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Q03161 (YMY9_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-epimerase
EC=5.1.3.15
Alternative name(s):
D-hexose-6-phosphate mutarotase
Gene names
Ordered Locus Names:YMR099C
ORF Names:YM6543.06C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). Ref.5

Catalytic activity

Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. Ref.5

Miscellaneous

Present with 8580 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the Glucose-6-phosphate 1-epimerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Glucose-6-phosphate 1-epimerase
PRO_0000213035

Sites

Active site1591 Ref.5
Active site2641 Ref.5
Binding site571Substrate
Binding site811Substrate
Binding site861Substrate

Amino acid modifications

Modified residue891Phosphothreonine Ref.4

Secondary structure

1 ............................................................. 297
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q03161 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 122BDC460BB9A32B

FASTA29733,956
        10         20         30         40         50         60 
MPIKETDKEV VLTHPADETT SVHILKYGAT VYSWKLKSEE QLWLSTAAKL DGSKPVRGGI 

        70         80         90        100        110        120 
PLVFPVFGKN STDEHLSKLP QHGLARNSTW EFLGQTKENP PTVQFGLKPE IANPELTKLW 

       130        140        150        160        170        180 
PMDYLLILTV ELGSDYLKTA IEVENTSSSK ELKFNWLFHT YFRIEDIEGT MVSNLAGMKL 

       190        200        210        220        230        240 
YDQLLKESYV DKHPVVTFNQ ETDVIYQNVS AERAIQIVDK GVQIHTLKRY NLPDTVVWNP 

       250        260        270        280        290 
WIEKSQGMAD FEPKTGYQQM ICIEPGHVHD FISLAPGKKW NAYQLLCKEE LKYQAIQ

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed: 9169872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-89, MASS SPECTROMETRY.
[5]"Structure-based functional annotation: yeast ymr099c codes for a D-hexose-6-phosphate mutarotase."
Graille M., Baltaze J.P., Leulliot N., Liger D., Quevillon-Cheruel S., van Tilbeurgh H.
J. Biol. Chem. 281:30175-30185(2006) [PubMed: 16857670] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) ALONE AND IN COMPLEX WITH GLC6P AND GAL6P, FUNCTION, CATALYTIC ACTIVITY, ACTIVE SITE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z49807 Genomic DNA. Translation: CAA89900.1.
BK006946 Genomic DNA. Translation: DAA09996.1.
PIRS55085.
RefSeqNP_013817.1. NM_001182599.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CIQX-ray1.70A1-297[»]
2CIRX-ray1.60A1-297[»]
2CISX-ray1.62A1-297[»]
ProteinModelPortalQ03161.
SMRQ03161. Positions 2-286.
ModBaseSearch...

Protein-protein interaction databases

IntActQ03161. 11 interactions.
STRINGQ03161.

Proteomic databases

PeptideAtlasQ03161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR099C; YMR099C; YMR099C.
GeneID855125.
KEGGsce:YMR099C.
NMPDRfig|4932.3.peg.4864.

Organism-specific databases

CYGDYMR099c.
SGDS000004705. YMR099C.

Phylogenomic databases

eggNOGfuNOG05014.
GeneTreeEFGT00050000001355.
HOGENOMHBG737737.
OMAKPFSFSI.
OrthoDBEOG4WM84D.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15670.

Gene expression databases

ArrayExpressQ03161.
GenevestigatorQ03161.
GermOnlineYMR099C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR008183. Aldose_1-epimerase.
IPR011013. Glyco_hydro-type_carb-bd.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
Gene3DG3DSA:2.70.98.10. Glyco_hydro_42_D5. 1 hit.
KOK01792.
PfamPF01263. Aldose_epim. 1 hit.
[Graphical view]
SUPFAMSSF74650. Gal_mut_like. 1 hit.
ProtoNetSearch...

Other

NextBio978487.

Entry information

Entry nameYMY9_YEAST
AccessionPrimary (citable) accession number: Q03161
Secondary accession number(s): D6VZS2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents