN
AccessioniPrimary (citable) accession number: Q03167
Secondary accession number(s): A0AUW8
, A8K5N0, B9EG88, Q5T2T4, Q5U731, Q9UGI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: July 22, 2015
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.