Q03167 (TGBR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transforming growth factor beta receptor type 3
Short name=TGF-beta receptor type 3
Short name=TGFR-3

Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name=TGF-beta receptor type III

Gene names

Name:

TGFBR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	851 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Subunit structure	Interacts with TCTEX1D4. Ref.7
Subcellular location	Secreted. Secreted › extracellular space. Cell membrane; Single-pass type I membrane protein Potential. Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
Post-translational modification	Extensively modified by glycosaminoglycan groups (GAG).
Sequence similarities	Contains 1 ZP domain.
Sequence caution	The sequence AAA67061.1 differs from that shown. Reason: Frameshift at positions 70, 73, 349 and 350.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay PubMed 18184661. Source: BHF-UCL blastocyst development Inferred from electronic annotation. Source: Compara blood vessel development Inferred from electronic annotation. Source: Compara cardiac epithelial to mesenchymal transition Inferred from direct assay PubMed 18184661. Source: BHF-UCL cardiac muscle cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL cell growth Inferred from sequence or structural similarity Ref.1. Source: BHF-UCL cell migration Inferred from sequence or structural similarity. Source: BHF-UCL definitive erythrocyte differentiation Inferred from sequence or structural similarity. Source: BHF-UCL heart trabecula formation Inferred from sequence or structural similarity. Source: BHF-UCL immune response Inferred from mutant phenotype PubMed 16886151. Source: BHF-UCL intracellular protein kinase cascade Inferred from mutant phenotype PubMed 14557487. Source: BHF-UCL liver development Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cellular component movement Inferred from direct assay PubMed 17999987. Source: BHF-UCL negative regulation of epithelial cell migration Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara negative regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara palate development Inferred from sequence or structural similarity. Source: BHF-UCL pathway-restricted SMAD protein phosphorylation Inferred from mutant phenotype PubMed 11157754. Source: BHF-UCL positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of protein binding Inferred from electronic annotation. Source: Compara response to follicle-stimulating hormone stimulus Inferred from direct assay PubMed 14557487. Source: BHF-UCL response to hypoxia Inferred from electronic annotation. Source: Compara response to luteinizing hormone stimulus Inferred from direct assay PubMed 14557487. Source: BHF-UCL response to prostaglandin E stimulus Inferred from direct assay PubMed 14557487. Source: BHF-UCL transforming growth factor beta receptor complex assembly Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 12958365. Source: BHF-UCL ventricular cardiac muscle tissue morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from direct assay PubMed 12958365. Source: BHF-UCL extracellular space Traceable author statement PubMed 18184661. Source: BHF-UCL inhibin-betaglycan-ActRII complex Inferred from direct assay PubMed 10746731. Source: BHF-UCL integral to plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL proteinaceous extracellular matrix Inferred from electronic annotation. Source: Compara
Molecular_function	PDZ domain binding Inferred from sequence or structural similarity. Source: BHF-UCL SMAD binding Inferred from mutant phenotype PubMed 11157754. Source: BHF-UCL coreceptor activity Inferred from direct assay PubMed 10746731. Source: BHF-UCL heparin binding Inferred from sequence or structural similarity Ref.1. Source: BHF-UCL transforming growth factor beta binding Inferred from direct assay PubMed 11157754PubMed 12958365. Source: BHF-UCL transforming growth factor beta receptor activity, type III Inferred from direct assay PubMed 10746731PubMed 11157754. Source: BHF-UCL type II transforming growth factor beta receptor binding Inferred from direct assay PubMed 11157754. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TGFB1	P01137	2	EBI-2852679,EBI-779636

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03167-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q03167-2)

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 851	831	Transforming growth factor beta receptor type 3		PRO_0000041663
Regions
	Topological domain	21 – 787	767	Extracellular Potential
	Transmembrane	788 – 809	22	Helical; Potential
	Topological domain	810 – 851	42	Cytoplasmic Potential
	Domain	455 – 730	276	ZP
Amino acid modifications
	Glycosylation	141	1	N-linked (GlcNAc...) Potential
	Glycosylation	492	1	N-linked (GlcNAc...) Potential
	Glycosylation	534	1	O-linked (Xyl...) (glycosaminoglycan) By similarity
	Glycosylation	545	1	O-linked (Xyl...) (glycosaminoglycan) By similarity
	Glycosylation	571	1	N-linked (GlcNAc...) Potential
	Glycosylation	590	1	N-linked (GlcNAc...) Potential
	Glycosylation	697	1	N-linked (GlcNAc...) Potential
	Disulfide bond	639 ↔ 705		By similarity
	Disulfide bond	660 ↔ 730		By similarity
Natural variations
	Alternative sequence	359	1	Missing in isoform 2.		VSP_040018
	Natural variant	14	1	S → N. Ref.3 Corresponds to variant rs17884205 [ dbSNP | Ensembl ].		VAR_020891
	Natural variant	15	1	S → F. Ref.1 Ref.2 Ref.3 Corresponds to variant rs1805110 [ dbSNP | Ensembl ].		VAR_014920
	Natural variant	163	1	W → L. Ref.3 Corresponds to variant rs17885124 [ dbSNP | Ensembl ].		VAR_020892
	Natural variant	351	1	F → I. Corresponds to variant rs11466592 [ dbSNP | Ensembl ].		VAR_057499
	Natural variant	635	1	A → T. Ref.3		VAR_020893
	Natural variant	765	1	G → R. Ref.3		VAR_020894
	Natural variant	777	1	P → S. Corresponds to variant rs35352606 [ dbSNP | Ensembl ].		VAR_066625
Experimental info
	Sequence conflict	89	1	P → S in BAF84034. Ref.4
	Sequence conflict	238	1	I → V in BAF84034. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: AEC56C4477C003B2	FASTA	851	93,499
	10 20 30 40 50 60 MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 70 80 90 100 110 120 PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 130 140 150 160 170 180 TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 190 200 210 220 230 240 RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 250 260 270 280 290 300 NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 310 320 330 340 350 360 GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNAE 370 380 390 400 410 420 EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG LPFPFPDISR RVWNEEGEDG 430 440 450 460 470 480 LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI ALSVKCDNEK MIVAVEKDSF QASGYSGMDV 490 500 510 520 530 540 TLLDPTCKAK MNGTHFVLES PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY 550 560 570 580 590 600 EDLESGDNGF PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT 610 620 630 640 650 660 DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM SHYTIIENIC 670 680 690 700 710 720 PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL LFLQCELTLC TKMEKHPQKL 730 740 750 760 770 780 PKCVPPDEAC TSLDASIIWA MMQNKKTFTK PLAVIHHEAE SKEKGPSMKE PNPISPPIFH 790 800 810 820 830 840 GLDTLTVMGI AFAAFVIGAL LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST 850 QSTPCSSSST A
	Isoform 2 [UniParc]. Checksum: 1469BB567BD05230	FASTA	850	93,428
	10 20 30 40 50 60 MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 70 80 90 100 110 120 PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 130 140 150 160 170 180 TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 190 200 210 220 230 240 RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 250 260 270 280 290 300 NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 310 320 330 340 350 360 GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNEE 370 380 390 400 410 420 MGDEEVHTIP PELRILLDPG ALPALQNPPI RGGEGQNGGL PFPFPDISRR VWNEEGEDGL 430 440 450 460 470 480 PRPKDPVIPS IQLFPGLREP EEVQGSVDIA LSVKCDNEKM IVAVEKDSFQ ASGYSGMDVT 490 500 510 520 530 540 LLDPTCKAKM NGTHFVLESP LNGCGTRPRW SALDGVVYYN SIVIQVPALG DSSGWPDGYE 550 560 570 580 590 600 DLESGDNGFP GDMDEGDASL FTRPEIVVFN CSLQQVRNPS SFQEQPHGNI TFNMELYNTD 610 620 630 640 650 660 LFLVPSQGVF SVPENGHVYV EVSVTKAEQE LGFAIQTCFI SPYSNPDRMS HYTIIENICP 670 680 690 700 710 720 KDESVKFYSP KRVHFPIPQA DMDKKRFSFV FKPVFNTSLL FLQCELTLCT KMEKHPQKLP 730 740 750 760 770 780 KCVPPDEACT SLDASIIWAM MQNKKTFTKP LAVIHHEAES KEKGPSMKEP NPISPPIFHG 790 800 810 820 830 840 LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETAGRQQV PTSPPASENS SAAHSIGSTQ 850 STPCSSSSTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors." Moren A., Ichijo H., Miyazono K. Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PHE-15. Tissue: Placenta.
[2]	"Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene." Zippert R., Baessler A., Holmer S.R., Hengstenberg C., Schunkert H. J. Hum. Genet. 45:250-253(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-15. Tissue: Blood.
[3]	NIEHS SNPs program Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-14; PHE-15; LEU-163; THR-635 AND ARG-765.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors." Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M. J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TCTEX1D4.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	L07594 mRNA. Translation: AAA67061.1. Frameshift. AJ251961 mRNA. Translation: CAB64374.1. AY796304 Genomic DNA. Translation: AAV50003.1. AK291345 mRNA. Translation: BAF84034.1. AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1. AL162263 , AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1. AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1. AL390780 , AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1. AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1. AL445992 , AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1. BC126116 mRNA. Translation: AAI26117.1. BC136295 mRNA. Translation: AAI36296.1.
IPI	IPI00304865. IPI00971143.
PIR	JC1350.
RefSeq	NP_001182612.1. NM_001195683.1. NP_001182613.1. NM_001195684.1. NP_003234.2. NM_003243.4.
UniGene	Hs.482390. Hs.735919.
3D structure databases
ProteinModelPortal	Q03167.
SMR	Q03167. Positions 587-755.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5940N.
IntAct	Q03167. 2 interactions.
MINT	MINT-1785606.
STRING	9606.ENSP00000212355.
PTM databases
PhosphoSite	Q03167.
Polymorphism databases
DMDM	311033535.
Proteomic databases
PaxDb	Q03167.
PRIDE	Q03167.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000212355; ENSP00000212355; ENSG00000069702. ENST00000370399; ENSP00000359426; ENSG00000069702. ENST00000465892; ENSP00000432638; ENSG00000069702. ENST00000525962; ENSP00000436127; ENSG00000069702.
GeneID	7049.
KEGG	hsa:7049.
UCSC	uc001doh.3. human. uc001doi.3. human.
Organism-specific databases
CTD	7049.
GeneCards	GC01M092145.
H-InvDB	HIX0028622.
HGNC	HGNC:11774. TGFBR3.
HPA	CAB018971. HPA008257.
MIM	600742. gene.
neXtProt	NX_Q03167.
PharmGKB	PA36487.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40778.
HOGENOM	HOG000090193.
HOVERGEN	HBG057515.
KO	K05843.
OMA	IENICPK.
OrthoDB	EOG4PVNXW.
Enzyme and pathway databases
Pathway_Interaction_DB	tgfbrpathway. TGF-beta receptor signaling.
Gene expression databases
ArrayExpress	Q03167.
Bgee	Q03167.
CleanEx	HS_TGFBR3.
Genevestigator	Q03167.
GermOnline	ENSG00000069702. Homo sapiens.
Family and domain databases
InterPro	IPR001507. ZP_dom. IPR017977. ZP_dom_CS. [Graphical view]
Pfam	PF00100. Zona_pellucida. 1 hit. [Graphical view]
PRINTS	PR00023. ZPELLUCIDA.
SMART	SM00241. ZP. 1 hit. [Graphical view]
PROSITE	PS00682. ZP_1. 1 hit. PS51034. ZP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TGFBR3. human.
GenomeRNAi	7049.
NextBio	27547.
SOURCE	Search...

Entry information

Entry name

TGBR3_HUMAN

Accession

Primary (citable) accession number: Q03167
Secondary accession number(s): A0AUW8 , A8K5N0, B9EG88, Q5T2T4, Q5U731, Q9UGI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.