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Protein

Glucose-6-phosphate 1-epimerase

Gene

YMR099C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).1 Publication

Catalytic activityi

Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571Substrate1 Publication
Binding sitei81 – 811Substrate1 Publication
Binding sitei86 – 861Substrate1 Publication
Active sitei159 – 15911 Publication
Binding sitei203 – 2031Substrate1 Publication
Active sitei264 – 26411 Publication

GO - Molecular functioni

  • carbohydrate binding Source: InterPro
  • glucose-6-phosphate 1-epimerase activity Source: SGD

GO - Biological processi

  • cellular carbohydrate metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15670.
YEAST:G3O-32799-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-epimeraseCurated (EC:5.1.3.151 Publication)
Alternative name(s):
D-hexose-6-phosphate mutarotase1 Publication
Gene namesi
Ordered Locus Names:YMR099C
ORF Names:YM6543.06C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR099C.
SGDiS000004705. YMR099C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Glucose-6-phosphate 1-epimerasePRO_0000213035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03161.

PTM databases

iPTMnetiQ03161.

Interactioni

Protein-protein interaction databases

BioGridi35275. 24 interactions.
IntActiQ03161. 11 interactions.
MINTiMINT-4497865.

Structurei

Secondary structure

1
297
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi7 – 148Combined sources
Beta strandi17 – 259Combined sources
Beta strandi30 – 367Combined sources
Beta strandi51 – 544Combined sources
Beta strandi57 – 604Combined sources
Beta strandi62 – 654Combined sources
Beta strandi71 – 733Combined sources
Helixi76 – 783Combined sources
Helixi85 – 873Combined sources
Beta strandi91 – 977Combined sources
Turni98 – 1014Combined sources
Beta strandi102 – 1076Combined sources
Helixi109 – 1113Combined sources
Helixi114 – 1196Combined sources
Beta strandi125 – 1328Combined sources
Beta strandi134 – 14411Combined sources
Beta strandi152 – 1587Combined sources
Beta strandi161 – 1633Combined sources
Helixi167 – 1693Combined sources
Beta strandi170 – 1745Combined sources
Beta strandi179 – 1824Combined sources
Turni183 – 1864Combined sources
Beta strandi187 – 1904Combined sources
Beta strandi193 – 1964Combined sources
Beta strandi202 – 2065Combined sources
Beta strandi215 – 2195Combined sources
Beta strandi222 – 23110Combined sources
Beta strandi234 – 2396Combined sources
Helixi241 – 2477Combined sources
Helixi256 – 2594Combined sources
Beta strandi260 – 27415Combined sources
Beta strandi279 – 2879Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CIQX-ray1.70A1-297[»]
2CIRX-ray1.60A1-297[»]
2CISX-ray1.62A1-297[»]
ProteinModelPortaliQ03161.
SMRiQ03161. Positions 2-286.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03161.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000015166.
HOGENOMiHOG000283048.
InParanoidiQ03161.
KOiK01792.
OMAiNEWTARV.
OrthoDBiEOG7SFJ8S.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR008183. Aldose_1/G6P_1-epimerase.
IPR025532. G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF016020. PHexose_mutarotase. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKETDKEV VLTHPADETT SVHILKYGAT VYSWKLKSEE QLWLSTAAKL
60 70 80 90 100
DGSKPVRGGI PLVFPVFGKN STDEHLSKLP QHGLARNSTW EFLGQTKENP
110 120 130 140 150
PTVQFGLKPE IANPELTKLW PMDYLLILTV ELGSDYLKTA IEVENTSSSK
160 170 180 190 200
ELKFNWLFHT YFRIEDIEGT MVSNLAGMKL YDQLLKESYV DKHPVVTFNQ
210 220 230 240 250
ETDVIYQNVS AERAIQIVDK GVQIHTLKRY NLPDTVVWNP WIEKSQGMAD
260 270 280 290
FEPKTGYQQM ICIEPGHVHD FISLAPGKKW NAYQLLCKEE LKYQAIQ
Length:297
Mass (Da):33,956
Last modified:November 1, 1997 - v1
Checksum:i122BDC460BB9A32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89900.1.
BK006946 Genomic DNA. Translation: DAA09996.1.
PIRiS55085.
RefSeqiNP_013817.1. NM_001182599.1.

Genome annotation databases

EnsemblFungiiYMR099C; YMR099C; YMR099C.
GeneIDi855125.
KEGGisce:YMR099C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89900.1.
BK006946 Genomic DNA. Translation: DAA09996.1.
PIRiS55085.
RefSeqiNP_013817.1. NM_001182599.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CIQX-ray1.70A1-297[»]
2CIRX-ray1.60A1-297[»]
2CISX-ray1.62A1-297[»]
ProteinModelPortaliQ03161.
SMRiQ03161. Positions 2-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35275. 24 interactions.
IntActiQ03161. 11 interactions.
MINTiMINT-4497865.

PTM databases

iPTMnetiQ03161.

Proteomic databases

MaxQBiQ03161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR099C; YMR099C; YMR099C.
GeneIDi855125.
KEGGisce:YMR099C.

Organism-specific databases

EuPathDBiFungiDB:YMR099C.
SGDiS000004705. YMR099C.

Phylogenomic databases

GeneTreeiENSGT00390000015166.
HOGENOMiHOG000283048.
InParanoidiQ03161.
KOiK01792.
OMAiNEWTARV.
OrthoDBiEOG7SFJ8S.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15670.
YEAST:G3O-32799-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ03161.
PROiQ03161.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR008183. Aldose_1/G6P_1-epimerase.
IPR025532. G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF016020. PHexose_mutarotase. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Structure-based functional annotation: yeast ymr099c codes for a D-hexose-6-phosphate mutarotase."
    Graille M., Baltaze J.P., Leulliot N., Liger D., Quevillon-Cheruel S., van Tilbeurgh H.
    J. Biol. Chem. 281:30175-30185(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) ALONE AND IN COMPLEX WITH GLC6P AND GAL6P, FUNCTION, CATALYTIC ACTIVITY, ACTIVE SITE.

Entry informationi

Entry nameiYMY9_YEAST
AccessioniPrimary (citable) accession number: Q03161
Secondary accession number(s): D6VZS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8580 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.