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Protein

Mitochondrial GTPase 1

Gene

MTG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial GTPase involved in assembly of the large ribosomal subunit (PubMed:12808030). Plays a role in expression of the mitochondrial translational machinery (PubMed:12808030).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 924GTPSequence analysis
Nucleotide bindingi160 – 1656GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrial translation Source: SGD
  • ribosome biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32797-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial GTPase 1
Gene namesi
Name:MTG1
Ordered Locus Names:YMR097C
ORF Names:YM6543.04C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR097C.
SGDiS000004703. MTG1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 367Mitochondrial GTPase 1PRO_0000203287
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ03151.

Interactioni

Protein-protein interaction databases

BioGridi35272. 13 interactions.
DIPiDIP-4441N.
IntActiQ03151. 3 interactions.
MINTiMINT-568915.

Structurei

3D structure databases

ProteinModelPortaliQ03151.
SMRiQ03151. Positions 37-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 228193CP-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00500000044923.
HOGENOMiHOG000173971.
InParanoidiQ03151.
KOiK19828.
OMAiQADYLLY.
OrthoDBiEOG73NGD9.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHINVRGTRK IISNVSSFTP RYEFPKYSMP LTDFKGHQVK ALKTFEKLLP
60 70 80 90 100
QMNMIIELRD IRAPLSTRNV VFDRIARKEH DVMKLVVYTR KDLMPGNKPY
110 120 130 140 150
IGKLKNWHEE LGEKFILLDC RNKTDVRNLL KILEWQNYEL ETNGGYLPMG
160 170 180 190 200
YRALITGMPN VGKSTLINSL RTIFHNQVNM GRKFKKVAKT GAEAGVTRAT
210 220 230 240 250
SEVIRVTSRN TESRNEIYLI DTPGIGVPGR VSDHNRMLGL ALCGSVKNNL
260 270 280 290 300
VDPIFQADYL LYLMNLQNLN DGRTELYPGS TNSPTNDIYD VLRRLQVNKS
310 320 330 340 350
QNEKSTAIEW TNKWRLHGKG IIFDPEVLLN NDEFSYKNYV NDQLEKLGDL
360
SYEGLSNKLK GNPNQVF
Length:367
Mass (Da):42,144
Last modified:November 1, 1997 - v1
Checksum:iC8FFF830B65A9E49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89898.1.
BK006946 Genomic DNA. Translation: DAA09994.1.
PIRiS55083.
RefSeqiNP_013815.1. NM_001182597.1.

Genome annotation databases

EnsemblFungiiYMR097C; YMR097C; YMR097C.
GeneIDi855122.
KEGGisce:YMR097C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49807 Genomic DNA. Translation: CAA89898.1.
BK006946 Genomic DNA. Translation: DAA09994.1.
PIRiS55083.
RefSeqiNP_013815.1. NM_001182597.1.

3D structure databases

ProteinModelPortaliQ03151.
SMRiQ03151. Positions 37-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35272. 13 interactions.
DIPiDIP-4441N.
IntActiQ03151. 3 interactions.
MINTiMINT-568915.

Proteomic databases

MaxQBiQ03151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR097C; YMR097C; YMR097C.
GeneIDi855122.
KEGGisce:YMR097C.

Organism-specific databases

EuPathDBiFungiDB:YMR097C.
SGDiS000004703. MTG1.

Phylogenomic databases

GeneTreeiENSGT00500000044923.
HOGENOMiHOG000173971.
InParanoidiQ03151.
KOiK19828.
OMAiQADYLLY.
OrthoDBiEOG73NGD9.

Enzyme and pathway databases

BioCyciYEAST:G3O-32797-MONOMER.

Miscellaneous databases

PROiQ03151.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "MTG1 codes for a conserved protein required for mitochondrial translation."
    Barrientos A., Korr D., Barwell K.J., Sjulsen C., Gajewski C.D., Manfredi G., Ackerman S., Tzagoloff A.
    Mol. Biol. Cell 14:2292-2302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTG1_YEAST
AccessioniPrimary (citable) accession number: Q03151
Secondary accession number(s): D6VZS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.