Q03153 (ATP25_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase synthesis protein 25, mitochondrial

Alternative name(s):
OLI1 mRNA stabilization factor

Gene names

Name:	ATP25
Ordered Locus Names:	YMR098C
ORF Names:	YM6543.05C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	612 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	mRNA stabilization factor specific for the 0.95 kb OLI1 mRNA. Also involved in OLI1 ring formation. Ref.6
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Ref.3 Ref.5 Ref.6.
Miscellaneous	Present with 2430 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ATP25 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA stabilization Inferred from mutant phenotype Ref.6. Source: SGD mitochondrial proton-transporting ATP synthase complex assembly Inferred from mutant phenotype Ref.6. Source: SGD
Cellular_component	mitochondrial inner membrane Inferred from direct assay Ref.6. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 14	14	Mitochondrion Potential
	Chain	15 – 612	598	ATPase synthesis protein 25, mitochondrial		PRO_0000203288

Sequences

	Sequence		Length	Mass (Da)
	Q03153 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: CC0B89608796A24F	FASTA	612	70,414
	10 20 30 40 50 60 MNKFCLLPFH GKRIGVANIP FTILFKKGPY FLHSHITAVY YSTKGKNDSH EQSRVSKKST 70 80 90 100 110 120 FTPLETPWYL RIVDNEKELM EGKKNNHHTM NKELEIPKTS PNSLRKIADL LTGKLGLDDF 130 140 150 160 170 180 LVFDLRKKSP NSVSAVNKLG DFMVICTARS TKHCHKSFLE LNKFLKHEFC SSAYVEGNFN 190 200 210 220 230 240 ERQESRRKRR LARKSNLSKL LGRSSECSAK DLNSEAWYMI DCRVDGIFVN ILTQRRRNEL 250 260 270 280 290 300 NLEELYAPEN EKSKFQNIDS GNVPTISGVN EISSNNNILL GLRRLAQQRR RYSTINPNGL 310 320 330 340 350 360 SNLRYFLQKE DFKGANKIIQ SSSGTETHNI RTLEHVKNTL KDLVGQERKV DVVQWKSLFD 370 380 390 400 410 420 EHSTFLTINQ SAAYWPLRLE YAILLNKADP QFYSDRVFLK DYLLLKKSLG QELIREDLIA 430 440 450 460 470 480 LLEMVLKTQH SSHSYFNLVK QNRVIIRALN LFKGLQTEDD GSVVYDEVVI SLLLNSMVAD 490 500 510 520 530 540 ERVKLRSLYE TIDHIFQTFG DKLTSGMIVS ILQNLAKIKD WNKLLQVWEA ITPTEGEGQD 550 560 570 580 590 600 KRPWNEFINV INQSGDSHVI SKIVNNGHLL WIRRLNVNVT PELCNSIKAL LKTAGMENST 610 LEEFLVRGTN NQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"ATP25, a new nuclear gene of Saccharomyces cerevisiae required for expression and assembly of the Atp9p subunit of mitochondrial ATPase." Zeng X., Barros M.H., Shulman T., Tzagoloff A. Mol. Biol. Cell 19:1366-1377(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49807 Genomic DNA. Translation: CAA89899.1. BK006946 Genomic DNA. Translation: DAA09995.1.
PIR	S55084.
RefSeq	NP_013816.1. NM_001182598.1.
3D structure databases
ProteinModelPortal	Q03153.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q03153. 2 interactions.
MINT	MINT-2492603.
STRING	4932.YMR098C.
Proteomic databases
PaxDb	Q03153.
PeptideAtlas	Q03153.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR098C; YMR098C; YMR098C.
GeneID	855123.
KEGG	sce:YMR098C.
Organism-specific databases
CYGD	YMR098c.
SGD	S000004704. ATP25.
Phylogenomic databases
eggNOG	NOG41172.
OMA	TETHNIR.
OrthoDB	EOG4TMVB1.
Gene expression databases
Genevestigator	Q03153.
GermOnline	YMR098C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR025210. ATP25_mRNA_stabil_dom. IPR025656. Oligomer_dom. [Graphical view]
Pfam	PF13929. mRNA_stabil. 1 hit. PF02410. Oligomerisation. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978482.

Entry information

Entry name

ATP25_YEAST

Accession

Primary (citable) accession number: Q03153
Secondary accession number(s): D6VZS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program