Pyridoxine biosynthesis protein SNZ1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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Q03148 (SNZ1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Pyridoxine biosynthesis protein SNZ1

Alternative name(s):
PDX1 homolog 1
p35

Gene names

Name:	SNZ1
Ordered Locus Names:	YMR096W
ORF Names:	YM6543.03

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the production of pyridoxine (vitamin B6). May be involved in growth arrest and cellular response to nutrient limitation. Required for growth in the presence of low level of intracellular pyridoxine. Ref.6 Ref.7
Subunit structure	Interacts with YHR198C/FMP22. Ref.6
Developmental stage	Shows increased synthesis after entry into stationary phase.
Disruption phenotype	Defects cause some sensibility to 6-azauracil, an inhibitor of purine and pyrimidine biosynthetic enzymes, and methylene blue, a producer of singlet oxygen. These effects are probably due to the inability to synthesize pyridoxine. Ref.6
Sequence similarities	Belongs to the pdxS/SNZ family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyridoxal phosphate biosynthetic process Inferred from electronic annotation. Source: InterPro pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SNO1	Q03144	4	EBI-17618,EBI-28190

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 297

297

Pyridoxine biosynthesis protein SNZ1

PRO_0000109358

Secondary structure

297

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q03148 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C5BC77711B415D9F
Show »

FASTA

297

31,817

        10         20         30         40         50         60 
MTGEDFKIKS GLAQMLKGGV IMDVVTPEQA KIAEKSGACA VMALESIPAD MRKSGKVCRM 

        70         80         90        100        110        120 
SDPKMIKDIM NSVSIPVMAK VRIGHFVEAQ IIEALEVDYI DESEVLTPAD WTHHIEKDKF 

       130        140        150        160        170        180 
KVPFVCGAKD LGEALRRINE GAAMIRTKGE AGTGDVSEAV KHIRRITEEI KACQQLKSED 

       190        200        210        220        230        240 
DIAKVAEEMR VPVSLLKDVL EKGKLPVVNF AAGGVATPAD AALLMQLGCD GVFVGSGIFK 

       250        260        270        280        290 
SSNPVRLATA VVEATTHFDN PSKLLEVSSD LGELMGGVSI ESISHASNGV RLSEIGW

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family." Braun E.L., Fuge E.K., Padilla P.A., Werner-Washburne M. J. Bacteriol. 178:6865-6872(1996) [PubMed: 8955308] [Abstract] Cited for: IDENTIFICATION.
[4]	"The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation." Padilla P.A., Fuge E.K., Crawford M.E., Errett A., Werner-Washburne M. J. Bacteriol. 180:5718-5726(1998) [PubMed: 9791124] [Abstract] Cited for: INDUCTION.
[5]	Erratum Padilla P.A., Fuge E.K., Crawford M.E., Errett A., Werner-Washburne M. J. Bacteriol. 180:6794-6794(1998)
[6]	"Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6." Rodriguez-Navarro S., Llorente B., Rodriguez-Manzaneque M.T., Ramne A., Uber G., Marchesan D., Dujon B., Herrero E., Sunnerhagen P., Perez-Ortin J.E. Yeast 19:1261-1276(2002) [PubMed: 12271461] [Abstract] Cited for: FUNCTION, INTERACTION WITH FMP22, DISRUPTION PHENOTYPE.
[7]	"Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae." Stolz J., Vielreicher M. J. Biol. Chem. 278:18990-18996(2003) [PubMed: 12649274] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z49807 Genomic DNA. Translation: CAA89897.1.
BK006946 Genomic DNA. Translation: DAA09993.1.

PIR

S55082.

RefSeq

NP_013814.1. NM_001182596.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FEM	X-ray	3.02	A/B/C/D/E/F	1-297	[»]
3O05	X-ray	2.20	A/B/C	15-297	[»]
3O06	X-ray	2.35	A/B/C	15-297	[»]
3O07	X-ray	1.80	A/B/C	15-297	[»]

ProteinModelPortal

Q03148.

SMR

Q03148. Positions 16-274.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-1643N.

IntAct

Q03148. 11 interactions.

MINT

MINT-386894.

STRING

Q03148.

2D gel databases

UCD-2DPAGE

Q03148.

Proteomic databases

PeptideAtlas

Q03148.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YMR096W; YMR096W; YMR096W.

GeneID

855121.

KEGG

sce:YMR096W.

NMPDR

fig|4932.3.peg.4861.

Organism-specific databases

CYGD

YMR096w.

SGD

S000004702. SNZ1.

Phylogenomic databases

eggNOG

fuNOG06628.

GeneTree

EFGT00050000004159.

HOGENOM

HBG292342.

OMA

VEATYNF.

OrthoDB

EOG4C5GTD.

Gene expression databases

ArrayExpress

Q03148.

Genevestigator

Q03148.

GermOnline

YMR096W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR001852. Snz1p/Sor1.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 2 hits.

K06215.

PANTHER

PTHR22854:SF9. PTHR22854:SF9. 1 hit.

Pfam

PF01680. SOR_SNZ. 1 hit.
[Graphical view]

PIRSF

PIRSF029271. Pdx1. 1 hit.

SUPFAM

SSF51366. RibP_bind_barrel. 1 hit.

TIGRFAMs

TIGR00343. TIGR00343. 1 hit.

PROSITE

PS01235. PDXS_SNZ_1. 1 hit.
PS51129. PDXS_SNZ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

978476.

Entry information

Entry name

SNZ1_YEAST

Accession

Primary (citable) accession number: Q03148
Secondary accession number(s): D6VZR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents