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Q03167

- TGBR3_HUMAN

UniProt

Q03167 - TGBR3_HUMAN

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Protein
Transforming growth factor beta receptor type 3
Gene
TGFBR3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

GO - Molecular functioni

  1. PDZ domain binding Source: BHF-UCL
  2. SMAD binding Source: BHF-UCL
  3. coreceptor activity Source: BHF-UCL
  4. glycosaminoglycan binding Source: BHF-UCL
  5. heparin binding Source: BHF-UCL
  6. protein binding Source: IntAct
  7. transforming growth factor beta binding Source: BHF-UCL
  8. transforming growth factor beta receptor activity, type III Source: BHF-UCL
  9. transforming growth factor beta receptor binding Source: BHF-UCL
  10. transforming growth factor beta-activated receptor activity Source: BHF-UCL
  11. type II transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

  1. BMP signaling pathway Source: BHF-UCL
  2. blastocyst development Source: Ensembl
  3. blood vessel development Source: Ensembl
  4. cardiac epithelial to mesenchymal transition Source: BHF-UCL
  5. cardiac muscle cell proliferation Source: BHF-UCL
  6. cell growth Source: BHF-UCL
  7. cell migration Source: BHF-UCL
  8. definitive erythrocyte differentiation Source: BHF-UCL
  9. definitive hemopoiesis Source: BHF-UCL
  10. epithelial to mesenchymal transition Source: BHF-UCL
  11. heart morphogenesis Source: BHF-UCL
  12. heart trabecula formation Source: BHF-UCL
  13. immune response Source: BHF-UCL
  14. intracellular signal transduction Source: BHF-UCL
  15. liver development Source: BHF-UCL
  16. negative regulation of cellular component movement Source: BHF-UCL
  17. negative regulation of epithelial cell migration Source: Ensembl
  18. negative regulation of epithelial cell proliferation Source: BHF-UCL
  19. negative regulation of epithelial to mesenchymal transition Source: Ensembl
  20. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  21. organ regeneration Source: Ensembl
  22. palate development Source: BHF-UCL
  23. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  24. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  25. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  26. regulation of protein binding Source: Ensembl
  27. response to follicle-stimulating hormone Source: BHF-UCL
  28. response to hypoxia Source: Ensembl
  29. response to luteinizing hormone Source: BHF-UCL
  30. response to prostaglandin E Source: BHF-UCL
  31. transforming growth factor beta receptor complex assembly Source: Ensembl
  32. transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  33. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:TGFBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11774. TGFBR3.

Subcellular locationi

Secreted. Secretedextracellular space. Cell membrane; Single-pass type I membrane protein Reviewed prediction
Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 787767Extracellular Reviewed prediction
Add
BLAST
Transmembranei788 – 80922Helical; Reviewed prediction
Add
BLAST
Topological domaini810 – 85142Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. endoplasmic reticulum Source: Ensembl
  3. external side of plasma membrane Source: BHF-UCL
  4. extracellular space Source: UniProt
  5. extracellular vesicular exosome Source: UniProt
  6. inhibin-betaglycan-ActRII complex Source: BHF-UCL
  7. integral component of plasma membrane Source: BHF-UCL
  8. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti231160. Familial cerebral saccular aneurysm.
PharmGKBiPA36487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 851831Transforming growth factor beta receptor type 3
PRO_0000041663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylationi545 – 5451O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi590 – 5901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi639 ↔ 705 By similarity
Disulfide bondi660 ↔ 730 By similarity
Glycosylationi697 – 6971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi710 ↔ 723 By similarity

Post-translational modificationi

Extensively modified by glycosaminoglycan groups (GAG).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ03167.
PaxDbiQ03167.
PRIDEiQ03167.

PTM databases

PhosphoSiteiQ03167.

Expressioni

Gene expression databases

ArrayExpressiQ03167.
BgeeiQ03167.
CleanExiHS_TGFBR3.
GenevestigatoriQ03167.

Organism-specific databases

HPAiCAB018971.
HPA008257.

Interactioni

Subunit structurei

Interacts with TCTEX1D4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GIPC1O149083EBI-2852679,EBI-373132
TGFB1P011372EBI-2852679,EBI-779636

Protein-protein interaction databases

BioGridi112907. 4 interactions.
DIPiDIP-5940N.
IntActiQ03167. 4 interactions.
MINTiMINT-1785606.
STRINGi9606.ENSP00000212355.

