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Protein

Glucose-6-phosphate 1-epimerase

Gene

YMR099C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).1 Publication

Catalytic activityi

Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57Substrate1 Publication1
Binding sitei81Substrate1 Publication1
Binding sitei86Substrate1 Publication1
Active sitei1591 Publication1
Binding sitei203Substrate1 Publication1
Active sitei2641 Publication1

GO - Molecular functioni

  • carbohydrate binding Source: InterPro
  • glucose-6-phosphate 1-epimerase activity Source: SGD

GO - Biological processi

  • cellular carbohydrate metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32799-MONOMER.
YEAST:G3O-32799-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-epimeraseCurated (EC:5.1.3.151 Publication)
Alternative name(s):
D-hexose-6-phosphate mutarotase1 Publication
Gene namesi
Ordered Locus Names:YMR099C
ORF Names:YM6543.06C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR099C.
SGDiS000004705. YMR099C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002130351 – 297Glucose-6-phosphate 1-epimeraseAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03161.
PRIDEiQ03161.

PTM databases

iPTMnetiQ03161.

Interactioni

Protein-protein interaction databases

BioGridi35275. 24 interactors.
IntActiQ03161. 11 interactors.
MINTiMINT-4497865.

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi7 – 14Combined sources8
Beta strandi17 – 25Combined sources9
Beta strandi30 – 36Combined sources7
Beta strandi51 – 54Combined sources4
Beta strandi57 – 60Combined sources4
Beta strandi62 – 65Combined sources4
Beta strandi71 – 73Combined sources3
Helixi76 – 78Combined sources3
Helixi85 – 87Combined sources3
Beta strandi91 – 97Combined sources7
Turni98 – 101Combined sources4
Beta strandi102 – 107Combined sources6
Helixi109 – 111Combined sources3
Helixi114 – 119Combined sources6
Beta strandi125 – 132Combined sources8
Beta strandi134 – 144Combined sources11
Beta strandi152 – 158Combined sources7
Beta strandi161 – 163Combined sources3
Helixi167 – 169Combined sources3
Beta strandi170 – 174Combined sources5
Beta strandi179 – 182Combined sources4
Turni183 – 186Combined sources4
Beta strandi187 – 190Combined sources4
Beta strandi193 – 196Combined sources4
Beta strandi202 – 206Combined sources5
Beta strandi215 – 219Combined sources5
Beta strandi222 – 231Combined sources10
Beta strandi234 – 239Combined sources6
Helixi241 – 247Combined sources7
Helixi256 – 259Combined sources4
Beta strandi260 – 274Combined sources15
Beta strandi279 – 287Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CIQX-ray1.70A1-297[»]
2CIRX-ray1.60A1-297[»]
2CISX-ray1.62A1-297[»]
ProteinModelPortaliQ03161.
SMRiQ03161.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03161.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000015166.
HOGENOMiHOG000283048.
InParanoidiQ03161.
KOiK01792.
OMAiCPGVIAV.
OrthoDBiEOG092C3OXQ.

Family and domain databases

CDDicd09020. D-hex-6-P-epi_like. 1 hit.
Gene3Di2.70.98.10. 1 hit.
InterProiIPR008183. Aldose_1/G6P_1-epimerase.
IPR025532. G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF016020. PHexose_mutarotase. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKETDKEV VLTHPADETT SVHILKYGAT VYSWKLKSEE QLWLSTAAKL
60 70 80 90 100
DGSKPVRGGI PLVFPVFGKN STDEHLSKLP QHGLARNSTW EFLGQTKENP
110 120 130 140 150
PTVQFGLKPE IANPELTKLW PMDYLLILTV ELGSDYLKTA IEVENTSSSK
160 170 180 190 200
ELKFNWLFHT YFRIEDIEGT MVSNLAGMKL YDQLLKESYV DKHPVVTFNQ
210 220 230 240 250
ETDVIYQNVS AERAIQIVDK GVQIHTLKRY NLPDTVVWNP WIEKSQGMAD
260 270 280 290
FEPKTGYQQM ICIEPGHVHD FISLAPGKKW NAYQLLCKEE LKYQAIQ
Length:297
Mass (Da):33,956
Last modified:November 1, 1997 - v1
Checksum:i122BDC460BB9A32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89900.1.
BK006946 Genomic DNA. Translation: DAA09996.1.
PIRiS55085.
RefSeqiNP_013817.1. NM_001182599.1.

Genome annotation databases

EnsemblFungiiYMR099C; YMR099C; YMR099C.
GeneIDi855125.
KEGGisce:YMR099C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89900.1.
BK006946 Genomic DNA. Translation: DAA09996.1.
PIRiS55085.
RefSeqiNP_013817.1. NM_001182599.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CIQX-ray1.70A1-297[»]
2CIRX-ray1.60A1-297[»]
2CISX-ray1.62A1-297[»]
ProteinModelPortaliQ03161.
SMRiQ03161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35275. 24 interactors.
IntActiQ03161. 11 interactors.
MINTiMINT-4497865.

PTM databases

iPTMnetiQ03161.

Proteomic databases

MaxQBiQ03161.
PRIDEiQ03161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR099C; YMR099C; YMR099C.
GeneIDi855125.
KEGGisce:YMR099C.

Organism-specific databases

EuPathDBiFungiDB:YMR099C.
SGDiS000004705. YMR099C.

Phylogenomic databases

GeneTreeiENSGT00390000015166.
HOGENOMiHOG000283048.
InParanoidiQ03161.
KOiK01792.
OMAiCPGVIAV.
OrthoDBiEOG092C3OXQ.

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32799-MONOMER.
YEAST:G3O-32799-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ03161.
PROiQ03161.

Family and domain databases

CDDicd09020. D-hex-6-P-epi_like. 1 hit.
Gene3Di2.70.98.10. 1 hit.
InterProiIPR008183. Aldose_1/G6P_1-epimerase.
IPR025532. G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF016020. PHexose_mutarotase. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYMY9_YEAST
AccessioniPrimary (citable) accession number: Q03161
Secondary accession number(s): D6VZS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8580 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.