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Protein

MYND-type zinc finger protein MUB1

Gene

MUB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the determination of the onset of polarized growth. Required for the ubiquitin-dependent degradation of RPN4. Cooperates with UBR2 to transfer ubiquitin from RAD6 to RPN4.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri514 – 55542MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MYND-type zinc finger protein MUB1
Alternative name(s):
Multi-budding protein
Gene namesi
Name:MUB1
Ordered Locus Names:YMR100W
ORF Names:YM6543.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR100W.
SGDiS000004706. MUB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • MUB1-RAD6-UBR2 ubiquitin ligase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620MYND-type zinc finger protein MUB1PRO_0000218323Add
BLAST

Proteomic databases

MaxQBiQ03162.

Interactioni

Subunit structurei

Interacts with UBR2 and RPN4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPN4Q034653EBI-28207,EBI-15931
UBR2Q079632EBI-28207,EBI-34338

Protein-protein interaction databases

BioGridi35276. 109 interactions.
DIPiDIP-6429N.
IntActiQ03162. 5 interactions.
MINTiMINT-707572.

Structurei

3D structure databases

ProteinModelPortaliQ03162.
SMRiQ03162. Positions 512-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The MYND-type zinc finger is essential for the ubiquitin-dependent degradation of RPN4.1 Publication

Sequence similaritiesi

Belongs to the MUB1/samB family.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri514 – 55542MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000066045.
InParanoidiQ03162.
OMAiAWKWTLA.
OrthoDBiEOG74N5S4.

Family and domain databases

InterProiIPR002893. Znf_MYND.
[Graphical view]
PfamiPF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDSNHRSLT SNKPIVTITS TVYDRRALDI NSSIPLINSL NYLTYLTSNS
60 70 80 90 100
SKVRETVAND GALERLVSIL RSCHLSLFEL LDLDLENFNE HENIKDLWKE
110 120 130 140 150
KRLALCAWKW TLTFQCLVLT GTRGTEQIRK KVVMSGVLSV LVTVLDNYLL
160 170 180 190 200
YHKNYDFIKD QTMTFDFKGI TTETMYKFMR KDENETYQQY IEFITGQDKL
210 220 230 240 250
KLSTDKNFLN ERLVAPSMTI PTDFSDIWGR FADLASNFEP DQERHDDDID
260 270 280 290 300
IDSEVESENF DAHKNFFSQP DINRPTISTP REFFLGRIVP KQDDVIWSLQ
310 320 330 340 350
LLAFVSKYTY MKSTLQNVEL VESLSFRSMA YKIKQRISEE NDLEEQERDV
360 370 380 390 400
TVKLSSLYPY LSKNPENNSK VKALDTSKMD PFFKELEELS NRCQQEEQNE
410 420 430 440 450
ICNNHCPVLN LFERYRVPKP SDDNAYGKDK ERINLRKKIS DNFERRWSYD
460 470 480 490 500
KMKKELTNIV YKNKVLTNVV NIFPLVEKYT VSAENTHDVI YWSSVIMRNS
510 520 530 540 550
CRKNEILGVR QCANFSCGKW EDFPRQFAKC RRCKRTKYCS RKCQLKAWGY
560 570 580 590 600
HRYWCHEVGS SHMRSTNTTT GVNTPNEPSS LNATATTAAD VSNSTSTFTP
610 620
NISTTVPDEI SNRDENSIPE
Length:620
Mass (Da):72,251
Last modified:November 1, 1997 - v1
Checksum:iE38AA57377082966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89901.1.
BK006946 Genomic DNA. Translation: DAA09997.1.
PIRiS55086.
RefSeqiNP_013818.1. NM_001182600.1.

Genome annotation databases

EnsemblFungiiYMR100W; YMR100W; YMR100W.
GeneIDi855126.
KEGGisce:YMR100W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89901.1.
BK006946 Genomic DNA. Translation: DAA09997.1.
PIRiS55086.
RefSeqiNP_013818.1. NM_001182600.1.

3D structure databases

ProteinModelPortaliQ03162.
SMRiQ03162. Positions 512-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35276. 109 interactions.
DIPiDIP-6429N.
IntActiQ03162. 5 interactions.
MINTiMINT-707572.

Proteomic databases

MaxQBiQ03162.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR100W; YMR100W; YMR100W.
GeneIDi855126.
KEGGisce:YMR100W.

Organism-specific databases

EuPathDBiFungiDB:YMR100W.
SGDiS000004706. MUB1.

Phylogenomic databases

HOGENOMiHOG000066045.
InParanoidiQ03162.
OMAiAWKWTLA.
OrthoDBiEOG74N5S4.

Enzyme and pathway databases

BioCyciYEAST:G3O-32800-MONOMER.

Miscellaneous databases

NextBioi978490.
PROiQ03162.

Family and domain databases

InterProiIPR002893. Znf_MYND.
[Graphical view]
PfamiPF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Integrity of a Zn finger-like domain in SamB is crucial for morphogenesis in ascomycetous fungi."
    Kruger M., Fischer R.
    EMBO J. 17:204-214(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation."
    Ju D., Wang X., Xu H., Xie Y.
    Mol. Cell. Biol. 28:1404-1412(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH UBR2 AND RPN4, DOMAIN.

Entry informationi

Entry nameiMUB1_YEAST
AccessioniPrimary (citable) accession number: Q03162
Secondary accession number(s): D6VZS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 125 molecules/cell in log phase SD medium.1 Publication
Is a short-lived protein whose degradation is dependent on the UBR2/RAD6 ubiquitin-protein ligase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.