Structurei

3D structure databases

ProteinModelPortaliQ03167.
SMRiQ03167. Positions 587-755.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini455 – 730276ZP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni737 – 75115Interaction with TGF-beta ligand By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 ZP domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40778.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
KOiK05843.
OMAiIENICPK.
OrthoDBiEOG72ZCDK.
PhylomeDBiQ03167.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q03167-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS    50
GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV 100
VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE 150
RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG 200
KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV 250
DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 300
GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR 350
FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG 400
LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI 450
ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES 500
PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF 550
PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT 600
DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM 650
SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL 700
LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK 750
PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL 800
LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST 850
A 851
Length:851
Mass (Da):93,499
Last modified:November 2, 2010 - v3
Checksum:iAEC56C4477C003B2
GO
Isoform 2 (identifier: Q03167-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: Missing.

Show »
Length:850
Mass (Da):93,428
Checksum:i1469BB567BD05230
GO

Sequence cautioni

The sequence AAA67061.1 differs from that shown. Reason: Frameshift at positions 70, 73, 349 and 350.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141S → N.1 Publication
Corresponds to variant rs17884205 [ dbSNP | Ensembl ].
VAR_020891
Natural varianti15 – 151S → F.3 Publications
Corresponds to variant rs1805110 [ dbSNP | Ensembl ].
VAR_014920
Natural varianti163 – 1631W → L.1 Publication
Corresponds to variant rs17885124 [ dbSNP | Ensembl ].
VAR_020892
Natural varianti351 – 3511F → I.
Corresponds to variant rs11466592 [ dbSNP | Ensembl ].
VAR_057499
Natural varianti635 – 6351A → T.1 Publication
Corresponds to variant rs17882578 [ dbSNP | Ensembl ].
VAR_020893
Natural varianti765 – 7651G → R.1 Publication
Corresponds to variant rs17882828 [ dbSNP | Ensembl ].
VAR_020894
Natural varianti777 – 7771P → S.
Corresponds to variant rs35352606 [ dbSNP | Ensembl ].
VAR_066625

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei359 – 3591Missing in isoform 2.
VSP_040018

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891P → S in BAF84034. 1 Publication
Sequence conflicti238 – 2381I → V in BAF84034. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07594 mRNA. Translation: AAA67061.1. Frameshift.
AJ251961 mRNA. Translation: CAB64374.1.
AY796304 Genomic DNA. Translation: AAV50003.1.
AK291345 mRNA. Translation: BAF84034.1.
AL162263, AL390780, AL445992 Genomic DNA. Translation: CAI22636.1.
AL162263
, AC099334, AL390780, AL445992 Genomic DNA. Translation: CAI22637.1.
AL390780, AL162263, AL445992 Genomic DNA. Translation: CAI14570.1.
AL390780
, AC099334, AL162263, AL445992 Genomic DNA. Translation: CAI14571.1.
AL445992, AL162263, AL390780 Genomic DNA. Translation: CAI13392.1.
AL445992
, AC099334, AL162263, AL390780 Genomic DNA. Translation: CAI13393.1.
BC126116 mRNA. Translation: AAI26117.1.
BC136295 mRNA. Translation: AAI36296.1.
CCDSiCCDS30770.1. [Q03167-1]
CCDS55614.1. [Q03167-2]
PIRiJC1350.
RefSeqiNP_001182612.1. NM_001195683.1. [Q03167-2]
NP_001182613.1. NM_001195684.1. [Q03167-2]
NP_003234.2. NM_003243.4. [Q03167-1]
XP_006710930.1. XM_006710867.1. [Q03167-1]
XP_006710931.1. XM_006710868.1. [Q03167-1]
UniGeneiHs.482390.
Hs.735919.

Genome annotation databases

EnsembliENST00000212355; ENSP00000212355; ENSG00000069702. [Q03167-1]
ENST00000370399; ENSP00000359426; ENSG00000069702. [Q03167-2]
ENST00000465892; ENSP00000432638; ENSG00000069702. [Q03167-2]
ENST00000525962; ENSP00000436127; ENSG00000069702. [Q03167-1]
GeneIDi7049.
KEGGihsa:7049.
UCSCiuc001doh.3. human. [Q03167-1]
uc001doi.3. human. [Q03167-2]

Polymorphism databases

DMDMi311033535.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07594 mRNA. Translation: AAA67061.1 . Frameshift.
AJ251961 mRNA. Translation: CAB64374.1 .
AY796304 Genomic DNA. Translation: AAV50003.1 .
AK291345 mRNA. Translation: BAF84034.1 .
AL162263 , AL390780 , AL445992 Genomic DNA. Translation: CAI22636.1 .
AL162263
, AC099334 , AL390780 , AL445992 Genomic DNA. Translation: CAI22637.1 .
AL390780 , AL162263 , AL445992 Genomic DNA. Translation: CAI14570.1 .
AL390780
, AC099334 , AL162263 , AL445992 Genomic DNA. Translation: CAI14571.1 .
AL445992 , AL162263 , AL390780 Genomic DNA. Translation: CAI13392.1 .
AL445992
, AC099334 , AL162263 , AL390780 Genomic DNA. Translation: CAI13393.1 .
BC126116 mRNA. Translation: AAI26117.1 .
BC136295 mRNA. Translation: AAI36296.1 .
CCDSi CCDS30770.1. [Q03167-1 ]
CCDS55614.1. [Q03167-2 ]
PIRi JC1350.
RefSeqi NP_001182612.1. NM_001195683.1. [Q03167-2 ]
NP_001182613.1. NM_001195684.1. [Q03167-2 ]
NP_003234.2. NM_003243.4. [Q03167-1 ]
XP_006710930.1. XM_006710867.1. [Q03167-1 ]
XP_006710931.1. XM_006710868.1. [Q03167-1 ]
UniGenei Hs.482390.
Hs.735919.

3D structure databases

ProteinModelPortali Q03167.
SMRi Q03167. Positions 587-755.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112907. 4 interactions.
DIPi DIP-5940N.
IntActi Q03167. 4 interactions.
MINTi MINT-1785606.
STRINGi 9606.ENSP00000212355.

PTM databases

PhosphoSitei Q03167.

Polymorphism databases

DMDMi 311033535.

Proteomic databases

MaxQBi Q03167.
PaxDbi Q03167.
PRIDEi Q03167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000212355 ; ENSP00000212355 ; ENSG00000069702 . [Q03167-1 ]
ENST00000370399 ; ENSP00000359426 ; ENSG00000069702 . [Q03167-2 ]
ENST00000465892 ; ENSP00000432638 ; ENSG00000069702 . [Q03167-2 ]
ENST00000525962 ; ENSP00000436127 ; ENSG00000069702 . [Q03167-1 ]
GeneIDi 7049.
KEGGi hsa:7049.
UCSCi uc001doh.3. human. [Q03167-1 ]
uc001doi.3. human. [Q03167-2 ]

Organism-specific databases

CTDi 7049.
GeneCardsi GC01M092145.
H-InvDB HIX0028622.
HGNCi HGNC:11774. TGFBR3.
HPAi CAB018971.
HPA008257.
MIMi 600742. gene.
neXtProti NX_Q03167.
Orphaneti 231160. Familial cerebral saccular aneurysm.
PharmGKBi PA36487.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40778.
HOGENOMi HOG000090193.
HOVERGENi HBG057515.
KOi K05843.
OMAi IENICPK.
OrthoDBi EOG72ZCDK.
PhylomeDBi Q03167.
TreeFami TF337375.

Miscellaneous databases

ChiTaRSi TGFBR3. human.
GeneWikii TGFBR3.
GenomeRNAii 7049.
NextBioi 27547.
PROi Q03167.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q03167.
Bgeei Q03167.
CleanExi HS_TGFBR3.
Genevestigatori Q03167.

Family and domain databases

InterProi IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
PROSITEi PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
    Moren A., Ichijo H., Miyazono K.
    Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PHE-15.
    Tissue: Placenta.
  2. "Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene."
    Zippert R., Baessler A., Holmer S.R., Hengstenberg C., Schunkert H.
    J. Hum. Genet. 45:250-253(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-15.
    Tissue: Blood.
  3. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-14; PHE-15; LEU-163; THR-635 AND ARG-765.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
    Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
    J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TCTEX1D4.

Entry informationi

Entry nameiTGBR3_HUMAN
AccessioniPrimary (citable) accession number: Q03167
Secondary accession number(s): A0AUW8
, A8K5N0, B9EG88, Q5T2T4, Q5U731, Q9UGI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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