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Protein

ATPase synthesis protein 25, mitochondrial

Gene

ATP25

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

mRNA stabilization factor specific for the 0.95 kb OLI1 mRNA. Also involved in OLI1 ring formation.1 Publication

GO - Biological processi

  1. mitochondrial proton-transporting ATP synthase complex assembly Source: SGD
  2. mRNA stabilization Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32798-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase synthesis protein 25, mitochondrial
Alternative name(s):
OLI1 mRNA stabilization factor
Gene namesi
Name:ATP25
Ordered Locus Names:YMR098C
ORF Names:YM6543.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR098c.
SGDiS000004704. ATP25.

Subcellular locationi

Mitochondrion inner membrane 3 Publications; Peripheral membrane protein 3 Publications; Matrix side 3 Publications

GO - Cellular componenti

  1. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1414MitochondrionSequence AnalysisAdd
BLAST
Chaini15 – 612598ATPase synthesis protein 25, mitochondrialPRO_0000203288Add
BLAST

Proteomic databases

MaxQBiQ03153.
PaxDbiQ03153.
PeptideAtlasiQ03153.

Expressioni

Gene expression databases

GenevestigatoriQ03153.

Interactioni

Protein-protein interaction databases

BioGridi35273. 7 interactions.
IntActiQ03153. 2 interactions.
MINTiMINT-2492603.
STRINGi4932.YMR098C.

Structurei

3D structure databases

ProteinModelPortaliQ03153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP25 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG41172.
InParanoidiQ03153.
OMAiTETHNIR.
OrthoDBiEOG70CRGD.

Family and domain databases

InterProiIPR025210. ATP25_mRNA_stabil_dom.
IPR025656. Oligomer_dom.
[Graphical view]
PfamiPF13929. mRNA_stabil. 1 hit.
PF02410. Oligomerisation. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKFCLLPFH GKRIGVANIP FTILFKKGPY FLHSHITAVY YSTKGKNDSH
60 70 80 90 100
EQSRVSKKST FTPLETPWYL RIVDNEKELM EGKKNNHHTM NKELEIPKTS
110 120 130 140 150
PNSLRKIADL LTGKLGLDDF LVFDLRKKSP NSVSAVNKLG DFMVICTARS
160 170 180 190 200
TKHCHKSFLE LNKFLKHEFC SSAYVEGNFN ERQESRRKRR LARKSNLSKL
210 220 230 240 250
LGRSSECSAK DLNSEAWYMI DCRVDGIFVN ILTQRRRNEL NLEELYAPEN
260 270 280 290 300
EKSKFQNIDS GNVPTISGVN EISSNNNILL GLRRLAQQRR RYSTINPNGL
310 320 330 340 350
SNLRYFLQKE DFKGANKIIQ SSSGTETHNI RTLEHVKNTL KDLVGQERKV
360 370 380 390 400
DVVQWKSLFD EHSTFLTINQ SAAYWPLRLE YAILLNKADP QFYSDRVFLK
410 420 430 440 450
DYLLLKKSLG QELIREDLIA LLEMVLKTQH SSHSYFNLVK QNRVIIRALN
460 470 480 490 500
LFKGLQTEDD GSVVYDEVVI SLLLNSMVAD ERVKLRSLYE TIDHIFQTFG
510 520 530 540 550
DKLTSGMIVS ILQNLAKIKD WNKLLQVWEA ITPTEGEGQD KRPWNEFINV
560 570 580 590 600
INQSGDSHVI SKIVNNGHLL WIRRLNVNVT PELCNSIKAL LKTAGMENST
610
LEEFLVRGTN NQ
Length:612
Mass (Da):70,414
Last modified:November 1, 1997 - v1
Checksum:iCC0B89608796A24F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89899.1.
BK006946 Genomic DNA. Translation: DAA09995.1.
PIRiS55084.
RefSeqiNP_013816.1. NM_001182598.1.

Genome annotation databases

EnsemblFungiiYMR098C; YMR098C; YMR098C.
GeneIDi855123.
KEGGisce:YMR098C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89899.1.
BK006946 Genomic DNA. Translation: DAA09995.1.
PIRiS55084.
RefSeqiNP_013816.1. NM_001182598.1.

3D structure databases

ProteinModelPortaliQ03153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35273. 7 interactions.
IntActiQ03153. 2 interactions.
MINTiMINT-2492603.
STRINGi4932.YMR098C.

Proteomic databases

MaxQBiQ03153.
PaxDbiQ03153.
PeptideAtlasiQ03153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR098C; YMR098C; YMR098C.
GeneIDi855123.
KEGGisce:YMR098C.

Organism-specific databases

CYGDiYMR098c.
SGDiS000004704. ATP25.

Phylogenomic databases

eggNOGiNOG41172.
InParanoidiQ03153.
OMAiTETHNIR.
OrthoDBiEOG70CRGD.

Enzyme and pathway databases

BioCyciYEAST:G3O-32798-MONOMER.

Miscellaneous databases

NextBioi978482.

Gene expression databases

GenevestigatoriQ03153.

Family and domain databases

InterProiIPR025210. ATP25_mRNA_stabil_dom.
IPR025656. Oligomer_dom.
[Graphical view]
PfamiPF13929. mRNA_stabil. 1 hit.
PF02410. Oligomerisation. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "ATP25, a new nuclear gene of Saccharomyces cerevisiae required for expression and assembly of the Atp9p subunit of mitochondrial ATPase."
    Zeng X., Barros M.H., Shulman T., Tzagoloff A.
    Mol. Biol. Cell 19:1366-1377(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATP25_YEAST
AccessioniPrimary (citable) accession number: Q03153
Secondary accession number(s): D6VZS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2430 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.