Reviewed, UniProtKB/Swiss-Prot Q03148 (SNZ1_YEAST)

Names and origin

Protein names

Recommended name:
    Pyridoxine biosynthesis protein SNZ1
Alternative name(s):
    PDX1 homolog 1
    p35

Gene names

Name:	SNZ1
Ordered Locus Names:	YMR096W
ORF Names:	YM6543.03

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for the production of pyridoxine (vitamin B6). May be involved in growth arrest and cellular response to nutrient limitation. Required for growth in the presence of low level of intracellular pyridoxine. Ref.5 Ref.6
Subunit structure	Interacts with YHR198C/FMP22. Ref.5
Developmental stage	Shows increased synthesis after entry into stationary phase.
Disruption phenotype	Defects cause some sensibility to 6-azauracil, an inhibitor of purine and pyrimidine biosynthetic enzymes, and methylene blue, a producer of singlet oxygen. These effects are probably due to the inability to synthesize pyridoxine. Ref.5
Sequence similarities	Belongs to the pdxS/SNZ family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-17618,EBI-17618
SNO1	Q03144	3	EBI-17618,EBI-28190
SNO3	P43544	2	EBI-17618,EBI-22871
SNZ2	P53824	1	EBI-17618,EBI-17623
SNZ3	P43545	1	EBI-17618,EBI-17629

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 297

297

Pyridoxine biosynthesis protein SNZ1

PRO_0000109358

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

297

Helix Strand Turn

Details...

Helix

5 – 9

5

Helix

14 – 16

3

Beta strand

21 – 26

6

Helix

27 – 34

8

Beta strand

40 – 43

4

Helix

48 – 51

4

Helix

63 – 70

8

Beta strand

77 – 81

5

Helix

86 – 95

10

Beta strand

98 – 102

5

Helix

117 – 119

3

Beta strand

124 – 126

3

Helix

134 – 139

6

Beta strand

144 – 146

3

Helix

157 – 174

18

Helix

179 – 188

10

Helix

193 – 201

9

Beta strand

206 – 210

5

Helix

218 – 226

9

Beta strand

241 – 243

3

Helix

244 – 256

13

Turn

257 – 259

3

Helix

261 – 267

7

Helix

280 – 282

3

Sequences

	Sequence		Length	Mass (Da)
	Q03148-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C5BC77711B415D9F	FASTA	297	31,817
	10 20 30 40 50 60 MTGEDFKIKS GLAQMLKGGV IMDVVTPEQA KIAEKSGACA VMALESIPAD MRKSGKVCRM 70 80 90 100 110 120 SDPKMIKDIM NSVSIPVMAK VRIGHFVEAQ IIEALEVDYI DESEVLTPAD WTHHIEKDKF 130 140 150 160 170 180 KVPFVCGAKD LGEALRRINE GAAMIRTKGE AGTGDVSEAV KHIRRITEEI KACQQLKSED 190 200 210 220 230 240 DIAKVAEEMR VPVSLLKDVL EKGKLPVVNF AAGGVATPAD AALLMQLGCD GVFVGSGIFK 250 260 270 280 290 SSNPVRLATA VVEATTHFDN PSKLLEVSSD LGELMGGVSI ESISHASNGV RLSEIGW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family." Braun E.L., Fuge E.K., Padilla P.A., Werner-Washburne M. J. Bacteriol. 178:6865-6872(1996) [PubMed: 8955308] [Abstract] Cited for: IDENTIFICATION.
[3]	"The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation." Padilla P.A., Fuge E.K., Crawford M.E., Errett A., Werner-Washburne M. J. Bacteriol. 180:5718-5726(1998) [PubMed: 9791124] [Abstract] Cited for: INDUCTION.
[4]	Erratum Padilla P.A., Fuge E.K., Crawford M.E., Errett A., Werner-Washburne M. J. Bacteriol. 180:6794-6794(1998)
[5]	"Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6." Rodriguez-Navarro S., Llorente B., Rodriguez-Manzaneque M.T., Ramne A., Uber G., Marchesan D., Dujon B., Herrero E., Sunnerhagen P., Perez-Ortin J.E. Yeast 19:1261-1276(2002) [PubMed: 12271461] [Abstract] Cited for: FUNCTION, INTERACTION WITH FMP22, DISRUPTION PHENOTYPE.
[6]	"Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae." Stolz J., Vielreicher M. J. Biol. Chem. 278:18990-18996(2003) [PubMed: 12649274] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

Z49807 Genomic DNA. Translation: CAA89897.1.

PIR

S55082.

RefSeq

NP_013814.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FEM	X-ray	3.02	A/B/C/D/E/F	1-297	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:1643N.

IntAct

Q03148. 10 interactions.

STRING

Q03148.

Proteomic databases

PeptideAtlas

Q03148.

PRIDE

Q03148.

Genome annotation databases

Ensembl

YMR096W; YMR096W; YMR096W; Saccharomyces cerevisiae. [Genome view]

GeneID

855121.

GenomeReviews

Gene locus YMR096W in contig Z71257_GR.

KEGG

sce:YMR096W.

NMPDR

fig|4932.3.peg.4861.

Organism-specific databases

CYGD

YMR096w.

SGD

S000004702. SNZ1.

Phylogenomic databases

HOGENOM

Q03148.

OMA

VGYKEMG.

Gene expression databases

ArrayExpress

Q03148.

Genevestigator

Q03148.

GermOnline

YMR096W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR001852. Snz1p/Sor1.
[Graphical view]

Pfam

PF01680. SOR_SNZ. 1 hit.
[Graphical view]

PIRSF

PIRSF029271. Pdx1. 1 hit.

ProDom

PD004958. Snz1p/Sor1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00343. Snz1p/Sor1. 1 hit.

PROSITE

PS01235. PDXS_SNZ_1. 1 hit.
PS51129. PDXS_SNZ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

978476.

Entry information

Entry name

SNZ1_YEAST

Accession

Primary (citable) accession number: Q03148

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 3, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)